Incidental Mutation 'R6004:Myh15'
ID 501969
Institutional Source Beutler Lab
Gene Symbol Myh15
Ensembl Gene ENSMUSG00000092009
Gene Name myosin, heavy chain 15
Synonyms EG667772
MMRRC Submission 044182-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.149) question?
Stock # R6004 (G1)
Quality Score 68.0074
Status Validated
Chromosome 16
Chromosomal Location 48877849-49019467 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 48980062 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Methionine to Leucine at position 1395 (M1395L)
Ref Sequence ENSEMBL: ENSMUSP00000127539 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000168680]
AlphaFold E9Q264
Predicted Effect probably benign
Transcript: ENSMUST00000168680
AA Change: M1395L

PolyPhen 2 Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)
SMART Domains Protein: ENSMUSP00000127539
Gene: ENSMUSG00000092009
AA Change: M1395L

DomainStartEndE-ValueType
Pfam:Myosin_N 30 70 5.2e-12 PFAM
MYSc 76 770 N/A SMART
Pfam:Myosin_tail_1 836 1915 9.5e-118 PFAM
Meta Mutation Damage Score 0.1131 question?
Coding Region Coverage
  • 1x: 99.8%
  • 3x: 99.4%
  • 10x: 96.8%
  • 20x: 89.1%
Validation Efficiency 98% (55/56)
Allele List at MGI
Other mutations in this stock
Total: 56 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acp6 C T 3: 97,082,997 (GRCm39) A336V probably benign Het
Adam5 T A 8: 25,271,685 (GRCm39) Y574F probably benign Het
Arl6 A T 16: 59,444,257 (GRCm39) W80R probably damaging Het
Bmal1 A T 7: 112,879,934 (GRCm39) D22V probably damaging Het
Cars2 A G 8: 11,597,743 (GRCm39) I111T probably damaging Het
Chrd T C 16: 20,553,987 (GRCm39) L317S possibly damaging Het
Cyp4a12b A G 4: 115,290,664 (GRCm39) D262G probably benign Het
Dcaf6 A G 1: 165,216,254 (GRCm39) S450P probably benign Het
Dnah3 T C 7: 119,685,520 (GRCm39) D164G probably benign Het
Gpx6 A C 13: 21,503,239 (GRCm39) T218P probably benign Het
Htr1f T C 16: 64,746,239 (GRCm39) N351S probably damaging Het
Idua A G 5: 108,828,510 (GRCm39) E241G probably benign Het
Ighv14-2 T A 12: 113,958,255 (GRCm39) Q62L probably damaging Het
Ighv1-65 C T 12: 115,496,056 (GRCm39) noncoding transcript Het
Inpp4a T C 1: 37,411,451 (GRCm39) S372P probably damaging Het
Itgax A T 7: 127,730,624 (GRCm39) H114L probably damaging Het
Lama2 A T 10: 27,111,781 (GRCm39) F746L probably benign Het
Lrrc37a C T 11: 103,393,362 (GRCm39) V688M possibly damaging Het
Ltbp2 A G 12: 84,922,923 (GRCm39) V28A probably benign Het
Mill2 A T 7: 18,590,463 (GRCm39) D166V probably benign Het
Mroh2a G A 1: 88,176,377 (GRCm39) C982Y probably damaging Het
Msh3 T A 13: 92,478,922 (GRCm39) probably null Het
Npepps T C 11: 97,113,950 (GRCm39) E642G probably benign Het
Nrg4 T C 9: 55,166,667 (GRCm39) T68A possibly damaging Het
Or10ag60 T A 2: 87,438,253 (GRCm39) F174I probably damaging Het
Or4b1d T C 2: 89,969,343 (GRCm39) N47D probably benign Het
Or4f60 G T 2: 111,902,371 (GRCm39) L186I probably damaging Het
Or6c66b T A 10: 129,376,759 (GRCm39) Y118N probably benign Het
Or8b41 A G 9: 38,055,256 (GRCm39) K270R probably damaging Het
Or9g20 A T 2: 85,629,726 (GRCm39) V296E probably damaging Het
Otogl T A 10: 107,715,390 (GRCm39) I429F probably damaging Het
Pank4 G T 4: 155,061,678 (GRCm39) G532C probably damaging Het
Plce1 A G 19: 38,710,315 (GRCm39) T1150A probably damaging Het
Ppp2r2b T C 18: 43,192,224 (GRCm39) probably null Het
