Mutagenetix > Incidental Mutation

Incidental Mutation 'R0539:Syne2'

49728

Institutional Source

Beutler Lab

Gene Symbol

Syne2

Ensembl Gene

ENSMUSG00000063450

Gene Name

spectrin repeat containing, nuclear envelope 2

Synonyms

Nesp2g, diminished cone electroretinogram, Cpfl8, dice, 6820443O06Rik, nesprin-2, syne-2, D12Ertd777e

MMRRC Submission

038731-MU

Accession Numbers

Essential gene?

Possibly non essential (E-score: 0.313) question?

Stock #

R0539 (G1)

Quality Score

214

Status

Validated

Chromosome

Chromosomal Location

75865092-76157702 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 76070895 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Arginine to Serine at position 103 (R103S)

Ref Sequence

ENSEMBL: ENSMUSP00000120371 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000044217] [ENSMUST00000143031] [ENSMUST00000148825]

AlphaFold

no structure available at present

Predicted Effect

possibly damaging
Transcript: ENSMUST00000044217
AA Change: R4449S

PolyPhen 2 Score 0.558 (Sensitivity: 0.88; Specificity: 0.91)

SMART Domains

Protein: ENSMUSP00000047697
Gene: ENSMUSG00000063450
AA Change: R4449S

Domain	Start	End	E-Value	Type
CH	33	134	7.97e-19	SMART
low complexity region	151	175	N/A	INTRINSIC
CH	185	283	1.34e-20	SMART
low complexity region	494	505	N/A	INTRINSIC
coiled coil region	541	572	N/A	INTRINSIC
low complexity region	665	674	N/A	INTRINSIC
coiled coil region	844	869	N/A	INTRINSIC
coiled coil region	936	969	N/A	INTRINSIC
coiled coil region	1006	1032	N/A	INTRINSIC
SPEC	1427	1525	4.96e0	SMART
SPEC	1528	1632	2.48e-1	SMART
coiled coil region	1660	1699	N/A	INTRINSIC
SPEC	2034	2131	1.83e0	SMART
coiled coil region	2173	2194	N/A	INTRINSIC
low complexity region	2295	2307	N/A	INTRINSIC
coiled coil region	2316	2348	N/A	INTRINSIC
SPEC	2720	2820	1.44e-5	SMART
coiled coil region	2905	2934	N/A	INTRINSIC
coiled coil region	2962	2989	N/A	INTRINSIC
coiled coil region	3108	3136	N/A	INTRINSIC
low complexity region	3333	3350	N/A	INTRINSIC
low complexity region	3514	3523	N/A	INTRINSIC
low complexity region	3666	3676	N/A	INTRINSIC
coiled coil region	3678	3708	N/A	INTRINSIC
coiled coil region	3761	3788	N/A	INTRINSIC
coiled coil region	3846	3903	N/A	INTRINSIC
coiled coil region	4015	4067	N/A	INTRINSIC
low complexity region	4102	4115	N/A	INTRINSIC
coiled coil region	4483	4511	N/A	INTRINSIC
low complexity region	4557	4569	N/A	INTRINSIC
coiled coil region	4655	4688	N/A	INTRINSIC
low complexity region	4749	4763	N/A	INTRINSIC
SPEC	4827	4926	5.25e-1	SMART
SPEC	4933	5038	2.64e-4	SMART
SPEC	5048	5152	1.47e-2	SMART
SPEC	5159	5259	4.29e0	SMART
SPEC	5263	5371	4.47e0	SMART
low complexity region	5373	5393	N/A	INTRINSIC
SPEC	5583	5681	5.7e-1	SMART
Blast:SPEC	5690	5793	2e-53	BLAST
SPEC	5800	5900	2.11e0	SMART
SPEC	5907	6005	6.91e-8	SMART
SPEC	6012	6119	4.45e-11	SMART
SPEC	6126	6228	6.39e-12	SMART
SPEC	6235	6335	7.75e-11	SMART
SPEC	6539	6642	5.53e-7	SMART
SPEC	6649	6753	5.12e-2	SMART
KASH	6817	6874	8.17e-34	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000143031
AA Change: R4450S

PolyPhen 2 Score 0.366 (Sensitivity: 0.90; Specificity: 0.89)

SMART Domains

Protein: ENSMUSP00000119120
Gene: ENSMUSG00000063450
AA Change: R4450S

Domain	Start	End	E-Value	Type
CH	33	134	7.97e-19	SMART
low complexity region	151	175	N/A	INTRINSIC
CH	185	283	1.34e-20	SMART
low complexity region	494	505	N/A	INTRINSIC
coiled coil region	541	572	N/A	INTRINSIC
coiled coil region	845	870	N/A	INTRINSIC
coiled coil region	937	970	N/A	INTRINSIC
coiled coil region	1007	1033	N/A	INTRINSIC
SPEC	1428	1526	4.96e0	SMART
SPEC	1529	1633	2.48e-1	SMART
coiled coil region	1661	1700	N/A	INTRINSIC
SPEC	2035	2132	1.83e0	SMART
coiled coil region	2174	2195	N/A	INTRINSIC
low complexity region	2296	2308	N/A	INTRINSIC
coiled coil region	2317	2349	N/A	INTRINSIC
SPEC	2721	2821	1.44e-5	SMART
coiled coil region	2906	2935	N/A	INTRINSIC
coiled coil region	2963	2990	N/A	INTRINSIC
coiled coil region	3109	3137	N/A	INTRINSIC
low complexity region	3334	3351	N/A	INTRINSIC
low complexity region	3515	3524	N/A	INTRINSIC
low complexity region	3667	3677	N/A	INTRINSIC
coiled coil region	3679	3709	N/A	INTRINSIC
coiled coil region	3762	3789	N/A	INTRINSIC
coiled coil region	3847	3904	N/A	INTRINSIC
coiled coil region	4016	4068	N/A	INTRINSIC
low complexity region	4103	4116	N/A	INTRINSIC
coiled coil region	4484	4512	N/A	INTRINSIC
low complexity region	4558	4570	N/A	INTRINSIC
coiled coil region	4656	4689	N/A	INTRINSIC
low complexity region	4750	4764	N/A	INTRINSIC
SPEC	4828	4927	5.25e-1	SMART
SPEC	4934	5039	2.64e-4	SMART
SPEC	5049	5153	1.47e-2	SMART
SPEC	5160	5260	4.29e0	SMART
SPEC	5264	5372	4.47e0	SMART
low complexity region	5374	5394	N/A	INTRINSIC
SPEC	5584	5682	5.7e-1	SMART
Blast:SPEC	5691	5794	2e-53	BLAST
SPEC	5801	5901	2.11e0	SMART
SPEC	5908	6006	6.91e-8	SMART
SPEC	6013	6120	4.45e-11	SMART
SPEC	6127	6229	6.39e-12	SMART
SPEC	6236	6336	7.75e-11	SMART
SPEC	6540	6643	5.53e-7	SMART
SPEC	6650	6754	5.12e-2	SMART
KASH	6813	6870	8.17e-34	SMART

