Incidental Mutation 'R6191:Robo1'
| ID |
502598 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Robo1
|
| Ensembl Gene |
ENSMUSG00000022883 |
| Gene Name |
roundabout guidance receptor 1 |
| Synonyms |
DUTT1 |
| MMRRC Submission |
044331-MU
|
| Accession Numbers |
|
| Essential gene? |
Essential
(E-score: 1.000)
|
| Stock # |
R6191 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
16 |
| Chromosomal Location |
72105194-72842983 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 72730696 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Serine to Proline
at position 266
(S266P)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000023600
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000023600]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000023600
AA Change: S266P
PolyPhen 2
Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
|
| SMART Domains |
Protein: ENSMUSP00000023600
Gene: ENSMUSG00000022883
AA Change: S266P
| Domain | Start | End | E-Value | Type |
|---|
|
IGc2
|
41 |
115 |
3.15e-10 |
SMART |
|
IGc2
|
143 |
208 |
2.52e-9 |
SMART |
|
IGc2
|
235 |
298 |
3.85e-14 |
SMART |
|
IGv
|
328 |
391 |
3.71e-7 |
SMART |
|
IGc2
|
428 |
493 |
2.46e-12 |
SMART |
|
FN3
|
522 |
604 |
3.17e-13 |
SMART |
|
FN3
|
634 |
721 |
1.66e0 |
SMART |
|
FN3
|
736 |
822 |
4.28e-10 |
SMART |
|
low complexity region
|
1108 |
1125 |
N/A |
INTRINSIC |
|
low complexity region
|
1148 |
1157 |
N/A |
INTRINSIC |
|
low complexity region
|
1186 |
1197 |
N/A |
INTRINSIC |
|
low complexity region
|
1249 |
1269 |
N/A |
INTRINSIC |
|
low complexity region
|
1282 |
1298 |
N/A |
INTRINSIC |
|
low complexity region
|
1345 |
1357 |
N/A |
INTRINSIC |
|
low complexity region
|
1362 |
1380 |
N/A |
INTRINSIC |
|
low complexity region
|
1442 |
1449 |
N/A |
INTRINSIC |
|
low complexity region
|
1563 |
1576 |
N/A |
INTRINSIC |
|
low complexity region
|
1602 |
1611 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000231265
|
| Predicted Effect |
unknown
Transcript: ENSMUST00000232205
AA Change: S275P
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.6%
- 20x: 98.8%
|
| Validation Efficiency |
99% (84/85) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Bilateral symmetric nervous systems have special midline structures that establish a partition between the two mirror image halves. Some axons project toward and across the midline in response to long-range chemoattractants emanating from the midline. The product of this gene is a member of the immunoglobulin gene superfamily and encodes an integral membrane protein that functions in axon guidance and neuronal precursor cell migration. This receptor is activated by SLIT-family proteins, resulting in a repulsive effect on glioma cell guidance in the developing brain. A related gene is located at an adjacent region on chromosome 3. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]
