Incidental Mutation 'R6189:Erbb4'
| ID |
502351 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Erbb4
|
| Ensembl Gene |
ENSMUSG00000062209 |
| Gene Name |
erb-b2 receptor tyrosine kinase 4 |
| Synonyms |
Her4, ErbB4 |
| MMRRC Submission |
044329-MU
|
| Accession Numbers |
|
| Essential gene? |
Essential
(E-score: 1.000)
|
| Stock # |
R6189 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
1 |
| Chromosomal Location |
68071345-69147218 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to A
at 68083075 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Methionine to Leucine
at position 1059
(M1059L)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000112713
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000119142]
[ENSMUST00000121473]
|
| AlphaFold |
Q61527 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000119142
AA Change: M1059L
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
| SMART Domains |
Protein: ENSMUSP00000112713
Gene: ENSMUSG00000062209
AA Change: M1059L
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
25 |
N/A |
INTRINSIC |
|
Pfam:Recep_L_domain
|
55 |
167 |
5e-34 |
PFAM |
|
FU
|
183 |
223 |
2.07e1 |
SMART |
|
FU
|
226 |
268 |
5.78e-10 |
SMART |
|
Pfam:Recep_L_domain
|
358 |
478 |
1e-29 |
PFAM |
|
FU
|
493 |
544 |
6.45e-8 |
SMART |
|
FU
|
549 |
599 |
3.51e-9 |
SMART |
|
FU
|
611 |
659 |
2.32e0 |
SMART |
|
TyrKc
|
718 |
974 |
7.53e-133 |
SMART |
|
low complexity region
|
1007 |
1023 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000121473
|
| SMART Domains |
Protein: ENSMUSP00000114123
Gene: ENSMUSG00000062209
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
25 |
N/A |
INTRINSIC |
|
Pfam:Recep_L_domain
|
55 |
167 |
1.6e-34 |
PFAM |
|
FU
|
183 |
223 |
2.07e1 |
SMART |
|
FU
|
226 |
268 |
5.78e-10 |
SMART |
|
Pfam:Recep_L_domain
|
358 |
478 |
5.5e-29 |
PFAM |
|
FU
|
493 |
544 |
6.45e-8 |
SMART |
|
FU
|
549 |
599 |
3.51e-9 |
SMART |
|
FU
|
611 |
659 |
2.32e0 |
SMART |
|
TyrKc
|
718 |
974 |
7.53e-133 |
SMART |
|
low complexity region
|
1007 |
1023 |
N/A |
INTRINSIC |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.5%
- 20x: 98.5%
|
| Validation Efficiency |
97% (74/76) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene is a member of the Tyr protein kinase family and the epidermal growth factor receptor subfamily. It encodes a single-pass type I membrane protein with multiple cysteine rich domains, a transmembrane domain, a tyrosine kinase domain, a phosphotidylinositol-3 kinase binding site and a PDZ domain binding motif. The protein binds to and is activated by neuregulins and other factors and induces a variety of cellular responses including mitogenesis and differentiation. Multiple proteolytic events allow for the release of a cytoplasmic fragment and an extracellular fragment. Mutations in this gene have been associated with cancer. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008]
PHENOTYPE: Homozygotes for a targeted null mutation exhibit cardiac defects, alterations in hindbrain development, and midgestational lethality. Heterozygotes show schizophrenia-like behavior. Genetically rescued females show mammary defects. [provided by MGI curators]
|
| Allele List at MGI |
All alleles(7) : Targeted(6) Gene trapped(1)
|
| Other mutations in this stock |
Total: 78 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| A530064D06Rik |
A |
G |
17: 48,474,222 (GRCm39) |
|
probably benign |
Het |
| Abca8a |
T |
C |
11: 109,921,710 (GRCm39) |
D1448G |
probably damaging |
Het |
| Actn2 |
C |
T |
13: 12,291,326 (GRCm39) |
D693N |
probably damaging |
Het |
| Adam3 |
A |
C |
8: 25,201,352 (GRCm39) |
I267R |