Predicted Effect

possibly damaging
Transcript: ENSMUST00000148825
AA Change: R103S

PolyPhen 2 Score 0.691 (Sensitivity: 0.86; Specificity: 0.92)

SMART Domains

Protein: ENSMUSP00000120371
Gene: ENSMUSG00000063450
AA Change: R103S

Domain	Start	End	E-Value	Type
coiled coil region	137	165	N/A	INTRINSIC

Meta Mutation Damage Score

0.1795

Coding Region Coverage

1x: 99.2%
3x: 98.5%
10x: 96.8%
20x: 94.3%

Validation Efficiency

100% (107/107)

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a nuclear outer membrane protein that binds cytoplasmic F-actin. This binding tethers the nucleus to the cytoskeleton and aids in the maintenance of the structural integrity of the nucleus. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]
PHENOTYPE: Homozygotes for one knock-out allele show normal myonuclear positioning of both synaptic and non-synaptic nuclei in skeletal muscle cells. Homozygotes for another knock-out allele exhibit a thickened epidermis and altered nuclear envelope architecture inprimary dermal fibroblasts and keratinocytes. Mice homozygous for a spontaneous mutation exhibit early retinal defects in photoreceptors, secondary Neurons, and muller glia. [provided by MGI curators]

Allele List at MGI

All alleles(5) : Targeted, knock-out(2) Gene trapped(3)

Other mutations in this stock

Total: 108 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
5730480H06Rik	T	A	5: 48,536,692 (GRCm39)	H129Q	probably damaging	Het
Abca14	G	A	7: 119,807,020 (GRCm39)	R22Q	probably damaging	Het
Abcg5	T	A	17: 84,976,503 (GRCm39)	M445L	probably benign	Het
Abhd3	T	A	18: 10,645,208 (GRCm39)	N357I	possibly damaging	Het
Adamts5	C	T	16: 85,665,580 (GRCm39)	G574S	probably damaging	Het
Adgrg5	T	A	8: 95,665,260 (GRCm39)	N389K	probably damaging	Het
Ankk1	A	G	9: 49,329,330 (GRCm39)	V80A	probably benign	Het
Arhgap20	A	G	9: 51,761,455 (GRCm39)	Q1066R	probably benign	Het
Arhgap21	T	A	2: 20,919,610 (GRCm39)	K32*	probably null	Het
AW209491	T	C	13: 14,812,317 (GRCm39)	F390S	probably damaging	Het
Axl	A	T	7: 25,478,142 (GRCm39)		probably benign	Het
Bri3bp	A	G	5: 125,531,603 (GRCm39)	Y183C	probably damaging	Het
Cad	T	C	5: 31,232,801 (GRCm39)		probably benign	Het
Capns2	A	G	8: 93,628,360 (GRCm39)	Q83R	possibly damaging	Het
Ccdc180	G	T	4: 45,922,010 (GRCm39)	R1028L	probably damaging	Het
Cdh19	C	A	1: 110,852,892 (GRCm39)	V348F	possibly damaging	Het
Chrm2	T	C	6: 36,500,641 (GRCm39)	V166A	possibly damaging	Het
Clmp	A	G	9: 40,693,782 (GRCm39)	Y333C	probably benign	Het
Cntn3	A	G	6: 102,254,178 (GRCm39)		probably null	Het
Copz1	A	G	15: 103,199,792 (GRCm39)	Y69C	probably damaging	Het
Crybg1	T	C	10: 43,874,894 (GRCm39)	D738G	probably benign	Het
Ctnna2	T	A	6: 76,950,882 (GRCm39)	I165F	probably damaging	Het
Dcaf7	T	G	11: 105,942,652 (GRCm39)	S200A	probably damaging	Het
Deup1	T	A	9: 15,493,893 (GRCm39)	R416S	possibly damaging	Het
Dmxl1	T	A	18: 49,990,497 (GRCm39)		probably benign	Het
Dnaaf11	A	T	15: 66,319,455 (GRCm39)	V305D	probably damaging	Het
Dnase2b	A	T	3: 146,294,910 (GRCm39)		probably benign	Het
Dst	C	T	1: 34,228,200 (GRCm39)	P1606L	probably damaging	Het
Eef2	C	CN	10: 81,014,602 (GRCm39)		probably null	Het
Ephb2	T	C	4: 136,383,287 (GRCm39)	Y931C	probably damaging	Het
Fam83h	T	C	15: 75,875,076 (GRCm39)	S754G	possibly damaging	Het
Fibp	T	A	19: 5,513,216 (GRCm39)	V177D	probably damaging	Het
Gfpt2	T	C	11: 49,723,725 (GRCm39)	I571T	probably damaging	Het
Grm7	T	G	6: 111,336,055 (GRCm39)		probably benign	Het
Gsdma3	A	G	11: 98,526,745 (GRCm39)	Y335C	probably damaging	Het
H2-T23	A	T	17: 36,343,033 (GRCm39)		probably benign	Het
H4c3	A	G	13: 23,882,131 (GRCm39)	F101S	probably damaging	Het
Hydin	A	G	8: 111,249,704 (GRCm39)	I2216V	probably benign	Het
Ipo8	A	G	6: 148,719,606 (GRCm39)	M113T	probably benign	Het
Kdm6a	A	G	X: 18,128,664 (GRCm39)	E1045G	probably damaging	Het
Kyat1	C	T	2: 30,078,229 (GRCm39)	E117K	probably damaging	Het
Lin7b	A	G	7: 45,019,326 (GRCm39)		probably benign	Het