PHENOTYPE: Mice homozygous for a reporter allele show altered axon guidance. Mice homozygous for a null allele die at birth showing aberrant axon pathfinding and cortical interneuron migration. Homozygotes for another null allele show neonatal death, aphagia, delayed lung maturation and bronchial hyperplasia. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 84 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 4930563M21Rik |
A |
C |
9: 55,909,807 (GRCm39) |
D144E |
possibly damaging |
Het |
| Amigo2 |
T |
A |
15: 97,143,419 (GRCm39) |
K334N |
probably benign |
Het |
| Ano6 |
T |
C |
15: 95,846,380 (GRCm39) |
|
probably null |
Het |
| Ap1m2 |
C |
A |
9: 21,210,601 (GRCm39) |
V343F |
probably benign |
Het |
| Apol6 |
T |
C |
15: 76,940,098 (GRCm39) |
V307A |
probably benign |
Het |
| Arsi |
C |
A |
18: 61,045,544 (GRCm39) |
A78E |
probably damaging |
Het |
| B2m |
A |
T |
2: 121,981,396 (GRCm39) |
N37I |
possibly damaging |
Het |
| Bltp3b |
G |
T |
10: 89,641,180 (GRCm39) |
G784C |
possibly damaging |
Het |
| C8a |
T |
C |
4: 104,703,100 (GRCm39) |
K363R |
probably benign |
Het |
| Ccdc117 |
C |
A |
11: 5,484,242 (GRCm39) |
|
probably null |
Het |
| Ccdc154 |
C |
A |
17: 25,386,945 (GRCm39) |
Q325K |
probably damaging |
Het |
| Cd300e |
A |
T |
11: 114,945,359 (GRCm39) |
V145E |
possibly damaging |
Het |
| Col19a1 |
G |
T |
1: 24,356,474 (GRCm39) |
P673Q |
probably damaging |
Het |
| Csn2 |
A |
G |
5: 87,843,885 (GRCm39) |
|
probably null |
Het |
| Ctnna1 |
T |
C |
18: 35,307,408 (GRCm39) |
V135A |
probably damaging |
Het |
| Dnah11 |
T |
A |
12: 118,154,632 (GRCm39) |
D216V |
probably benign |
Het |
| Dnah12 |
A |
G |
14: 26,431,412 (GRCm39) |
H410R |
probably benign |
Het |
| Dock2 |
C |
T |
11: 34,181,652 (GRCm39) |
R1637H |
possibly damaging |
Het |
| Dspp |
A |
G |
5: 104,325,214 (GRCm39) |
N526D |
unknown |
Het |
| Frem2 |
T |
C |
3: 53,562,701 (GRCm39) |
H602R |
probably benign |
Het |
| Galc |
A |
T |
12: 98,218,293 (GRCm39) |
H186Q |
probably damaging |
Het |
| Grina |
T |
C |
15: 76,133,218 (GRCm39) |
V262A |
probably damaging |
Het |
| Gse1 |
G |
A |
8: 121,280,542 (GRCm39) |
|
probably null |
Het |
| H2-Oa |
C |
A |
17: 34,312,842 (GRCm39) |
Q40K |
probably damaging |
Het |
| Hfm1 |
C |
A |
5: 107,034,419 (GRCm39) |
D763Y |
possibly damaging |
Het |
| Hmcn2 |
T |
A |
2: 31,348,758 (GRCm39) |
Y4925N |
probably damaging |
Het |
| Hs3st3b1 |
C |
A |
11: 63,780,029 (GRCm39) |
R366L |
probably benign |
Het |
| Idh2 |
TCCCAGG |
T |
7: 79,748,079 (GRCm39) |
|
probably benign |
Het |
| Iqank1 |
T |
C |
15: 75,918,218 (GRCm39) |
|
probably null |
Het |
| Itpr2 |
A |
G |
6: 146,229,833 (GRCm39) |
V1221A |
probably benign |
Het |
| Kdm6b |
T |
C |
11: 69,297,584 (GRCm39) |
N285S |
probably benign |
Het |
| Klk1b1 |
T |
A |
7: 43,620,081 (GRCm39) |
N181K |
probably damaging |
Het |
| Kmt2a |
C |
A |
9: 44,738,125 (GRCm39) |
|
probably benign |
Het |
| Lama5 |
T |
C |
2: 179,827,752 (GRCm39) |
D2170G |
probably damaging |
Het |
| Lama5 |
T |
A |
2: 179,822,404 (GRCm39) |
T2890S |
probably damaging |
Het |
| Lsm2 |
T |
A |