probably benign |
Het |
| Aldh1l2 |
A |
G |
10: 83,343,877 (GRCm39) |
|
probably null |
Het |
| C4bp |
T |
C |
1: 130,564,556 (GRCm39) |
Y376C |
probably damaging |
Het |
| Cacna1h |
A |
G |
17: 25,616,818 (GRCm39) |
W101R |
probably damaging |
Het |
| Ccdc97 |
T |
A |
7: 25,415,523 (GRCm39) |
T47S |
probably benign |
Het |
| Cenatac |
G |
A |
9: 44,321,618 (GRCm39) |
R328C |
probably benign |
Het |
| Cnot6l |
G |
A |
5: 96,246,136 (GRCm39) |
T171I |
probably benign |
Het |
| Cntnap2 |
T |
A |
6: 47,248,232 (GRCm39) |
S1213T |
probably damaging |
Het |
| Cxcl10 |
A |
T |
5: 92,495,972 (GRCm39) |
L55Q |
probably benign |
Het |
| Cyp1a1 |
T |
C |
9: 57,607,966 (GRCm39) |
V198A |
probably damaging |
Het |
| Dclre1b |
A |
G |
3: 103,710,849 (GRCm39) |
V354A |
probably damaging |
Het |
| Dmxl1 |
C |
T |
18: 50,026,402 (GRCm39) |
H1837Y |
probably benign |
Het |
| Dnajc13 |
G |
C |
9: 104,091,085 (GRCm39) |
D665E |
probably benign |
Het |
| Dnmbp |
T |
C |
19: 43,878,748 (GRCm39) |
T108A |
probably benign |
Het |
| Dnmbp |
T |
A |
19: 43,889,950 (GRCm39) |
T606S |
probably benign |
Het |
| Dok5 |
T |
A |
2: 170,642,771 (GRCm39) |
I23N |
probably damaging |
Het |
| Eml2 |
G |
A |
7: 18,935,088 (GRCm39) |
V432I |
probably damaging |
Het |
| Epha5 |
A |
T |
5: 84,385,399 (GRCm39) |
F311I |
probably damaging |
Het |
| Fbxo40 |
A |
G |
16: 36,786,526 (GRCm39) |
I681T |
probably benign |
Het |
| Flg2 |
T |
A |
3: 93,127,381 (GRCm39) |
C2098S |
unknown |
Het |
| Gpr87 |
T |
A |
3: 59,086,650 (GRCm39) |
D285V |
probably damaging |
Het |
| Hrh1 |
T |
A |
6: 114,456,959 (GRCm39) |
V80D |
probably damaging |
Het |
| Hunk |
G |
A |
16: 90,284,769 (GRCm39) |
R351K |
probably benign |
Het |
| Ifna12 |
A |
G |
4: 88,521,248 (GRCm39) |
W100R |
probably damaging |
Het |
| Ift57 |
G |
A |
16: 49,584,176 (GRCm39) |
G310S |
probably damaging |
Het |
| Igf1r |
T |
A |
7: 67,857,084 (GRCm39) |
Y1015* |
probably null |
Het |
| Igkv14-130 |
T |
C |
6: 67,768,432 (GRCm39) |
I96T |
probably damaging |
Het |
| Il34 |
C |
T |
8: 111,469,350 (GRCm39) |
S155N |
probably benign |
Het |
| Itga7 |
T |
C |
10: 128,786,272 (GRCm39) |
S938P |
possibly damaging |
Het |
| Itgam |
A |
G |
7: 127,711,676 (GRCm39) |
M764V |
probably benign |
Het |
| Lao1 |
T |
A |
4: 118,825,077 (GRCm39) |
M299K |
probably benign |
Het |
| Lnpep |
A |
T |
17: 17,787,001 (GRCm39) |
S533T |
possibly damaging |
Het |
| Lrp4 |
T |
C |
2: 91,305,579 (GRCm39) |
V283A |
possibly damaging |
Het |
| Magi3 |
G |
T |
3: 103,958,181 (GRCm39) |
H635N |
probably damaging |
Het |
| Mecr |
A |
T |
4: 131,592,565 (GRCm39) |
|
probably null |
Het |
| Mgrn1 |
T |
C |
16: 4,728,674 (GRCm39) |
|
probably null |
Het |
| Mical2 |
A |
C |
7: 112,012,087 (GRCm39) |
N646H |
probably damaging |
Het |
| Mymk |
C |
T |
2: 26,957,377 (GRCm39) |
V39I |
possibly damaging |
Het |
| Nav3 |
T |
C |
10: 109,555,880 (GRCm39) |
S1684G |
probably damaging |
Het |
| Ntn5 |
A |
T |
7: 45,342,644 (GRCm39) |
D330V |
probably benign |
Het |
| Nup42 |
G |
T |
5: 24,380,452 (GRCm39) |
G149V |
probably damaging |
Het |
| Nutm2 |
T |
A |
13: 50,623,774 (GRCm39) |
V157D |
possibly damaging |
Het |
| Obscn |
T |
C |
11: 58,960,760 (GRCm39) |
I3460V |
probably benign |
Het |
| Or8u10 |
A |
T |
2: 85,915,257 (GRCm39) |
M288K |
possibly damaging |
Het |
| Pakap |
A |
G |
4: 57,855,928 (GRCm39) |
E419G |
probably benign |
Het |
| Pcdh15 |
C |
T |
10: 74,178,483 (GRCm39) |
A580V |
probably null |
Het |
| Pcdhb10 |
T |
A |
18: 37,545,456 (GRCm39) |
H177Q |
probably damaging |
Het |
| Pitx2 |
T |
C |
3: 129,012,118 (GRCm39) |
Y130H |
probably damaging |
Het |
| Pmch |
G |
T |
10: 87,927,248 (GRCm39) |
|