Lipn	G	A	19: 34,062,003 (GRCm39)		probably benign	Het
Lrfn2	C	A	17: 49,378,072 (GRCm39)	N384K	probably damaging	Het
Map1b	T	C	13: 99,570,526 (GRCm39)	K732E	unknown	Het
Mpl	A	G	4: 118,300,705 (GRCm39)	M541T	possibly damaging	Het
Mprip	T	C	11: 59,631,943 (GRCm39)		probably benign	Het
Mrc1	T	C	2: 14,274,937 (GRCm39)		probably benign	Het
Ms4a13	T	C	19: 11,149,235 (GRCm39)		probably benign	Het
Myo18b	G	T	5: 112,871,734 (GRCm39)	R2116S	probably damaging	Het
Nav2	A	G	7: 49,111,686 (GRCm39)	T731A	probably damaging	Het
Ncoa6	G	T	2: 155,257,617 (GRCm39)	A642D	probably benign	Het
Ndufs7	T	A	10: 80,090,665 (GRCm39)		probably benign	Het
Nfkbiz	G	A	16: 55,638,242 (GRCm39)	T406M	probably benign	Het
Nr4a1	A	G	15: 101,168,765 (GRCm39)	E267G	probably damaging	Het
Nrxn2	T	G	19: 6,543,434 (GRCm39)	F1103V	probably damaging	Het
Or10ab4	C	T	7: 107,655,029 (GRCm39)	T280I	probably damaging	Het
Or10d3	A	T	9: 39,461,593 (GRCm39)	D191E	probably damaging	Het
Or1e22	T	C	11: 73,376,889 (GRCm39)	T254A	probably benign	Het
Or5a3	C	T	19: 12,400,173 (GRCm39)	L167F	probably damaging	Het
Or5g27	T	A	2: 85,410,119 (GRCm39)	C179S	probably damaging	Het
Or5m11	G	T	2: 85,782,353 (GRCm39)	M315I	probably benign	Het
Or8u9	A	T	2: 86,001,387 (GRCm39)	M258K	probably damaging	Het
Phf1	A	G	17: 27,153,432 (GRCm39)		probably null	Het
Pip	C	T	6: 41,826,819 (GRCm39)	Q53*	probably null	Het
Ppp2ca	T	C	11: 52,008,989 (GRCm39)		probably null	Het
Prl2c5	A	G	13: 13,363,906 (GRCm39)		probably null	Het
Psph	T	A	5: 129,843,641 (GRCm39)		probably benign	Het
Ptch1	C	T	13: 63,691,294 (GRCm39)		probably benign	Het
Ptprs	C	T	17: 56,765,255 (GRCm39)	V10M	probably damaging	Het
Rarg	T	C	15: 102,147,312 (GRCm39)	R358G	probably damaging	Het
Rbl2	T	C	8: 91,839,133 (GRCm39)		probably benign	Het
Robo2	A	T	16: 73,782,462 (GRCm39)		probably benign	Het
Scin	A	T	12: 40,131,765 (GRCm39)	D256E	possibly damaging	Het
Scn8a	T	C	15: 100,914,449 (GRCm39)	Y1152H	probably damaging	Het
Sh2b2	T	G	5: 136,254,155 (GRCm39)		probably benign	Het
Slc13a2	G	A	11: 78,289,964 (GRCm39)	P450L	probably damaging	Het
Slc2a12	A	G	10: 22,568,129 (GRCm39)	I519V	probably benign	Het
Slc30a9	C	T	5: 67,491,953 (GRCm39)	T260M	probably damaging	Het
Slc9a7	A	T	X: 20,069,001 (GRCm39)	F184Y	probably damaging	Het
Smc2	G	T	4: 52,458,558 (GRCm39)	K466N	probably benign	Het
Snx16	T	C	3: 10,491,278 (GRCm39)	E209G	probably damaging	Het
Sp3	A	T	2: 72,800,876 (GRCm39)	I423N	possibly damaging	Het
Ssh2	G	T	11: 77,345,620 (GRCm39)	V1202F	probably benign	Het
Stam2	A	T	2: 52,593,268 (GRCm39)		probably benign	Het
Stox2	T	C	8: 47,647,070 (GRCm39)	Y194C	probably damaging	Het
Sult3a1	A	G	10: 33,742,519 (GRCm39)	T49A	probably damaging	Het
Supt3	A	T	17: 45,314,018 (GRCm39)	I136F	possibly damaging	Het
Synj2	T	A	17: 6,047,163 (GRCm39)	M1K	probably null	Het
Tas2r110	T	C	6: 132,845,334 (GRCm39)	S122P	possibly damaging	Het
Tln1	A	G	4: 43,543,434 (GRCm39)		probably null	Het
Tmem117	A	G	15: 94,612,793 (GRCm39)	T110A	possibly damaging	Het
Tmem247	A	G	17: 87,224,906 (GRCm39)	D5G	probably benign	Het
Tmem39a	T	A	16: 38,411,337 (GRCm39)	F363I	probably benign	Het
Tmem80	G	A	7: 140,915,808 (GRCm39)	A73T	possibly damaging	Het
Trpm4	C	T	7: 44,954,896 (GRCm39)	G901S	probably damaging	Het
Upk3bl	T	C	5: 136,092,840 (GRCm39)		probably benign	Het
Vmn1r120	A	T	7: 20,787,397 (GRCm39)	C105S	probably damaging	Het
Vmn1r69	A	T	7: 10,314,874 (GRCm39)		probably benign	Het
Vmn2r95	T	C	17: 18,672,362 (GRCm39)	F700L	probably damaging	Het
Wdr70	G	A	15: 7,915,118 (GRCm39)	T550M	possibly damaging	Het
Zbtb22	A	G	17: 34,137,118 (GRCm39)	D421G	possibly damaging	Het
Zbtb45	G	A	7: 12,740,260 (GRCm39)	R452C	probably damaging	Het
Zfhx3	T	C	8: 109,527,141 (GRCm39)	Y1013H	probably damaging	Het
Zfp329	C	T	7: 12,540,520 (GRCm39)		probably null	Het
Zfp532	T	A	18: 65,756,837 (GRCm39)	S257T	probably benign	Het
Zfp933	G	A	4: 147,911,005 (GRCm39)	T197I	probably benign	Het
Zgrf1	T	A	3: 127,408,841 (GRCm39)	N1649K	probably damaging	Het

