Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01126:Ugt1a10'

50313

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Ugt1a10

Ensembl Gene

ENSMUSG00000090165

Gene Name

UDP glycosyltransferase 1 family, polypeptide A10

Synonyms

A13

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.130) question?

Stock #

IGL01126

Quality Score

Status

Chromosome

Chromosomal Location

87983110-88146726 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

C to A at 87983709 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Alanine to Glutamic Acid at position 169 (A169E)

Ref Sequence

ENSEMBL: ENSMUSP00000108767 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000113142] [ENSMUST00000138182] [ENSMUST00000173325]

AlphaFold

no structure available at present

Predicted Effect

possibly damaging
Transcript: ENSMUST00000113142
AA Change: A169E

PolyPhen 2 Score 0.721 (Sensitivity: 0.86; Specificity: 0.92)

SMART Domains

Protein: ENSMUSP00000108767
Gene: ENSMUSG00000090165
AA Change: A169E

Domain	Start	End	E-Value	Type
signal peptide	1	25	N/A	INTRINSIC
Pfam:UDPGT	26	521	7.3e-231	PFAM
Pfam:Glyco_tran_28_C	360	449	1.3e-9	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000138182

SMART Domains

Protein: ENSMUSP00000119985
Gene: ENSMUSG00000090165

Domain	Start	End	E-Value	Type
signal peptide	1	25	N/A	INTRINSIC
Pfam:UDPGT	26	62	7e-11	PFAM
Pfam:UDPGT	58	207	1.9e-90	PFAM
Pfam:Glyco_tran_28_C	137	207	4.8e-9	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000173165

Predicted Effect

probably benign
Transcript: ENSMUST00000173325

SMART Domains

Protein: ENSMUSP00000134443
Gene: ENSMUSG00000090165

Domain	Start	End	E-Value	Type
signal peptide	1	25	N/A	INTRINSIC
Pfam:UDPGT	26	61	3.4e-10	PFAM
Pfam:UDPGT	59	210	8.9e-92	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 19 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Aen	G	A	7: 78,557,050 (GRCm39)	M299I	probably damaging	Het
Aldh9a1	C	T	1: 167,192,143 (GRCm39)	T425I	probably benign	Het
Cc2d1a	G	T	8: 84,870,033 (GRCm39)	H161N	probably benign	Het
Col1a2	G	A	6: 4,535,846 (GRCm39)	D939N	unknown	Het
Dnah5	T	G	15: 28,302,545 (GRCm39)	F1601V	possibly damaging	Het
Dock7	A	G	4: 98,861,789 (GRCm39)		probably benign	Het
Dync2h1	T	C	9: 7,116,588 (GRCm39)	I83V	probably benign	Het
Fbxw17	A	G	13: 50,577,336 (GRCm39)	E76G	possibly damaging	Het
Map3k19	T	A	1: 127,752,068 (GRCm39)	K428*	probably null	Het
Phkb	T	C	8: 86,672,730 (GRCm39)	M365T	probably benign	Het
Phyhip	A	G	14: 70,700,797 (GRCm39)	S95G	probably benign	Het
Pla1a	T	C	16: 38,228,001 (GRCm39)	D292G	probably benign	Het
Prkdc	T	A	16: 15,487,185 (GRCm39)	V496D	probably benign	Het
Rasal3	T	C	17: 32,616,379 (GRCm39)	T271A	possibly damaging	Het
Slc22a19	T	C	19: 7,651,648 (GRCm39)	N520D	possibly damaging	Het
Sugp2	T	C	8: 70,704,524 (GRCm39)	L687P	probably damaging	Het
Ttn	A	T	2: 76,537,590 (GRCm39)	H34779Q	probably benign	Het
Txlna	A	G	4: 129,528,158 (GRCm39)		probably benign	Het
Ubr4	T	A	4: 139,129,866 (GRCm39)	M662K	probably benign	Het

