Incidental Mutation 'R0539:Ncoa6'
| ID |
49668 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Ncoa6
|
| Ensembl Gene |
ENSMUSG00000038369 |
| Gene Name |
nuclear receptor coactivator 6 |
| Synonyms |
ASC-2, RAP250, NRC, AIB3, ASC2, PRIP |
| MMRRC Submission |
038731-MU
|
| Accession Numbers |
|
| Essential gene? |
Essential
(E-score: 1.000)
|
| Stock # |
R0539 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
2 |
| Chromosomal Location |
155232585-155315741 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
G to T
at 155257617 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Alanine to Aspartic acid
at position 642
(A642D)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000118113
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000043126]
[ENSMUST00000109669]
[ENSMUST00000109670]
[ENSMUST00000123293]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000043126
AA Change: A642D
PolyPhen 2
Score 0.077 (Sensitivity: 0.93; Specificity: 0.85)
|
| SMART Domains |
Protein: ENSMUSP00000045386
Gene: ENSMUSG00000038369
AA Change: A642D
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:Nucleic_acid_bd
|
47 |
190 |
3.3e-55 |
PFAM |
|
coiled coil region
|
256 |
296 |
N/A |
INTRINSIC |
|
low complexity region
|
375 |
383 |
N/A |
INTRINSIC |
|
internal_repeat_1
|
450 |
597 |
3.31e-5 |
PROSPERO |
|
low complexity region
|
615 |
630 |
N/A |
INTRINSIC |
|
internal_repeat_1
|
636 |
793 |
3.31e-5 |
PROSPERO |
|
low complexity region
|
844 |
860 |
N/A |
INTRINSIC |
|
low complexity region
|
909 |
931 |
N/A |
INTRINSIC |
|
low complexity region
|
986 |
998 |
N/A |
INTRINSIC |
|
low complexity region
|
1002 |
1046 |
N/A |
INTRINSIC |
|
low complexity region
|
1126 |
1139 |
N/A |
INTRINSIC |
|
low complexity region
|
1258 |
1273 |
N/A |
INTRINSIC |
|
low complexity region
|
1328 |
1351 |
N/A |
INTRINSIC |
|
low complexity region
|
1543 |
1564 |
N/A |
INTRINSIC |
|
low complexity region
|
1578 |
1599 |
N/A |
INTRINSIC |
|
low complexity region
|
1607 |
1618 |
N/A |
INTRINSIC |
|
low complexity region
|
1808 |
1825 |
N/A |
INTRINSIC |
|
low complexity region
|
1894 |
1908 |
N/A |
INTRINSIC |
|
low complexity region
|
2043 |
2053 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000109669
|
| SMART Domains |
Protein: ENSMUSP00000105294
Gene: ENSMUSG00000038369
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:Nucleic_acid_bd
|
45 |
195 |
2.6e-61 |
PFAM |
|
SCOP:d1lsha3
|
239 |
321 |
5e-3 |
SMART |
|
low complexity region
|
375 |
383 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000109670
AA Change: A642D
PolyPhen 2
Score 0.077 (Sensitivity: 0.93; Specificity: 0.85)
|
| SMART Domains |
Protein: ENSMUSP00000105295
Gene: ENSMUSG00000038369
AA Change: A642D
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:Nucleic_acid_bd
|
45 |
195 |
3.6e-60 |
PFAM |
|
coiled coil region
|
256 |
296 |
N/A |
INTRINSIC |
|
low complexity region
|
375 |
383 |
N/A |
INTRINSIC |
|
internal_repeat_1
|
450 |
597 |
3.31e-5 |
PROSPERO |
|
low complexity region
|
615 |
630 |
N/A |
INTRINSIC |
|
internal_repeat_1
|
636 |
793 |
3.31e-5 |
PROSPERO |
|
low complexity region
|
844 |
860 |
N/A |
INTRINSIC |
|
low complexity region
|
909 |
931 |
N/A |
INTRINSIC |
|
low complexity region
|
986 |
998 |
N/A |
INTRINSIC |
|
low complexity region
|
1002 |
1046 |