Other mutations in Syne2

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00329:Syne2	APN	12	76,078,474 (GRCm39)	unclassified	probably benign
IGL00595:Syne2	APN	12	75,972,420 (GRCm39)	missense	possibly damaging	0.76
IGL00672:Syne2	APN	12	76,110,958 (GRCm39)	missense	probably damaging	1.00
IGL00781:Syne2	APN	12	76,070,836 (GRCm39)	missense	probably benign	0.00
IGL00823:Syne2	APN	12	76,036,016 (GRCm39)	missense	probably damaging	0.98
IGL01014:Syne2	APN	12	75,952,051 (GRCm39)	missense	probably damaging	0.99
IGL01074:Syne2	APN	12	76,078,361 (GRCm39)	nonsense	probably null
IGL01074:Syne2	APN	12	76,033,785 (GRCm39)	missense	probably benign	0.00
IGL01324:Syne2	APN	12	76,090,526 (GRCm39)	missense	probably damaging	1.00
IGL01325:Syne2	APN	12	75,973,288 (GRCm39)	missense	probably benign	0.01
IGL01331:Syne2	APN	12	75,976,027 (GRCm39)	splice site	probably benign
IGL01338:Syne2	APN	12	76,107,000 (GRCm39)	missense	possibly damaging	0.55
IGL01373:Syne2	APN	12	76,033,881 (GRCm39)	missense	probably damaging	1.00
IGL01446:Syne2	APN	12	76,088,149 (GRCm39)	missense	probably damaging	1.00
IGL01556:Syne2	APN	12	76,134,589 (GRCm39)	missense	probably damaging	1.00
IGL01585:Syne2	APN	12	75,995,834 (GRCm39)	critical splice acceptor site	probably null
IGL01629:Syne2	APN	12	76,051,377 (GRCm39)	missense	possibly damaging	0.49
IGL01686:Syne2	APN	12	75,956,110 (GRCm39)	missense	probably benign
IGL01935:Syne2	APN	12	75,972,087 (GRCm39)	missense	probably damaging	1.00
IGL01941:Syne2	APN	12	76,013,994 (GRCm39)	missense	probably benign	0.01
IGL01956:Syne2	APN	12	76,144,748 (GRCm39)	missense	probably damaging	1.00
IGL01967:Syne2	APN	12	75,988,077 (GRCm39)	missense	probably damaging	1.00
IGL01990:Syne2	APN	12	76,101,707 (GRCm39)	missense	probably damaging	1.00
IGL02000:Syne2	APN	12	76,062,419 (GRCm39)	missense	probably damaging	0.99
IGL02063:Syne2	APN	12	76,098,874 (GRCm39)	missense	probably damaging	0.96
IGL02069:Syne2	APN	12	75,974,186 (GRCm39)	missense	probably benign	0.13
IGL02120:Syne2	APN	12	75,993,480 (GRCm39)	missense	probably damaging	1.00
IGL02222:Syne2	APN	12	75,999,617 (GRCm39)	missense	probably damaging	0.96
IGL02223:Syne2	APN	12	76,155,079 (GRCm39)	missense	probably benign	0.00
IGL02321:Syne2	APN	12	75,965,773 (GRCm39)	missense	possibly damaging	0.58
IGL02488:Syne2	APN	12	76,012,512 (GRCm39)	missense	probably benign	0.24
IGL02491:Syne2	APN	12	76,118,953 (GRCm39)	missense	probably benign	0.10
IGL02525:Syne2	APN	12	76,147,777 (GRCm39)	missense	probably damaging	0.99
IGL02578:Syne2	APN	12	76,069,053 (GRCm39)	missense	possibly damaging	0.76
IGL02615:Syne2	APN	12	76,143,768 (GRCm39)	missense	probably damaging	1.00
IGL02702:Syne2	APN	12	76,144,698 (GRCm39)	missense	probably damaging	1.00
IGL02726:Syne2	APN	12	76,062,356 (GRCm39)	missense	probably damaging	0.99
IGL02795:Syne2	APN	12	76,013,323 (GRCm39)	missense	probably damaging	0.99
IGL02803:Syne2	APN	12	76,078,320 (GRCm39)	missense	probably damaging	1.00
IGL02814:Syne2	APN	12	75,992,150 (GRCm39)	missense	possibly damaging	0.64
IGL03013:Syne2	APN	12	75,976,111 (GRCm39)	missense	probably benign	0.00
IGL03131:Syne2	APN	12	76,104,264 (GRCm39)	missense	probably damaging	1.00
IGL03152:Syne2	APN	12	76,012,486 (GRCm39)	missense	probably benign	0.12
IGL03216:Syne2	APN	12	75,989,735 (GRCm39)	splice site	probably benign
IGL03228:Syne2	APN	12	76,026,686 (GRCm39)	missense	probably benign	0.01
IGL03259:Syne2	APN	12	76,035,853 (GRCm39)	missense	probably benign	0.05
IGL03374:Syne2	APN	12	76,121,360 (GRCm39)	missense	possibly damaging	0.66
IGL03375:Syne2	APN	12	75,972,209 (GRCm39)	missense	possibly damaging	0.57
3-1:Syne2	UTSW	12	75,977,406 (GRCm39)	missense	probably benign	0.02
B5639:Syne2	UTSW	12	75,976,564 (GRCm39)	missense	probably benign
K3955:Syne2	UTSW	12	75,977,439 (GRCm39)	missense	probably damaging	1.00
P0026:Syne2	UTSW	12	75,926,994 (GRCm39)	splice site	probably benign
PIT4514001:Syne2	UTSW	12	76,151,789 (GRCm39)	missense	probably damaging	0.99
R0089:Syne2	UTSW	12	76,010,650 (GRCm39)	missense	probably damaging	1.00
R0110:Syne2	UTSW	12	76,144,734 (GRCm39)	nonsense	probably null
R0113:Syne2	UTSW	12	76,080,496 (GRCm39)	missense	probably damaging	1.00
R0113:Syne2	UTSW	12	75,977,352 (GRCm39)	missense	probably damaging	1.00
R0141:Syne2	UTSW	12	75,988,072 (GRCm39)	missense	probably damaging	1.00
R0211:Syne2	UTSW	12	76,144,731 (GRCm39)	missense	probably damaging	1.00
R0219:Syne2	UTSW	12	76,088,778 (GRCm39)	missense	probably damaging	1.00
R0242:Syne2	UTSW	12	76,144,808 (GRCm39)	missense	probably damaging	1.00
R0242:Syne2	UTSW	12	76,144,808 (GRCm39)	missense	probably damaging	1.00
R0279:Syne2	UTSW	12	76,142,387 (GRCm39)	missense	probably damaging	1.00
R0319:Syne2	UTSW	12	76,110,936 (GRCm39)	missense	probably damaging	0.99
R0325:Syne2	UTSW	12	76,009,415 (GRCm39)	missense	probably benign	0.00
R0329:Syne2	UTSW	12	76,013,727 (GRCm39)	missense	probably benign
R0330:Syne2	UTSW	12	76,013,727 (GRCm39)	missense	probably benign
R0361:Syne2	UTSW	12	75,965,384 (GRCm39)	missense	probably benign	0.22
R0363:Syne2	UTSW	12	76,118,981 (GRCm39)	missense	probably damaging	0.98
