Incidental Mutation 'R6173:Zp3r'
ID 501874
Institutional Source Beutler Lab
Gene Symbol Zp3r
Ensembl Gene ENSMUSG00000042554
Gene Name zona pellucida 3 receptor
Synonyms SP56
MMRRC Submission 044316-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.126) question?
Stock # R6173 (G1)
Quality Score 225.009
Status Validated
Chromosome 1
Chromosomal Location 130504450-130557358 bp(-) (GRCm39)
Type of Mutation splice site
DNA Base Change (assembly) A to T at 130519305 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000118784 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000039862] [ENSMUST00000128128] [ENSMUST00000142416]
AlphaFold no structure available at present
Predicted Effect probably null
Transcript: ENSMUST00000039862
SMART Domains Protein: ENSMUSP00000045443
Gene: ENSMUSG00000042554

DomainStartEndE-ValueType
signal peptide 1 32 N/A INTRINSIC
CCP 34 91 2.52e-7 SMART
CCP 96 153 3.17e-13 SMART
CCP 158 218 8.23e-12 SMART
CCP 223 278 1.77e-11 SMART
CCP 283 345 5.32e-6 SMART
CCP 350 411 3.67e-9 SMART
CCP 456 509 6.95e-10 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000082461
Predicted Effect probably null
Transcript: ENSMUST00000128128
SMART Domains Protein: ENSMUSP00000114401
Gene: ENSMUSG00000042554

DomainStartEndE-ValueType
CCP 55 112 2.52e-7 SMART
CCP 117 174 3.17e-13 SMART
CCP 179 234 1.77e-11 SMART
CCP 239 301 5.32e-6 SMART
CCP 306 367 3.67e-9 SMART
CCP 412 465 6.95e-10 SMART
PDB:4B0F|G 468 513 8e-8 PDB
Predicted Effect probably null
Transcript: ENSMUST00000142416
SMART Domains Protein: ENSMUSP00000118784
Gene: ENSMUSG00000042554

DomainStartEndE-ValueType
signal peptide 1 32 N/A INTRINSIC
CCP 34 91 2.52e-7 SMART
CCP 96 153 3.17e-13 SMART
CCP 158 213 1.77e-11 SMART
CCP 218 280 5.32e-6 SMART
CCP 285 346 3.67e-9 SMART
CCP 391 444 6.95e-10 SMART
PDB:4B0F|G 447 492 8e-8 PDB
Meta Mutation Damage Score 0.9755 question?
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.6%
  • 10x: 98.3%
  • 20x: 95.2%
Validation Efficiency 96% (52/54)
MGI Phenotype PHENOTYPE: Mice homozygous for a knock-out allele exhibit normal fertility and sperm morphology and physiology. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 56 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ank2 T C 3: 126,846,395 (GRCm39) D219G probably damaging Het
Arap2 A T 5: 62,906,965 (GRCm39) I18N probably damaging Het
Baz1b T C 5: 135,271,361 (GRCm39) S1315P probably benign Het
Bbs7 A T 3: 36,646,523 (GRCm39) C432* probably null Het
Bend3 A G 10: 43,385,864 (GRCm39) T86A probably benign Het
Cadm2 C T 16: 66,679,729 (GRCm39) V35I probably benign Het
Ch25h A G 19: 34,451,896 (GRCm39) S211P probably damaging Het
Chd5 A T 4: 152,463,848 (GRCm39) H1476L probably damaging Het
Chia1 T C 3: 106,036,338 (GRCm39) probably null Het
Clpx C A 9: 65,209,161 (GRCm39) S92* probably null Het
Dazl A T 17: 50,594,599 (GRCm39) M152K probably benign Het
Dnah17 A G 11: 117,930,772 (GRCm39) S3748P probably damaging Het
Dock2 T C 11: 34,212,388 (GRCm39) K1251R probably null Het
Esr1 T C 10: 4,696,760 (GRCm39) V203A probably damaging Het
F830045P16Rik A G 2: 129,305,588 (GRCm39) I262T probably damaging Het
Foxp1 G A 6: 98,992,471 (GRCm39) Q41* probably null Het
