Incidental Mutation 'R0532:Shprh'
| ID |
49263 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Shprh
|
| Ensembl Gene |
ENSMUSG00000090112 |
| Gene Name |
SNF2 histone linker PHD RING helicase |
| Synonyms |
2610103K11Rik, D230017O13Rik |
| MMRRC Submission |
038724-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R0532 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
10 |
| Chromosomal Location |
11025171-11093339 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
C to A
at 11038556 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Threonine to Lysine
at position 437
(T437K)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000125457
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000044053]
[ENSMUST00000054814]
[ENSMUST00000159541]
[ENSMUST00000159810]
[ENSMUST00000160461]
|
| AlphaFold |
Q7TPQ3 |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000044053
AA Change: T437K
PolyPhen 2
Score 0.903 (Sensitivity: 0.82; Specificity: 0.94)
|
| SMART Domains |
Protein: ENSMUSP00000039422
Gene: ENSMUSG00000090112
AA Change: T437K
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
42 |
56 |
N/A |
INTRINSIC |
|
Blast:DEXDc
|
195 |
250 |
3e-12 |
BLAST |
|
low complexity region
|
253 |
265 |
N/A |
INTRINSIC |
|
DEXDc
|
295 |
866 |
4.02e-17 |
SMART |
|
H15
|
431 |
497 |
3.76e-5 |
SMART |
|
PHD
|
651 |
698 |
2.33e-5 |
SMART |
|
low complexity region
|
1393 |
1404 |
N/A |
INTRINSIC |
|
RING
|
1423 |
1469 |
9.68e-3 |
SMART |
|
Pfam:Helicase_C
|
1500 |
1613 |
1.6e-8 |
PFAM |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000054814
AA Change: T437K
PolyPhen 2
Score 0.903 (Sensitivity: 0.82; Specificity: 0.94)
|
| SMART Domains |
Protein: ENSMUSP00000125849
Gene: ENSMUSG00000090112
AA Change: T437K
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
42 |
56 |
N/A |
INTRINSIC |
|
Blast:DEXDc
|
195 |
250 |
3e-12 |
BLAST |
|
low complexity region
|
253 |
265 |
N/A |
INTRINSIC |
|
DEXDc
|
295 |
866 |
4.02e-17 |
SMART |
|
H15
|
431 |
497 |
3.76e-5 |
SMART |
|
PHD
|
651 |
698 |
2.33e-5 |
SMART |
|
low complexity region
|
1393 |
1404 |
N/A |
INTRINSIC |
|
RING
|
1423 |
1469 |
9.68e-3 |
SMART |
|
SCOP:d1fuka_
|
1504 |
1616 |
6e-8 |
SMART |
|
Blast:HELICc
|
1533 |
1613 |
4e-46 |
BLAST |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000159541
AA Change: T437K
PolyPhen 2
Score 0.903 (Sensitivity: 0.82; Specificity: 0.94)
|
| SMART Domains |
Protein: ENSMUSP00000132870
Gene: ENSMUSG00000090112
AA Change: T437K
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
42 |
56 |
N/A |
INTRINSIC |
|
Blast:DEXDc
|
195 |
250 |
3e-12 |
BLAST |
|
low complexity region
|
253 |
265 |
N/A |
INTRINSIC |
|
DEXDc
|
295 |
866 |
4.02e-17 |
SMART |
|
H15
|
431 |
497 |
3.76e-5 |
SMART |
|
PHD
|
651 |
698 |
2.33e-5 |
SMART |
|
low complexity region
|
1393 |
1404 |
N/A |
INTRINSIC |
|
RING
|
1423 |
1469 |
9.68e-3 |
SMART |
|
SCOP:d1fuka_
|
1504 |
1619 |
4e-8 |
SMART |
|
Blast:HELICc
|
1533 |
1613 |
6e-46 |
BLAST |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000159553
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000159810
AA Change: T437K
PolyPhen 2
Score 0.903 (Sensitivity: 0.82; Specificity: 0.94)
|
| SMART Domains |
Protein: ENSMUSP00000125457
Gene: ENSMUSG00000090112
AA Change: T437K