R0367:Syne2	UTSW	12	75,926,951 (GRCm39)	missense	probably damaging	1.00
R0371:Syne2	UTSW	12	75,980,619 (GRCm39)	missense	probably damaging	1.00
R0374:Syne2	UTSW	12	75,968,000 (GRCm39)	nonsense	probably null
R0388:Syne2	UTSW	12	76,033,749 (GRCm39)	missense	probably benign	0.41
R0411:Syne2	UTSW	12	76,106,358 (GRCm39)	splice site	probably null
R0432:Syne2	UTSW	12	75,995,838 (GRCm39)	missense	probably damaging	0.99
R0469:Syne2	UTSW	12	75,900,923 (GRCm39)	critical splice donor site	probably null
R0492:Syne2	UTSW	12	76,028,837 (GRCm39)	critical splice donor site	probably null
R0496:Syne2	UTSW	12	76,085,714 (GRCm39)	missense	possibly damaging	0.80
R0504:Syne2	UTSW	12	76,080,365 (GRCm39)	splice site	probably benign
R0505:Syne2	UTSW	12	76,146,238 (GRCm39)	missense	probably damaging	1.00
R0510:Syne2	UTSW	12	75,900,923 (GRCm39)	critical splice donor site	probably null
R0518:Syne2	UTSW	12	76,155,636 (GRCm39)	critical splice acceptor site	probably null
R0552:Syne2	UTSW	12	75,977,778 (GRCm39)	missense	probably benign	0.00
R0557:Syne2	UTSW	12	75,976,075 (GRCm39)	missense	probably benign	0.04
R0567:Syne2	UTSW	12	75,937,004 (GRCm39)	missense	probably damaging	0.98
R0599:Syne2	UTSW	12	76,144,734 (GRCm39)	nonsense	probably null
R0602:Syne2	UTSW	12	76,144,734 (GRCm39)	nonsense	probably null
R0608:Syne2	UTSW	12	76,010,587 (GRCm39)	missense	probably damaging	1.00
R0614:Syne2	UTSW	12	75,959,127 (GRCm39)	splice site	probably null
R0636:Syne2	UTSW	12	75,977,757 (GRCm39)	missense	possibly damaging	0.75
R0647:Syne2	UTSW	12	75,934,977 (GRCm39)	missense	probably benign
R0654:Syne2	UTSW	12	76,144,734 (GRCm39)	nonsense	probably null
R0658:Syne2	UTSW	12	76,141,110 (GRCm39)	missense	probably damaging	1.00
R0666:Syne2	UTSW	12	75,969,787 (GRCm39)	missense	probably damaging	0.99
R0707:Syne2	UTSW	12	76,028,837 (GRCm39)	critical splice donor site	probably null
R0714:Syne2	UTSW	12	76,144,734 (GRCm39)	nonsense	probably null
R0841:Syne2	UTSW	12	76,121,209 (GRCm39)	splice site	probably benign
R0848:Syne2	UTSW	12	76,144,734 (GRCm39)	nonsense	probably null
R0848:Syne2	UTSW	12	76,144,733 (GRCm39)	frame shift	probably null
R1077:Syne2	UTSW	12	76,088,809 (GRCm39)	missense	possibly damaging	0.94
R1103:Syne2	UTSW	12	76,156,609 (GRCm39)	missense	probably benign	0.00
R1144:Syne2	UTSW	12	76,013,298 (GRCm39)	missense	probably benign	0.04
R1194:Syne2	UTSW	12	75,981,287 (GRCm39)	missense	probably damaging	1.00
R1247:Syne2	UTSW	12	76,014,264 (GRCm39)	missense	probably benign	0.39
R1276:Syne2	UTSW	12	75,987,963 (GRCm39)	critical splice acceptor site	probably null
R1343:Syne2	UTSW	12	76,080,417 (GRCm39)	missense	probably damaging	1.00
R1442:Syne2	UTSW	12	75,993,489 (GRCm39)	missense	probably damaging	1.00
R1448:Syne2	UTSW	12	76,098,952 (GRCm39)	missense	possibly damaging	0.56
R1448:Syne2	UTSW	12	76,067,099 (GRCm39)	splice site	probably null
R1522:Syne2	UTSW	12	76,150,557 (GRCm39)	missense	probably damaging	0.98
R1528:Syne2	UTSW	12	76,012,874 (GRCm39)	missense	probably benign	0.00
R1636:Syne2	UTSW	12	76,051,506 (GRCm39)	missense	probably benign	0.01
R1637:Syne2	UTSW	12	76,042,776 (GRCm39)	missense	probably damaging	1.00
R1650:Syne2	UTSW	12	75,951,033 (GRCm39)	nonsense	probably null
R1654:Syne2	UTSW	12	76,147,868 (GRCm39)	missense	possibly damaging	0.56
R1714:Syne2	UTSW	12	76,101,713 (GRCm39)	missense	probably benign	0.26
R1750:Syne2	UTSW	12	76,099,579 (GRCm39)	missense	probably damaging	1.00
R1772:Syne2	UTSW	12	75,985,503 (GRCm39)	missense	probably benign	0.19
R1797:Syne2	UTSW	12	76,010,557 (GRCm39)	missense	probably benign	0.00
R1830:Syne2	UTSW	12	76,156,636 (GRCm39)	missense	probably damaging	1.00
R1837:Syne2	UTSW	12	76,014,434 (GRCm39)	missense	probably damaging	0.99
R1908:Syne2	UTSW	12	76,141,053 (GRCm39)	critical splice acceptor site	probably null
R1913:Syne2	UTSW	12	75,946,020 (GRCm39)	missense	possibly damaging	0.60
R1944:Syne2	UTSW	12	76,121,318 (GRCm39)	missense	probably damaging	1.00
R1950:Syne2	UTSW	12	75,999,644 (GRCm39)	missense	probably benign
R1958:Syne2	UTSW	12	76,016,319 (GRCm39)	missense	probably benign	0.11
R2018:Syne2	UTSW	12	76,121,353 (GRCm39)	missense	probably damaging	1.00
R2037:Syne2	UTSW	12	76,072,343 (GRCm39)	missense	probably benign	0.04
R2067:Syne2	UTSW	12	75,935,116 (GRCm39)	critical splice donor site	probably null
R2073:Syne2	UTSW	12	76,062,353 (GRCm39)	missense	possibly damaging	0.54
R2099:Syne2	UTSW	12	76,026,747 (GRCm39)	missense	probably benign	0.06
R2102:Syne2	UTSW	12	76,074,853 (GRCm39)	missense	probably benign	0.01
R2134:Syne2	UTSW	12	75,999,560 (GRCm39)	missense	probably damaging	0.99
R2135:Syne2	UTSW	12	75,999,560 (GRCm39)	missense	probably damaging	0.99
R2157:Syne2	UTSW	12	76,141,230 (GRCm39)	missense	probably damaging	1.00
R2173:Syne2	UTSW	12	76,147,763 (GRCm39)	splice site	probably benign
R2248:Syne2	UTSW	12	76,143,678 (GRCm39)	missense	probably damaging	1.00
R2276:Syne2	UTSW	12	75,974,240 (GRCm39)	missense	possibly damaging	0.87
R2277:Syne2	UTSW	12	75,974,240 (GRCm39)	missense	possibly damaging	0.87
R2278:Syne2	UTSW	12	75,974,240 (GRCm39)	missense	possibly damaging	0.87
