Incidental Mutation 'R5357:Tnks2'
ID 501122
Institutional Source Beutler Lab
Gene Symbol Tnks2
Ensembl Gene ENSMUSG00000024811
Gene Name tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2
Synonyms 5430432P15Rik
MMRRC Submission 042936-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R5357 (G1)
Quality Score 225
Status Not validated
Chromosome 19
Chromosomal Location 36811632-36870877 bp(+) (GRCm39)
Type of Mutation splice site
DNA Base Change (assembly) G to A at 36826690 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000025729 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000025729]
AlphaFold Q3UES3
Predicted Effect silent
Transcript: ENSMUST00000025729
SMART Domains Protein: ENSMUSP00000025729
Gene: ENSMUSG00000024811

DomainStartEndE-ValueType
low complexity region 2 18 N/A INTRINSIC
ANK 57 86 8.07e-5 SMART
ANK 90 119 1.78e-6 SMART
ANK 123 152 6.46e-4 SMART
ANK 210 239 1.76e-5 SMART
ANK 243 272 3.91e-3 SMART
ANK 276 305 3.23e-4 SMART
ANK 363 395 1.57e-2 SMART
ANK 399 428 4.5e-3 SMART
ANK 432 461 4.89e-4 SMART
ANK 525 554 1.43e-5 SMART
ANK 558 587 6.55e-5 SMART
ANK 591 620 1.24e-5 SMART
low complexity region 641 659 N/A INTRINSIC
ANK 678 707 1.69e-7 SMART
ANK 711 740 3.65e-3 SMART
ANK 744 773 3.36e-2 SMART
low complexity region 822 863 N/A INTRINSIC
SAM 870 936 1.03e-10 SMART
Pfam:PARP 952 1157 4.9e-28 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000168656
Predicted Effect noncoding transcript
Transcript: ENSMUST00000168973
Coding Region Coverage
  • 1x: 98.9%
  • 3x: 97.4%
  • 10x: 94.5%
  • 20x: 87.7%
Validation Efficiency
MGI Phenotype PHENOTYPE: Mice homozygous for a null allele are viable but display decreased body weight and abnormal adipocyte glucose uptake in response to insulin stimulation. Mice homozygous for a different null allele show partial postnatal lethality as well as decreased body weight. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 43 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700013G24Rik T C 4: 137,182,463 (GRCm39) V206A possibly damaging Het
5730522E02Rik A T 11: 25,598,148 (GRCm39) C102* probably null Het
Brsk2 C A 7: 141,538,248 (GRCm39) D131E possibly damaging Het
Cacng7 T C 7: 3,387,452 (GRCm39) F112L probably benign Het
Ceacam12 T A 7: 17,811,384 (GRCm39) C282* probably null Het
Dnm1 T C 2: 32,226,253 (GRCm39) D312G probably null Het
Dyrk1b T C 7: 27,884,743 (GRCm39) V326A possibly damaging Het
Eloa T C 4: 135,736,559 (GRCm39) D563G probably benign Het
Evi5l A G 8: 4,253,623 (GRCm39) K489R possibly damaging Het
Fkbpl G A 17: 34,864,303 (GRCm39) A24T probably benign Het
Galntl6 T C 8: 58,337,497 (GRCm39) E326G probably damaging Het
Gm1758 G A 16: 14,320,218 (GRCm39) noncoding transcript Het
Grm8 A T 6: 27,762,418 (GRCm39) L269Q probably damaging Het
Hsd17b12 A G 2: 93,863,990 (GRCm39) I284T possibly damaging Het
Hyal6 T A 6: 24,734,517 (GRCm39) M150K probably benign Het
Ift80 T A 3: 68,898,113 (GRCm39) Q74L possibly damaging Het
Krt76 T C 15: 101,795,820 (GRCm39) K450R probably benign Het
Larp1b A G 3: 40,978,950 (GRCm39) E2G probably benign Het
Ltbr G A 6: 125,289,757 (GRCm39) R146W probably damaging Het
Map2k7 A T 8: 4,294,461 (GRCm39) H253L probably damaging Het
Melk C T 4: 44,363,730 (GRCm39) T592M probably damaging Het
Mmp2 A G 8: 93,559,780 (GRCm39) T248A possibly damaging Het
Mt1 T A 8: 94,906,732 (GRCm39) C33S probably damaging Het
Obox5 T A 7: 15,491,463 (GRCm39) M1K probably null Het
Pak4 A G 7: 28,263,831 (GRCm39) S302P probably damaging Het
Pcsk2 T C 2: 143,415,384 (GRCm39) Y66H probably benign Het
Pgm3 G A 9: 86,438,310 (GRCm39) R451* probably null Het
Phf10 A T 17: 15,174,275 (GRCm39) probably null Het
Pkd1 T G 17: 24,784,764 (GRCm39) V402G probably damaging Het
Plekha4 G T 7: 45,184,195 (GRCm39) V61F probably damaging Het