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
42 |
56 |
N/A |
INTRINSIC |
|
Blast:DEXDc
|
195 |
250 |
2e-12 |
BLAST |
|
low complexity region
|
253 |
265 |
N/A |
INTRINSIC |
|
DEXDc
|
295 |
866 |
4.02e-17 |
SMART |
|
H15
|
431 |
497 |
3.76e-5 |
SMART |
|
PHD
|
651 |
698 |
2.33e-5 |
SMART |
|
Blast:DEXDc
|
948 |
1026 |
2e-9 |
BLAST |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000160461
|
| SMART Domains |
Protein: ENSMUSP00000125127
Gene: ENSMUSG00000090112
| Domain | Start | End | E-Value | Type |
|---|
|
PHD
|
131 |
178 |
2.33e-5 |
SMART |
|
| Meta Mutation Damage Score |
0.1416 |
| Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.4%
- 10x: 96.5%
- 20x: 93.2%
|
| Validation Efficiency |
100% (90/90) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] SHPRH is a ubiquitously expressed protein that contains motifs characteristics of several DNA repair proteins, transcription factors, and helicases. SHPRH is a functional homolog of S. cerevisiae RAD5 (Unk et al., 2006 [PubMed 17108083]).[supplied by OMIM, Mar 2008]
PHENOTYPE: The gene product is an E3 ligase involved in poly-ubiquitination of Pcna. Neither homozygous truncation nor KO affect B cell somatic hypermutation or class switching. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 91 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 4921524L21Rik |
A |
T |
18: 6,638,618 (GRCm39) |
E339V |
possibly damaging |
Het |
| 9230009I02Rik |
A |
T |
11: 50,982,405 (GRCm39) |
|
noncoding transcript |
Het |
| 9230112D13Rik |
A |
T |
14: 34,234,054 (GRCm39) |
I79K |
unknown |
Het |
| Adam25 |
C |
T |
8: 41,208,987 (GRCm39) |
T751I |
probably benign |
Het |
| Adgrv1 |
C |
A |
13: 81,727,015 (GRCm39) |
V446L |
probably damaging |
Het |
| Afap1 |
C |
A |
5: 36,125,944 (GRCm39) |
A313D |
possibly damaging |
Het |
| Akap6 |
A |
G |
12: 52,934,766 (GRCm39) |
T753A |
probably benign |
Het |
| Aldh16a1 |
G |
T |
7: 44,792,262 (GRCm39) |
T730N |
probably damaging |
Het |
| Amfr |
A |
T |
8: 94,725,736 (GRCm39) |
M215K |
probably damaging |
Het |
| Apob |
A |
G |
12: 8,066,188 (GRCm39) |
R4386G |
possibly damaging |
Het |
| Arhgap45 |
A |
T |
10: 79,857,917 (GRCm39) |
M217L |
possibly damaging |
Het |
| Baiap2l2 |
C |
T |
15: 79,168,276 (GRCm39) |
E49K |
possibly damaging |
Het |
| Baz1a |
C |
T |
12: 54,981,605 (GRCm39) |
E350K |
possibly damaging |
Het |
| Bbx |
A |
T |
16: 50,086,647 (GRCm39) |
V83D |
probably damaging |
Het |
| Btaf1 |
T |
C |
19: 36,928,586 (GRCm39) |
|
probably benign |
Het |
| Cacna2d1 |
G |
A |
5: 16,567,271 (GRCm39) |
E942K |
probably benign |
Het |
| Cad |
T |
C |
5: 31,219,531 (GRCm39) |
|
probably benign |
Het |
| Ccdc96 |
A |
G |
5: 36,643,710 (GRCm39) |
K572R |
probably benign |
Het |
| Cdc5l |
G |
A |
17: 45,726,610 (GRCm39) |
R321W |
probably damaging |
Het |
| Cep164 |
G |
A |
9: 45,721,124 (GRCm39) |
R93* |
probably null |
Het |
| Cir1 |
A |
G |
2: 73,140,799 (GRCm39) |
|
probably null |
Het |
| Crocc |
A |
G |
4: 140,757,558 (GRCm39) |
S912P |
possibly damaging |
Het |
| Cwf19l2 |
T |
C |
9: 3,431,057 (GRCm39) |
L463P |
probably benign |
Het |
| Cyp3a59 |
C |
T |
5: 146,033,463 (GRCm39) |
Q200* |
probably null |
Het |
| Cyp4b1 |
G |
T |
4: 115,484,073 (GRCm39) |
P303T |
probably damaging |
Het |
| Dcbld1 |
C |
A |
10: 52,193,173 (GRCm39) |