R2279:Syne2	UTSW	12	75,974,240 (GRCm39)	missense	possibly damaging	0.87
R2483:Syne2	UTSW	12	76,142,311 (GRCm39)	missense	probably damaging	1.00
R2877:Syne2	UTSW	12	76,047,605 (GRCm39)	missense	probably benign	0.00
R2884:Syne2	UTSW	12	76,010,533 (GRCm39)	missense	probably benign	0.00
R3119:Syne2	UTSW	12	75,956,058 (GRCm39)	missense	probably benign	0.01
R3499:Syne2	UTSW	12	76,101,752 (GRCm39)	splice site	probably null
R3827:Syne2	UTSW	12	76,033,805 (GRCm39)	missense	probably benign	0.02
R3847:Syne2	UTSW	12	76,095,396 (GRCm39)	missense	probably damaging	1.00
R3849:Syne2	UTSW	12	76,092,839 (GRCm39)	nonsense	probably null
R3850:Syne2	UTSW	12	76,095,396 (GRCm39)	missense	probably damaging	1.00
R3859:Syne2	UTSW	12	75,976,558 (GRCm39)	missense	possibly damaging	0.55
R3861:Syne2	UTSW	12	76,013,253 (GRCm39)	missense	probably damaging	0.98
R4078:Syne2	UTSW	12	76,082,398 (GRCm39)	missense	probably damaging	1.00
R4116:Syne2	UTSW	12	75,977,853 (GRCm39)	missense	probably damaging	1.00
R4326:Syne2	UTSW	12	75,999,516 (GRCm39)	missense	probably damaging	1.00
R4335:Syne2	UTSW	12	76,074,866 (GRCm39)	missense	probably damaging	1.00
R4410:Syne2	UTSW	12	76,141,167 (GRCm39)	missense	probably damaging	1.00
R4412:Syne2	UTSW	12	76,152,834 (GRCm39)	missense	probably benign	0.01
R4444:Syne2	UTSW	12	76,069,804 (GRCm39)	missense	probably damaging	1.00
R4595:Syne2	UTSW	12	76,013,845 (GRCm39)	missense	possibly damaging	0.88
R4604:Syne2	UTSW	12	76,014,484 (GRCm39)	missense	probably damaging	0.99
R4606:Syne2	UTSW	12	76,036,027 (GRCm39)	missense	probably damaging	1.00
R4651:Syne2	UTSW	12	76,036,013 (GRCm39)	missense	probably damaging	0.99
R4656:Syne2	UTSW	12	76,078,147 (GRCm39)	missense	probably damaging	1.00
R4675:Syne2	UTSW	12	75,996,075 (GRCm39)	missense	probably damaging	1.00
R4790:Syne2	UTSW	12	76,067,165 (GRCm39)	missense	probably benign	0.19
R4791:Syne2	UTSW	12	75,956,018 (GRCm39)	missense	possibly damaging	0.96
R4799:Syne2	UTSW	12	75,945,941 (GRCm39)	missense	probably benign	0.04
R4836:Syne2	UTSW	12	76,026,593 (GRCm39)	missense	probably damaging	1.00
R4880:Syne2	UTSW	12	76,026,593 (GRCm39)	missense	probably damaging	1.00
R4881:Syne2	UTSW	12	76,026,593 (GRCm39)	missense	probably damaging	1.00
R4899:Syne2	UTSW	12	75,900,875 (GRCm39)	missense	probably benign	0.03
R4934:Syne2	UTSW	12	75,946,046 (GRCm39)	missense	probably benign	0.14
R4981:Syne2	UTSW	12	75,987,993 (GRCm39)	missense	probably damaging	0.98
R4996:Syne2	UTSW	12	75,990,724 (GRCm39)	missense	possibly damaging	0.87
R5056:Syne2	UTSW	12	75,955,905 (GRCm39)	unclassified	probably benign
R5066:Syne2	UTSW	12	76,013,325 (GRCm39)	missense	probably benign	0.05
R5095:Syne2	UTSW	12	75,999,600 (GRCm39)	missense	probably damaging	0.99
R5151:Syne2	UTSW	12	76,090,484 (GRCm39)	missense	probably benign	0.06
R5193:Syne2	UTSW	12	76,141,194 (GRCm39)	missense	probably damaging	1.00
R5267:Syne2	UTSW	12	75,985,515 (GRCm39)	missense	possibly damaging	0.74
R5288:Syne2	UTSW	12	76,146,112 (GRCm39)	missense	possibly damaging	0.94
R5402:Syne2	UTSW	12	76,106,213 (GRCm39)	missense	probably damaging	0.98
R5434:Syne2	UTSW	12	76,018,649 (GRCm39)	missense	probably damaging	1.00
R5441:Syne2	UTSW	12	76,035,917 (GRCm39)	missense	possibly damaging	0.75
R5488:Syne2	UTSW	12	75,934,946 (GRCm39)	missense	probably benign	0.13
R5497:Syne2	UTSW	12	75,927,163 (GRCm39)	missense	probably benign	0.19
R5506:Syne2	UTSW	12	75,985,495 (GRCm39)	missense	probably benign	0.01
R5509:Syne2	UTSW	12	75,968,018 (GRCm39)	missense	probably damaging	1.00
R5518:Syne2	UTSW	12	75,991,944 (GRCm39)	missense	possibly damaging	0.88
R5561:Syne2	UTSW	12	76,141,232 (GRCm39)	nonsense	probably null
R5581:Syne2	UTSW	12	75,991,859 (GRCm39)	missense	probably benign	0.01
R5625:Syne2	UTSW	12	76,141,886 (GRCm39)	missense	probably benign	0.06
R5642:Syne2	UTSW	12	75,965,306 (GRCm39)	missense	probably damaging	1.00
R5665:Syne2	UTSW	12	76,154,991 (GRCm39)	critical splice donor site	probably null
R5666:Syne2	UTSW	12	75,997,733 (GRCm39)	missense	probably benign	0.16
R5670:Syne2	UTSW	12	75,997,733 (GRCm39)	missense	probably benign	0.16
R5691:Syne2	UTSW	12	76,074,630 (GRCm39)	frame shift	probably null
R5696:Syne2	UTSW	12	76,040,919 (GRCm39)	missense	probably benign	0.00
R5720:Syne2	UTSW	12	76,014,441 (GRCm39)	missense	probably benign	0.03
R5739:Syne2	UTSW	12	76,044,239 (GRCm39)	missense	possibly damaging	0.53
R5840:Syne2	UTSW	12	75,927,065 (GRCm39)	splice site	probably null
R5846:Syne2	UTSW	12	76,074,898 (GRCm39)	missense	probably benign	0.01
R5850:Syne2	UTSW	12	76,144,749 (GRCm39)	missense	probably damaging	1.00
R5889:Syne2	UTSW	12	76,119,026 (GRCm39)	nonsense	probably null
R5912:Syne2	UTSW	12	75,955,721 (GRCm39)	critical splice donor site	probably null
R5931:Syne2	UTSW	12	76,055,639 (GRCm39)	missense	probably benign	0.37
R5985:Syne2	UTSW	12	76,012,933 (GRCm39)	missense	probably damaging	0.96
R5988:Syne2	UTSW	12	75,976,191 (GRCm39)	critical splice donor site	probably null
R5990:Syne2	UTSW	12	76,070,918 (GRCm39)	missense	probably benign	0.10
R6038:Syne2	UTSW	12	75,925,158 (GRCm39)	nonsense	probably null
R6038:Syne2	UTSW	12	75,925,158 (GRCm39)	nonsense	probably null