Foxp1 C A 6: 98,992,475 (GRCm39) probably null Het
Fshb T C 2: 106,887,638 (GRCm39) E127G possibly damaging Het
Galk2 A G 2: 125,701,137 (GRCm39) probably benign Het
Gid4 A G 11: 60,323,241 (GRCm39) D111G probably damaging Het
Gm14412 G A 2: 177,006,330 (GRCm39) P522S probably damaging Het
Iqank1 A G 15: 75,917,237 (GRCm39) E290G probably damaging Het
Mfap4 A G 11: 61,376,245 (GRCm39) probably null Het
Mfsd2a A G 4: 122,845,039 (GRCm39) V224A probably benign Het
Mocos A T 18: 24,809,639 (GRCm39) Y414F probably benign Het
Mrto4 T C 4: 139,077,755 (GRCm39) I27V probably benign Het
Muc4 A G 16: 32,554,958 (GRCm39) probably benign Het
Mug1 T A 6: 121,840,752 (GRCm39) I534N probably damaging Het
Mup20 A T 4: 61,972,267 (GRCm39) L7Q unknown Het
Nlrp2 T C 7: 5,340,808 (GRCm39) E2G probably damaging Het
Or11g1 A G 14: 50,651,654 (GRCm39) I218V possibly damaging Het
Or12k7 A G 2: 36,959,091 (GRCm39) Y258C possibly damaging Het
Or2y16 T C 11: 49,335,299 (GRCm39) V207A probably benign Het
Or6z5 C T 7: 6,477,835 (GRCm39) A242V probably damaging Het
Parn T C 16: 13,469,675 (GRCm39) T209A possibly damaging Het
Psip1 T A 4: 83,391,286 (GRCm39) probably null Het
Ptprc A C 1: 137,995,628 (GRCm39) C1157G probably damaging Het
Rad17 A C 13: 100,759,389 (GRCm39) V546G probably benign Het
Rc3h2 GCC GCCC 2: 37,304,745 (GRCm39) probably null Het
Safb A G 17: 56,904,798 (GRCm39) E124G probably damaging Het
Sart3 C T 5: 113,881,267 (GRCm39) A938T probably benign Het
Skint5 T C 4: 113,392,907 (GRCm39) T1242A unknown Het
Slc13a5 C T 11: 72,144,023 (GRCm39) E352K probably benign Het
Sohlh2 G T 3: 55,104,419 (GRCm39) V263F probably benign Het
Strn A G 17: 79,008,298 (GRCm39) Y107H probably damaging Het
Tbx15 G T 3: 99,161,203 (GRCm39) E3* probably null Het
Tespa1 A G 10: 130,183,172 (GRCm39) D39G probably benign Het
Trp73 A T 4: 154,188,798 (GRCm39) D54E probably damaging Het
Ttll5 A T 12: 85,980,151 (GRCm39) S912C probably damaging Het
Utp14b A T 1: 78,643,554 (GRCm39) D484V probably benign Het
Utp14b A C 1: 78,643,557 (GRCm39) N485T probably benign Het
Vmn2r29 T C 7: 7,234,369 (GRCm39) E839G probably benign Het
Vmn2r6 G C 3: 64,467,176 (GRCm39) P108A probably damaging Het
Vps8 T G 16: 21,314,682 (GRCm39) probably null Het
Zfp36l1 A T 12: 80,156,320 (GRCm39) probably null Het
Zfp998 T A 13: 66,579,608 (GRCm39) T292S probably benign Het
Other mutations in Zp3r
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01352:Zp3r APN 1 130,547,093 (GRCm39) missense possibly damaging 0.88
IGL01783:Zp3r APN 1 130,526,603 (GRCm39) missense possibly damaging 0.72
IGL01820:Zp3r APN 1 130,526,657 (GRCm39) missense probably benign 0.01
IGL01959:Zp3r APN 1 130,519,188 (GRCm39) nonsense probably null
IGL01978:Zp3r APN 1 130,526,678 (GRCm39) missense probably damaging 1.00
IGL02232:Zp3r APN 1 130,524,404 (GRCm39) missense probably damaging 1.00
IGL02290:Zp3r APN 1 130,547,102 (GRCm39) missense possibly damaging 0.89
IGL02878:Zp3r APN 1 130,510,588 (GRCm39) missense probably benign 0.02
IGL02960:Zp3r APN 1 130,511,175 (GRCm39) missense possibly damaging 0.67
BB006:Zp3r UTSW 1 130,519,217 (GRCm39) missense probably benign 0.31
BB016:Zp3r UTSW 1 130,519,217 (GRCm39) missense probably benign 0.31