Prkrip1 A G 5: 136,226,636 (GRCm39) M68T probably damaging Het
Psme4 T A 11: 30,806,896 (GRCm39) probably benign Het
Raet1d T A 10: 22,247,293 (GRCm39) I123N probably damaging Het
Rp1 T G 1: 4,267,808 (GRCm39) T825P unknown Het
Rttn T C 18: 89,039,816 (GRCm39) I839T probably damaging Het
Sgo2b G A 8: 64,379,707 (GRCm39) Q1042* probably null Het
Skint11 A G 4: 114,088,925 (GRCm39) T240A probably benign Het
Speg A T 1: 75,392,247 (GRCm39) K1382* probably null Het
Srsf7 A T 17: 80,513,282 (GRCm39) D68E probably damaging Het
Stag3 A T 5: 138,287,468 (GRCm39) D131V probably damaging Het
Strip2 T A 6: 29,926,570 (GRCm39) C152S probably damaging Het
Timm44 G T 8: 4,317,747 (GRCm39) D191E probably benign Het
Tlnrd1 A G 7: 83,531,987 (GRCm39) V148A probably damaging Het
Trp63 T C 16: 25,582,146 (GRCm39) probably null Het
Tusc3 G C 8: 39,538,560 (GRCm39) G200R probably damaging Het
Vmn2r10 T G 5: 109,146,944 (GRCm39) N448T probably benign Het
Vmn2r50 G A 7: 9,783,986 (GRCm39) R163C probably benign Het
Vmn2r53 T C 7: 12,316,328 (GRCm39) H497R probably benign Het
Vps39 A G 2: 120,176,131 (GRCm39) V83A possibly damaging Het
Ylpm1 A T 12: 85,075,858 (GRCm39) N861I possibly damaging Het
Zfp712 A G 13: 67,189,769 (GRCm39) C253R probably damaging Het
Zfp930 A G 8: 69,680,556 (GRCm39) T84A probably benign Het
Other mutations in Myh15
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00943:Myh15 APN 16 48,986,176 (GRCm39) missense probably damaging 0.98
IGL01095:Myh15 APN 16 48,952,378 (GRCm39) missense probably damaging 1.00
IGL01343:Myh15 APN 16 48,976,040 (GRCm39) missense probably benign 0.09
IGL01474:Myh15 APN 16 48,952,461 (GRCm39) missense probably damaging 1.00
IGL01572:Myh15 APN 16 48,920,585 (GRCm39) missense possibly damaging 0.55
IGL01595:Myh15 APN 16 48,993,312 (GRCm39) missense probably damaging 1.00
IGL01632:Myh15 APN 16 48,881,874 (GRCm39) missense probably benign 0.00
IGL01638:Myh15 APN 16 48,889,843 (GRCm39) missense probably damaging 1.00
IGL01667:Myh15 APN 16 49,015,942 (GRCm39) missense probably benign 0.20
IGL01715:Myh15 APN 16 48,877,847 (GRCm39) unclassified probably benign
IGL01833:Myh15 APN 16 48,934,421 (GRCm39) missense probably damaging 1.00
IGL02004:Myh15 APN 16 48,930,892 (GRCm39) splice site probably benign
IGL02033:Myh15 APN 16 48,965,707 (GRCm39) missense probably benign 0.05
IGL02148:Myh15 APN 16 48,936,678 (GRCm39) missense probably damaging 1.00
IGL02225:Myh15 APN 16 48,911,526 (GRCm39) missense probably benign 0.14
IGL02249:Myh15 APN 16 48,930,847 (GRCm39) missense probably damaging 0.99
IGL02505:Myh15 APN 16 48,937,626 (GRCm39) missense possibly damaging 0.90
IGL02622:Myh15 APN 16 48,997,317 (GRCm39) missense probably benign 0.02
IGL02814:Myh15 APN 16 48,965,801 (GRCm39) splice site probably benign
IGL02869:Myh15 APN 16 48,965,767 (GRCm39) missense probably benign
IGL02879:Myh15 APN 16 48,993,422 (GRCm39) missense possibly damaging 0.68
IGL02881:Myh15 APN 16 48,937,628 (GRCm39) missense possibly damaging 0.51
IGL03077:Myh15 APN 16 48,916,901 (GRCm39) missense probably benign 0.10
IGL03354:Myh15 APN 16 48,992,373 (GRCm39) missense probably benign 0.01
IGL03411:Myh15 APN 16 48,980,330 (GRCm39) missense possibly damaging 0.58
ANU74:Myh15 UTSW 16 48,993,295 (GRCm39) missense possibly damaging 0.58
P0027:Myh15 UTSW 16 48,901,571 (GRCm39) missense possibly damaging 0.77
