Incidental Mutation 'R6186:Adgrg5'
ID 502178
Institutional Source Beutler Lab
Gene Symbol Adgrg5
Ensembl Gene ENSMUSG00000061577
Gene Name adhesion G protein-coupled receptor G5
Synonyms Gpr114, PGR27, LOC382045
MMRRC Submission 044326-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R6186 (G1)
Quality Score 225.009
Status Not validated
Chromosome 8
Chromosomal Location 95650322-95669908 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 95660652 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Alanine at position 93 (V93A)
Ref Sequence ENSEMBL: ENSMUSP00000120217 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000074570] [ENSMUST00000128308] [ENSMUST00000153448] [ENSMUST00000166802]
AlphaFold Q3V3Z3
Predicted Effect probably benign
Transcript: ENSMUST00000074570
AA Change: V97A

PolyPhen 2 Score 0.137 (Sensitivity: 0.92; Specificity: 0.86)
SMART Domains Protein: ENSMUSP00000074155
Gene: ENSMUSG00000061577
AA Change: V97A

DomainStartEndE-ValueType
signal peptide 1 23 N/A INTRINSIC
low complexity region 87 95 N/A INTRINSIC
GPS 181 234 4.7e-13 SMART
Pfam:7tm_2 240 494 2.1e-36 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000128308
AA Change: V93A

PolyPhen 2 Score 0.904 (Sensitivity: 0.82; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000120217
Gene: ENSMUSG00000061577
AA Change: V93A

DomainStartEndE-ValueType
signal peptide 1 23 N/A INTRINSIC
low complexity region 83 91 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000142991
Predicted Effect probably benign
Transcript: ENSMUST00000153448
SMART Domains Protein: ENSMUSP00000122780
Gene: ENSMUSG00000061577

DomainStartEndE-ValueType
signal peptide 1 23 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000166802
AA Change: V97A

PolyPhen 2 Score 0.253 (Sensitivity: 0.91; Specificity: 0.88)
SMART Domains Protein: ENSMUSP00000132628
Gene: ENSMUSG00000061577
AA Change: V97A

