Incidental Mutation 'R0535:Vmn1r1'
ID 49398
Institutional Source Beutler Lab
Gene Symbol Vmn1r1
Ensembl Gene ENSMUSG00000091013
Gene Name vomeronasal 1 receptor 1
Synonyms Gm6628
MMRRC Submission 038727-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.074) question?
Stock # R0535 (G1)
Quality Score 225
Status Validated
Chromosome 1
Chromosomal Location 181984743-181985663 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 181985516 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Leucine at position 50 (I50L)
Ref Sequence ENSEMBL: ENSMUSP00000153940 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000169123] [ENSMUST00000227586] [ENSMUST00000227629]
AlphaFold E9PVR6
Predicted Effect probably benign
Transcript: ENSMUST00000169123
AA Change: I50L

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000133035
Gene: ENSMUSG00000091013
AA Change: I50L

DomainStartEndE-ValueType
Pfam:V1R 38 301 8e-79 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000227586
AA Change: I50L

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
Predicted Effect probably benign
Transcript: ENSMUST00000227629
AA Change: I50L

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.6%
  • 3x: 98.9%
  • 10x: 97.0%
  • 20x: 94.2%
Validation Efficiency 96% (52/54)
Allele List at MGI
Other mutations in this stock
Total: 51 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aatk A G 11: 119,901,019 (GRCm39) S1069P probably benign Het
Acmsd A T 1: 127,693,680 (GRCm39) I305L probably benign Het
Aco2 G A 15: 81,797,418 (GRCm39) E625K possibly damaging Het
Acox1 G A 11: 116,065,264 (GRCm39) T561I possibly damaging Het
Acox2 T A 14: 8,256,753 (GRCm38) T37S probably damaging Het
Apc A T 18: 34,394,125 (GRCm39) K17M probably damaging Het
Cant1 T C 11: 118,301,969 (GRCm39) D116G probably damaging Het
Col11a1 A G 3: 113,855,184 (GRCm39) E148G unknown Het
Cyp51 T C 5: 4,149,202 (GRCm39) Q225R probably benign Het
E2f8 T C 7: 48,521,558 (GRCm39) probably benign Het
Fam163b T C 2: 27,002,778 (GRCm39) Y73C probably benign Het
Fbxw9 T C 8: 85,791,229 (GRCm39) C271R probably damaging Het
Gbp10 T C 5: 105,368,877 (GRCm39) N321D possibly damaging Het
Gle1 T C 2: 29,847,817 (GRCm39) F675L probably damaging Het
Gm6327 T C 16: 12,578,241 (GRCm39) noncoding transcript Het
Gphn T A 12: 78,538,824 (GRCm39) F157I possibly damaging Het
Gtpbp1 A T 15: 79,591,933 (GRCm39) T94S probably damaging Het
Hdac2 T C 10: 36,869,895 (GRCm39) F286L probably benign Het
Ighv3-6 A T 12: 114,252,090 (GRCm39) probably benign Het
Itga2b A G 11: 102,348,359 (GRCm39) V791A possibly damaging Het
Itgb4 A T 11: 115,881,835 (GRCm39) I796F possibly damaging Het
Kel T C 6: 41,667,772 (GRCm39) K390R probably null Het
Krt42 C T 11: 100,155,412 (GRCm39) C368Y probably damaging Het
Lancl1 A G 1: 67,049,065 (GRCm39) probably benign Het
Lipg A G 18: 75,087,291 (GRCm39) Y177H probably damaging Het
Lnpep T C 17: 17,791,935 (GRCm39) E402G possibly damaging Het
Ltbp2 A G 12: 84,837,826 (GRCm39) F1185L probably damaging Het
Ltbp2 A T 12: 84,831,632 (GRCm39) I1727N probably damaging Het