N/A |
INTRINSIC |
|
low complexity region
|
1126 |
1139 |
N/A |
INTRINSIC |
|
low complexity region
|
1258 |
1273 |
N/A |
INTRINSIC |
|
low complexity region
|
1328 |
1351 |
N/A |
INTRINSIC |
|
low complexity region
|
1543 |
1564 |
N/A |
INTRINSIC |
|
low complexity region
|
1578 |
1599 |
N/A |
INTRINSIC |
|
low complexity region
|
1607 |
1618 |
N/A |
INTRINSIC |
|
low complexity region
|
1808 |
1825 |
N/A |
INTRINSIC |
|
low complexity region
|
1894 |
1908 |
N/A |
INTRINSIC |
|
low complexity region
|
2043 |
2053 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000123293
AA Change: A642D
PolyPhen 2
Score 0.077 (Sensitivity: 0.93; Specificity: 0.85)
|
| SMART Domains |
Protein: ENSMUSP00000118113
Gene: ENSMUSG00000038369
AA Change: A642D
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:Nucleic_acid_bd
|
45 |
195 |
2.4e-60 |
PFAM |
|
coiled coil region
|
256 |
296 |
N/A |
INTRINSIC |
|
low complexity region
|
375 |
383 |
N/A |
INTRINSIC |
|
low complexity region
|
564 |
573 |
N/A |
INTRINSIC |
|
low complexity region
|
615 |
630 |
N/A |
INTRINSIC |
|
low complexity region
|
844 |
860 |
N/A |
INTRINSIC |
|
low complexity region
|
909 |
931 |
N/A |
INTRINSIC |
|
low complexity region
|
986 |
998 |
N/A |
INTRINSIC |
|
low complexity region
|
1002 |
1046 |
N/A |
INTRINSIC |
|
low complexity region
|
1126 |
1139 |
N/A |
INTRINSIC |
|
low complexity region
|
1258 |
1273 |
N/A |
INTRINSIC |
|
low complexity region
|
1328 |
1351 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000141928
|
| Meta Mutation Damage Score |
0.0898 |
| Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.5%
- 10x: 96.8%
- 20x: 94.3%
|
| Validation Efficiency |
100% (107/107) |
| MGI Phenotype |
PHENOTYPE: Homozygotes for targeted null mutations exhibit retarded embryonic growth and defects of the placenta, heart, liver, and nervous system. Mutants die around midgestation. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 108 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 5730480H06Rik |
T |
A |
5: 48,536,692 (GRCm39) |
H129Q |
probably damaging |
Het |
| Abca14 |
G |
A |
7: 119,807,020 (GRCm39) |
R22Q |
probably damaging |
Het |
| Abcg5 |
T |
A |
17: 84,976,503 (GRCm39) |
M445L |
probably benign |
Het |
| Abhd3 |
T |
A |
18: 10,645,208 (GRCm39) |
N357I |
possibly damaging |
Het |
| Adamts5 |
C |
T |
16: 85,665,580 (GRCm39) |
G574S |
probably damaging |
Het |
| Adgrg5 |
T |
A |
8: 95,665,260 (GRCm39) |
N389K |
probably damaging |
Het |
| Ankk1 |
A |
G |
9: 49,329,330 (GRCm39) |
V80A |
probably benign |
Het |
| Arhgap20 |
A |
G |
9: 51,761,455 (GRCm39) |
Q1066R |
probably benign |
Het |
| Arhgap21 |
T |
A |
2: 20,919,610 (GRCm39) |
K32* |
probably null |
Het |
| AW209491 |
T |
C |
13: 14,812,317 (GRCm39) |
F390S |
probably damaging |
Het |
| Axl |
A |
T |
7: 25,478,142 (GRCm39) |
|
probably benign |
Het |
| Bri3bp |
A |
G |
5: 125,531,603 (GRCm39) |
Y183C |
probably damaging |
Het |
| Cad |
T |
C |
5: 31,232,801 (GRCm39) |
|
probably benign |
Het |
| Capns2 |
A |
G |
8: 93,628,360 (GRCm39) |
Q83R |
possibly damaging |
Het |
| Ccdc180 |
G |
T |
4: 45,922,010 (GRCm39) |
R1028L |
probably damaging |
Het |
| Cdh19 |
C |
A |
1: 110,852,892 (GRCm39) |
V348F |
possibly damaging |
Het |
| Chrm2 |
T |
C |
6: 36,500,641 (GRCm39) |
V166A |
possibly damaging |
Het |
