Incidental Mutation 'R5709:Lrrc66'
ID 501425
Institutional Source Beutler Lab
Gene Symbol Lrrc66
Ensembl Gene ENSMUSG00000067206
Gene Name leucine rich repeat containing 66
Synonyms
MMRRC Submission 043184-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.056) question?
Stock # R5709 (G1)
Quality Score 225
Status Not validated
Chromosome 5
Chromosomal Location 73763985-73789771 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 73766206 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glutamic Acid to Glycine at position 279 (E279G)
Ref Sequence ENSEMBL: ENSMUSP00000084423 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000087177]
AlphaFold Q8K0B3
Predicted Effect probably benign
Transcript: ENSMUST00000087177
AA Change: E279G

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000084423
Gene: ENSMUSG00000067206
AA Change: E279G

DomainStartEndE-ValueType
signal peptide 1 20 N/A INTRINSIC
LRR 140 162 1.81e1 SMART
LRR_TYP 163 186 9.44e-2 SMART
LRR 187 210 1.26e2 SMART
LRR 211 234 4.84e1 SMART
low complexity region 298 309 N/A INTRINSIC
transmembrane domain 369 391 N/A INTRINSIC
low complexity region 434 445 N/A INTRINSIC
low complexity region 842 859 N/A INTRINSIC
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.7%
  • 10x: 97.4%
  • 20x: 95.7%
Validation Efficiency
Allele List at MGI

All alleles(2) : Targeted, other(1) Gene trapped(1)