Mettl22 T C 16: 8,302,210 (GRCm39) probably benign Het
Mtcl2 T C 2: 156,875,209 (GRCm39) E847G possibly damaging Het
Mug1 G A 6: 121,828,413 (GRCm39) G275E probably benign Het
Nell2 T A 15: 95,329,488 (GRCm39) T278S probably benign Het
Nomo1 T A 7: 45,721,941 (GRCm39) S961T probably damaging Het
Or5ak22 A G 2: 85,230,439 (GRCm39) L146P possibly damaging Het
Pcare A G 17: 72,059,434 (GRCm39) V81A probably benign Het
Phf2 A G 13: 48,967,423 (GRCm39) Y675H unknown Het
Phldb2 A G 16: 45,577,490 (GRCm39) V1145A probably damaging Het
Phrf1 T C 7: 140,839,978 (GRCm39) S1058P probably benign Het
Prss3 T C 6: 41,351,903 (GRCm39) N120S probably benign Het
Reln G T 5: 22,256,274 (GRCm39) probably benign Het
Spag5 A G 11: 78,195,554 (GRCm39) Y287C probably benign Het
Syde2 G A 3: 145,694,925 (GRCm39) probably null Het
Synj1 C A 16: 90,744,975 (GRCm39) V1190F possibly damaging Het
Taok1 A T 11: 77,444,530 (GRCm39) I515N probably benign Het
Tmem259 A T 10: 79,814,429 (GRCm39) V309E probably damaging Het
Tmem62 T A 2: 120,833,077 (GRCm39) V494E possibly damaging Het
Trak1 A T 9: 121,272,778 (GRCm39) E119V probably null Het
Vps35l T C 7: 118,347,404 (GRCm39) F118S possibly damaging Het
Xpc C T 6: 91,481,560 (GRCm39) V254I possibly damaging Het
Zfp58 G A 13: 67,640,201 (GRCm39) Q97* probably null Het
Zscan5b A G 7: 6,236,911 (GRCm39) E220G possibly damaging Het
Other mutations in Vmn1r1
AlleleSourceChrCoordTypePredicted EffectPPH Score
R1330:Vmn1r1 UTSW 1 181,985,572 (GRCm39) missense probably damaging 1.00
R1696:Vmn1r1 UTSW 1 181,985,624 (GRCm39) missense probably benign 0.26
R1809:Vmn1r1 UTSW 1 181,985,371 (GRCm39) missense possibly damaging 0.82
R4661:Vmn1r1 UTSW 1 181,984,789 (GRCm39) missense possibly damaging 0.90
R4717:Vmn1r1 UTSW 1 181,984,774 (GRCm39) missense possibly damaging 0.66
R4765:Vmn1r1 UTSW 1 181,985,471 (GRCm39) missense probably benign 0.00
R4772:Vmn1r1 UTSW 1 181,985,111 (GRCm39) missense probably benign 0.41
R4864:Vmn1r1 UTSW 1 181,985,332 (GRCm39) missense probably benign
R5369:Vmn1r1 UTSW 1 181,985,341 (GRCm39) missense possibly damaging 0.87
R5594:Vmn1r1 UTSW 1 181,984,972 (GRCm39) missense probably damaging 1.00
R6240:Vmn1r1 UTSW 1 181,985,186 (GRCm39) missense probably damaging 1.00
R6667:Vmn1r1 UTSW 1 181,985,342 (GRCm39) missense probably benign 0.22
R7075:Vmn1r1 UTSW 1 181,985,597 (GRCm39) missense probably benign 0.00
R7686:Vmn1r1 UTSW 1 181,985,590 (GRCm39) missense probably damaging 1.00
R7908:Vmn1r1 UTSW 1 181,984,915 (GRCm39) missense probably benign 0.45
R8514:Vmn1r1 UTSW 1 181,985,138 (GRCm39) missense probably benign 0.04
R8951:Vmn1r1 UTSW 1 181,985,309 (GRCm39) missense probably damaging 1.00
R9332:Vmn1r1 UTSW 1 181,985,002 (GRCm39) missense probably damaging 1.00
R9450:Vmn1r1 UTSW 1 181,984,770 (GRCm39) nonsense probably null
R9459:Vmn1r1 UTSW 1 181,985,503 (GRCm39) missense probably benign 0.08
Predicted Primers PCR Primer
(F):5'- CAAACAGGAACTTCTGGGGCTGAG -3'
(R):5'- ACAGCCATAGTGTGGGCTGAGATG -3'

Sequencing Primer
(F):5'- ATGACCTGGAGGACGCTC -3'
(R):5'- GCATTGCTTTCAGATGTGTCC -3'
Posted On 2013-06-12