DomainStartEndE-ValueType
signal peptide 1 23 N/A INTRINSIC
low complexity region 87 95 N/A INTRINSIC
GPS 181 234 1.37e-14 SMART
Pfam:7tm_2 241 495 1.3e-36 PFAM
Meta Mutation Damage Score 0.2609 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.6%
  • 20x: 98.9%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the adhesion family of G-protein coupled receptors. Members of this family are characterized by long N-termini and multiple functional domains. They may play a role in the immune system as well as in the central nervous system. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]
Allele List at MGI
Other mutations in this stock
Total: 57 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adgb A G 10: 10,298,502 (GRCm39) S409P probably damaging Het
Akap8l C T 17: 32,552,018 (GRCm39) V420I probably benign Het
Ankrd36 T G 11: 5,593,812 (GRCm39) D472E possibly damaging Het
Apbb1 T C 7: 105,216,933 (GRCm39) E250G probably damaging Het
Cacna2d4 G A 6: 119,258,650 (GRCm39) E579K possibly damaging Het
Capn7 G T 14: 31,092,875 (GRCm39) G780W probably damaging Het
Celsr1 T C 15: 85,805,394 (GRCm39) E2419G possibly damaging Het
Cep164 A T 9: 45,705,407 (GRCm39) S363R probably damaging Het
Cfap221 T A 1: 119,862,340 (GRCm39) I581F probably damaging Het
Cog2 C A 8: 125,273,425 (GRCm39) T588N probably damaging Het
Cyp2a5 T C 7: 26,542,813 (GRCm39) probably benign Het
Cyp2j6 G C 4: 96,424,323 (GRCm39) L145V probably damaging Het
Evx1 T C 6: 52,291,203 (GRCm39) probably null Het
Fam186a T C 15: 99,845,206 (GRCm39) H346R unknown Het
Fam53b T A 7: 132,317,445 (GRCm39) D399V possibly damaging Het
Fcho2 T A 13: 98,951,591 (GRCm39) N9I probably benign Het
Fjx1 T C 2: 102,281,152 (GRCm39) E261G probably benign Het
Fkbpl G A 17: 34,864,303 (GRCm39) A24T probably benign Het
Fkbpl T C 17: 34,865,153 (GRCm39) F307S probably benign Het
Fn1 A G 1: 71,676,449 (GRCm39) I594T probably damaging Het
Inpp4b T A 8: 82,772,863 (GRCm39) V719E probably damaging Het
Ldlr C T 9: 21,635,055 (GRCm39) probably benign Het
Macf1 A G 4: 123,377,968 (GRCm39) V1419A probably damaging Het
Mapkap1 A G 2: 34,453,126 (GRCm39) T340A possibly damaging Het
Mark2 A G 19: 7,260,567 (GRCm39) V403A probably benign Het
Mast3 T C 8: 71,238,127 (GRCm39) T521A probably damaging Het
Mrtfa T C 15: 80,900,853 (GRCm39) K546R probably damaging Het
Myo1h C T 5: 114,457,864 (GRCm39) T125I possibly damaging Het
Ndufa8 A G 2: 35,929,752 (GRCm39) V118A probably benign Het
Nphs1 A G 7: 30,165,059 (GRCm39) T551A probably damaging Het
Or2k2 T C 4: 58,784,948 (GRCm39) Y258C probably damaging Het
Or4k15c T A 14: 50,321,982 (GRCm39) D52V probably damaging Het
Pcm1 T C 8: 41,746,830 (GRCm39) L1343P probably benign Het
Pdcd1 T A 1: 93,967,846 (GRCm39) R202* probably null Het
Pramel52-ps T A 5: 94,531,835 (GRCm39) Y240N probably benign Het
Prkab2 A G 3: 97,571,307 (GRCm39) probably null Het
Ptdss2 T C 7: 140,734,862 (GRCm39) probably benign Het
Rap1b G T 10: 117,656,457 (GRCm39) F78L probably damaging Het
Rbl2 C T 8: 91,833,358 (GRCm39) T711I probably damaging Het
Rhobtb2 A G 14: 70,035,693 (GRCm39) I126T probably damaging Het
Rimoc1 C A 15: 4,015,851 (GRCm39) D238Y possibly damaging Het
Rnf123 A C 9: 107,947,157 (GRCm39) S210A possibly damaging Het
Shank1 T A 7: 44,001,990 (GRCm39) F1228L probably benign Het
Spata31f3 T C 4: 42,872,000 (GRCm39) K125R possibly damaging Het
Sumo1 C A 1: 59,683,729 (GRCm39) V38L probably benign Het
