Incidental Mutation 'G5030:Ccng1'
ID 494
Institutional Source Beutler Lab
Gene Symbol Ccng1
Ensembl Gene ENSMUSG00000020326
Gene Name cyclin G1
Synonyms cyclin G
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.340) question?
Stock # G5030 (G3) of strain 560
Quality Score
Status Validated
Chromosome 11
Chromosomal Location 40639379-40646044 bp(-) (GRCm39)
Type of Mutation splice site
DNA Base Change (assembly) A to G at 40644629 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000020576 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000020576]
AlphaFold P51945
Predicted Effect probably benign
Transcript: ENSMUST00000020576
SMART Domains Protein: ENSMUSP00000020576
Gene: ENSMUSG00000020326

DomainStartEndE-ValueType
CYCLIN 56 142 3.63e-17 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000151359
Coding Region Coverage
  • 1x: 81.1%
  • 3x: 60.2%
Het Detection Efficiency 35.6%
Validation Efficiency 87% (206/237)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The eukaryotic cell cycle is governed by cyclin-dependent protein kinases (CDKs) whose activities are regulated by cyclins and CDK inhibitors. The protein encoded by this gene is a member of the cyclin family and contains the cyclin box. The encoded protein lacks the protein destabilizing (PEST) sequence that is present in other family members. Transcriptional activation of this gene can be induced by tumor protein p53. Two transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jul 2008]
PHENOTYPE: Depending on the allele, homozygous mutants exhibit increased cellular sensitivity to gamma-irradiation or decreased incidence of induced hepatic tumors. [provided by MGI curators]
Allele List at MGI

All alleles(7) : Targeted, knock-out(2) Targeted, other(1) Gene trapped(4)

Other mutations in this stock
Total: 30 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca8a T A 11: 109,961,165 (GRCm39) I585F probably damaging Het
Adam18 C G 8: 25,141,872 (GRCm39) L232F probably benign Homo
Atp13a4 A G 16: 29,274,306 (GRCm39) I385T probably damaging Homo
Ccdc17 T A 4: 116,455,699 (GRCm39) S277T probably benign Het
Ces1f T C 8: 94,000,847 (GRCm39) D99G probably benign Het
Clec16a G A 16: 10,389,425 (GRCm39) R187Q probably damaging Homo
Cryl1 C T 14: 57,579,595 (GRCm39) probably benign Het
Cryzl2 C T 1: 157,292,580 (GRCm39) Q48* probably null Het
Dtx4 A G 19: 12,446,943 (GRCm39) L583P probably benign Het
Ephx4 A T 5: 107,577,693 (GRCm39) D339V probably damaging Het
Eri2 A T 7: 119,385,601 (GRCm39) V300E possibly damaging Het
F3 T A 3: 121,518,648 (GRCm39) N37K probably damaging Homo
Fpr1 A T 17: 18,097,068 (GRCm39) L307H probably damaging Het
Fv1 T A 4: 147,953,618 (GRCm39) N61K possibly damaging Het
Gm5548 T C 3: 112,961,512 (GRCm39) noncoding transcript Homo
Il1r1 A G 1: 40,352,323 (GRCm39) K498E possibly damaging Homo
Myh11 T C 16: 14,068,443 (GRCm39) I192M probably damaging Homo
Nckap5 T C 1: 125,953,591 (GRCm39) K923R probably damaging Het
Nmbr A T 10: 14,642,747 (GRCm39) Y102F possibly damaging Het
Or6c75 A G 10: 129,337,406 (GRCm39) T218A probably benign Homo
Pde1a C T 2: 79,718,180 (GRCm39) probably benign Het
Pex6 T C 17: 47,026,382 (GRCm39) probably benign Het
Rtn2 T C 7: 19,027,099 (GRCm39) S305P probably damaging Homo
Saal1 G A 7: 46,342,207 (GRCm39) T412I probably damaging Homo
Slc46a2 A T 4: 59,913,867 (GRCm39) I352N probably damaging Het
Trim37 A T 11: 87,033,967 (GRCm39) H99L probably damaging Het
Tubgcp4 C T 2: 121,014,815 (GRCm39) R242C probably damaging Het
Twf2 C A 9: 106,084,141 (GRCm39) L27I possibly damaging Het
Usp40 A T 1: 87,921,941 (GRCm39) H307Q probably damaging Het
Zfhx3 T G 8: 109,678,091 (GRCm39) V3047G possibly damaging Het
Other mutations in Ccng1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00693:Ccng1 APN 11 40,644,885 (GRCm39) missense probably benign 0.00
IGL01875:Ccng1 APN 11 40,643,183 (GRCm39) missense probably benign 0.09
IGL02986:Ccng1 APN 11 40,641,690 (GRCm39) utr 3 prime probably benign
R1375:Ccng1 UTSW 11 40,642,941 (GRCm39) missense probably benign 0.02
R1377:Ccng1 UTSW 11 40,642,941 (GRCm39) missense probably benign 0.02
R1715:Ccng1 UTSW 11 40,642,941 (GRCm39) missense probably benign 0.02
R3620:Ccng1 UTSW 11 40,642,992 (GRCm39) missense probably benign 0.01
R3857:Ccng1 UTSW 11 40,644,660 (GRCm39) missense probably damaging 0.99
R3858:Ccng1 UTSW 11 40,644,660 (GRCm39) missense probably damaging 0.99
R5082:Ccng1 UTSW 11 40,643,015 (GRCm39) missense possibly damaging 0.77
R5172:Ccng1 UTSW 11 40,642,113 (GRCm39) missense probably benign
R5521:Ccng1 UTSW 11 40,643,093 (GRCm39) missense possibly damaging 0.87
R7431:Ccng1 UTSW 11 40,644,745 (GRCm39) missense possibly damaging 0.74
R7961:Ccng1 UTSW 11 40,642,096 (GRCm39) missense probably benign 0.00
R8009:Ccng1 UTSW 11 40,642,096 (GRCm39) missense probably benign 0.00
R8794:Ccng1 UTSW 11 40,644,826 (GRCm39) missense probably benign
R9036:Ccng1 UTSW 11 40,643,078 (GRCm39) missense possibly damaging 0.55
R9530:Ccng1 UTSW 11 40,644,885 (GRCm39) missense probably benign 0.00
T0975:Ccng1 UTSW 11 40,644,871 (GRCm39) missense probably benign
Nature of Mutation
DNA sequencing using the SOLiD technique identified a T to C transition at base pair 40567304 in the Genbank genomic region NC_000077 (Build 37.1) for the Ccng1 gene on Chromosome 2 (GTATGTTTAT ->GTATGCTTAT). The mutation is located within intron 1 from the ATG exon, six nucleotides from the previous exon. The Ccng1 gene contains 6 total exons. Two transcripts of the Ccng1 gene are displayed on Ensembl and Vega. The mutation has been confirmed by DNA sequencing using the Sanger method (Figure 1).
Protein Function and Prediction

The Ccng1 gene encodes the 294 amino acid cyclin G1 that may play a role in growth regulation. The protein is associated with G2/M phase arrest in response to DNA damage. P53 is thought to act through cyclin G in order to inhibit cellular proliferation (Uniprot P51945). Depending on the allele, homozygous mouse mutants exhibit increased cellular sensitivity to gamma-irradiation or decreased incidence of induced hepatic tumors.

Posted On 2010-10-26