17: 35,201,131 (GRCm39) |
|
probably benign |
Het |
| Map3k5 |
G |
T |
10: 19,899,415 (GRCm39) |
C232F |
probably damaging |
Het |
| Mapk9 |
T |
G |
11: 49,754,383 (GRCm39) |
D45E |
probably damaging |
Het |
| Mpnd |
T |
C |
17: 56,319,482 (GRCm39) |
V315A |
possibly damaging |
Het |
| Msh2 |
A |
G |
17: 88,030,900 (GRCm39) |
I926V |
probably benign |
Het |
| Mtcl1 |
C |
T |
17: 66,650,521 (GRCm39) |
R1345H |
probably damaging |
Het |
| Nbeal2 |
A |
G |
9: 110,457,058 (GRCm39) |
|
probably null |
Het |
| Neo1 |
T |
C |
9: 58,796,312 (GRCm39) |
D1205G |
probably damaging |
Het |
| Nhlrc2 |
A |
G |
19: 56,559,291 (GRCm39) |
S259G |
probably benign |
Het |
| Nkain4 |
G |
A |
2: 180,577,796 (GRCm39) |
P186L |
probably damaging |
Het |
| Nkain4 |
G |
A |
2: 180,577,797 (GRCm39) |
P186S |
probably damaging |
Het |
| Nlrp1b |
T |
A |
11: 71,109,283 (GRCm39) |
R73* |
probably null |
Het |
| Nr5a2 |
T |
C |
1: 136,818,536 (GRCm39) |
D330G |
probably damaging |
Het |
| Nup54 |
A |
G |
5: 92,572,153 (GRCm39) |
L299P |
probably damaging |
Het |
| Or2v1 |
T |
C |
11: 49,025,877 (GRCm39) |
L286P |
probably damaging |
Het |
| Or5aq7 |
A |
G |
2: 86,938,296 (GRCm39) |
V145A |
probably damaging |
Het |
| Pcdhb8 |
T |
A |
18: 37,489,279 (GRCm39) |
V319E |
probably benign |
Het |
| Pcsk6 |
T |
A |
7: 65,578,875 (GRCm39) |
D129E |
probably benign |
Het |
| Pld5 |
G |
A |
1: 175,798,100 (GRCm39) |
T433I |
probably benign |
Het |
| Plin1 |
A |
T |
7: 79,371,347 (GRCm39) |
L459H |
probably benign |
Het |
| Psd4 |
T |
C |
2: 24,284,499 (GRCm39) |
V121A |
probably damaging |
Het |
| Pxdn |
A |
T |
12: 30,032,716 (GRCm39) |
I167F |
possibly damaging |
Het |
| R3hdm2 |
T |
C |
10: 127,320,384 (GRCm39) |
S569P |
probably damaging |
Het |
| Rfng |
T |
A |
11: 120,673,516 (GRCm39) |
T202S |
probably damaging |
Het |
| Sema3c |
G |
T |
5: 17,858,804 (GRCm39) |
V68L |
probably damaging |
Het |
| Slco6c1 |
C |
T |
1: 96,993,808 (GRCm39) |
R645H |
possibly damaging |
Het |
| Slfn8 |
A |
G |
11: 82,907,626 (GRCm39) |
Y306H |
possibly damaging |
Het |
| Snap91 |
T |
C |
9: 86,720,105 (GRCm39) |
D144G |
probably damaging |
Het |
| St7l |
T |
G |
3: 104,775,349 (GRCm39) |
F75C |
probably damaging |
Het |
| Stard10 |
A |
G |
7: 100,992,468 (GRCm39) |
I145V |
probably damaging |
Het |
| Tekt3 |
C |
T |
11: 62,968,999 (GRCm39) |
A242V |
probably damaging |
Het |
| Tex44 |
A |
G |
1: 86,354,306 (GRCm39) |
|
probably benign |
Het |
| Thg1l |
T |
C |
11: 45,844,988 (GRCm39) |
Q88R |
probably benign |
Het |
| Trav8n-2 |
T |
A |
14: 53,583,744 (GRCm39) |
I67N |
probably damaging |
Het |
| Ttn |
G |
A |
2: 76,677,770 (GRCm39) |
|
probably benign |
Het |
| Ube4a |
A |
T |
9: 44,861,051 (GRCm39) |
L253* |
probably null |
Het |
| Uggt1 |
A |
T |
1: 36,201,289 (GRCm39) |
N1150K |
probably damaging |
Het |
| Ush2a |
T |
A |
1: 187,995,298 (GRCm39) |
L23* |
probably null |
Het |
| Usp22 |
T |
A |
11: 61,065,602 (GRCm39) |
N37I |
probably benign |
Het |
| Usp53 |
T |
A |