| Clmp |
A |
G |
9: 40,693,782 (GRCm39) |
Y333C |
probably benign |
Het |
| Cntn3 |
A |
G |
6: 102,254,178 (GRCm39) |
|
probably null |
Het |
| Copz1 |
A |
G |
15: 103,199,792 (GRCm39) |
Y69C |
probably damaging |
Het |
| Crybg1 |
T |
C |
10: 43,874,894 (GRCm39) |
D738G |
probably benign |
Het |
| Ctnna2 |
T |
A |
6: 76,950,882 (GRCm39) |
I165F |
probably damaging |
Het |
| Dcaf7 |
T |
G |
11: 105,942,652 (GRCm39) |
S200A |
probably damaging |
Het |
| Deup1 |
T |
A |
9: 15,493,893 (GRCm39) |
R416S |
possibly damaging |
Het |
| Dmxl1 |
T |
A |
18: 49,990,497 (GRCm39) |
|
probably benign |
Het |
| Dnaaf11 |
A |
T |
15: 66,319,455 (GRCm39) |
V305D |
probably damaging |
Het |
| Dnase2b |
A |
T |
3: 146,294,910 (GRCm39) |
|
probably benign |
Het |
| Dst |
C |
T |
1: 34,228,200 (GRCm39) |
P1606L |
probably damaging |
Het |
| Eef2 |
C |
CN |
10: 81,014,602 (GRCm39) |
|
probably null |
Het |
| Ephb2 |
T |
C |
4: 136,383,287 (GRCm39) |
Y931C |
probably damaging |
Het |
| Fam83h |
T |
C |
15: 75,875,076 (GRCm39) |
S754G |
possibly damaging |
Het |
| Fibp |
T |
A |
19: 5,513,216 (GRCm39) |
V177D |
probably damaging |
Het |
| Gfpt2 |
T |
C |
11: 49,723,725 (GRCm39) |
I571T |
probably damaging |
Het |
| Grm7 |
T |
G |
6: 111,336,055 (GRCm39) |
|
probably benign |
Het |
| Gsdma3 |
A |
G |
11: 98,526,745 (GRCm39) |
Y335C |
probably damaging |
Het |
| H2-T23 |
A |
T |
17: 36,343,033 (GRCm39) |
|
probably benign |
Het |
| H4c3 |
A |
G |
13: 23,882,131 (GRCm39) |
F101S |
probably damaging |
Het |
| Hydin |
A |
G |
8: 111,249,704 (GRCm39) |
I2216V |
probably benign |
Het |
| Ipo8 |
A |
G |
6: 148,719,606 (GRCm39) |
M113T |
probably benign |
Het |
| Kdm6a |
A |
G |
X: 18,128,664 (GRCm39) |
E1045G |
probably damaging |
Het |
| Kyat1 |
C |
T |
2: 30,078,229 (GRCm39) |
E117K |
probably damaging |
Het |
| Lin7b |
A |
G |
7: 45,019,326 (GRCm39) |
|
probably benign |
Het |
| Lipn |
G |
A |
19: 34,062,003 (GRCm39) |
|
probably benign |
Het |
| Lrfn2 |
C |
A |
17: 49,378,072 (GRCm39) |
N384K |
probably damaging |
Het |
| Map1b |
T |
C |
13: 99,570,526 (GRCm39) |
K732E |
unknown |
Het |
| Mpl |
A |
G |
4: 118,300,705 (GRCm39) |
M541T |
possibly damaging |
Het |
| Mprip |
T |
C |
11: 59,631,943 (GRCm39) |
|
probably benign |
Het |
| Mrc1 |
T |
C |
2: 14,274,937 (GRCm39) |
|
probably benign |
Het |
| Ms4a13 |
T |
C |
19: 11,149,235 (GRCm39) |
|
probably benign |
Het |
| Myo18b |
G |
T |
5: 112,871,734 (GRCm39) |
R2116S |
probably damaging |
Het |
| Nav2 |
A |
G |
7: 49,111,686 (GRCm39) |
T731A |
probably damaging |
Het |
| Ndufs7 |
T |
A |
10: 80,090,665 (GRCm39) |
|
probably benign |
Het |
| Nfkbiz |
G |
A |
16: 55,638,242 (GRCm39) |
T406M |
probably benign |
Het |
| Nr4a1 |
A |
G |
15: 101,168,765 (GRCm39) |
E267G |
probably damaging |
Het |
| Nrxn2 |
T |
G |
19: 6,543,434 (GRCm39) |
F1103V |
probably damaging |
Het |
| Or10ab4 |
C |
T |
7: 107,655,029 (GRCm39) |
T280I |
probably damaging |
Het |
| Or10d3 |
A |
T |
9: 39,461,593 (GRCm39) |
D191E |
probably damaging |
Het |
| Or1e22 |
T |
C |
11: 73,376,889 (GRCm39) |
T254A |
probably benign |
Het |
| Or5a3 |
C |
T |
19: 12,400,173 (GRCm39) |
L167F |
probably damaging |
Het |
| Or5g27 |
T |
A |
2: 85,410,119 (GRCm39) |
C179S |
probably damaging |
Het |
| Or5m11 |
G |
T |
2: 85,782,353 (GRCm39) |
M315I |
probably benign |
Het |