Other mutations in this stock
Total: 33 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Armt1 T G 10: 4,384,903 (GRCm39) H39Q probably damaging Het
Car14 A T 3: 95,806,300 (GRCm39) L284Q possibly damaging Het
Ccdc154 T C 17: 25,389,118 (GRCm39) S437P probably damaging Het
Dpp9 C T 17: 56,496,393 (GRCm39) V772I probably benign Het
Gm973 A T 1: 59,591,714 (GRCm39) K366I possibly damaging Het
Gtf2h3 C T 5: 124,722,360 (GRCm39) T121I probably benign Het
Iglc2 T C 16: 19,017,384 (GRCm39) T74A probably benign Het
Inhbb T A 1: 119,345,260 (GRCm39) Y343F probably damaging Het
Krt13 C T 11: 100,008,469 (GRCm39) G423R unknown Het
Lama3 T G 18: 12,672,856 (GRCm39) M2483R probably damaging Het
Matr3 A G 18: 35,715,015 (GRCm39) E205G probably damaging Het
Mkks G A 2: 136,722,656 (GRCm39) T167I probably benign Het
Mmp24 T A 2: 155,634,462 (GRCm39) Y61N probably damaging Het
Nfkb2 A G 19: 46,298,960 (GRCm39) T665A probably damaging Het
Nlrp3 G A 11: 59,446,574 (GRCm39) W773* probably null Het
Or10d5j A T 9: 39,867,859 (GRCm39) V136E probably damaging Het
Prol1 A T 5: 88,475,711 (GRCm39) R34* probably null Het
Rcn1 T C 2: 105,225,128 (GRCm39) Y109C probably damaging Het
Rint1 T G 5: 24,020,831 (GRCm39) V618G probably damaging Het
Rtkn2 T A 10: 67,837,800 (GRCm39) N117K probably benign Het
Sbno2 T C 10: 79,922,171 (GRCm39) M1V probably null Het
Shb T C 4: 45,458,327 (GRCm39) E279G probably damaging Het
Smarcad1 A G 6: 65,051,746 (GRCm39) D293G probably benign Het
Sohlh2 T C 3: 55,099,723 (GRCm39) L165P probably benign Het
Spred2 T C 11: 19,971,415 (GRCm39) C428R probably damaging Het
Stra8 A T 6: 34,904,697 (GRCm39) D13V possibly damaging Het
Tdrd12 A G 7: 35,175,478 (GRCm39) V976A probably damaging Het
Ttn A G 2: 76,773,731 (GRCm39) S2297P unknown Het
Ttn A G 2: 76,725,002 (GRCm39) probably null Het
Usp1 A G 4: 98,819,360 (GRCm39) D274G probably damaging Het
Vmn1r4 A G 6: 56,933,604 (GRCm39) K36R probably benign Het
Zfp386 T A 12: 116,023,305 (GRCm39) I306N probably benign Het
Zmpste24 T C 4: 120,923,075 (GRCm39) D380G probably benign Het
Other mutations in Lrrc66
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00507:Lrrc66 APN 5 73,764,457 (GRCm39) missense probably benign 0.10
IGL00913:Lrrc66 APN 5 73,765,499 (GRCm39) missense possibly damaging 0.76
IGL00954:Lrrc66 APN 5 73,765,741 (GRCm39) missense possibly damaging 0.94
IGL01061:Lrrc66 APN 5 73,772,842 (GRCm39) missense probably benign 0.01
IGL01343:Lrrc66 APN 5 73,765,806 (GRCm39) missense probably damaging 0.98
IGL01714:Lrrc66 APN 5 73,787,320 (GRCm39) missense probably benign 0.10
IGL01822:Lrrc66 APN 5 73,787,311 (GRCm39) missense probably benign 0.17
IGL02005:Lrrc66 APN 5 73,766,077 (GRCm39) missense possibly damaging 0.83
IGL02166:Lrrc66 APN 5 73,764,634 (GRCm39) missense probably damaging 0.99
IGL02380:Lrrc66 APN 5 73,787,009 (GRCm39) missense possibly damaging 0.55
IGL03162:Lrrc66 APN 5 73,764,725 (GRCm39) missense probably benign
BB002:Lrrc66 UTSW 5 73,765,835 (GRCm39) missense possibly damaging 0.81
BB012:Lrrc66 UTSW 5 73,765,835 (GRCm39) missense possibly damaging 0.81
D4043:Lrrc66 UTSW 5 73,764,869 (GRCm39) missense probably benign 0.03
R0126:Lrrc66 UTSW 5 73,764,431 (GRCm39) missense probably benign 0.10
R0437:Lrrc66 UTSW 5 73,765,030 (GRCm39) missense probably benign 0.23
R0638:Lrrc66 UTSW 5 73,772,816 (GRCm39) splice site probably benign
R0658:Lrrc66 UTSW 5 73,768,287 (GRCm39) missense probably benign 0.40
R0729:Lrrc66 UTSW 5 73,765,757 (GRCm39) missense probably benign
R1603:Lrrc66 UTSW 5 73,764,769 (GRCm39) missense possibly damaging 0.61
R1774:Lrrc66 UTSW 5 73,768,198 (GRCm39) missense probably benign 0.16
R1831:Lrrc66 UTSW 5 73,764,769 (GRCm39) missense possibly damaging 0.61
R1832:Lrrc66 UTSW 5 73,764,769 (GRCm39) missense possibly damaging 0.61
R1902:Lrrc66 UTSW 5 73,764,965 (GRCm39) missense probably damaging 0.99
R2858:Lrrc66 UTSW 5 73,764,646 (GRCm39) missense probably benign 0.08
R4097:Lrrc66 UTSW 5 73,765,047 (GRCm39) missense possibly damaging 0.94
R4164:Lrrc66 UTSW 5 73,787,119 (GRCm39) splice site probably null
R4582:Lrrc66 UTSW 5 73,765,580 (GRCm39) missense possibly damaging 0.94
R4708:Lrrc66 UTSW 5 73,787,005 (GRCm39) missense probably benign 0.06
R4856:Lrrc66 UTSW 5 73,765,910 (GRCm39) missense probably benign 0.10
R4886:Lrrc66 UTSW 5 73,765,910 (GRCm39) missense probably benign 0.10
R5074:Lrrc66 UTSW 5 73,765,354 (GRCm39) missense probably damaging 1.00
R5464:Lrrc66 UTSW 5 73,765,622 (GRCm39) missense probably benign 0.05
R5640:Lrrc66 UTSW 5 73,765,977 (GRCm39) missense probably benign 0.00
R5811:Lrrc66 UTSW 5 73,772,860 (GRCm39) missense possibly damaging 0.82
R6146:Lrrc66 UTSW 5 73,765,432 (GRCm39) missense probably benign 0.10
R7037:Lrrc66 UTSW 5 73,764,504 (GRCm39) missense probably benign 0.10
R7041:Lrrc66 UTSW 5 73,765,899 (GRCm39) missense possibly damaging 0.81
R7141:Lrrc66 UTSW 5 73,787,320 (GRCm39) missense probably benign 0.10
R7201:Lrrc66 UTSW 5 73,787,240 (GRCm39) missense probably benign 0.11
R7250:Lrrc66 UTSW 5 73,768,224 (GRCm39) missense probably benign 0.03
R7367:Lrrc66 UTSW 5 73,765,724 (GRCm39) missense probably benign 0.13
R7773:Lrrc66 UTSW 5 73,764,664 (GRCm39) missense probably damaging 0.98
R7925:Lrrc66 UTSW 5 73,765,835 (GRCm39) missense possibly damaging 0.81
R8057:Lrrc66 UTSW 5 73,764,875 (GRCm39) nonsense probably null
R8167:Lrrc66 UTSW 5 73,786,952 (GRCm39) nonsense probably null
R8552:Lrrc66 UTSW 5 73,768,228 (GRCm39) missense probably benign 0.16
R8834:Lrrc66 UTSW 5 73,765,928 (GRCm39) missense possibly damaging 0.56
R8992:Lrrc66 UTSW 5 73,787,227 (GRCm39) missense probably benign 0.04
R9017:Lrrc66 UTSW 5 73,765,244 (GRCm39) missense possibly damaging 0.94
R9051:Lrrc66 UTSW 5 73,765,268 (GRCm39) missense probably benign 0.00
R9051:Lrrc66 UTSW 5 73,765,267 (GRCm39) missense probably benign 0.05
Predicted Primers PCR Primer
(F):5'- ATCTCTGAGTTCTACTGGGGAC -3'
(R):5'- GCACACTGTGACCTTTGAACAG -3'

Sequencing Primer
(F):5'- TGAGATCACCATAGCCATCCTTCG -3'
(R):5'- CACACTGTGACCTTTGAACAGGAATG -3'
Posted On 2017-12-01