Incidental Mutation 'R4096:Srpk2'
ID 500488
Institutional Source Beutler Lab
Gene Symbol Srpk2
Ensembl Gene ENSMUSG00000062604
Gene Name serine/arginine-rich protein specific kinase 2
Synonyms WBP6, mSRPK2
MMRRC Submission 041629-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R4096 (G1)
Quality Score 225
Status Not validated
Chromosome 5
Chromosomal Location 23708262-23889615 bp(-) (GRCm39)
Type of Mutation intron
DNA Base Change (assembly) A to T at 23745500 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000143216 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000088392] [ENSMUST00000196388] [ENSMUST00000196929]
AlphaFold no structure available at present
Predicted Effect probably benign
Transcript: ENSMUST00000088392
SMART Domains Protein: ENSMUSP00000085734
Gene: ENSMUSG00000062604

DomainStartEndE-ValueType
low complexity region 5 46 N/A INTRINSIC
Pfam:Pkinase 79 228 1.3e-22 PFAM
Pfam:Pkinase_Tyr 79 228 1e-9 PFAM
coiled coil region 263 314 N/A INTRINSIC
coiled coil region 339 373 N/A INTRINSIC
low complexity region 393 406 N/A INTRINSIC
Pfam:Pkinase 506 680 1.9e-18 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000196388
SMART Domains Protein: ENSMUSP00000143453
Gene: ENSMUSG00000062604

DomainStartEndE-ValueType
S_TKc 3 129 7.2e-6 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000196929
SMART Domains Protein: ENSMUSP00000143216
Gene: ENSMUSG00000062604

DomainStartEndE-ValueType
Pfam:Pkinase_Tyr 1 131 2.6e-8 PFAM
Pfam:Pkinase 2 130 2.3e-18 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000197622
Predicted Effect noncoding transcript
Transcript: ENSMUST00000200173
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.7%
  • 10x: 97.6%
  • 20x: 96.2%
Validation Efficiency 97% (31/32)
MGI Phenotype PHENOTYPE: Mice homozygous for a targeted allele exhibit normal phenotype. [provided by MGI curators]
Allele List at MGI

All alleles(39) : Targeted(3) Gene trapped(36)