PIT4403001:Zp3r UTSW 1 130,510,609 (GRCm39) missense possibly damaging 0.93
R0433:Zp3r UTSW 1 130,504,870 (GRCm39) splice site probably benign
R0491:Zp3r UTSW 1 130,546,071 (GRCm39) missense probably damaging 1.00
R0781:Zp3r UTSW 1 130,505,621 (GRCm39) critical splice donor site probably null
R1110:Zp3r UTSW 1 130,505,621 (GRCm39) critical splice donor site probably null
R1126:Zp3r UTSW 1 130,546,079 (GRCm39) missense probably damaging 1.00
R1295:Zp3r UTSW 1 130,519,181 (GRCm39) missense probably damaging 1.00
R1680:Zp3r UTSW 1 130,510,617 (GRCm39) missense probably benign 0.15
R1728:Zp3r UTSW 1 130,547,151 (GRCm39) missense possibly damaging 0.68
R1728:Zp3r UTSW 1 130,524,551 (GRCm39) missense probably benign 0.00
R1729:Zp3r UTSW 1 130,547,151 (GRCm39) missense possibly damaging 0.68
R1729:Zp3r UTSW 1 130,524,551 (GRCm39) missense probably benign 0.00
R1730:Zp3r UTSW 1 130,547,151 (GRCm39) missense possibly damaging 0.68
R1730:Zp3r UTSW 1 130,524,551 (GRCm39) missense probably benign 0.00
R1739:Zp3r UTSW 1 130,547,151 (GRCm39) missense possibly damaging 0.68
R1739:Zp3r UTSW 1 130,524,551 (GRCm39) missense probably benign 0.00
R1762:Zp3r UTSW 1 130,547,151 (GRCm39) missense possibly damaging 0.68
R1762:Zp3r UTSW 1 130,524,551 (GRCm39) missense probably benign 0.00
R1783:Zp3r UTSW 1 130,547,151 (GRCm39) missense possibly damaging 0.68
R1783:Zp3r UTSW 1 130,524,551 (GRCm39) missense probably benign 0.00
R1784:Zp3r UTSW 1 130,547,151 (GRCm39) missense possibly damaging 0.68
R1784:Zp3r UTSW 1 130,524,551 (GRCm39) missense probably benign 0.00
R1785:Zp3r UTSW 1 130,524,551 (GRCm39) missense probably benign 0.00
R1785:Zp3r UTSW 1 130,547,151 (GRCm39) missense possibly damaging 0.68
R3942:Zp3r UTSW 1 130,504,791 (GRCm39) missense possibly damaging 0.94
R4429:Zp3r UTSW 1 130,519,128 (GRCm39) missense possibly damaging 0.95
R4571:Zp3r UTSW 1 130,505,757 (GRCm39) missense probably damaging 1.00
R4626:Zp3r UTSW 1 130,542,912 (GRCm39) missense probably damaging 1.00
R4647:Zp3r UTSW 1 130,505,697 (GRCm39) missense probably damaging 1.00
R4790:Zp3r UTSW 1 130,510,629 (GRCm39) missense probably damaging 1.00
R4815:Zp3r UTSW 1 130,526,649 (GRCm39) missense probably damaging 1.00
R5355:Zp3r UTSW 1 130,524,518 (GRCm39) missense probably benign 0.09
R5554:Zp3r UTSW 1 130,511,208 (GRCm39) missense probably benign 0.42
R5629:Zp3r UTSW 1 130,510,616 (GRCm39) missense probably damaging 0.99
R6154:Zp3r UTSW 1 130,526,642 (GRCm39) missense probably damaging 1.00
R6949:Zp3r UTSW 1 130,505,632 (GRCm39) missense probably benign 0.00
R7346:Zp3r UTSW 1 130,511,217 (GRCm39) missense probably benign 0.02
R7399:Zp3r UTSW 1 130,504,790 (GRCm39) missense probably damaging 0.98
R7929:Zp3r UTSW 1 130,519,217 (GRCm39) missense probably benign 0.31
R7944:Zp3r UTSW 1 130,524,560 (GRCm39) missense probably damaging 1.00
R7945:Zp3r UTSW 1 130,524,560 (GRCm39) missense probably damaging 1.00
R8367:Zp3r UTSW 1 130,526,610 (GRCm39) missense probably damaging 1.00
R8742:Zp3r UTSW 1 130,511,230 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TTCCTGACAAGTCACAGTCTGG -3'
(R):5'- TGTTAACCCTTTAGTCACTGGTTAC -3'

Sequencing Primer
(F):5'- GGGATCGTTAAGACTTGCTCGATAAC -3'
(R):5'- GTCACTGGTTACTTTTAATACTCTGG -3'
Posted On 2017-12-04