3: 122,743,390 (GRCm39) |
K515N |
probably damaging |
Het |
| Vmn2r4 |
T |
C |
3: 64,322,702 (GRCm39) |
K6E |
probably benign |
Het |
| Vps13d |
C |
T |
4: 144,875,918 (GRCm39) |
V1530M |
probably damaging |
Het |
| Vwa3b |
A |
G |
1: 37,153,612 (GRCm39) |
I485V |
possibly damaging |
Het |
| Wnk4 |
T |
C |
11: 101,155,156 (GRCm39) |
Y356H |
probably damaging |
Het |
| Zcchc2 |
A |
G |
1: 105,917,900 (GRCm39) |
|
probably benign |
Het |
| Zfp345 |
A |
C |
2: 150,315,010 (GRCm39) |
Y176D |
probably benign |
Het |
| Zfp598 |
T |
C |
17: 24,896,850 (GRCm39) |
F238S |
possibly damaging |
Het |
| Zkscan17 |
T |
C |
11: 59,393,820 (GRCm39) |
D10G |
probably damaging |
Het |
| Zmat4 |
T |
G |
8: 24,392,083 (GRCm39) |
M13R |
probably damaging |
Het |
|
| Other mutations in Robo1 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01766:Robo1
|
APN |
16 |
72,801,553 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01937:Robo1
|
APN |
16 |
72,759,114 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01945:Robo1
|
APN |
16 |
72,759,114 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02151:Robo1
|
APN |
16 |
72,786,504 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02232:Robo1
|
APN |
16 |
72,768,872 (GRCm39) |
missense |
possibly damaging |
0.59 |
|
IGL02282:Robo1
|
APN |
16 |
72,539,026 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02590:Robo1
|
APN |
16 |
72,840,020 (GRCm39) |
missense |
probably benign |
0.06 |
|
IGL02874:Robo1
|
APN |
16 |
72,809,806 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL02974:Robo1
|
APN |
16 |
72,803,750 (GRCm39) |
missense |
probably benign |
0.09 |
|
IGL03233:Robo1
|
APN |
16 |
72,767,081 (GRCm39) |
missense |
probably damaging |
0.99 |
|
PIT4378001:Robo1
|
UTSW |
16 |
72,801,423 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0079:Robo1
|
UTSW |
16 |
72,730,230 (GRCm39) |
splice site |
probably benign |
|
|
R0254:Robo1
|
UTSW |
16 |
72,461,058 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0366:Robo1
|
UTSW |
16 |
72,539,133 (GRCm39) |
missense |
possibly damaging |
0.52 |
|
R0410:Robo1
|
UTSW |
16 |
72,768,872 (GRCm39) |
missense |
possibly damaging |
0.59 |
|
R0511:Robo1
|
UTSW |
16 |
72,810,013 (GRCm39) |
critical splice donor site |
probably null |
|
|
R0563:Robo1
|
UTSW |
16 |
72,769,174 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0637:Robo1
|
UTSW |
16 |
72,798,839 (GRCm39) |
missense |
probably benign |
0.29 |
|
R1239:Robo1
|
UTSW |
16 |
72,821,430 (GRCm39) |
splice site |
probably null |
|
|
R1773:Robo1
|
UTSW |
16 |
72,801,399 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1777:Robo1
|
UTSW |
16 |
72,801,555 (GRCm39) |
missense |
probably benign |
|
|
R1901:Robo1
|
UTSW |
16 |
72,757,092 (GRCm39) |
missense |
probably null |
1.00 |
|
R1902:Robo1
|
UTSW |
16 |
72,757,092 (GRCm39) |
missense |
probably null |
1.00 |
|
R1903:Robo1
|
UTSW |
16 |
72,757,092 (GRCm39) |
missense |
probably null |
1.00 |
|
R1996:Robo1
|
UTSW |
16 |
72,767,067 (GRCm39) |
