Incidental Mutation 'R0164:Sgo2b'
ID 500097
Institutional Source Beutler Lab
Gene Symbol Sgo2b
Ensembl Gene ENSMUSG00000094443
Gene Name shugoshin 2B
Synonyms Gm4975, Sgol2b
MMRRC Submission 038440-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.071) question?
Stock # R0164 (G1)
Quality Score 225
Status Not validated
Chromosome 8
Chromosomal Location 64377728-64405204 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 64391417 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Histidine to Arginine at position 150 (H150R)
Ref Sequence ENSEMBL: ENSMUSP00000136323 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000179944]
AlphaFold J3QMK1
Predicted Effect possibly damaging
Transcript: ENSMUST00000179944
AA Change: H150R

PolyPhen 2 Score 0.915 (Sensitivity: 0.81; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000136323
Gene: ENSMUSG00000094443
AA Change: H150R

DomainStartEndE-ValueType
coiled coil region 54 113 N/A INTRINSIC
low complexity region 122 135 N/A INTRINSIC
low complexity region 163 172 N/A INTRINSIC
low complexity region 400 414 N/A INTRINSIC
internal_repeat_1 528 618 9.12e-8 PROSPERO
internal_repeat_1 713 809 9.12e-8 PROSPERO
low complexity region 1009 1024 N/A INTRINSIC
low complexity region 1059 1081 N/A INTRINSIC
low complexity region 1112 1126 N/A INTRINSIC
low complexity region 1130 1148 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000210915
Meta Mutation Damage Score 0.1795 question?
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.4%
  • 10x: 96.7%
  • 20x: 94.0%
Validation Efficiency 98% (85/87)
Allele List at MGI
Other mutations in this stock
Total: 89 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2010315B03Rik T C 9: 124,057,789 (GRCm39) probably benign Het
4732465J04Rik GATCTATCTATCTATCTATCTATCTATCTATCTATCTATC GATCTATCTATCTATCTATCTATCTATCTATCTATCTATCTATC 10: 95,630,440 (GRCm39) probably null Het
4930522L14Rik T C 5: 109,884,713 (GRCm39) K382E probably damaging Het
Adck1 A G 12: 88,422,280 (GRCm39) E297G probably damaging Het
Ahrr G A 13: 74,431,143 (GRCm39) probably benign Het
Aldh3a2 C T 11: 61,139,714 (GRCm39) V473I probably benign Het
Arfgef3 A T 10: 18,523,663 (GRCm39) I369K possibly damaging Het
Atl2 A G 17: 80,161,260 (GRCm39) probably benign Het
Atp1b3 T C 9: 96,220,762 (GRCm39) I178V possibly damaging Het
Axdnd1 T C 1: 156,205,956 (GRCm39) E520G possibly damaging Het
Bahcc1 A T 11: 120,175,900 (GRCm39) probably benign Het
BB019430 A T 10: 58,540,093 (GRCm39) noncoding transcript Het
BC028528 A T 3: 95,794,646 (GRCm39) probably benign Het
Btbd1 T A 7: 81,450,751 (GRCm39) Q343L probably benign Het
Catsper1 A G 19: 5,389,503 (GRCm39) T473A possibly damaging Het
Ccn4 T C 15: 66,791,059 (GRCm39) L287P probably damaging Het
Chmp6 G A 11: 119,806,349 (GRCm39) probably null Het
Cstdc7 T A 18: 42,306,608 (GRCm39) D58E probably damaging Het
D130040H23Rik T C 8: 69,755,195 (GRCm39) V200A possibly damaging Het
D830013O20Rik C T 12: 73,411,105 (GRCm39) noncoding transcript Het
Dcaf1 T A 9: 106,721,344 (GRCm39) S379T possibly damaging Het
Dcaf4 G A 12: 83,582,762 (GRCm39) probably benign Het
