Incidental Mutation 'R0537:Or5w16'
ID 49487
Institutional Source Beutler Lab
Gene Symbol Or5w16
Ensembl Gene ENSMUSG00000068817
Gene Name olfactory receptor family 5 subfamily W member 16
Synonyms Olfr1140, GA_x6K02T2Q125-49250025-49250960, MOR177-6
MMRRC Submission 038729-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.205) question?
Stock # R0537 (G1)
Quality Score 225
Status Validated
Chromosome 2
Chromosomal Location 87576505-87577524 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 87577017 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glutamine to Leucine at position 159 (Q159L)
Ref Sequence ENSEMBL: ENSMUSP00000149645 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000111568] [ENSMUST00000214723] [ENSMUST00000217572]
AlphaFold Q7TR39
Predicted Effect probably benign
Transcript: ENSMUST00000111568
AA Change: Q159L

PolyPhen 2 Score 0.062 (Sensitivity: 0.94; Specificity: 0.84)
SMART Domains Protein: ENSMUSP00000107194
Gene: ENSMUSG00000068815
AA Change: Q159L

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 1.5e-44 PFAM
Pfam:7tm_1 41 290 2.8e-16 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000214723
AA Change: Q159L

PolyPhen 2 Score 0.062 (Sensitivity: 0.94; Specificity: 0.84)
Predicted Effect noncoding transcript
Transcript: ENSMUST00000217102
Predicted Effect probably benign
Transcript: ENSMUST00000217572
AA Change: Q159L