Ppfia2 G A 10: 106,740,708 (GRCm39) probably null Het
R3hdm4 C T 10: 79,748,292 (GRCm39) E162K possibly damaging Het
Skil A G 3: 31,167,700 (GRCm39) H444R probably benign Het
Tcn2 T G 11: 3,876,017 (GRCm39) D137A possibly damaging Het
Trh T A 6: 92,219,815 (GRCm39) D167V probably benign Het
Tshz1 C T 18: 84,033,205 (GRCm39) G401D probably damaging Het
Ttn A T 2: 76,641,587 (GRCm39) L5176Q possibly damaging Het
Ubqlnl T A 7: 103,798,138 (GRCm39) Q453L probably damaging Het
Vmn2r111 T A 17: 22,767,083 (GRCm39) K805* probably null Het
Wnt16 T G 6: 22,291,231 (GRCm39) probably benign Het
Zc3h11a A T 1: 133,550,780 (GRCm39) V665E probably damaging Het
Zfp456 A T 13: 67,520,328 (GRCm39) M63K possibly damaging Het
Zzef1 C T 11: 72,734,159 (GRCm39) Q584* probably null Het
Other mutations in Tnks2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01325:Tnks2 APN 19 36,849,033 (GRCm39) missense probably benign 0.00
IGL01977:Tnks2 APN 19 36,849,990 (GRCm39) critical splice donor site probably null
IGL02389:Tnks2 APN 19 36,861,503 (GRCm39) missense probably benign 0.32
IGL02653:Tnks2 APN 19 36,849,851 (GRCm39) missense probably damaging 1.00
IGL02678:Tnks2 APN 19 36,823,143 (GRCm39) missense possibly damaging 0.63
R0053:Tnks2 UTSW 19 36,852,765 (GRCm39) missense probably damaging 1.00
R0053:Tnks2 UTSW 19 36,852,765 (GRCm39) missense probably damaging 1.00
R0426:Tnks2 UTSW 19 36,830,221 (GRCm39) missense probably damaging 1.00
R0436:Tnks2 UTSW 19 36,826,758 (GRCm39) missense possibly damaging 0.51
R0591:Tnks2 UTSW 19 36,849,962 (GRCm39) missense probably damaging 0.99
R0648:Tnks2 UTSW 19 36,839,474 (GRCm39) splice site probably null
R0894:Tnks2 UTSW 19 36,867,450 (GRCm39) critical splice donor site probably null
R1397:Tnks2 UTSW 19 36,857,901 (GRCm39) splice site probably benign
R1459:Tnks2 UTSW 19 36,822,931 (GRCm39) splice site probably benign
R1674:Tnks2 UTSW 19 36,849,022 (GRCm39) missense probably benign 0.03
R1742:Tnks2 UTSW 19 36,853,661 (GRCm39) missense probably damaging 1.00
R1928:Tnks2 UTSW 19 36,823,068 (GRCm39) nonsense probably null
R2025:Tnks2 UTSW 19 36,843,466 (GRCm39) missense probably damaging 0.99
R2898:Tnks2 UTSW 19 36,849,990 (GRCm39) critical splice donor site probably null
R4422:Tnks2 UTSW 19 36,823,053 (GRCm39) missense probably damaging 1.00
R4676:Tnks2 UTSW 19 36,852,671 (GRCm39) nonsense probably null
R5202:Tnks2 UTSW 19 36,866,252 (GRCm39) missense probably damaging 1.00
R5467:Tnks2 UTSW 19 36,859,176 (GRCm39) missense probably damaging 1.00
R5550:Tnks2 UTSW 19 36,839,746 (GRCm39) missense probably damaging 1.00
R6119:Tnks2 UTSW 19 36,856,752 (GRCm39) missense possibly damaging 0.79
R6219:Tnks2 UTSW 19 36,843,604 (GRCm39) intron probably benign
R7270:Tnks2 UTSW 19 36,836,545 (GRCm39) missense
R7309:Tnks2 UTSW 19 36,829,936 (GRCm39) missense probably damaging 1.00
R7310:Tnks2 UTSW 19 36,856,839 (GRCm39) missense probably benign 0.12
R7516:Tnks2 UTSW 19 36,849,064 (GRCm39) missense possibly damaging 0.85
R7823:Tnks2 UTSW 19 36,829,954 (GRCm39) critical splice donor site probably null
R7951:Tnks2 UTSW 19 36,839,555 (GRCm39) missense
R7961:Tnks2 UTSW 19 36,829,901 (GRCm39) missense probably benign 0.15
R8009:Tnks2 UTSW 19 36,829,901 (GRCm39) missense probably benign 0.15
R8193:Tnks2 UTSW 19 36,832,353 (GRCm39) missense possibly damaging 0.70
R8919:Tnks2 UTSW 19 36,823,088 (GRCm39) missense probably damaging 0.97
R9329:Tnks2 UTSW 19 36,835,284 (GRCm39) missense probably damaging 1.00
Z1177:Tnks2 UTSW 19 36,866,280 (GRCm39) missense probably benign 0.10
Z1177:Tnks2 UTSW 19 36,811,977 (GRCm39) missense probably benign 0.20
Predicted Primers PCR Primer
(F):5'- AAGCTTTTGAGCCAGTTTCCC -3'
(R):5'- TGGAGGCTTCTGTCTACCTAG -3'

Sequencing Primer
(F):5'- CTGGAACTTACTCTATGGACCAGG -3'
(R):5'- ACCTAGCCCCTCAGGTATTG -3'
Posted On 2017-12-01