Other mutations in this stock
Total: 30 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2310003L06Rik A G 5: 88,120,008 (GRCm39) D255G possibly damaging Het
4930407I10Rik G A 15: 81,946,406 (GRCm39) G101D probably benign Het
Angpt2 G A 8: 18,748,111 (GRCm39) A383V probably damaging Het
Cemip2 G T 19: 21,770,016 (GRCm39) M1I probably null Het
Ctns A G 11: 73,077,212 (GRCm39) M252T probably benign Het
Dmxl1 T A 18: 50,094,264 (GRCm39) H2913Q probably damaging Het
Enox1 C T 14: 77,815,160 (GRCm39) T106M probably damaging Het
Ext1 A T 15: 52,936,753 (GRCm39) V664E probably damaging Het
Fat4 A T 3: 38,942,024 (GRCm39) T306S possibly damaging Het
Fbxl5 T C 5: 43,915,583 (GRCm39) I610V probably benign Het
Glb1l T A 1: 75,186,084 (GRCm39) M1L probably benign Het
Hmcn1 T C 1: 150,534,259 (GRCm39) K3005R probably benign Het
Homer2 A G 7: 81,261,052 (GRCm39) probably null Het
Il36b C T 2: 24,048,826 (GRCm39) T77M possibly damaging Het
Kcnq3 C A 15: 66,157,664 (GRCm39) probably null Het
Mad1l1 C T 5: 140,293,428 (GRCm39) R130H probably benign Het
Man2b1 A G 8: 85,811,366 (GRCm39) E120G probably damaging Het
Mtus1 T C 8: 41,537,284 (GRCm39) D144G probably damaging Het
Oprk1 T A 1: 5,673,034 (GRCm39) probably benign Het
Or5m10 T C 2: 85,717,767 (GRCm39) S208P probably damaging Het
Or7g17 T C 9: 18,767,933 (GRCm39) I4T probably benign Het
Or9g3 T C 2: 85,590,040 (GRCm39) I227V possibly damaging Het
Rrp12 A G 19: 41,875,587 (GRCm39) I252T probably benign Het
Sbno1 A T 5: 124,529,983 (GRCm39) probably null Het
Secisbp2l C T 2: 125,582,657 (GRCm39) G933D possibly damaging Het
Slc10a4-ps A G 5: 72,743,709 (GRCm39) L3P probably damaging Het
Slc28a2b A G 2: 122,353,209 (GRCm39) Y463C probably damaging Het
Ube3b A G 5: 114,531,147 (GRCm39) T214A possibly damaging Het
Wwc2 T C 8: 48,295,937 (GRCm39) E1111G unknown Het
Zpld1 C G 16: 55,053,881 (GRCm39) D304H probably damaging Het
Other mutations in Srpk2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00697:Srpk2 APN 5 23,745,377 (GRCm39) missense probably benign 0.10
IGL02057:Srpk2 APN 5 23,723,705 (GRCm39) missense probably damaging 0.99
IGL02217:Srpk2 APN 5 23,750,568 (GRCm39) missense probably damaging 1.00
IGL03115:Srpk2 APN 5 23,729,616 (GRCm39) splice site probably null
FR4737:Srpk2 UTSW 5 23,750,194 (GRCm39) splice site probably null
P0008:Srpk2 UTSW 5 23,718,976 (GRCm39) missense probably damaging 1.00
R0142:Srpk2 UTSW 5 23,732,928 (GRCm39) missense probably damaging 0.97
R0462:Srpk2 UTSW 5 23,723,424 (GRCm39) missense probably damaging 1.00
R0992:Srpk2 UTSW 5 23,750,541 (GRCm39) missense probably damaging 0.99
R1569:Srpk2 UTSW 5 23,719,024 (GRCm39) missense probably damaging 1.00
R1677:Srpk2 UTSW 5 23,730,748 (GRCm39) splice site probably null
R1696:Srpk2 UTSW 5 23,753,492 (GRCm39) nonsense probably null
R1752:Srpk2 UTSW 5 23,733,017 (GRCm39) missense probably damaging 1.00
R1862:Srpk2 UTSW 5 23,729,148 (GRCm39) missense probably benign 0.32
R1989:Srpk2 UTSW 5 23,723,421 (GRCm39) missense probably damaging 1.00
R2173:Srpk2 UTSW 5 23,723,613 (GRCm39) splice site probably null
R4271:Srpk2 UTSW 5 23,753,513 (GRCm39) missense possibly damaging 0.95
R4894:Srpk2 UTSW 5 23,750,527 (GRCm39) missense probably damaging 1.00
R5043:Srpk2 UTSW 5 23,729,515 (GRCm39) missense probably benign
R5044:Srpk2 UTSW 5 23,729,390 (GRCm39) missense possibly damaging 0.91
R5309:Srpk2 UTSW 5 23,730,716 (GRCm39) missense probably damaging 0.97
R5478:Srpk2 UTSW 5 23,729,181 (GRCm39) missense possibly damaging 0.71
R5568:Srpk2 UTSW 5 23,730,697 (GRCm39) missense possibly damaging 0.73
R5665:Srpk2 UTSW 5 23,723,475 (GRCm39) missense probably damaging 0.99
R5678:Srpk2 UTSW 5 23,729,604 (GRCm39) frame shift probably null
R6364:Srpk2 UTSW 5 23,745,465 (GRCm39) missense probably damaging 1.00
R7201:Srpk2 UTSW 5 23,712,626 (GRCm39) missense possibly damaging 0.64
R7597:Srpk2 UTSW 5 23,753,517 (GRCm39) missense possibly damaging 0.96
R8251:Srpk2 UTSW 5 23,729,266 (GRCm39) missense probably benign
R8477:Srpk2 UTSW 5 23,718,986 (GRCm39) missense probably benign 0.03
R9348:Srpk2 UTSW 5 23,719,671 (GRCm39) missense probably damaging 0.98
R9606:Srpk2 UTSW 5 23,729,604 (GRCm39) missense probably benign
R9745:Srpk2 UTSW 5 23,880,874 (GRCm39) intron probably benign
RF035:Srpk2 UTSW 5 23,730,573 (GRCm39) utr 3 prime probably benign
RF042:Srpk2 UTSW 5 23,730,573 (GRCm39) utr 3 prime probably benign
Predicted Primers
Posted On 2017-12-01