Dhx58 T C 11: 100,586,150 (GRCm39) I624V probably benign Het
Disp3 T C 4: 148,338,708 (GRCm39) E821G probably damaging Het
Dlc1 T A 8: 37,066,594 (GRCm39) E464V probably damaging Het
Dnah10 G A 5: 124,860,898 (GRCm39) V2151I probably damaging Het
Dnah6 C T 6: 73,165,518 (GRCm39) probably benign Het
Dnah8 G A 17: 30,967,639 (GRCm39) G2617D probably benign Het
Dnah9 C A 11: 65,809,630 (GRCm39) E872* probably null Het
Dock9 T C 14: 121,835,077 (GRCm39) Y99C probably damaging Het
Dpy19l3 T A 7: 35,416,071 (GRCm39) I310F probably damaging Het
Fggy A T 4: 95,725,891 (GRCm39) I137F probably damaging Het
Gli2 A G 1: 118,818,013 (GRCm39) probably benign Het
Gm14421 A T 2: 176,748,515 (GRCm39) noncoding transcript Het
Grin2a A G 16: 9,812,685 (GRCm39) probably null Het
Grin2b A G 6: 135,755,646 (GRCm39) probably benign Het
Incenp A G 19: 9,872,243 (GRCm39) S72P probably benign Het
Ipo11 A G 13: 107,046,702 (GRCm39) probably benign Het
Klc3 T A 7: 19,128,851 (GRCm39) N469Y possibly damaging Het
Lrrc42 A G 4: 107,104,702 (GRCm39) S88P probably benign Het
Lrrc49 G A 9: 60,587,883 (GRCm39) T93I probably benign Het
Ltn1 G A 16: 87,202,407 (GRCm39) probably benign Het
Mlycd A T 8: 120,134,380 (GRCm39) Q294L probably damaging Het
Mmrn1 T A 6: 60,952,799 (GRCm39) probably benign Het
Mrpl22 T A 11: 58,062,647 (GRCm39) I19N probably benign Het
Msh3 T A 13: 92,485,717 (GRCm39) K202N probably damaging Het
N4bp2 T C 5: 65,960,916 (GRCm39) probably benign Het
Ncam1 C T 9: 49,479,709 (GRCm39) D90N probably damaging Het
Nckap5 A T 1: 125,952,144 (GRCm39) D1405E possibly damaging Het
Ncoa2 A G 1: 13,256,955 (GRCm39) probably null Het
Ncoa6 TGC TGCGC 2: 155,250,211 (GRCm39) probably null Het
Nlrp1b A T 11: 71,054,925 (GRCm39) W844R probably damaging Het
Nmnat1 G T 4: 149,553,607 (GRCm39) N168K possibly damaging Het
Or5b96 A G 19: 12,867,809 (GRCm39) L44P probably damaging Het
Ost4 T C 5: 31,064,803 (GRCm39) H26R probably damaging Het
Otog G A 7: 45,953,655 (GRCm39) V2638M probably damaging Het
Otogl A T 10: 107,710,391 (GRCm39) I566N probably damaging Het
Pcyt1a T C 16: 32,289,004 (GRCm39) S282P probably damaging Het
Prkcg G A 7: 3,377,635 (GRCm39) E581K probably damaging Het
Ralgps2 A G 1: 156,714,659 (GRCm39) probably null Het
Rnf157 A G 11: 116,245,636 (GRCm39) probably benign Het
Scmh1 T C 4: 120,387,062 (GRCm39) probably benign Het
Sh2b3 T G 5: 121,967,100 (GRCm39) T5P probably damaging Het
Skint6 A T 4: 112,848,433 (GRCm39) probably benign Het
Slfn10-ps T C 11: 82,926,128 (GRCm39) noncoding transcript Het
Sspo T A 6: 48,471,128 (GRCm39) probably benign Het
Tcp1 T A 17: 13,141,634 (GRCm39) probably benign Het
Tdp2 A G 13: 25,022,222 (GRCm39) M214V probably damaging Het
Tenm4 T G 7: 96,378,547 (GRCm39) probably benign Het
Tmem144 G A 3: 79,746,580 (GRCm39) probably benign Het
Tmem204 A G 17: 25,277,324 (GRCm39) I187T probably damaging Het
Tmem208 T G 8: 106,061,326 (GRCm39) D117E probably benign Het
Tnks1bp1 C T 2: 84,889,565 (GRCm39) P631S possibly damaging Het
Tomm70a T C 16: 56,968,184 (GRCm39) V517A probably damaging Het
Ttc7 T C 17: 87,687,323 (GRCm39) V801A probably damaging Het