T306K |
probably benign |
Het |
| Dgat2 |
A |
G |
7: 98,818,988 (GRCm39) |
V56A |
possibly damaging |
Het |
| Dnajc16 |
A |
C |
4: 141,516,320 (GRCm39) |
L16R |
probably damaging |
Het |
| Dnmt1 |
A |
C |
9: 20,829,852 (GRCm39) |
|
probably benign |
Het |
| Dus3l |
A |
G |
17: 57,076,308 (GRCm39) |
I528V |
probably damaging |
Het |
| Egflam |
T |
C |
15: 7,263,718 (GRCm39) |
D744G |
probably benign |
Het |
| Epb41 |
A |
C |
4: 131,706,106 (GRCm39) |
|
probably benign |
Het |
| Eri2 |
C |
T |
7: 119,385,206 (GRCm39) |
V432I |
probably benign |
Het |
| Esyt2 |
A |
G |
12: 116,320,818 (GRCm39) |
|
probably benign |
Het |
| Extl3 |
A |
T |
14: 65,315,122 (GRCm39) |
M20K |
probably benign |
Het |
| Fam32a |
A |
G |
8: 72,976,063 (GRCm39) |
Y103C |
probably damaging |
Het |
| Fat4 |
T |
C |
3: 39,035,870 (GRCm39) |
V3174A |
probably benign |
Het |
| Fbxo40 |
T |
A |
16: 36,789,984 (GRCm39) |
E375D |
possibly damaging |
Het |
| Frrs1 |
A |
G |
3: 116,676,813 (GRCm39) |
T182A |
probably benign |
Het |
| Fry |
A |
G |
5: 150,357,172 (GRCm39) |
|
probably benign |
Het |
| Fry |
T |
C |
5: 150,402,226 (GRCm39) |
|
probably benign |
Het |
| Fsip2 |
A |
G |
2: 82,808,129 (GRCm39) |
I1483V |
probably benign |
Het |
| Glra3 |
T |
A |
8: 56,578,111 (GRCm39) |
D389E |
probably benign |
Het |
| Gpr3 |
A |
T |
4: 132,937,796 (GRCm39) |
I292N |
probably damaging |
Het |
| Grina |
T |
C |
15: 76,133,045 (GRCm39) |
M230T |
probably damaging |
Het |
| Igkv11-125 |
G |
A |
6: 67,890,603 (GRCm39) |
W16* |
probably null |
Het |
| Il18r1 |
T |
C |
1: 40,514,061 (GRCm39) |
V89A |
probably damaging |
Het |
| Ino80 |
T |
C |
2: 119,212,464 (GRCm39) |
E1286G |
possibly damaging |
Het |
| Iqch |
G |
A |
9: 63,415,514 (GRCm39) |
|
probably benign |
Het |
| Itpr2 |
G |
T |
6: 146,013,898 (GRCm39) |
Q2666K |
probably damaging |
Het |
| Kcnh3 |
A |
G |
15: 99,130,844 (GRCm39) |
D487G |
probably damaging |
Het |
| Kdm1a |
A |
G |
4: 136,288,377 (GRCm39) |
L402P |
probably damaging |
Het |
| Klhl10 |
T |
G |
11: 100,337,937 (GRCm39) |
|
probably benign |
Het |
| Krt39 |
T |
C |
11: 99,405,617 (GRCm39) |
T428A |
possibly damaging |
Het |
| Mapk3 |
G |
A |
7: 126,362,558 (GRCm39) |
|
probably benign |
Het |
| Med13l |
T |
A |
5: 118,897,188 (GRCm39) |
S2089T |
possibly damaging |
Het |
| Mex3c |
G |
A |
18: 73,723,124 (GRCm39) |
D406N |
possibly damaging |
Het |
| Mki67 |
G |
A |
7: 135,299,893 (GRCm39) |
R1714* |
probably null |
Het |
| Mmp9 |
C |
A |
2: 164,791,740 (GRCm39) |
S211* |
probably null |
Het |
| Nat8f2 |
G |
T |
6: 85,844,784 (GRCm39) |
Q193K |
probably benign |
Het |
| Omt2a |
C |
A |
9: 78,220,187 (GRCm39) |
A71S |
possibly damaging |
Het |
| Or10ak11 |
T |
G |
4: 118,686,897 (GRCm39) |
T247P |
probably damaging |
Het |
| Or5ac22 |
T |
C |
16: 59,134,964 (GRCm39) |
K269E |
probably benign |
Het |
| Pdgfra |
G |
A |
5: 75,331,434 (GRCm39) |
V315I |
probably benign |
Het |
| Pdgfrb |
A |
G |
18: 61,216,337 (GRCm39) |
D1065G |
probably damaging |
Het |
| Pfas |
A |
T |
11: 68,893,455 (GRCm39) |
|
probably benign |
Het |
| Pramel5 |
T |
C |
4: 143,999,310 (GRCm39) |
E259G |
probably benign |
Het |
| Prpf6 |
A |
G |
2: 181,264,004 (GRCm39) |
Y222C |
possibly damaging |
Het |
| Rbck1 |
C |
A |
2: 152,166,250 (GRCm39) |
Q229H |