Sycp2 C T 2: 178,025,353 (GRCm39) S363N probably damaging Het
Tbx2 G T 11: 85,728,672 (GRCm39) E352* probably null Het
Timm44 T C 8: 4,316,824 (GRCm39) N270D probably damaging Het
Topaz1 A T 9: 122,577,891 (GRCm39) Q267L probably benign Het
Trp63 T C 16: 25,695,483 (GRCm39) probably benign Het
Ushbp1 T A 8: 71,843,647 (GRCm39) T264S possibly damaging Het
Vav3 A G 3: 109,423,383 (GRCm39) Y334C probably damaging Het
Wdr36 G C 18: 32,985,954 (GRCm39) A553P probably benign Het
Zfhx2 A T 14: 55,300,617 (GRCm39) I2378K probably damaging Het
Zfp276 T A 8: 123,982,672 (GRCm39) Y145* probably null Het
Zfp458 T C 13: 67,405,701 (GRCm39) E246G probably damaging Het
Zfp526 A G 7: 24,925,561 (GRCm39) T607A probably benign Het
Other mutations in Adgrg5
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01340:Adgrg5 APN 8 95,664,257 (GRCm39) missense probably damaging 1.00
IGL02617:Adgrg5 APN 8 95,660,610 (GRCm39) missense probably benign 0.01
R0483:Adgrg5 UTSW 8 95,660,136 (GRCm39) missense possibly damaging 0.73
R0539:Adgrg5 UTSW 8 95,665,260 (GRCm39) missense probably damaging 1.00
R0580:Adgrg5 UTSW 8 95,663,972 (GRCm39) critical splice donor site probably null
R0650:Adgrg5 UTSW 8 95,660,785 (GRCm39) critical splice donor site probably null
R0652:Adgrg5 UTSW 8 95,660,785 (GRCm39) critical splice donor site probably null
R0828:Adgrg5 UTSW 8 95,668,413 (GRCm39) splice site probably null
R1546:Adgrg5 UTSW 8 95,668,258 (GRCm39) missense probably benign 0.27
R1567:Adgrg5 UTSW 8 95,664,326 (GRCm39) missense probably damaging 0.97
R1695:Adgrg5 UTSW 8 95,664,373 (GRCm39) missense probably damaging 1.00
R1753:Adgrg5 UTSW 8 95,668,680 (GRCm39) missense possibly damaging 0.65
R1852:Adgrg5 UTSW 8 95,664,428 (GRCm39) missense probably damaging 1.00
R2018:Adgrg5 UTSW 8 95,661,108 (GRCm39) missense probably damaging 1.00
R2051:Adgrg5 UTSW 8 95,668,695 (GRCm39) missense probably benign 0.01
R2190:Adgrg5 UTSW 8 95,660,579 (GRCm39) missense probably damaging 1.00
R2299:Adgrg5 UTSW 8 95,665,204 (GRCm39) missense possibly damaging 0.88
R2568:Adgrg5 UTSW 8 95,660,649 (GRCm39) missense probably damaging 0.99
R4283:Adgrg5 UTSW 8 95,664,326 (GRCm39) missense probably benign 0.21
R4512:Adgrg5 UTSW 8 95,660,652 (GRCm39) missense possibly damaging 0.90
R4825:Adgrg5 UTSW 8 95,668,362 (GRCm39) missense possibly damaging 0.77
R5422:Adgrg5 UTSW 8 95,660,580 (GRCm39) missense probably damaging 1.00
R5427:Adgrg5 UTSW 8 95,661,730 (GRCm39) missense probably benign 0.27
R6522:Adgrg5 UTSW 8 95,668,696 (GRCm39) missense probably benign 0.13
R6608:Adgrg5 UTSW 8 95,668,348 (GRCm39) missense probably damaging 1.00
R6810:Adgrg5 UTSW 8 95,660,570 (GRCm39) missense probably damaging 0.97
R6816:Adgrg5 UTSW 8 95,668,311 (GRCm39) missense probably damaging 0.99
R7214:Adgrg5 UTSW 8 95,660,646 (GRCm39) missense
R7686:Adgrg5 UTSW 8 95,664,430 (GRCm39) missense
R7955:Adgrg5 UTSW 8 95,664,325 (GRCm39) missense
R9383:Adgrg5 UTSW 8 95,661,162 (GRCm39) missense
R9653:Adgrg5 UTSW 8 95,663,864 (GRCm39) missense
R9729:Adgrg5 UTSW 8 95,668,133 (GRCm39) missense
X0027:Adgrg5 UTSW 8 95,663,966 (GRCm39) missense probably benign 0.07
Z1176:Adgrg5 UTSW 8 95,661,779 (GRCm39) missense
Predicted Primers PCR Primer
(F):5'- AGGCTGTCTCCAGATCCTTC -3'
(R):5'- TGTTTACACCAGGGTCCTAAAAGG -3'

Sequencing Primer
(F):5'- CTCCCATTTCTAGGCATATCCACAG -3'
(R):5'- AGGTAACCGTAGCTGCTACCAG -3'
Posted On 2018-02-27