Incidental Mutation 'R0536:Or8g24'
ID 49460
Institutional Source Beutler Lab
Gene Symbol Or8g24
Ensembl Gene ENSMUSG00000048501
Gene Name olfactory receptor family 8 subfamily G member 24
Synonyms MOR171-25, Olfr938, GA_x6K02T2PVTD-32774646-32773699
MMRRC Submission 038728-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.072) question?
Stock # R0536 (G1)
Quality Score 225
Status Validated
Chromosome 9
Chromosomal Location 38989092-38990039 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to T at 38989625 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glutamine to Lysine at position 139 (Q139K)
Ref Sequence ENSEMBL: ENSMUSP00000055053 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000056499]
AlphaFold Q9EQ93
Predicted Effect probably benign
Transcript: ENSMUST00000056499
AA Change: Q139K

PolyPhen 2 Score 0.026 (Sensitivity: 0.95; Specificity: 0.81)
SMART Domains Protein: ENSMUSP00000055053
Gene: ENSMUSG00000048501
AA Change: Q139K

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 8e-49 PFAM
Pfam:7tm_1 41 290 5.5e-18 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000175411
Predicted Effect noncoding transcript
Transcript: ENSMUST00000215888
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.7%
  • 10x: 97.1%
  • 20x: 95.1%
Validation Efficiency 100% (29/29)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 28 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acaca T C 11: 84,171,342 (GRCm39) probably benign Het
Agrn A T 4: 156,264,010 (GRCm39) D84E probably benign Het
Akap11 A G 14: 78,751,464 (GRCm39) S308P probably damaging Het
Atp6v1c2 A T 12: 17,357,509 (GRCm39) probably null Het
AW209491 A G 13: 14,811,558 (GRCm39) Y137C probably damaging Het
Chst9 G A 18: 15,628,387 (GRCm39) probably benign Het
Dok7 A G 5: 35,223,826 (GRCm39) T122A probably damaging Het
Hoxb5 T C 11: 96,194,854 (GRCm39) S139P possibly damaging Het
Ikzf4 T A 10: 128,477,118 (GRCm39) E64D probably benign Het
Kif21a C A 15: 90,843,886 (GRCm39) probably benign Het
Klhl41 G A 2: 69,500,554 (GRCm39) R5Q probably benign Het
Lama3 C T 18: 12,658,951 (GRCm39) R2036C probably damaging Het
Lrba T A 3: 86,622,839 (GRCm39) V311D probably damaging Het
Mroh2a A G 1: 88,186,386 (GRCm39) S64G probably benign Het
Mylk T C 16: 34,820,757 (GRCm39) V1903A possibly damaging Het
Naa30 C T 14: 49,410,534 (GRCm39) A154V possibly damaging Het
Or2ag1 T A 7: 106,313,528 (GRCm39) Y120F probably damaging Het
Or52z12 T C 7: 103,233,468 (GRCm39) S80P probably damaging Het
Pgm3 C T 9: 86,449,589 (GRCm39) V144M possibly damaging Het
Ptpro T A 6: 137,420,592 (GRCm39) V1007D probably damaging Het
Rgsl1 T A 1: 153,701,927 (GRCm39) S211C probably damaging Het
Setx T C 2: 29,048,260 (GRCm39) Y1954H possibly damaging Het
Sorcs3 C T 19: 48,791,137 (GRCm39) Q1162* probably null Het
Sptbn2 T A 19: 4,776,718 (GRCm39) D255E probably damaging Het
Ttc39b T C 4: 83,145,435 (GRCm39) E597G probably damaging Het
Vldlr G A 19: 27,217,364 (GRCm39) A436T probably damaging Het
Wdr72 G A 9: 74,064,690 (GRCm39) G574D probably damaging Het
Zzz3 T G 3: 152,154,465 (GRCm39) I572S probably damaging Het
Other mutations in Or8g24
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01020:Or8g24 APN 9 38,989,747 (GRCm39) missense probably damaging 0.96
IGL01298:Or8g24 APN 9 38,990,020 (GRCm39) missense possibly damaging 0.63
IGL02930:Or8g24 APN 9 38,989,308 (GRCm39) missense probably damaging 1.00
IGL03346:Or8g24 APN 9 38,989,257 (GRCm39) missense probably benign 0.35
IGL03346:Or8g24 APN 9 38,989,258 (GRCm39) missense probably damaging 0.99
IGL03399:Or8g24 APN 9 38,989,533 (GRCm39) nonsense probably null
R1170:Or8g24 UTSW 9 38,989,525 (GRCm39) missense possibly damaging 0.50
R1951:Or8g24 UTSW 9 38,989,580 (GRCm39) missense probably benign 0.07
R1952:Or8g24 UTSW 9 38,989,580 (GRCm39) missense probably benign 0.07
R2066:Or8g24 UTSW 9 38,989,510 (GRCm39) missense probably damaging 1.00
R2906:Or8g24 UTSW 9 38,989,669 (GRCm39) missense probably benign 0.39
R4707:Or8g24 UTSW 9 38,989,558 (GRCm39) missense probably benign 0.00
R4767:Or8g24 UTSW 9 38,989,988 (GRCm39) missense possibly damaging 0.71
R4951:Or8g24 UTSW 9 38,989,555 (GRCm39) missense probably benign 0.10
R5888:Or8g24 UTSW 9 38,989,263 (GRCm39) nonsense probably null
R5905:Or8g24 UTSW 9 38,989,379 (GRCm39) missense probably damaging 1.00
R6028:Or8g24 UTSW 9 38,989,379 (GRCm39) missense probably damaging 1.00
R6329:Or8g24 UTSW 9 38,989,199 (GRCm39) missense probably benign 0.02
R7240:Or8g24 UTSW 9 38,989,906 (GRCm39) missense probably damaging 0.99
R7345:Or8g24 UTSW 9 38,989,630 (GRCm39) missense probably damaging 1.00
R8058:Or8g24 UTSW 9 38,989,862 (GRCm39) missense probably damaging 1.00
R9023:Or8g24 UTSW 9 38,989,307 (GRCm39) missense probably benign 0.09
R9547:Or8g24 UTSW 9 38,989,927 (GRCm39) missense probably damaging 0.99
R9682:Or8g24 UTSW 9 38,989,874 (GRCm39) missense possibly damaging 0.95
R9760:Or8g24 UTSW 9 38,989,271 (GRCm39) missense possibly damaging 0.95
X0062:Or8g24 UTSW 9 38,989,762 (GRCm39) missense probably benign 0.15
Predicted Primers PCR Primer
(F):5'- CTCTGCCTCCAGTGGATTGAATGTG -3'
(R):5'- TCCCAAAATGCTGTTGAACTTTGTGAC -3'

Sequencing Primer
(F):5'- TCCAGTGGATTGAATGTGGAGAAC -3'
(R):5'- CTGTTGAACTTTGTGACAGAGATG -3'
Posted On 2013-06-12