PIT1430001:Myh15 UTSW 16 49,017,254 (GRCm39) critical splice donor site probably null
R0017:Myh15 UTSW 16 48,983,423 (GRCm39) missense probably damaging 0.97
R0038:Myh15 UTSW 16 48,891,504 (GRCm39) splice site probably benign
R0149:Myh15 UTSW 16 48,934,368 (GRCm39) missense probably benign 0.01
R0361:Myh15 UTSW 16 48,934,368 (GRCm39) missense probably benign 0.01
R0373:Myh15 UTSW 16 49,003,322 (GRCm39) missense possibly damaging 0.86
R0433:Myh15 UTSW 16 48,965,599 (GRCm39) missense probably damaging 1.00
R0525:Myh15 UTSW 16 48,952,414 (GRCm39) missense probably benign 0.03
R0586:Myh15 UTSW 16 48,992,250 (GRCm39) splice site probably benign
R0601:Myh15 UTSW 16 48,881,944 (GRCm39) missense probably damaging 1.00
R0717:Myh15 UTSW 16 48,963,356 (GRCm39) missense probably benign 0.03
R0963:Myh15 UTSW 16 48,952,512 (GRCm39) missense probably damaging 0.97
R1075:Myh15 UTSW 16 48,940,417 (GRCm39) missense possibly damaging 0.63
R1143:Myh15 UTSW 16 48,885,449 (GRCm39) missense probably benign 0.02
R1200:Myh15 UTSW 16 48,916,882 (GRCm39) missense probably damaging 1.00
R1644:Myh15 UTSW 16 48,952,566 (GRCm39) missense probably benign 0.12
R1646:Myh15 UTSW 16 49,015,931 (GRCm39) missense probably damaging 1.00
R1720:Myh15 UTSW 16 48,913,145 (GRCm39) missense probably damaging 1.00
R1768:Myh15 UTSW 16 48,983,498 (GRCm39) missense probably benign 0.27
R1881:Myh15 UTSW 16 48,891,446 (GRCm39) missense probably damaging 0.98
R2048:Myh15 UTSW 16 48,975,928 (GRCm39) missense probably damaging 0.99
R2064:Myh15 UTSW 16 48,975,984 (GRCm39) missense possibly damaging 0.50
R2184:Myh15 UTSW 16 48,957,874 (GRCm39) missense probably damaging 0.99
R2212:Myh15 UTSW 16 48,959,095 (GRCm39) missense probably benign 0.02
R2216:Myh15 UTSW 16 48,986,201 (GRCm39) nonsense probably null
R2321:Myh15 UTSW 16 48,933,436 (GRCm39) missense possibly damaging 0.93
R2327:Myh15 UTSW 16 48,963,313 (GRCm39) missense probably benign 0.01
R2395:Myh15 UTSW 16 48,889,877 (GRCm39) missense probably benign 0.04
R2399:Myh15 UTSW 16 48,957,952 (GRCm39) missense probably damaging 0.97
R3413:Myh15 UTSW 16 48,959,095 (GRCm39) missense probably benign 0.02
R4234:Myh15 UTSW 16 48,983,405 (GRCm39) missense probably benign 0.04
R4382:Myh15 UTSW 16 48,963,306 (GRCm39) missense probably benign 0.03
R4421:Myh15 UTSW 16 48,929,707 (GRCm39) missense probably damaging 0.99
R4580:Myh15 UTSW 16 48,885,388 (GRCm39) missense possibly damaging 0.93
R4657:Myh15 UTSW 16 48,992,421 (GRCm39) nonsense probably null
R4780:Myh15 UTSW 16 48,940,420 (GRCm39) missense probably benign 0.13
R5004:Myh15 UTSW 16 48,952,411 (GRCm39) missense probably damaging 0.99
R5175:Myh15 UTSW 16 48,889,789 (GRCm39) missense possibly damaging 0.85
R5189:Myh15 UTSW 16 48,921,870 (GRCm39) missense probably benign 0.20
R5311:Myh15 UTSW 16 48,986,204 (GRCm39) missense possibly damaging 0.94
R5318:Myh15 UTSW 16 48,930,834 (GRCm39) missense probably damaging 0.99
R5404:Myh15 UTSW 16 48,980,341 (GRCm39) missense probably benign 0.15
R5415:Myh15 UTSW 16 48,937,658 (GRCm39) missense probably null 1.00
R5558:Myh15 UTSW 16 48,889,900 (GRCm39) missense probably benign 0.32
R5977:Myh15 UTSW 16 48,973,866 (GRCm39) missense probably damaging 1.00
R6275:Myh15 UTSW 16 48,965,610 (GRCm39) missense probably benign 0.00
R6381:Myh15 UTSW 16 48,921,844 (GRCm39) missense probably damaging 1.00