| Or8u9 |
A |
T |
2: 86,001,387 (GRCm39) |
M258K |
probably damaging |
Het |
| Phf1 |
A |
G |
17: 27,153,432 (GRCm39) |
|
probably null |
Het |
| Pip |
C |
T |
6: 41,826,819 (GRCm39) |
Q53* |
probably null |
Het |
| Ppp2ca |
T |
C |
11: 52,008,989 (GRCm39) |
|
probably null |
Het |
| Prl2c5 |
A |
G |
13: 13,363,906 (GRCm39) |
|
probably null |
Het |
| Psph |
T |
A |
5: 129,843,641 (GRCm39) |
|
probably benign |
Het |
| Ptch1 |
C |
T |
13: 63,691,294 (GRCm39) |
|
probably benign |
Het |
| Ptprs |
C |
T |
17: 56,765,255 (GRCm39) |
V10M |
probably damaging |
Het |
| Rarg |
T |
C |
15: 102,147,312 (GRCm39) |
R358G |
probably damaging |
Het |
| Rbl2 |
T |
C |
8: 91,839,133 (GRCm39) |
|
probably benign |
Het |
| Robo2 |
A |
T |
16: 73,782,462 (GRCm39) |
|
probably benign |
Het |
| Scin |
A |
T |
12: 40,131,765 (GRCm39) |
D256E |
possibly damaging |
Het |
| Scn8a |
T |
C |
15: 100,914,449 (GRCm39) |
Y1152H |
probably damaging |
Het |
| Sh2b2 |
T |
G |
5: 136,254,155 (GRCm39) |
|
probably benign |
Het |
| Slc13a2 |
G |
A |
11: 78,289,964 (GRCm39) |
P450L |
probably damaging |
Het |
| Slc2a12 |
A |
G |
10: 22,568,129 (GRCm39) |
I519V |
probably benign |
Het |
| Slc30a9 |
C |
T |
5: 67,491,953 (GRCm39) |
T260M |
probably damaging |
Het |
| Slc9a7 |
A |
T |
X: 20,069,001 (GRCm39) |
F184Y |
probably damaging |
Het |
| Smc2 |
G |
T |
4: 52,458,558 (GRCm39) |
K466N |
probably benign |
Het |
| Snx16 |
T |
C |
3: 10,491,278 (GRCm39) |
E209G |
probably damaging |
Het |
| Sp3 |
A |
T |
2: 72,800,876 (GRCm39) |
I423N |
possibly damaging |
Het |
| Ssh2 |
G |
T |
11: 77,345,620 (GRCm39) |
V1202F |
probably benign |
Het |
| Stam2 |
A |
T |
2: 52,593,268 (GRCm39) |
|
probably benign |
Het |
| Stox2 |
T |
C |
8: 47,647,070 (GRCm39) |
Y194C |
probably damaging |
Het |
| Sult3a1 |
A |
G |
10: 33,742,519 (GRCm39) |
T49A |
probably damaging |
Het |
| Supt3 |
A |
T |
17: 45,314,018 (GRCm39) |
I136F |
possibly damaging |
Het |
| Syne2 |
A |
T |
12: 76,070,895 (GRCm39) |
R103S |
possibly damaging |
Het |
| Synj2 |
T |
A |
17: 6,047,163 (GRCm39) |
M1K |
probably null |
Het |
| Tas2r110 |
T |
C |
6: 132,845,334 (GRCm39) |
S122P |
possibly damaging |
Het |
| Tln1 |
A |
G |
4: 43,543,434 (GRCm39) |
|
probably null |
Het |
| Tmem117 |
A |
G |
15: 94,612,793 (GRCm39) |
T110A |
possibly damaging |
Het |
| Tmem247 |
A |
G |
17: 87,224,906 (GRCm39) |
D5G |
probably benign |
Het |
| Tmem39a |
T |
A |
16: 38,411,337 (GRCm39) |
F363I |
probably benign |
Het |
| Tmem80 |
G |
A |
7: 140,915,808 (GRCm39) |
A73T |
possibly damaging |
Het |
| Trpm4 |
C |
T |
7: 44,954,896 (GRCm39) |
G901S |
probably damaging |
Het |
| Upk3bl |
T |
C |
5: 136,092,840 (GRCm39) |
|
probably benign |
Het |
| Vmn1r120 |
A |
T |
7: 20,787,397 (GRCm39) |
C105S |
probably damaging |
Het |
| Vmn1r69 |
A |
T |
7: 10,314,874 (GRCm39) |
|
probably benign |
Het |
| Vmn2r95 |
T |
C |
17: 18,672,362 (GRCm39) |
F700L |
probably damaging |
Het |
| Wdr70 |
G |
A |
15: 7,915,118 (GRCm39) |
T550M |
possibly damaging |
Het |
| Zbtb22 |
A |
G |
17: 34,137,118 (GRCm39) |
D421G |
possibly damaging |
Het |
| Zbtb45 |
G |
A |
7: 12,740,260 (GRCm39) |
R452C |
probably damaging |
Het |
| Zfhx3 |
T |
C |
8: 109,527,141 (GRCm39) |
Y1013H |
probably damaging |
Het |
| Zfp329 |
C |
T |
7: 12,540,520 (GRCm39) |
|
probably null |
Het |