R6132:Syne2	UTSW	12	75,991,921 (GRCm39)	missense	probably benign	0.14
R6136:Syne2	UTSW	12	75,952,099 (GRCm39)	missense	probably benign	0.24
R6229:Syne2	UTSW	12	75,967,994 (GRCm39)	missense	probably benign	0.00
R6252:Syne2	UTSW	12	76,016,210 (GRCm39)	missense	probably benign	0.39
R6271:Syne2	UTSW	12	75,937,155 (GRCm39)	missense	probably damaging	1.00
R6320:Syne2	UTSW	12	76,108,424 (GRCm39)	missense	probably damaging	0.96
R6339:Syne2	UTSW	12	76,035,927 (GRCm39)	missense	probably benign	0.34
R6380:Syne2	UTSW	12	76,151,754 (GRCm39)	missense	probably damaging	0.98
R6394:Syne2	UTSW	12	76,037,269 (GRCm39)	missense	probably benign	0.09
R6419:Syne2	UTSW	12	76,143,740 (GRCm39)	missense	probably damaging	1.00
R6426:Syne2	UTSW	12	75,969,857 (GRCm39)	missense	probably null	0.97
R6434:Syne2	UTSW	12	76,088,230 (GRCm39)	missense	probably damaging	0.99
R6437:Syne2	UTSW	12	76,037,188 (GRCm39)	missense	possibly damaging	0.87
R6466:Syne2	UTSW	12	75,990,675 (GRCm39)	missense	probably damaging	0.97
R6501:Syne2	UTSW	12	76,074,621 (GRCm39)	splice site	probably null
R6552:Syne2	UTSW	12	75,937,015 (GRCm39)	missense	possibly damaging	0.89
R6744:Syne2	UTSW	12	76,121,221 (GRCm39)	missense	probably damaging	1.00
R6810:Syne2	UTSW	12	75,989,659 (GRCm39)	missense	probably benign	0.00
R6831:Syne2	UTSW	12	76,013,568 (GRCm39)	missense	probably benign	0.39
R6861:Syne2	UTSW	12	75,956,040 (GRCm39)	missense	probably damaging	1.00
R6875:Syne2	UTSW	12	76,082,404 (GRCm39)	missense	probably damaging	0.99
R6892:Syne2	UTSW	12	76,009,302 (GRCm39)	missense	probably damaging	0.98
R6899:Syne2	UTSW	12	76,142,503 (GRCm39)	splice site	probably null
R6906:Syne2	UTSW	12	76,042,760 (GRCm39)	missense	possibly damaging	0.93
R6909:Syne2	UTSW	12	76,110,969 (GRCm39)	missense	probably benign	0.04
R6925:Syne2	UTSW	12	75,900,906 (GRCm39)	missense	possibly damaging	0.58
R6949:Syne2	UTSW	12	76,012,771 (GRCm39)	missense	probably benign	0.00
R6952:Syne2	UTSW	12	75,974,205 (GRCm39)	missense	possibly damaging	0.76
R6996:Syne2	UTSW	12	76,074,786 (GRCm39)	missense	probably damaging	0.99
R7080:Syne2	UTSW	12	76,099,501 (GRCm39)	missense	probably benign	0.00
R7083:Syne2	UTSW	12	75,990,662 (GRCm39)	missense	probably damaging	1.00
R7090:Syne2	UTSW	12	75,989,125 (GRCm39)	missense	probably benign
R7144:Syne2	UTSW	12	76,052,152 (GRCm39)	missense	probably benign	0.03
R7154:Syne2	UTSW	12	76,106,231 (GRCm39)	missense	possibly damaging	0.63
R7177:Syne2	UTSW	12	76,018,654 (GRCm39)	nonsense	probably null
R7190:Syne2	UTSW	12	76,113,361 (GRCm39)	missense	probably benign	0.01
R7206:Syne2	UTSW	12	76,051,531 (GRCm39)	missense	probably benign	0.02
R7208:Syne2	UTSW	12	76,078,172 (GRCm39)	splice site	probably null
R7230:Syne2	UTSW	12	75,980,674 (GRCm39)	missense	probably benign	0.12
R7260:Syne2	UTSW	12	75,991,853 (GRCm39)	missense	probably damaging	1.00
R7272:Syne2	UTSW	12	76,095,417 (GRCm39)	missense	probably benign	0.00
R7296:Syne2	UTSW	12	76,149,810 (GRCm39)	missense	probably benign	0.00
R7322:Syne2	UTSW	12	76,030,798 (GRCm39)	missense	probably damaging	1.00
R7329:Syne2	UTSW	12	76,013,758 (GRCm39)	missense	probably benign	0.01
R7332:Syne2	UTSW	12	76,014,529 (GRCm39)	critical splice donor site	probably null
R7381:Syne2	UTSW	12	75,973,263 (GRCm39)	missense	probably benign	0.11
R7401:Syne2	UTSW	12	76,014,155 (GRCm39)	missense	probably damaging	0.98
R7403:Syne2	UTSW	12	75,962,020 (GRCm39)	missense	not run
R7429:Syne2	UTSW	12	76,087,184 (GRCm39)	nonsense	probably null
R7429:Syne2	UTSW	12	75,980,770 (GRCm39)	missense	probably damaging	1.00
R7430:Syne2	UTSW	12	76,087,184 (GRCm39)	nonsense	probably null
R7430:Syne2	UTSW	12	75,980,770 (GRCm39)	missense	probably damaging	1.00
R7438:Syne2	UTSW	12	76,062,337 (GRCm39)	missense	probably benign	0.04
R7447:Syne2	UTSW	12	76,074,853 (GRCm39)	missense	probably benign	0.01
R7466:Syne2	UTSW	12	76,092,960 (GRCm39)	missense	possibly damaging	0.92
R7493:Syne2	UTSW	12	76,012,654 (GRCm39)	missense	probably benign	0.00
R7502:Syne2	UTSW	12	76,141,100 (GRCm39)	missense	probably damaging	1.00
R7543:Syne2	UTSW	12	75,953,616 (GRCm39)	missense	possibly damaging	0.93
R7569:Syne2	UTSW	12	75,974,164 (GRCm39)	missense	probably benign	0.00
R7599:Syne2	UTSW	12	76,013,145 (GRCm39)	missense	probably benign	0.04
R7618:Syne2	UTSW	12	75,992,108 (GRCm39)	missense	probably benign	0.01
R7639:Syne2	UTSW	12	75,981,273 (GRCm39)	missense	probably damaging	1.00
R7698:Syne2	UTSW	12	75,995,838 (GRCm39)	missense	probably damaging	0.99
R7702:Syne2	UTSW	12	76,037,161 (GRCm39)	missense	probably benign	0.16
R7737:Syne2	UTSW	12	75,989,622 (GRCm39)	missense	probably damaging	1.00
R7742:Syne2	UTSW	12	76,106,209 (GRCm39)	missense	probably benign	0.02
R7753:Syne2	UTSW	12	76,085,697 (GRCm39)	missense	probably benign	0.43
R7755:Syne2	UTSW	12	76,044,181 (GRCm39)	missense	probably benign	0.19
R7757:Syne2	UTSW	12	76,108,553 (GRCm39)	missense	possibly damaging	0.87
R7790:Syne2	UTSW	12	75,975,877 (GRCm39)	splice site	probably null
R7808:Syne2	UTSW	12	76,030,501 (GRCm39)	splice site	probably null
R7809:Syne2	UTSW	12	76,014,230 (GRCm39)	missense	probably benign	0.00