R6448:Myh15 UTSW 16 48,992,295 (GRCm39) missense probably damaging 0.99
R6516:Myh15 UTSW 16 48,957,996 (GRCm39) missense probably benign 0.19
R6752:Myh15 UTSW 16 49,003,290 (GRCm39) missense probably damaging 1.00
R6847:Myh15 UTSW 16 48,965,451 (GRCm39) missense possibly damaging 0.70
R6868:Myh15 UTSW 16 48,889,766 (GRCm39) missense probably damaging 1.00
R6889:Myh15 UTSW 16 48,973,474 (GRCm39) missense possibly damaging 0.75
R6896:Myh15 UTSW 16 48,933,434 (GRCm39) missense probably benign 0.44
R6955:Myh15 UTSW 16 48,901,598 (GRCm39) critical splice donor site probably null
R6984:Myh15 UTSW 16 48,930,775 (GRCm39) missense probably damaging 1.00
R7046:Myh15 UTSW 16 48,929,662 (GRCm39) nonsense probably null
R7095:Myh15 UTSW 16 48,992,272 (GRCm39) missense possibly damaging 0.90
R7098:Myh15 UTSW 16 48,997,420 (GRCm39) missense possibly damaging 0.53
R7134:Myh15 UTSW 16 48,901,705 (GRCm39) missense possibly damaging 0.86
R7159:Myh15 UTSW 16 48,881,937 (GRCm39) missense probably damaging 0.97
R7244:Myh15 UTSW 16 49,017,149 (GRCm39) missense probably damaging 1.00
R7278:Myh15 UTSW 16 48,911,468 (GRCm39) missense probably damaging 0.98
R7309:Myh15 UTSW 16 48,916,828 (GRCm39) missense probably benign 0.34
R7327:Myh15 UTSW 16 48,993,369 (GRCm39) missense possibly damaging 0.88
R7418:Myh15 UTSW 16 48,975,900 (GRCm39) missense possibly damaging 0.69
R7937:Myh15 UTSW 16 48,976,009 (GRCm39) missense probably benign 0.00
R8053:Myh15 UTSW 16 48,963,302 (GRCm39) missense possibly damaging 0.89
R8313:Myh15 UTSW 16 48,940,381 (GRCm39) missense probably damaging 0.99
R8315:Myh15 UTSW 16 48,940,381 (GRCm39) missense probably damaging 0.99
R8316:Myh15 UTSW 16 48,940,381 (GRCm39) missense probably damaging 0.99
R8317:Myh15 UTSW 16 48,940,381 (GRCm39) missense probably damaging 0.99
R8342:Myh15 UTSW 16 48,913,120 (GRCm39) missense probably benign
R8379:Myh15 UTSW 16 48,901,551 (GRCm39) missense probably benign
R8445:Myh15 UTSW 16 48,940,381 (GRCm39) missense probably damaging 0.99
R8707:Myh15 UTSW 16 48,973,450 (GRCm39) missense probably damaging 1.00
R8729:Myh15 UTSW 16 48,881,851 (GRCm39) missense probably damaging 0.97
R8773:Myh15 UTSW 16 49,015,900 (GRCm39) missense possibly damaging 0.89
R8869:Myh15 UTSW 16 48,997,366 (GRCm39) missense probably benign
R8890:Myh15 UTSW 16 48,959,130 (GRCm39) missense probably damaging 1.00
R9026:Myh15 UTSW 16 49,007,433 (GRCm39) missense probably damaging 1.00
R9063:Myh15 UTSW 16 48,913,118 (GRCm39) missense probably benign 0.00
R9290:Myh15 UTSW 16 48,997,375 (GRCm39) missense probably damaging 1.00
R9630:Myh15 UTSW 16 48,980,341 (GRCm39) missense probably benign 0.15
R9710:Myh15 UTSW 16 48,959,044 (GRCm39) missense probably damaging 1.00
X0012:Myh15 UTSW 16 48,963,341 (GRCm39) missense probably damaging 1.00
X0020:Myh15 UTSW 16 48,986,237 (GRCm39) missense probably damaging 1.00
Z1176:Myh15 UTSW 16 48,916,894 (GRCm39) missense probably damaging 0.98
Z1177:Myh15 UTSW 16 48,980,189 (GRCm39) missense probably benign 0.09
Z1177:Myh15 UTSW 16 48,975,981 (GRCm39) missense probably damaging 0.97
Z1177:Myh15 UTSW 16 48,901,591 (GRCm39) missense probably benign 0.02
Predicted Primers PCR Primer
(F):5'- GTCCAAAGAGAGTCCGAATTTCAG -3'
(R):5'- GCTTCTGCTTCCAGGAAGTC -3'

Sequencing Primer
(F):5'- GTAAGTAGCATCCCTGTGGACAC -3'
(R):5'- CAGGAAGTCAGTGCCTTGTCAG -3'
Posted On 2018-01-31