Txndc5 A T 13: 38,691,929 (GRCm39) C146S probably damaging Het
Ubac2 A G 14: 122,246,329 (GRCm39) probably benign Het
Ube4b G T 4: 149,444,781 (GRCm39) T493K probably damaging Het
Ufl1 A T 4: 25,256,008 (GRCm39) Y504N probably benign Het
Ugt1a6a T C 1: 88,066,992 (GRCm39) V266A possibly damaging Het
Ugt1a6b T A 1: 88,035,189 (GRCm39) C176S probably damaging Het
Ulk3 T A 9: 57,497,969 (GRCm39) I90N probably damaging Het
Unc13c T C 9: 73,602,174 (GRCm39) I1357M probably benign Het
Vmn1r28 G A 6: 58,242,702 (GRCm39) A182T probably benign Het
Vmn2r114 A G 17: 23,528,800 (GRCm39) probably null Het
Vmn2r91 A C 17: 18,326,399 (GRCm39) N228T probably benign Het
Wdr43 T G 17: 71,938,992 (GRCm39) probably benign Het
Zbtb6 G T 2: 37,319,600 (GRCm39) Y109* probably null Het
Zfp980 A G 4: 145,428,567 (GRCm39) D432G probably benign Het
Other mutations in Sgo2b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01017:Sgo2b APN 8 64,379,557 (GRCm39) missense probably benign
IGL01343:Sgo2b APN 8 64,380,349 (GRCm39) nonsense probably null
IGL02027:Sgo2b APN 8 64,379,863 (GRCm39) missense probably benign
IGL02090:Sgo2b APN 8 64,380,123 (GRCm39) missense probably damaging 0.99
IGL02121:Sgo2b APN 8 64,384,316 (GRCm39) missense possibly damaging 0.94
IGL02206:Sgo2b APN 8 64,394,118 (GRCm39) missense possibly damaging 0.94
IGL02554:Sgo2b APN 8 64,379,571 (GRCm39) missense probably damaging 0.96
IGL02663:Sgo2b APN 8 64,396,148 (GRCm39) missense probably damaging 0.97
IGL03149:Sgo2b APN 8 64,379,617 (GRCm39) missense probably benign 0.14
floater UTSW 8 64,391,451 (GRCm39) nonsense probably null
R0164:Sgo2b UTSW 8 64,391,417 (GRCm39) missense possibly damaging 0.92
R0201:Sgo2b UTSW 8 64,379,670 (GRCm39) missense probably benign
R0285:Sgo2b UTSW 8 64,381,823 (GRCm39) nonsense probably null
R0325:Sgo2b UTSW 8 64,381,410 (GRCm39) missense probably benign 0.20
R0727:Sgo2b UTSW 8 64,380,816 (GRCm39) missense probably damaging 0.98
R0943:Sgo2b UTSW 8 64,384,369 (GRCm39) missense possibly damaging 0.82
R1148:Sgo2b UTSW 8 64,379,889 (GRCm39) missense probably damaging 0.99
R1266:Sgo2b UTSW 8 64,381,455 (GRCm39) missense probably benign 0.00
R1484:Sgo2b UTSW 8 64,384,507 (GRCm39) missense possibly damaging 0.77
R1493:Sgo2b UTSW 8 64,379,889 (GRCm39) missense probably damaging 0.99
R1537:Sgo2b UTSW 8 64,379,536 (GRCm39) missense possibly damaging 0.94
R1630:Sgo2b UTSW 8 64,380,831 (GRCm39) missense possibly damaging 0.90
R1803:Sgo2b UTSW 8 64,380,426 (GRCm39) missense probably benign 0.01
R1912:Sgo2b UTSW 8 64,384,503 (GRCm39) missense probably damaging 0.98
R1993:Sgo2b UTSW 8 64,379,867 (GRCm39) missense probably benign 0.36
R2042:Sgo2b UTSW 8 64,381,561 (GRCm39) missense probably benign
R2130:Sgo2b UTSW 8 64,380,181 (GRCm39) missense probably benign 0.09
R2146:Sgo2b UTSW 8 64,381,057 (GRCm39) missense probably benign 0.00
R2881:Sgo2b UTSW 8 64,380,570 (GRCm39) missense probably damaging 0.99
R3686:Sgo2b UTSW 8 64,384,361 (GRCm39) missense probably benign 0.20
R3706:Sgo2b UTSW 8 64,381,179 (GRCm39) missense probably damaging 0.98