R7811:Syne2	UTSW	12	76,030,501 (GRCm39)	splice site	probably null
R7834:Syne2	UTSW	12	76,014,021 (GRCm39)	missense	probably benign	0.00
R7853:Syne2	UTSW	12	76,078,278 (GRCm39)	missense	probably damaging	1.00
R7867:Syne2	UTSW	12	76,030,501 (GRCm39)	splice site	probably null
R7896:Syne2	UTSW	12	76,082,397 (GRCm39)	missense	probably damaging	0.99
R7903:Syne2	UTSW	12	76,110,958 (GRCm39)	missense	probably damaging	1.00
R7944:Syne2	UTSW	12	75,951,079 (GRCm39)	missense	probably damaging	0.98
R7945:Syne2	UTSW	12	75,951,079 (GRCm39)	missense	probably damaging	0.98
R7963:Syne2	UTSW	12	76,067,174 (GRCm39)	missense	probably benign	0.38
R7996:Syne2	UTSW	12	76,051,441 (GRCm39)	missense	probably damaging	1.00
R7998:Syne2	UTSW	12	76,134,632 (GRCm39)	missense	probably damaging	1.00
R8010:Syne2	UTSW	12	75,977,512 (GRCm39)	missense	probably benign	0.39
R8016:Syne2	UTSW	12	75,989,681 (GRCm39)	missense	probably benign	0.19
R8140:Syne2	UTSW	12	75,959,127 (GRCm39)	missense	possibly damaging	0.63
R8141:Syne2	UTSW	12	76,108,442 (GRCm39)	missense	possibly damaging	0.66
R8206:Syne2	UTSW	12	76,062,365 (GRCm39)	missense	probably benign	0.03
R8258:Syne2	UTSW	12	75,996,143 (GRCm39)	missense	possibly damaging	0.95
R8259:Syne2	UTSW	12	75,996,143 (GRCm39)	missense	possibly damaging	0.95
R8320:Syne2	UTSW	12	76,150,604 (GRCm39)	missense	probably damaging	0.99
R8464:Syne2	UTSW	12	76,012,546 (GRCm39)	missense	probably benign	0.39
R8465:Syne2	UTSW	12	75,900,898 (GRCm39)	missense	possibly damaging	0.92
R8486:Syne2	UTSW	12	76,088,881 (GRCm39)	nonsense	probably null
R8488:Syne2	UTSW	12	76,012,546 (GRCm39)	missense	probably benign	0.39
R8511:Syne2	UTSW	12	76,055,647 (GRCm39)	missense	probably benign	0.03
R8540:Syne2	UTSW	12	76,141,148 (GRCm39)	missense	probably damaging	1.00
R8711:Syne2	UTSW	12	76,104,258 (GRCm39)	missense	probably damaging	1.00
R8722:Syne2	UTSW	12	75,972,095 (GRCm39)	missense	probably benign	0.04
R8827:Syne2	UTSW	12	76,095,357 (GRCm39)	missense	probably benign	0.00
R8867:Syne2	UTSW	12	75,989,620 (GRCm39)	missense	probably damaging	1.00
R8878:Syne2	UTSW	12	75,952,067 (GRCm39)	missense	probably benign
R8924:Syne2	UTSW	12	75,943,444 (GRCm39)	missense	probably damaging	0.97
R8966:Syne2	UTSW	12	76,146,197 (GRCm39)	missense	probably damaging	1.00
R9007:Syne2	UTSW	12	76,146,224 (GRCm39)	missense	possibly damaging	0.82
R9019:Syne2	UTSW	12	75,999,618 (GRCm39)	missense	possibly damaging	0.93
R9057:Syne2	UTSW	12	75,937,167 (GRCm39)	missense	probably damaging	1.00
R9067:Syne2	UTSW	12	75,950,994 (GRCm39)	missense	probably damaging	1.00
R9081:Syne2	UTSW	12	76,016,290 (GRCm39)	nonsense	probably null
R9091:Syne2	UTSW	12	75,977,834 (GRCm39)	missense	probably damaging	1.00
R9123:Syne2	UTSW	12	76,040,838 (GRCm39)	missense	probably damaging	1.00
R9147:Syne2	UTSW	12	75,937,158 (GRCm39)	missense	probably damaging	1.00
R9148:Syne2	UTSW	12	75,937,158 (GRCm39)	missense	probably damaging	1.00
R9163:Syne2	UTSW	12	76,009,349 (GRCm39)	missense	possibly damaging	0.88
R9192:Syne2	UTSW	12	76,156,703 (GRCm39)	missense	probably damaging	1.00
R9248:Syne2	UTSW	12	76,154,230 (GRCm39)	intron	probably benign
R9270:Syne2	UTSW	12	75,977,834 (GRCm39)	missense	probably damaging	1.00
R9292:Syne2	UTSW	12	75,997,823 (GRCm39)	missense	probably benign
R9397:Syne2	UTSW	12	76,040,849 (GRCm39)	missense	possibly damaging	0.59
R9454:Syne2	UTSW	12	76,141,844 (GRCm39)	nonsense	probably null
R9454:Syne2	UTSW	12	76,067,275 (GRCm39)	missense	probably damaging	0.99
R9478:Syne2	UTSW	12	76,154,387 (GRCm39)	missense	probably damaging	0.96
R9492:Syne2	UTSW	12	75,995,839 (GRCm39)	missense	possibly damaging	0.77
R9573:Syne2	UTSW	12	75,927,134 (GRCm39)	missense	probably damaging	1.00
R9611:Syne2	UTSW	12	76,080,460 (GRCm39)	missense	probably benign	0.05
R9623:Syne2	UTSW	12	75,986,760 (GRCm39)	missense	probably benign	0.12
R9647:Syne2	UTSW	12	76,151,875 (GRCm39)	missense	possibly damaging	0.55
R9652:Syne2	UTSW	12	76,101,620 (GRCm39)	missense	probably benign	0.00
R9667:Syne2	UTSW	12	75,926,951 (GRCm39)	missense	probably damaging	1.00
R9701:Syne2	UTSW	12	76,037,197 (GRCm39)	missense	probably damaging	1.00
R9794:Syne2	UTSW	12	76,047,617 (GRCm39)	missense	probably benign	0.04
R9802:Syne2	UTSW	12	76,037,197 (GRCm39)	missense	probably damaging	1.00
X0019:Syne2	UTSW	12	76,020,061 (GRCm39)	missense	probably benign	0.41
X0026:Syne2	UTSW	12	76,147,790 (GRCm39)	missense	possibly damaging	0.78
X0061:Syne2	UTSW	12	75,974,285 (GRCm39)	critical splice donor site	probably null
X0066:Syne2	UTSW	12	76,143,701 (GRCm39)	missense	probably damaging	1.00
Z1176:Syne2	UTSW	12	76,087,157 (GRCm39)	missense	possibly damaging	0.48
Z1176:Syne2	UTSW	12	76,014,315 (GRCm39)	missense	probably benign	0.01
Z1177:Syne2	UTSW	12	76,020,197 (GRCm39)	missense	probably damaging	1.00
Z1177:Syne2	UTSW	12	76,144,748 (GRCm39)	missense	probably damaging	1.00
Z1177:Syne2	UTSW	12	76,110,912 (GRCm39)	missense	possibly damaging	0.51

Predicted Primers

PCR Primer
(F):5'- TGCGTGGAACATCGGCTAAATGTAA -3'
(R):5'- GCAAATGGGCATTGTAGCGAGC -3'

Sequencing Primer
(F):5'- GGAACATCGGCTAAATGTAATATGAG -3'
(R):5'- AGCTCTAGAACCAGAGGAGG -3'

Posted On

2013-06-12