probably damaging |
Het |
| Rdm1 |
T |
A |
11: 101,526,661 (GRCm39) |
C278S |
probably benign |
Het |
| Sall1 |
T |
C |
8: 89,759,819 (GRCm39) |
D95G |
probably benign |
Het |
| Scn1a |
T |
A |
2: 66,148,167 (GRCm39) |
D1126V |
probably damaging |
Het |
| Scn4a |
C |
T |
11: 106,221,226 (GRCm39) |
G811D |
probably benign |
Het |
| Sh2b1 |
A |
G |
7: 126,071,444 (GRCm39) |
I247T |
probably benign |
Het |
| Slc13a4 |
A |
T |
6: 35,264,339 (GRCm39) |
|
probably null |
Het |
| Slc16a1 |
C |
A |
3: 104,560,734 (GRCm39) |
Y346* |
probably null |
Het |
| Slc25a38 |
G |
T |
9: 119,949,772 (GRCm39) |
A163S |
probably damaging |
Het |
| Slc6a12 |
G |
A |
6: 121,333,877 (GRCm39) |
V238I |
probably damaging |
Het |
| Slc8b1 |
C |
A |
5: 120,657,736 (GRCm39) |
D66E |
probably damaging |
Het |
| Snapin |
A |
G |
3: 90,396,893 (GRCm39) |
L106P |
probably damaging |
Het |
| Tas2r122 |
G |
A |
6: 132,688,791 (GRCm39) |
S34F |
possibly damaging |
Het |
| Tiam2 |
A |
G |
17: 3,471,921 (GRCm39) |
K521R |
probably damaging |
Het |
| Tmem81 |
C |
G |
1: 132,435,567 (GRCm39) |
I124M |
probably damaging |
Het |
| Ttc3 |
T |
C |
16: 94,188,189 (GRCm39) |
|
probably benign |
Het |
| Uba1y |
T |
C |
Y: 820,911 (GRCm39) |
F31L |
probably benign |
Het |
| Ucp3 |
A |
G |
7: 100,131,186 (GRCm39) |
|
probably benign |
Het |
| Vcan |
T |
C |
13: 89,851,891 (GRCm39) |
E1023G |
probably damaging |
Het |
| Vmn2r45 |
A |
G |
7: 8,474,820 (GRCm39) |
I736T |
probably damaging |
Het |
| Vps36 |
T |
C |
8: 22,708,261 (GRCm39) |
F342L |
probably benign |
Het |
| Zc3hc1 |
A |
G |
6: 30,374,929 (GRCm39) |
|
probably benign |
Het |
| Zmym4 |
G |
A |
4: 126,792,194 (GRCm39) |
Q596* |
probably null |
Het |
|
| Other mutations in Shprh |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00492:Shprh
|
APN |
10 |
11,063,902 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00583:Shprh
|
APN |
10 |
11,063,764 (GRCm39) |
missense |
probably benign |
0.37 |
|
IGL00684:Shprh
|
APN |
10 |
11,038,781 (GRCm39) |
missense |
probably benign |
0.11 |
|
IGL01295:Shprh
|
APN |
10 |
11,059,612 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL01387:Shprh
|
APN |
10 |
11,045,998 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01635:Shprh
|
APN |
10 |
11,045,763 (GRCm39) |
nonsense |
probably null |
|
|
IGL01833:Shprh
|
APN |
10 |
11,066,806 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02013:Shprh
|
APN |
10 |
11,057,246 (GRCm39) |
splice site |
probably benign |
|
|
IGL02502:Shprh
|
APN |
10 |
11,070,101 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
IGL02819:Shprh
|
APN |
10 |
11,030,509 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
PIT4581001:Shprh
|
UTSW |
10 |
11,068,238 (GRCm39) |
frame shift |
probably null |
|
|
R0010:Shprh
|
UTSW |
10 |
11,027,675 (GRCm39) |
missense |
probably benign |
|
|
R0010:Shprh
|
UTSW |
10 |
11,027,675 (GRCm39) |
missense |
probably benign |
|
|
R0053:Shprh
|
UTSW |
10 |
11,070,116 (GRCm39) |
splice site |
probably null |
|
|
R0053:Shprh
|
UTSW |
10 |
11,070,116 (GRCm39) |
splice site |
probably null |
|
|
R0255:Shprh
|
UTSW |
10 |
11,062,135 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R0325:Shprh
|
UTSW |
10 |
11,045,853 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0331:Shprh
|
UTSW |
10 |
