Incidental Mutation 'IGL00532:Zfp558'
ID4933
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Zfp558
Ensembl Gene ENSMUSG00000074500
Gene Namezinc finger protein 558
SynonymsZfp558-ps, 1700007A21Rik, 4932704I17Rik
Accession Numbers
Is this an essential gene? Non essential (E-score: 0.000) question?
Stock #IGL00532
Quality Score
Status
Chromosome9
Chromosomal Location18455575-18478268 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to T at 18456587 bp
ZygosityHeterozygous
Amino Acid Change Cysteine to Serine at position 302 (C302S)
Ref Sequence ENSEMBL: ENSMUSP00000132305 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000034647] [ENSMUST00000159596]
Predicted Effect possibly damaging
Transcript: ENSMUST00000034647
AA Change: C302S

PolyPhen 2 Score 0.717 (Sensitivity: 0.86; Specificity: 0.92)
SMART Domains Protein: ENSMUSP00000132305
Gene: ENSMUSG00000074500
AA Change: C302S

DomainStartEndE-ValueType
KRAB 43 103 2.52e-29 SMART
ZnF_C2H2 156 178 1.45e-2 SMART
ZnF_C2H2 184 206 2.79e-4 SMART
ZnF_C2H2 212 234 6.52e-5 SMART
ZnF_C2H2 240 262 2.02e-1 SMART
ZnF_C2H2 269 291 5.14e-3 SMART
ZnF_C2H2 297 319 5.21e-4 SMART
ZnF_C2H2 325 347 1.3e-4 SMART
ZnF_C2H2 353 375 2.99e-4 SMART
ZnF_C2H2 381 403 3.39e-3 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000159596
SMART Domains Protein: ENSMUSP00000126946
Gene: ENSMUSG00000074500

DomainStartEndE-ValueType
KRAB 43 100 1.24e-19 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000162441
Predicted Effect noncoding transcript
Transcript: ENSMUST00000174973
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 6 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Arhgap11a A G 2: 113,834,066 V624A probably benign Het
Catsperb G A 12: 101,463,119 V184M probably damaging Het
Eprs G T 1: 185,407,148 C910F probably benign Het
Olfm4 T C 14: 80,021,143 V277A probably benign Het
Ppp4r3a A G 12: 101,044,653 L556P probably damaging Het
Samd3 A G 10: 26,251,846 H247R probably damaging Het
Other mutations in Zfp558
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00722:Zfp558 APN 9 18456521 missense probably damaging 0.97
R0270:Zfp558 UTSW 9 18467956 missense probably damaging 1.00
R0708:Zfp558 UTSW 9 18456827 missense possibly damaging 0.75
R1521:Zfp558 UTSW 9 18456563 missense possibly damaging 0.86
R1618:Zfp558 UTSW 9 18469283 missense possibly damaging 0.73
R2323:Zfp558 UTSW 9 18469277 critical splice donor site probably null
R2939:Zfp558 UTSW 9 18456628 missense possibly damaging 0.71
R4537:Zfp558 UTSW 9 18457502 missense probably null 0.72
R4569:Zfp558 UTSW 9 18456503 missense possibly damaging 0.72
R4570:Zfp558 UTSW 9 18456503 missense possibly damaging 0.72
R4571:Zfp558 UTSW 9 18456503 missense possibly damaging 0.72
R4619:Zfp558 UTSW 9 18456281 missense possibly damaging 0.96
R5207:Zfp558 UTSW 9 18457000 missense possibly damaging 0.93
R5530:Zfp558 UTSW 9 18456373 missense probably benign 0.05
R6631:Zfp558 UTSW 9 18456923 nonsense probably null
Posted On2012-04-20