| Zfp532 |
T |
A |
18: 65,756,837 (GRCm39) |
S257T |
probably benign |
Het |
| Zfp933 |
G |
A |
4: 147,911,005 (GRCm39) |
T197I |
probably benign |
Het |
| Zgrf1 |
T |
A |
3: 127,408,841 (GRCm39) |
N1649K |
probably damaging |
Het |
|
| Other mutations in Ncoa6 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00484:Ncoa6
|
APN |
2 |
155,248,128 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL00849:Ncoa6
|
APN |
2 |
155,263,608 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
IGL00933:Ncoa6
|
APN |
2 |
155,257,317 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00981:Ncoa6
|
APN |
2 |
155,248,099 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL01420:Ncoa6
|
APN |
2 |
155,249,507 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02160:Ncoa6
|
APN |
2 |
155,263,003 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
IGL03049:Ncoa6
|
APN |
2 |
155,260,934 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03194:Ncoa6
|
APN |
2 |
155,257,788 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
IGL03269:Ncoa6
|
APN |
2 |
155,248,409 (GRCm39) |
missense |
probably damaging |
0.97 |
|
IGL03299:Ncoa6
|
APN |
2 |
155,249,207 (GRCm39) |
missense |
probably damaging |
0.97 |
|
IGL03306:Ncoa6
|
APN |
2 |
155,247,427 (GRCm39) |
missense |
probably benign |
0.30 |
|
alcoa
|
UTSW |
2 |
155,244,584 (GRCm39) |
unclassified |
probably benign |
|
|
Aluminum
|
UTSW |
2 |
155,241,613 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
balboa
|
UTSW |
2 |
155,248,869 (GRCm39) |
missense |
probably benign |
0.05 |
|
mauna_loa
|
UTSW |
2 |
155,257,147 (GRCm39) |
missense |
probably damaging |
0.99 |
|
PIT4466001:Ncoa6
|
UTSW |
2 |
155,247,577 (GRCm39) |
missense |
probably benign |
|
|
R0011:Ncoa6
|
UTSW |
2 |
155,250,211 (GRCm39) |
frame shift |
probably null |
|
|
R0014:Ncoa6
|
UTSW |
2 |
155,279,963 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R0079:Ncoa6
|
UTSW |
2 |
155,250,211 (GRCm39) |
frame shift |
probably null |
|
|
R0080:Ncoa6
|
UTSW |
2 |
155,250,211 (GRCm39) |
frame shift |
probably null |
|
|
R0081:Ncoa6
|
UTSW |
2 |
155,250,211 (GRCm39) |
frame shift |
probably null |
|
|
R0164:Ncoa6
|
UTSW |
2 |
155,250,211 (GRCm39) |
frame shift |
probably null |
|
|
R0166:Ncoa6
|
UTSW |
2 |
155,250,211 (GRCm39) |
frame shift |
probably null |
|
|
R0172:Ncoa6
|
UTSW |
2 |
155,250,211 (GRCm39) |
frame shift |
probably null |
|
|
R0173:Ncoa6
|
UTSW |
2 |
155,250,211 (GRCm39) |
frame shift |
probably null |
|
|
R0245:Ncoa6
|
UTSW |
2 |
155,233,131 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0284:Ncoa6
|
UTSW |
2 |
155,250,211 (GRCm39) |
frame shift |
probably null |
|
|
R0285:Ncoa6
|
UTSW |
2 |
155,257,621 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R0285:Ncoa6
|
UTSW |
2 |
155,250,211 (GRCm39) |
frame shift |
probably null |
|
|
R0288:Ncoa6
|
UTSW |
2 |
155,250,211 (GRCm39) |
frame shift |
probably null |
|
|
R0652:Ncoa6
|
UTSW |
2 |
155,233,131 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0781:Ncoa6
|
UTSW |
2 |
155,253,440 (GRCm39) |
splice site |
probably benign |
|
|
R1053:Ncoa6
|
UTSW |
2 |
155,275,960 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1110:Ncoa6
|
UTSW |
2 |
155,253,440 (GRCm39) |
splice site |
probably benign |
|
|
R1420:Ncoa6
|
UTSW |
2 |
155,263,073 (GRCm39) |
nonsense |