missense |
probably benign |
0.40 |
|
R2040:Robo1
|
UTSW |
16 |
72,730,630 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2266:Robo1
|
UTSW |
16 |
72,775,660 (GRCm39) |
missense |
probably benign |
|
|
R2269:Robo1
|
UTSW |
16 |
72,775,660 (GRCm39) |
missense |
probably benign |
|
|
R2433:Robo1
|
UTSW |
16 |
72,767,127 (GRCm39) |
missense |
probably benign |
0.01 |
|
R3084:Robo1
|
UTSW |
16 |
72,801,625 (GRCm39) |
missense |
probably benign |
0.02 |
|
R3085:Robo1
|
UTSW |
16 |
72,798,898 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R3150:Robo1
|
UTSW |
16 |
72,767,157 (GRCm39) |
missense |
possibly damaging |
0.57 |
|
R3418:Robo1
|
UTSW |
16 |
72,832,805 (GRCm39) |
missense |
probably benign |
0.00 |
|
R3610:Robo1
|
UTSW |
16 |
72,780,658 (GRCm39) |
missense |
probably benign |
0.00 |
|
R3940:Robo1
|
UTSW |
16 |
72,806,631 (GRCm39) |
missense |
probably benign |
|
|
R3953:Robo1
|
UTSW |
16 |
72,821,226 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4692:Robo1
|
UTSW |
16 |
72,757,090 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4726:Robo1
|
UTSW |
16 |
72,768,931 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4814:Robo1
|
UTSW |
16 |
72,768,923 (GRCm39) |
missense |
probably benign |
0.11 |
|
R4884:Robo1
|
UTSW |
16 |
72,701,639 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4992:Robo1
|
UTSW |
16 |
72,776,756 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R5150:Robo1
|
UTSW |
16 |
72,769,192 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
R5183:Robo1
|
UTSW |
16 |
72,539,038 (GRCm39) |
missense |
probably benign |
0.03 |
|
R5360:Robo1
|
UTSW |
16 |
72,732,665 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R5629:Robo1
|
UTSW |
16 |
72,780,598 (GRCm39) |
missense |
probably benign |
0.33 |
|
R5804:Robo1
|
UTSW |
16 |
72,840,077 (GRCm39) |
critical splice donor site |
probably null |
|
|
R6107:Robo1
|
UTSW |
16 |
72,780,717 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6127:Robo1
|
UTSW |
16 |
72,809,956 (GRCm39) |
missense |
probably benign |
|
|
R6128:Robo1
|
UTSW |
16 |
72,809,956 (GRCm39) |
missense |
probably benign |
|
|
R6129:Robo1
|
UTSW |
16 |
72,809,956 (GRCm39) |
missense |
probably benign |
|
|
R6357:Robo1
|
UTSW |
16 |
72,767,190 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6408:Robo1
|
UTSW |
16 |
72,768,934 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6516:Robo1
|
UTSW |
16 |
72,821,241 (GRCm39) |
missense |
probably benign |
0.14 |
|
R6600:Robo1
|
UTSW |
16 |
72,786,543 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6802:Robo1
|
UTSW |
16 |
72,730,201 (GRCm39) |
missense |
probably benign |
0.17 |
|
R7105:Robo1
|
UTSW |
16 |
72,539,049 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7189:Robo1
|
UTSW |
16 |
72,757,039 (GRCm39) |
nonsense |
probably null |
|
|
R7290:Robo1
|
UTSW |
16 |
72,801,408 (GRCm39) |
missense |
probably benign |
0.03 |
|
R7296:Robo1
|
UTSW |
16 |
72,786,519 (GRCm39) |
nonsense |
probably null |
|
|
