Incidental Mutation 'R5537:Zfp974'
ID 501140
Institutional Source Beutler Lab
Gene Symbol Zfp974
Ensembl Gene ENSMUSG00000070709
Gene Name zinc finger protein 974
Synonyms 1700049G17Rik
MMRRC Submission 043095-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.063) question?
Stock # R5537 (G1)
Quality Score 217
Status Not validated
Chromosome 7
Chromosomal Location 27606817-27628885 bp(-) (GRCm39)
Type of Mutation critical splice acceptor site
DNA Base Change (assembly) TAATCTGTCTCCAAATCTG to TAATCTG at 27611671 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000115940 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000098639] [ENSMUST00000129341]
AlphaFold Q3UVF6
Predicted Effect probably benign
Transcript: ENSMUST00000098639
SMART Domains Protein: ENSMUSP00000096238
Gene: ENSMUSG00000070709

DomainStartEndE-ValueType
ZnF_C2H2 99 121 8.81e-2 SMART
ZnF_C2H2 127 149 1.82e-3 SMART
ZnF_C2H2 155 177 3.11e-2 SMART
ZnF_C2H2 201 223 2.15e-5 SMART
ZnF_C2H2 229 251 1.18e-2 SMART
ZnF_C2H2 257 279 1.47e-3 SMART
ZnF_C2H2 285 307 1.79e-2 SMART
ZnF_C2H2 313 335 2.24e-3 SMART
ZnF_C2H2 341 363 9.73e-4 SMART
ZnF_C2H2 369 391 7.26e-3 SMART
ZnF_C2H2 397 419 6.42e-4 SMART
ZnF_C2H2 425 447 3.63e-3 SMART
ZnF_C2H2 453 475 1.28e-3 SMART
ZnF_C2H2 481 503 1.26e-2 SMART
ZnF_C2H2 509 531 1.38e-3 SMART
ZnF_C2H2 537 559 3.83e-2 SMART
ZnF_C2H2 565 587 1.95e-3 SMART
ZnF_C2H2 593 615 4.61e-5 SMART
ZnF_C2H2 621 643 1.95e-3 SMART
ZnF_C2H2 649 671 1.03e-2 SMART
ZnF_C2H2 677 699 5.5e-3 SMART
ZnF_C2H2 705 727 2.37e2 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000129341
SMART Domains Protein: ENSMUSP00000115940
Gene: ENSMUSG00000070709