probably null |
|
|
R1521:Ncoa6
|
UTSW |
2 |
155,257,142 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
R1541:Ncoa6
|
UTSW |
2 |
155,257,224 (GRCm39) |
missense |
probably benign |
0.35 |
|
R1677:Ncoa6
|
UTSW |
2 |
155,244,584 (GRCm39) |
unclassified |
probably benign |
|
|
R1858:Ncoa6
|
UTSW |
2 |
155,263,559 (GRCm39) |
missense |
probably benign |
0.13 |
|
R1954:Ncoa6
|
UTSW |
2 |
155,248,741 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R1955:Ncoa6
|
UTSW |
2 |
155,248,741 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R2040:Ncoa6
|
UTSW |
2 |
155,248,000 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R2087:Ncoa6
|
UTSW |
2 |
155,248,079 (GRCm39) |
nonsense |
probably null |
|
|
R2159:Ncoa6
|
UTSW |
2 |
155,249,633 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2278:Ncoa6
|
UTSW |
2 |
155,249,570 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R2696:Ncoa6
|
UTSW |
2 |
155,279,935 (GRCm39) |
missense |
probably benign |
0.45 |
|
R2891:Ncoa6
|
UTSW |
2 |
155,279,881 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R3618:Ncoa6
|
UTSW |
2 |
155,249,709 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R3747:Ncoa6
|
UTSW |
2 |
155,253,561 (GRCm39) |
missense |
probably benign |
0.01 |
|
R3778:Ncoa6
|
UTSW |
2 |
155,263,115 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3784:Ncoa6
|
UTSW |
2 |
155,249,677 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3802:Ncoa6
|
UTSW |
2 |
155,247,484 (GRCm39) |
missense |
probably benign |
|
|
R3820:Ncoa6
|
UTSW |
2 |
155,248,858 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3821:Ncoa6
|
UTSW |
2 |
155,248,858 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3822:Ncoa6
|
UTSW |
2 |
155,248,858 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3870:Ncoa6
|
UTSW |
2 |
155,257,477 (GRCm39) |
splice site |
probably null |
|
|
R4037:Ncoa6
|
UTSW |
2 |
155,249,290 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R4488:Ncoa6
|
UTSW |
2 |
155,249,396 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R4719:Ncoa6
|
UTSW |
2 |
155,233,081 (GRCm39) |
unclassified |
probably benign |
|
|
R4732:Ncoa6
|
UTSW |
2 |
155,263,221 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4733:Ncoa6
|
UTSW |
2 |
155,263,221 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4829:Ncoa6
|
UTSW |
2 |
155,257,147 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4835:Ncoa6
|
UTSW |
2 |
155,249,053 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R4883:Ncoa6
|
UTSW |
2 |
155,248,687 (GRCm39) |
missense |
probably benign |
0.29 |
|
R4967:Ncoa6
|
UTSW |
2 |
155,263,252 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R5021:Ncoa6
|
UTSW |
2 |
155,248,869 (GRCm39) |
missense |
probably benign |
0.05 |
|
R5234:Ncoa6
|
UTSW |
2 |
155,279,933 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5356:Ncoa6
|
UTSW |
2 |
155,263,112 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5358:Ncoa6
|
UTSW |
2 |
155,248,907 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R5375:Ncoa6
|
UTSW |
2 |
155,275,915 (GRCm39) |
missense |
probably benign |
0.16 |
|
R5412:Ncoa6
|
UTSW |
2 |
155,249,701 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R5579:Ncoa6
|
UTSW |
2 |
155,248,597 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5618:Ncoa6
|
UTSW |
2 |