R3889:Sgo2b UTSW 8 64,380,777 (GRCm39) missense possibly damaging 0.82
R3894:Sgo2b UTSW 8 64,381,767 (GRCm39) missense possibly damaging 0.91
R3895:Sgo2b UTSW 8 64,381,767 (GRCm39) missense possibly damaging 0.91
R4058:Sgo2b UTSW 8 64,379,981 (GRCm39) missense probably damaging 0.98
R4259:Sgo2b UTSW 8 64,381,330 (GRCm39) missense probably benign 0.06
R4260:Sgo2b UTSW 8 64,381,330 (GRCm39) missense probably benign 0.06
R4704:Sgo2b UTSW 8 64,380,824 (GRCm39) missense probably damaging 0.98
R4815:Sgo2b UTSW 8 64,384,448 (GRCm39) missense probably benign
R4922:Sgo2b UTSW 8 64,379,664 (GRCm39) missense possibly damaging 0.66
R5232:Sgo2b UTSW 8 64,381,636 (GRCm39) missense possibly damaging 0.55
R5262:Sgo2b UTSW 8 64,396,171 (GRCm39) missense probably damaging 0.99
R5444:Sgo2b UTSW 8 64,379,590 (GRCm39) missense possibly damaging 0.90
R5677:Sgo2b UTSW 8 64,380,008 (GRCm39) missense possibly damaging 0.77
R5959:Sgo2b UTSW 8 64,380,322 (GRCm39) missense probably benign 0.01
R6004:Sgo2b UTSW 8 64,379,707 (GRCm39) nonsense probably null
R6267:Sgo2b UTSW 8 64,380,827 (GRCm39) missense probably benign
R6296:Sgo2b UTSW 8 64,380,827 (GRCm39) missense probably benign
R6328:Sgo2b UTSW 8 64,381,345 (GRCm39) nonsense probably null
R6517:Sgo2b UTSW 8 64,384,528 (GRCm39) missense probably damaging 0.99
R6523:Sgo2b UTSW 8 64,380,538 (GRCm39) missense probably benign 0.11
R6726:Sgo2b UTSW 8 64,380,769 (GRCm39) nonsense probably null
R6957:Sgo2b UTSW 8 64,384,489 (GRCm39) small deletion probably benign
R7031:Sgo2b UTSW 8 64,393,078 (GRCm39) missense possibly damaging 0.94
R7034:Sgo2b UTSW 8 64,379,868 (GRCm39) missense probably benign 0.36
R7145:Sgo2b UTSW 8 64,381,218 (GRCm39) missense probably damaging 1.00
R7289:Sgo2b UTSW 8 64,394,192 (GRCm39) missense probably damaging 0.97
R7366:Sgo2b UTSW 8 64,391,451 (GRCm39) nonsense probably null
R7660:Sgo2b UTSW 8 64,393,108 (GRCm39) missense probably benign 0.27
R7761:Sgo2b UTSW 8 64,379,946 (GRCm39) missense probably benign
R7762:Sgo2b UTSW 8 64,379,531 (GRCm39) missense probably benign 0.03
R7822:Sgo2b UTSW 8 64,380,318 (GRCm39) missense probably damaging 0.98
R8111:Sgo2b UTSW 8 64,396,138 (GRCm39) missense probably damaging 0.98
R8129:Sgo2b UTSW 8 64,381,834 (GRCm39) missense possibly damaging 0.90
R8273:Sgo2b UTSW 8 64,377,735 (GRCm39) missense unknown
R8856:Sgo2b UTSW 8 64,393,091 (GRCm39) missense probably null 0.99
R9249:Sgo2b UTSW 8 64,391,407 (GRCm39) nonsense probably null
R9428:Sgo2b UTSW 8 64,393,067 (GRCm39) missense probably damaging 0.99
R9616:Sgo2b UTSW 8 64,380,274 (GRCm39) missense probably benign
R9621:Sgo2b UTSW 8 64,380,651 (GRCm39) missense probably damaging 0.99
RF014:Sgo2b UTSW 8 64,384,439 (GRCm39) missense possibly damaging 0.94
RF055:Sgo2b UTSW 8 64,396,203 (GRCm39) missense probably damaging 1.00
Z1088:Sgo2b UTSW 8 64,381,456 (GRCm39) missense possibly damaging 0.61
Z1088:Sgo2b UTSW 8 64,380,039 (GRCm39) missense probably damaging 1.00
Z1177:Sgo2b UTSW 8 64,381,419 (GRCm39) missense possibly damaging 0.82
Z1177:Sgo2b UTSW 8 64,380,473 (GRCm39) missense probably benign 0.03
Predicted Primers
Posted On 2017-12-01