probably null |
Het |
| Pofut2 |
T |
A |
10: 77,104,420 (GRCm39) |
I399N |
probably damaging |
Het |
| Prr36 |
C |
A |
8: 4,264,177 (GRCm39) |
|
probably benign |
Het |
| Ptprq |
C |
A |
10: 107,353,748 (GRCm39) |
C2256F |
probably damaging |
Het |
| Rassf5 |
G |
A |
1: 131,172,716 (GRCm39) |
A51V |
probably damaging |
Het |
| Retnla |
A |
G |
16: 48,663,258 (GRCm39) |
I54V |
probably benign |
Het |
| Rimbp2 |
A |
G |
5: 128,880,961 (GRCm39) |
L142P |
probably benign |
Het |
| Ripk1 |
A |
G |
13: 34,216,484 (GRCm39) |
T564A |
probably benign |
Het |
| Robo4 |
G |
A |
9: 37,314,829 (GRCm39) |
E228K |
probably benign |
Het |
| Rsf1 |
GGCG |
GGCGACGGCTGCG |
7: 97,229,113 (GRCm39) |
|
probably benign |
Homo |
| Rusc1 |
A |
T |
3: 88,996,319 (GRCm39) |
L132Q |
probably damaging |
Het |
| Serpinb9h |
A |
T |
13: 33,588,427 (GRCm39) |
E337D |
probably benign |
Het |
| Setd1a |
T |
C |
7: 127,377,455 (GRCm39) |
|
probably null |
Het |
| Slc38a6 |
A |
T |
12: 73,356,970 (GRCm39) |
K122M |
probably damaging |
Het |
| Speer4a2 |
A |
G |
5: 26,290,691 (GRCm39) |
I160T |
probably benign |
Het |
| Susd5 |
A |
T |
9: 113,924,726 (GRCm39) |
D203V |
probably damaging |
Het |
| Trip4 |
G |
A |
9: 65,786,434 (GRCm39) |
R110* |
probably null |
Het |
| Tuba4a |
T |
A |
1: 75,193,518 (GRCm39) |
I95F |
probably benign |
Het |
| Ube2q2 |
T |
A |
9: 55,070,267 (GRCm39) |
S70T |
probably benign |
Het |
| Umodl1 |
A |
G |
17: 31,215,256 (GRCm39) |
I1027V |
possibly damaging |
Het |
| Unc80 |
G |
A |
1: 66,716,630 (GRCm39) |
V2917I |
probably benign |
Het |
| Vmn1r70 |
T |
A |
7: 10,367,598 (GRCm39) |
C29S |
probably benign |
Het |
| Vmn2r94 |
A |
T |
17: 18,477,996 (GRCm39) |
D138E |
probably benign |
Het |
| Wee2 |
C |
T |
6: 40,426,617 (GRCm39) |
H129Y |
probably damaging |
Het |
| Zfp318 |
TGAAGAAGAAGAAGAAGAAGAAGAAGAAG |
TGAAGAAGAAGAAGAAGAAGAAG |
17: 46,723,440 (GRCm39) |
|
probably benign |
Het |
| Zfp872 |
A |
T |
9: 22,108,427 (GRCm39) |
D42V |
probably benign |
Het |
| Zic5 |
T |
G |
14: 122,702,386 (GRCm39) |
D115A |
unknown |
Het |
|
| Other mutations in Erbb4 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00965:Erbb4
|
APN |
1 |
68,110,789 (GRCm39) |
nonsense |
probably null |
|
|
IGL01020:Erbb4
|
APN |
1 |
68,337,608 (GRCm39) |
splice site |
probably benign |
|
|
IGL01349:Erbb4
|
APN |
1 |
68,385,752 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01386:Erbb4
|
APN |
1 |
68,383,090 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01516:Erbb4
|
APN |
1 |
68,367,404 (GRCm39) |
nonsense |
probably null |
|
|
IGL01536:Erbb4
|
APN |
1 |
68,329,441 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01721:Erbb4
|
APN |
1 |
68,293,722 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
IGL01832:Erbb4
|
APN |
1 |
68,293,725 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
IGL02002:Erbb4
|
APN |
1 |
68,119,885 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02040:Erbb4
|
APN |
1 |
68,081,694 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02371:Erbb4
|
APN |
1 |
68,329,453 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02399:Erbb4
|
APN |
1 |
68,081,596 (GRCm39) |
splice site |
probably benign |
|
|
IGL02553:Erbb4
|
APN |
1 |
68,345,023 (GRCm39) |
missense |
probably benign |
0.17 |
|
IGL03118:Erbb4
|
APN |
1 |
68,081,878 (GRCm39) |
missense |
probably benign |
0.11 |
|
IGL03329:Erbb4
|
APN |
1 |
68,367,281 (GRCm39) |
missense |
probably benign |
0.30 |
|
IGL03405:Erbb4
|
APN |
1 |
68,369,397 (GRCm39) |
missense |
probably benign |
0.02 |
|
earthworm
|
UTSW |
1 |
68,289,739 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
excrescence
|
UTSW |
1 |