11,069,914 (GRCm39) |
splice site |
probably benign |
|
|
R0494:Shprh
|
UTSW |
10 |
11,032,935 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0546:Shprh
|
UTSW |
10 |
11,059,631 (GRCm39) |
splice site |
probably benign |
|
|
R0574:Shprh
|
UTSW |
10 |
11,038,821 (GRCm39) |
unclassified |
probably benign |
|
|
R0605:Shprh
|
UTSW |
10 |
11,082,856 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0662:Shprh
|
UTSW |
10 |
11,062,591 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1148:Shprh
|
UTSW |
10 |
11,089,226 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R1148:Shprh
|
UTSW |
10 |
11,089,226 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R1263:Shprh
|
UTSW |
10 |
11,035,274 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1588:Shprh
|
UTSW |
10 |
11,040,488 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1638:Shprh
|
UTSW |
10 |
11,032,822 (GRCm39) |
missense |
probably benign |
|
|
R1830:Shprh
|
UTSW |
10 |
11,062,655 (GRCm39) |
splice site |
probably null |
|
|
R1898:Shprh
|
UTSW |
10 |
11,062,613 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1903:Shprh
|
UTSW |
10 |
11,059,541 (GRCm39) |
nonsense |
probably null |
|
|
R2060:Shprh
|
UTSW |
10 |
11,027,864 (GRCm39) |
missense |
probably benign |
0.03 |
|
R2225:Shprh
|
UTSW |
10 |
11,037,979 (GRCm39) |
unclassified |
probably benign |
|
|
R2363:Shprh
|
UTSW |
10 |
11,047,697 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2509:Shprh
|
UTSW |
10 |
11,042,468 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2891:Shprh
|
UTSW |
10 |
11,040,100 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3077:Shprh
|
UTSW |
10 |
11,046,157 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3150:Shprh
|
UTSW |
10 |
11,045,774 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R3796:Shprh
|
UTSW |
10 |
11,054,501 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R4196:Shprh
|
UTSW |
10 |
11,083,604 (GRCm39) |
utr 3 prime |
probably benign |
|
|
R4423:Shprh
|
UTSW |
10 |
11,062,262 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R4488:Shprh
|
UTSW |
10 |
11,036,215 (GRCm39) |
missense |
probably benign |
0.17 |
|
R4748:Shprh
|
UTSW |
10 |
11,046,220 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4768:Shprh
|
UTSW |
10 |
11,057,284 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R4867:Shprh
|
UTSW |
10 |
11,040,301 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4937:Shprh
|
UTSW |
10 |
11,032,863 (GRCm39) |
missense |
probably benign |
|
|
R5140:Shprh
|
UTSW |
10 |
11,030,449 (GRCm39) |
missense |
probably benign |
0.03 |
|
R5318:Shprh
|
UTSW |
10 |
11,042,301 (GRCm39) |
missense |
probably benign |
0.04 |
|
R5323:Shprh
|
UTSW |
10 |
11,046,041 (GRCm39) |
splice site |
probably null |
|
|
R5450:Shprh
|
UTSW |
10 |
11,088,074 (GRCm39) |
missense |
possibly damaging |
0.70 |
|
R5872:Shprh
|
UTSW |
10 |
11,063,817 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6030:Shprh
|
UTSW |
10 |
11,027,735 (GRCm39) |
missense |
probably benign |
0.37 |
|
R6030:Shprh
|
UTSW |
10 |
11,027,735 (GRCm39) |
missense |
probably benign |
0.37 |
|
R6392:Shprh
|
UTSW |
10 |
11,054,485 (GRCm39) |
nonsense |
probably null |
|
|
R6416:Shprh
|
UTSW |
10 |
11,043,617 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6470:Shprh
|