PolyPhen 2 Score 0.062 (Sensitivity: 0.94; Specificity: 0.84)
Predicted Effect noncoding transcript
Transcript: ENSMUST00000217634
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.5%
  • 10x: 96.7%
  • 20x: 93.9%
Validation Efficiency 100% (53/53)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 51 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930474N05Rik A T 14: 35,818,657 (GRCm39) K218N probably benign Het
Acot11 T C 4: 106,619,652 (GRCm39) E156G probably benign Het
Arhgef28 A T 13: 98,094,224 (GRCm39) N973K probably damaging Het
B4galt3 T C 1: 171,101,821 (GRCm39) probably benign Het
Bmpr1a T C 14: 34,165,769 (GRCm39) probably benign Het
Camkmt A T 17: 85,702,087 (GRCm39) I184F probably benign Het
Ccdc33 T C 9: 58,024,737 (GRCm39) Y163C probably damaging Het
Ccdc9 A G 7: 16,014,701 (GRCm39) probably benign Het
Dars2 A T 1: 160,888,318 (GRCm39) C201S possibly damaging Het
Dnajc1 A T 2: 18,312,767 (GRCm39) S194R possibly damaging Het
Dock8 A G 19: 25,148,941 (GRCm39) D1473G probably benign Het
Dpm2 T A 2: 32,462,961 (GRCm39) probably null Het
Dsg4 T C 18: 20,591,628 (GRCm39) S456P probably damaging Het
Gys1 T C 7: 45,089,425 (GRCm39) S195P probably damaging Het
Heatr6 G T 11: 83,670,290 (GRCm39) E948* probably null Het
Itgal G A 7: 126,910,445 (GRCm39) R518Q possibly damaging Het
Klhdc8b G C 9: 108,326,422 (GRCm39) R158G possibly damaging Het
Klhl41 G A 2: 69,500,554 (GRCm39) R5Q probably benign Het
Lrrtm4 A T 6: 79,999,103 (GRCm39) T172S probably benign Het
Lypd1 A G 1: 125,840,604 (GRCm39) probably benign Het
Mei1 T C 15: 81,975,562 (GRCm39) F121S possibly damaging Het
Mtor C T 4: 148,622,817 (GRCm39) R1966W probably damaging Het
Myh7 A G 14: 55,228,256 (GRCm39) F247L possibly damaging Het
Nebl G T 2: 17,409,026 (GRCm39) D392E possibly damaging Het
Notch2 C A 3: 98,024,057 (GRCm39) N840K possibly damaging Het
Nubp1 T C 16: 10,240,678 (GRCm39) probably benign Het
Or7g19 T C 9: 18,856,444 (GRCm39) S167P probably damaging Het
Pcdh17 T A 14: 84,684,897 (GRCm39) S455T probably damaging Het
Picalm C A 7: 89,779,876 (GRCm39) H32Q probably benign Het
Pold1 T C 7: 44,184,516 (GRCm39) E828G probably damaging Het
Ptpro T A 6: 137,420,592 (GRCm39) V1007D probably damaging Het
Rala A T 13: 18,063,233 (GRCm39) N119K probably benign Het
Rasal2 A T 1: 156,975,362 (GRCm39) V1149E possibly damaging Het
Rd3 A G 1: 191,715,501 (GRCm39) Y92C probably damaging Het
Rps18-ps6 A T 13: 97,897,071 (GRCm39) F9Y probably benign Het
Sart1 A T 19: 5,431,752 (GRCm39) D635E probably damaging Het
Sec16b A G 1: 157,365,116 (GRCm39) T335A possibly damaging Het
Slc11a2 C T 15: 100,303,679 (GRCm39) G185R probably damaging Het
Slc2a12 G A 10: 22,540,967 (GRCm39) R274H probably damaging Het
Spag17 T C 3: 100,032,618 (GRCm39) V2276A probably damaging Het
Tcam1 G A 11: 106,174,904 (GRCm39) E120K probably benign Het
Tenm2 T C 11: 36,054,557 (GRCm39) D601G probably damaging Het
Tmem168 C A 6: 13,603,360 (GRCm39) C2F probably damaging Het
Tmem80 A G 7: 140,913,609 (GRCm39) Y13C probably damaging Het
Try4 T A 6: 41,281,296 (GRCm39) N79K probably benign Het
Vldlr C A 19: 27,225,318 (GRCm39) N798K probably damaging Het
Wdr41 A G 13: 95,131,813 (GRCm39) probably benign Het
Zfp30 A T 7: 29,492,160 (GRCm39) E138V probably damaging Het
Zfp366 A C 13: 99,365,786 (GRCm39) T316P probably damaging Het
Zfp563 A T 17: 33,323,659 (GRCm39) S85C possibly damaging Het
Znfx1 T C 2: 166,883,621 (GRCm39) H162R probably damaging Het
Other mutations in Or5w16
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01014:Or5w16 APN 2 87,577,469 (GRCm39) missense probably benign 0.03
IGL01538:Or5w16 APN 2 87,576,942 (GRCm39) missense probably benign 0.10
IGL01735:Or5w16 APN 2 87,576,650 (GRCm39) missense probably benign 0.00
IGL02224:Or5w16 APN 2 87,576,757 (GRCm39) nonsense probably null
IGL03047:Or5w16 UTSW 2 87,577,338 (GRCm39) missense possibly damaging 0.63
R1701:Or5w16 UTSW 2 87,576,894 (GRCm39) missense probably damaging 0.99
R1998:Or5w16 UTSW 2 87,577,316 (GRCm39) missense probably damaging 1.00
R2430:Or5w16 UTSW 2 87,576,999 (GRCm39) missense possibly damaging 0.52
R4750:Or5w16 UTSW 2 87,576,852 (GRCm39) missense probably benign
R5048:Or5w16 UTSW 2 87,576,663 (GRCm39) missense probably benign 0.01
R5494:Or5w16 UTSW 2 87,576,950 (GRCm39) missense probably damaging 1.00
R5521:Or5w16 UTSW 2 87,577,406 (GRCm39) missense probably benign 0.24
R7786:Or5w16 UTSW 2 87,576,645 (GRCm39) missense probably damaging 1.00
R8017:Or5w16 UTSW 2 87,577,392 (GRCm39) missense probably damaging 0.98
R8019:Or5w16 UTSW 2 87,577,392 (GRCm39) missense probably damaging 0.98
R8463:Or5w16 UTSW 2 87,577,437 (GRCm39) missense probably benign 0.01
R8827:Or5w16 UTSW 2 87,576,777 (GRCm39) missense possibly damaging 0.63
R9038:Or5w16 UTSW 2 87,577,125 (GRCm39) missense probably damaging 1.00
X0019:Or5w16 UTSW 2 87,576,764 (GRCm39) missense possibly damaging 0.96
Z1088:Or5w16 UTSW 2 87,576,833 (GRCm39) missense probably damaging 0.99
Z1177:Or5w16 UTSW 2 87,576,968 (GRCm39) missense possibly damaging 0.48
Predicted Primers PCR Primer
(F):5'- ACTGCTGTTGGACCAAAGATGCTG -3'
(R):5'- CAGGCTGTAAATCAGAGGGTTGAGC -3'

Sequencing Primer
(F):5'- CACAAATCTTTATCTTTTTTGGGCTG -3'
(R):5'- GCTGATCTTCAAGACTGATGC -3'
Posted On 2013-06-12