68,369,405 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Mole
|
UTSW |
1 |
68,599,735 (GRCm39) |
missense |
probably damaging |
1.00 |
|
P0018:Erbb4
|
UTSW |
1 |
68,110,835 (GRCm39) |
missense |
probably benign |
0.05 |
|
PIT4480001:Erbb4
|
UTSW |
1 |
68,114,702 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0193:Erbb4
|
UTSW |
1 |
68,083,119 (GRCm39) |
intron |
probably benign |
|
|
R0329:Erbb4
|
UTSW |
1 |
68,337,439 (GRCm39) |
splice site |
probably benign |
|
|
R0335:Erbb4
|
UTSW |
1 |
68,298,418 (GRCm39) |
missense |
probably benign |
|
|
R0362:Erbb4
|
UTSW |
1 |
68,369,429 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0579:Erbb4
|
UTSW |
1 |
68,081,621 (GRCm39) |
missense |
probably benign |
0.17 |
|
R0730:Erbb4
|
UTSW |
1 |
68,298,449 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1029:Erbb4
|
UTSW |
1 |
68,348,773 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R1444:Erbb4
|
UTSW |
1 |
68,293,759 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1469:Erbb4
|
UTSW |
1 |
68,599,841 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1469:Erbb4
|
UTSW |
1 |
68,599,841 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1503:Erbb4
|
UTSW |
1 |
68,385,705 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1523:Erbb4
|
UTSW |
1 |
68,435,411 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R1528:Erbb4
|
UTSW |
1 |
68,117,741 (GRCm39) |
nonsense |
probably null |
|
|
R1604:Erbb4
|
UTSW |
1 |
68,385,728 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R1611:Erbb4
|
UTSW |
1 |
68,079,547 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1642:Erbb4
|
UTSW |
1 |
68,370,393 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1905:Erbb4
|
UTSW |
1 |
68,114,569 (GRCm39) |
splice site |
probably benign |
|
|
R1929:Erbb4
|
UTSW |
1 |
68,238,047 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R2046:Erbb4
|
UTSW |
1 |
68,337,482 (GRCm39) |
missense |
probably benign |
0.02 |
|
R2139:Erbb4
|
UTSW |
1 |
68,385,788 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R2271:Erbb4
|
UTSW |
1 |
68,238,047 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R2298:Erbb4
|
UTSW |
1 |
68,081,690 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2356:Erbb4
|
UTSW |
1 |
68,117,755 (GRCm39) |
missense |
probably benign |
0.00 |
|
R3821:Erbb4
|
UTSW |
1 |
68,345,072 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R4007:Erbb4
|
UTSW |
1 |
68,779,560 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4012:Erbb4
|
UTSW |
1 |
68,599,735 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4077:Erbb4
|
UTSW |
1 |
68,079,496 (GRCm39) |
missense |
probably benign |
0.07 |
|
R4196:Erbb4
|
UTSW |
1 |
68,383,014 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R4536:Erbb4
|
UTSW |
1 |
68,385,781 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4561:Erbb4
|
UTSW |
1 |
68,383,080 (GRCm39) |
nonsense |
probably null |
|
|
R4642:Erbb4
|
UTSW |
1 |
68,289,791 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4737:Erbb4
|
UTSW |
1 |
68,383,059 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R4739:Erbb4
|
UTSW |
1 |
68,383,059 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R4780:Erbb4
|
UTSW |
1 |
68,337,473 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4801:Erbb4
|
UTSW |
1 |
68,369,405 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4802:Erbb4
|
UTSW |
1 |
68,369,405 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4811:Erbb4
|
UTSW |
1 |
68,293,703 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4832:Erbb4
|
UTSW |
1 |
68,369,397 (GRCm39) |
missense |
probably benign |
0.02 |
|
R5068:Erbb4
|
UTSW |
1 |
68,083,061 (GRCm39) |