155,279,817 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R5641:Ncoa6
|
UTSW |
2 |
155,263,756 (GRCm39) |
missense |
probably benign |
0.22 |
|
R5757:Ncoa6
|
UTSW |
2 |
155,253,528 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5761:Ncoa6
|
UTSW |
2 |
155,250,061 (GRCm39) |
missense |
probably benign |
0.11 |
|
R5778:Ncoa6
|
UTSW |
2 |
155,248,688 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5852:Ncoa6
|
UTSW |
2 |
155,247,419 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R5940:Ncoa6
|
UTSW |
2 |
155,257,785 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R6155:Ncoa6
|
UTSW |
2 |
155,249,368 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6374:Ncoa6
|
UTSW |
2 |
155,263,076 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6389:Ncoa6
|
UTSW |
2 |
155,237,736 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R6669:Ncoa6
|
UTSW |
2 |
155,241,613 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R7097:Ncoa6
|
UTSW |
2 |
155,279,983 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7385:Ncoa6
|
UTSW |
2 |
155,249,721 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7963:Ncoa6
|
UTSW |
2 |
155,247,916 (GRCm39) |
missense |
probably benign |
0.30 |
|
R8356:Ncoa6
|
UTSW |
2 |
155,248,172 (GRCm39) |
missense |
possibly damaging |
0.59 |
|
R8698:Ncoa6
|
UTSW |
2 |
155,257,041 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R8859:Ncoa6
|
UTSW |
2 |
155,248,388 (GRCm39) |
missense |
possibly damaging |
0.63 |
|
R8870:Ncoa6
|
UTSW |
2 |
155,263,078 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9041:Ncoa6
|
UTSW |
2 |
155,257,450 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R9062:Ncoa6
|
UTSW |
2 |
155,263,348 (GRCm39) |
missense |
probably benign |
0.42 |
|
R9088:Ncoa6
|
UTSW |
2 |
155,249,726 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R9225:Ncoa6
|
UTSW |
2 |
155,249,441 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R9445:Ncoa6
|
UTSW |
2 |
155,250,063 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9497:Ncoa6
|
UTSW |
2 |
155,248,238 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R9514:Ncoa6
|
UTSW |
2 |
155,248,133 (GRCm39) |
missense |
probably benign |
0.19 |
|
R9656:Ncoa6
|
UTSW |
2 |
155,274,846 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9720:Ncoa6
|
UTSW |
2 |
155,250,304 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R9732:Ncoa6
|
UTSW |
2 |
155,244,636 (GRCm39) |
missense |
probably damaging |
0.99 |
|
RF033:Ncoa6
|
UTSW |
2 |
155,263,651 (GRCm39) |
small deletion |
probably benign |
|
|
RF040:Ncoa6
|
UTSW |
2 |
155,263,651 (GRCm39) |
small deletion |
probably benign |
|
|
RF048:Ncoa6
|
UTSW |
2 |
155,263,632 (GRCm39) |
small deletion |
probably benign |
|
|
X0017:Ncoa6
|
UTSW |
2 |
155,248,460 (GRCm39) |
missense |
probably benign |
0.05 |
|
Z1176:Ncoa6
|
UTSW |
2 |
155,263,222 (GRCm39) |
missense |
probably damaging |
0.99 |
|
Z1177:Ncoa6
|
UTSW |
2 |
155,263,138 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1177:Ncoa6
|
UTSW |
2 |
155,248,062 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
| Predicted Primers |
PCR Primer
(F):5'- TCTGCTGGAGCAAAACTTGCCC -3'
(R):5'- GCTGGTCCTCCTCAAAACCAGATG -3'
Sequencing Primer
(F):5'- GAGGCCCCATCATCTGGTTATG -3'
(R):5'- AACCAGATGCAGGTGTCTC -3'
|
| Posted On |
2013-06-12 |
Incidental Mutation