DomainStartEndE-ValueType
KRAB 14 75 7.5e-37 SMART
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.7%
  • 10x: 98.3%
  • 20x: 95.1%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 43 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcb4 A T 5: 9,005,485 (GRCm39) I1123F probably damaging Het
Acsl3 C T 1: 78,684,073 (GRCm39) R702C probably damaging Het
Ank1 A G 8: 23,604,892 (GRCm39) E1031G probably damaging Het
Ankle2 T C 5: 110,397,361 (GRCm39) S536P probably damaging Het
Arfgef2 G T 2: 166,698,513 (GRCm39) probably null Het
Bahd1 G T 2: 118,746,461 (GRCm39) D27Y probably damaging Het
Brinp2 C T 1: 158,082,583 (GRCm39) V246I probably damaging Het
Ccdc187 C A 2: 26,166,237 (GRCm39) A731S probably benign Het
Cdc37l1 T A 19: 28,972,518 (GRCm39) N70K probably damaging Het
Cdk5r1 A G 11: 80,368,825 (GRCm39) Y164C probably damaging Het
Clrn3 A T 7: 135,115,791 (GRCm39) H186Q probably benign Het
Col12a1 G A 9: 79,606,872 (GRCm39) T517I probably damaging Het
Crhr1 T A 11: 104,054,682 (GRCm39) N98K possibly damaging Het
Dst C T 1: 34,228,959 (GRCm39) S2362L probably benign Het
Eapp G A 12: 54,738,844 (GRCm39) T98I probably benign Het
Iqsec3 T C 6: 121,389,603 (GRCm39) probably benign Het
Kctd12 A G 14: 103,219,713 (GRCm39) V55A probably benign Het
Kmt2d G A 15: 98,749,990 (GRCm39) probably benign Het
Lgr5 T C 10: 115,292,594 (GRCm39) D432G probably benign Het
Mrgprx1 T A 7: 47,670,898 (GRCm39) H283L probably benign Het
Nlrp4e T C 7: 23,019,914 (GRCm39) F134L probably benign Het
Or1e34 T C 11: 73,778,523 (GRCm39) K225R probably benign Het
Or4f14b A T 2: 111,775,393 (GRCm39) M136K probably damaging Het
Or5m5 T A 2: 85,814,570 (GRCm39) Y129N possibly damaging Het
Or8b43 T A 9: 38,360,538 (GRCm39) Y123* probably null Het
Pfkp C A 13: 6,669,278 (GRCm39) W235L probably damaging Het
Prom1 C T 5: 44,158,118 (GRCm39) probably null Het
Psma5-ps A G 10: 85,149,913 (GRCm39) noncoding transcript Het
Rab14 A T 2: 35,082,649 (GRCm39) F12L possibly damaging Het
Rnf40 T A 7: 127,195,261 (GRCm39) I429N probably benign Het
S100pbp G A 4: 129,075,981 (GRCm39) P115S probably benign Het
Scarf1 G A 11: 75,416,357 (GRCm39) A600T probably damaging Het
Slc6a5 T C 7: 49,609,059 (GRCm39) F755L probably benign Het
Slc7a2 A T 8: 41,367,023 (GRCm39) I510F probably benign Het
Spag16 T C 1: 69,866,175 (GRCm39) S5P probably benign Het
Tex15 A G 8: 34,061,641 (GRCm39) Y631C probably damaging Het
Tmem182 A T 1: 40,894,069 (GRCm39) I195F probably benign Het
Tox A G 4: 6,697,510 (GRCm39) L431P probably damaging Het
Tprn G A 2: 25,153,369 (GRCm39) A224T probably benign Het
Tsg101 T C 7: 46,540,876 (GRCm39) K294E probably benign Het
Tubb2a C A 13: 34,259,434 (GRCm39) V119L probably benign Het
Vps37d C T 5: 135,103,256 (GRCm39) E129K possibly damaging Het
Zpld1 A G 16: 55,054,003 (GRCm39) V263A possibly damaging Het
Other mutations in Zfp974
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00836:Zfp974 APN 7 27,610,315 (GRCm39) missense possibly damaging 0.83
IGL01805:Zfp974 APN 7 27,611,689 (GRCm39) splice site probably benign
IGL02313:Zfp974 APN 7 27,611,678 (GRCm39) missense possibly damaging 0.53
IGL02449:Zfp974 APN 7 27,611,152 (GRCm39) missense probably benign
R0362:Zfp974 UTSW 7 27,626,819 (GRCm39) splice site probably benign
R0372:Zfp974 UTSW 7 27,620,120 (GRCm39) critical splice donor site probably null
R0379:Zfp974 UTSW 7 27,610,357 (GRCm39) missense probably damaging 0.98
R0699:Zfp974 UTSW 7 27,611,416 (GRCm39) missense possibly damaging 0.56
R0791:Zfp974 UTSW 7 27,609,510 (GRCm39) nonsense probably null
R1411:Zfp974 UTSW 7 27,610,634 (GRCm39) missense probably benign 0.00
R1567:Zfp974 UTSW 7 27,610,148 (GRCm39) missense probably damaging 0.99
R1747:Zfp974 UTSW 7 27,610,506 (GRCm39) missense possibly damaging 0.61
R1837:Zfp974 UTSW 7 27,609,781 (GRCm39) missense possibly damaging 0.93
R1838:Zfp974 UTSW 7 27,609,781 (GRCm39) missense possibly damaging 0.93
R1839:Zfp974 UTSW 7 27,609,781 (GRCm39) missense possibly damaging 0.93
R2311:Zfp974 UTSW 7 27,609,866 (GRCm39) missense possibly damaging 0.73
R4006:Zfp974 UTSW 7 27,611,677 (GRCm39) missense possibly damaging 0.86
R4303:Zfp974 UTSW 7 27,609,657 (GRCm39) missense possibly damaging 0.85
R4541:Zfp974 UTSW 7 27,625,829 (GRCm39) missense probably damaging 0.99
R4771:Zfp974 UTSW 7 27,625,733 (GRCm39) missense probably damaging 0.96
R4889:Zfp974 UTSW 7 27,610,244 (GRCm39) missense possibly damaging 0.86
R5332:Zfp974 UTSW 7 27,625,715 (GRCm39) missense probably benign 0.01
R5906:Zfp974 UTSW 7 27,610,230 (GRCm39) missense possibly damaging 0.72
R5908:Zfp974 UTSW 7 27,610,382 (GRCm39) missense probably benign 0.01
R6419:Zfp974 UTSW 7 27,610,940 (GRCm39) missense possibly damaging 0.72
R6654:Zfp974 UTSW 7 27,625,828 (GRCm39) missense probably damaging 1.00
R6731:Zfp974 UTSW 7 27,611,074 (GRCm39) missense possibly damaging 0.93
R7162:Zfp974 UTSW 7 27,610,944 (GRCm39) missense possibly damaging 0.71
R7316:Zfp974 UTSW 7 27,609,863 (GRCm39) missense possibly damaging 0.93
R7484:Zfp974 UTSW 7 27,611,559 (GRCm39) missense possibly damaging 0.72
R7663:Zfp974 UTSW 7 27,611,110 (GRCm39) missense possibly damaging 0.74
R7664:Zfp974 UTSW 7 27,610,137 (GRCm39) missense possibly damaging 0.86
R8052:Zfp974 UTSW 7 27,610,697 (GRCm39) missense probably damaging 1.00
R8698:Zfp974 UTSW 7 27,610,361 (GRCm39) missense possibly damaging 0.90
R8700:Zfp974 UTSW 7 27,609,472 (GRCm39) missense possibly damaging 0.86
R8938:Zfp974 UTSW 7 27,610,311 (GRCm39) missense possibly damaging 0.74
R8972:Zfp974 UTSW 7 27,610,589 (GRCm39) missense probably benign 0.06
R9212:Zfp974 UTSW 7 27,610,052 (GRCm39) missense possibly damaging 0.86
R9236:Zfp974 UTSW 7 27,610,342 (GRCm39) missense possibly damaging 0.51
R9335:Zfp974 UTSW 7 27,611,476 (GRCm39) missense probably benign 0.02
R9436:Zfp974 UTSW 7 27,611,094 (GRCm39) missense probably benign 0.24
R9740:Zfp974 UTSW 7 27,610,025 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- GTGAGCAAGAGTCTGGCAGGTATA -3'
(R):5'- CATAAACTTTCCTTACTGCTGCT -3'

Sequencing Primer
(F):5'- CAGGTATAAGGAGGCATTTCTTCC -3'
(R):5'- GCTGCTCTCCTTACTCTTGTTCAG -3'
Posted On 2017-12-01