R7576:Robo1
|
UTSW |
16 |
72,767,069 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7605:Robo1
|
UTSW |
16 |
72,821,189 (GRCm39) |
missense |
probably benign |
0.14 |
|
R7607:Robo1
|
UTSW |
16 |
72,360,626 (GRCm39) |
missense |
|
|
|
R7634:Robo1
|
UTSW |
16 |
72,839,866 (GRCm39) |
splice site |
probably null |
|
|
R7636:Robo1
|
UTSW |
16 |
72,360,615 (GRCm39) |
missense |
|
|
|
R7857:Robo1
|
UTSW |
16 |
72,767,099 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7966:Robo1
|
UTSW |
16 |
72,780,760 (GRCm39) |
missense |
possibly damaging |
0.62 |
|
R7997:Robo1
|
UTSW |
16 |
72,701,581 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8101:Robo1
|
UTSW |
16 |
72,775,469 (GRCm39) |
missense |
probably benign |
0.03 |
|
R8191:Robo1
|
UTSW |
16 |
72,730,142 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8218:Robo1
|
UTSW |
16 |
72,786,678 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R8228:Robo1
|
UTSW |
16 |
72,809,768 (GRCm39) |
missense |
probably benign |
0.30 |
|
R8292:Robo1
|
UTSW |
16 |
72,769,420 (GRCm39) |
missense |
possibly damaging |
0.61 |
|
R8298:Robo1
|
UTSW |
16 |
72,769,020 (GRCm39) |
intron |
probably benign |
|
|
R8332:Robo1
|
UTSW |
16 |
72,775,466 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8402:Robo1
|
UTSW |
16 |
72,821,385 (GRCm39) |
missense |
probably benign |
0.16 |
|
R8492:Robo1
|
UTSW |
16 |
72,809,911 (GRCm39) |
missense |
probably benign |
0.06 |
|
R8730:Robo1
|
UTSW |
16 |
72,786,495 (GRCm39) |
missense |
probably benign |
0.08 |
|
R8774:Robo1
|
UTSW |
16 |
72,832,719 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8774-TAIL:Robo1
|
UTSW |
16 |
72,832,719 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8776:Robo1
|
UTSW |
16 |
72,821,141 (GRCm39) |
nonsense |
probably null |
|
|
R8776-TAIL:Robo1
|
UTSW |
16 |
72,821,141 (GRCm39) |
nonsense |
probably null |
|
|
R8905:Robo1
|
UTSW |
16 |
72,539,173 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8913:Robo1
|
UTSW |
16 |
72,701,622 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9003:Robo1
|
UTSW |
16 |
72,539,002 (GRCm39) |
splice site |
probably benign |
|
|
R9246:Robo1
|
UTSW |
16 |
72,769,178 (GRCm39) |
missense |
probably benign |
|
|
R9451:Robo1
|
UTSW |
16 |
72,803,718 (GRCm39) |
missense |
probably benign |
0.10 |
|
R9509:Robo1
|
UTSW |
16 |
72,759,167 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R9652:Robo1
|
UTSW |
16 |
72,821,330 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R9653:Robo1
|
UTSW |
16 |
72,821,330 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R9749:Robo1
|
UTSW |
16 |
72,105,257 (GRCm39) |
start gained |
probably benign |
|
|
Z1176:Robo1
|
UTSW |
16 |
72,774,688 (GRCm39) |
missense |
probably benign |
0.16 |
|
| Predicted Primers |
PCR Primer
(F):5'- GTCCTTACTGAACATCCTAAGGG -3'
(R):5'- GCTGGAGACAAGATGGTACC -3'
Sequencing Primer
(F):5'- CCTAAGGGATTTTCCATTCATTCATC -3'
(R):5'- CTGGAGACAAGATGGTACCCTTCTG -3'
|
| Posted On |
2018-02-27 |
Incidental Mutation