splice site |
probably null |
|
|
R5546:Erbb4
|
UTSW |
1 |
68,337,452 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5755:Erbb4
|
UTSW |
1 |
68,599,678 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
R6257:Erbb4
|
UTSW |
1 |
68,435,432 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6276:Erbb4
|
UTSW |
1 |
68,599,735 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6521:Erbb4
|
UTSW |
1 |
68,081,689 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6602:Erbb4
|
UTSW |
1 |
68,409,662 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6808:Erbb4
|
UTSW |
1 |
68,079,462 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7087:Erbb4
|
UTSW |
1 |
68,779,650 (GRCm39) |
missense |
probably null |
1.00 |
|
R7215:Erbb4
|
UTSW |
1 |
68,378,619 (GRCm39) |
missense |
probably benign |
|
|
R7356:Erbb4
|
UTSW |
1 |
68,378,514 (GRCm39) |
critical splice donor site |
probably null |
|
|
R7509:Erbb4
|
UTSW |
1 |
68,289,739 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R7593:Erbb4
|
UTSW |
1 |
68,293,758 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7743:Erbb4
|
UTSW |
1 |
68,367,278 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7784:Erbb4
|
UTSW |
1 |
68,114,658 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7815:Erbb4
|
UTSW |
1 |
68,081,885 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7923:Erbb4
|
UTSW |
1 |
68,298,368 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8071:Erbb4
|
UTSW |
1 |
68,435,470 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8288:Erbb4
|
UTSW |
1 |
68,337,509 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8356:Erbb4
|
UTSW |
1 |
68,110,789 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8456:Erbb4
|
UTSW |
1 |
68,110,789 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8464:Erbb4
|
UTSW |
1 |
68,348,785 (GRCm39) |
missense |
probably benign |
|
|
R8783:Erbb4
|
UTSW |
1 |
68,079,331 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R8830:Erbb4
|
UTSW |
1 |
68,114,627 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8881:Erbb4
|
UTSW |
1 |
68,382,997 (GRCm39) |
critical splice donor site |
probably null |
|
|
R9053:Erbb4
|
UTSW |
1 |
68,289,779 (GRCm39) |
missense |
possibly damaging |
0.63 |
|
R9142:Erbb4
|
UTSW |
1 |
68,388,552 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9237:Erbb4
|
UTSW |
1 |
68,081,601 (GRCm39) |
missense |
possibly damaging |
0.72 |
|
R9350:Erbb4
|
UTSW |
1 |
68,329,638 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9374:Erbb4
|
UTSW |
1 |
68,779,642 (GRCm39) |
nonsense |
probably null |
|
|
R9434:Erbb4
|
UTSW |
1 |
68,081,773 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R9499:Erbb4
|
UTSW |
1 |
68,779,642 (GRCm39) |
nonsense |
probably null |
|
|
R9551:Erbb4
|
UTSW |
1 |
68,779,642 (GRCm39) |
nonsense |
probably null |
|
|
R9753:Erbb4
|
UTSW |
1 |
68,238,062 (GRCm39) |
missense |
probably benign |
0.00 |
|
X0019:Erbb4
|
UTSW |
1 |
68,112,304 (GRCm39) |
missense |
probably benign |
0.00 |
|
Z1176:Erbb4
|
UTSW |
1 |
68,367,418 (GRCm39) |
nonsense |
probably null |
|
|
Z1176:Erbb4
|
UTSW |
1 |
68,337,561 (GRCm39) |
frame shift |
probably null |
|
|
Z1177:Erbb4
|
UTSW |
1 |
68,348,802 (GRCm39) |
missense |
probably benign |
0.06 |
|
Z1177:Erbb4
|
UTSW |
1 |
68,329,635 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1177:Erbb4
|
UTSW |
1 |
68,298,342 (GRCm39) |
frame shift |
probably null |
|
|
| Predicted Primers |
PCR Primer
(F):5'- TCAGTTATCACCCAAGTTACAGAC -3'
(R):5'- TGCTTGTAGTGAGAATGAACACAG -3'
Sequencing Primer
(F):5'- GACATCTAAGACATCTACACAGGCAG -3'
(R):5'- TGTAGTGAGAATGAACACAGTTTGAC -3'
|
| Posted On |
2018-02-27 |
Incidental Mutation