UTSW |
10 |
11,047,681 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R6513:Shprh
|
UTSW |
10 |
11,062,637 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6530:Shprh
|
UTSW |
10 |
11,070,011 (GRCm39) |
missense |
probably benign |
0.02 |
|
R6678:Shprh
|
UTSW |
10 |
11,042,289 (GRCm39) |
missense |
probably benign |
0.16 |
|
R6757:Shprh
|
UTSW |
10 |
11,057,252 (GRCm39) |
splice site |
probably null |
|
|
R6971:Shprh
|
UTSW |
10 |
11,042,437 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7158:Shprh
|
UTSW |
10 |
11,042,474 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R7582:Shprh
|
UTSW |
10 |
11,040,449 (GRCm39) |
missense |
probably benign |
|
|
R7757:Shprh
|
UTSW |
10 |
11,037,924 (GRCm39) |
missense |
probably benign |
0.30 |
|
R7812:Shprh
|
UTSW |
10 |
11,027,735 (GRCm39) |
missense |
probably benign |
|
|
R7998:Shprh
|
UTSW |
10 |
11,061,085 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8061:Shprh
|
UTSW |
10 |
11,088,077 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R8082:Shprh
|
UTSW |
10 |
11,027,555 (GRCm39) |
missense |
probably benign |
0.22 |
|
R8116:Shprh
|
UTSW |
10 |
11,089,205 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8390:Shprh
|
UTSW |
10 |
11,063,727 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R8445:Shprh
|
UTSW |
10 |
11,057,313 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R8530:Shprh
|
UTSW |
10 |
11,027,678 (GRCm39) |
missense |
probably benign |
0.37 |
|
R8759:Shprh
|
UTSW |
10 |
11,032,908 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R8937:Shprh
|
UTSW |
10 |
11,061,181 (GRCm39) |
missense |
possibly damaging |
0.60 |
|
R8995:Shprh
|
UTSW |
10 |
11,040,574 (GRCm39) |
nonsense |
probably null |
|
|
R9053:Shprh
|
UTSW |
10 |
11,030,446 (GRCm39) |
missense |
probably benign |
0.04 |
|
R9131:Shprh
|
UTSW |
10 |
11,038,589 (GRCm39) |
missense |
possibly damaging |
0.58 |
|
R9176:Shprh
|
UTSW |
10 |
11,036,320 (GRCm39) |
missense |
probably benign |
0.02 |
|
R9391:Shprh
|
UTSW |
10 |
11,038,633 (GRCm39) |
missense |
probably benign |
0.05 |
|
R9423:Shprh
|
UTSW |
10 |
11,081,007 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9563:Shprh
|
UTSW |
10 |
11,042,235 (GRCm39) |
nonsense |
probably null |
|
|
R9668:Shprh
|
UTSW |
10 |
11,082,076 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R9709:Shprh
|
UTSW |
10 |
11,038,574 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R9718:Shprh
|
UTSW |
10 |
11,089,248 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9750:Shprh
|
UTSW |
10 |
11,040,204 (GRCm39) |
missense |
probably damaging |
0.98 |
|
RF012:Shprh
|
UTSW |
10 |
11,040,585 (GRCm39) |
missense |
probably benign |
0.02 |
|
V8831:Shprh
|
UTSW |
10 |
11,062,606 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1176:Shprh
|
UTSW |
10 |
11,062,191 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1176:Shprh
|
UTSW |
10 |
11,040,297 (GRCm39) |
missense |
probably benign |
|
|
Z1177:Shprh
|
UTSW |
10 |
11,027,506 (GRCm39) |
frame shift |
probably null |
|
|
| Predicted Primers |
PCR Primer
(F):5'- AAAGAGAAAGTTCACTGCCCTCGTAAG -3'
(R):5'- TGGCCTTTGATCTGTTTCACAAGACC -3'
Sequencing Primer
(F):5'- AGAATTGGTCCCAGTACTACCTG -3'
(R):5'- GATCTGTTTCACAAGACCTTCAAAG -3'
|
| Posted On |
2013-06-12 |
Incidental Mutation