Other mutations in Ugt1a10

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02219:Ugt1a10	APN	1	87,983,780 (GRCm39)	missense	probably benign	0.00
IGL02511:Ugt1a10	APN	1	87,983,585 (GRCm39)	missense	probably damaging	1.00
IGL02990:Ugt1a10	APN	1	87,983,601 (GRCm39)	missense	probably damaging	1.00
PIT4142001:Ugt1a10	UTSW	1	88,143,880 (GRCm39)	small deletion	probably benign
R0201:Ugt1a10	UTSW	1	88,145,971 (GRCm39)	missense	probably damaging	1.00
R0201:Ugt1a10	UTSW	1	88,142,845 (GRCm39)	missense	probably damaging	1.00
R0522:Ugt1a10	UTSW	1	88,145,971 (GRCm39)	missense	probably damaging	1.00
R0525:Ugt1a10	UTSW	1	88,145,971 (GRCm39)	missense	probably damaging	1.00
R0554:Ugt1a10	UTSW	1	87,983,817 (GRCm39)	missense	probably damaging	1.00
R0748:Ugt1a10	UTSW	1	88,142,845 (GRCm39)	missense	probably damaging	1.00
R0811:Ugt1a10	UTSW	1	87,983,904 (GRCm39)	missense	probably benign	0.33
R0812:Ugt1a10	UTSW	1	87,983,904 (GRCm39)	missense	probably benign	0.33
R1129:Ugt1a10	UTSW	1	87,983,331 (GRCm39)	missense	probably benign
R1207:Ugt1a10	UTSW	1	88,143,976 (GRCm39)	missense	probably damaging	1.00
R1432:Ugt1a10	UTSW	1	88,143,982 (GRCm39)	missense	probably damaging	1.00
R1457:Ugt1a10	UTSW	1	87,983,433 (GRCm39)	missense	probably damaging	1.00
R1469:Ugt1a10	UTSW	1	88,143,976 (GRCm39)	missense	probably damaging	1.00
R1972:Ugt1a10	UTSW	1	87,983,769 (GRCm39)	missense	probably damaging	1.00
R1973:Ugt1a10	UTSW	1	87,983,769 (GRCm39)	missense	probably damaging	1.00
R2039:Ugt1a10	UTSW	1	87,983,703 (GRCm39)	missense	probably benign	0.32
R2307:Ugt1a10	UTSW	1	87,983,669 (GRCm39)	missense	probably benign	0.01
R3952:Ugt1a10	UTSW	1	88,143,862 (GRCm39)	missense	probably damaging	1.00
R3973:Ugt1a10	UTSW	1	88,143,862 (GRCm39)	missense	probably damaging	1.00
R4232:Ugt1a10	UTSW	1	87,983,932 (GRCm39)	missense	probably benign	0.39
R4392:Ugt1a10	UTSW	1	88,142,845 (GRCm39)	missense	probably damaging	1.00
R4393:Ugt1a10	UTSW	1	88,142,845 (GRCm39)	missense	probably damaging	1.00
R4402:Ugt1a10	UTSW	1	88,142,845 (GRCm39)	missense	probably damaging	1.00
R4417:Ugt1a10	UTSW	1	87,983,717 (GRCm39)	missense	probably benign
R4474:Ugt1a10	UTSW	1	88,143,650 (GRCm39)	intron	probably benign
R4476:Ugt1a10	UTSW	1	88,143,650 (GRCm39)	intron	probably benign
R4515:Ugt1a10	UTSW	1	87,983,919 (GRCm39)	missense	probably damaging	1.00
R4579:Ugt1a10	UTSW	1	87,983,838 (GRCm39)	missense	probably benign
R4582:Ugt1a10	UTSW	1	87,983,463 (GRCm39)	missense	possibly damaging	0.90
R4609:Ugt1a10	UTSW	1	87,983,204 (GRCm39)	start codon destroyed	possibly damaging	0.92
R4627:Ugt1a10	UTSW	1	88,146,112 (GRCm39)	missense	probably damaging	1.00
R4790:Ugt1a10	UTSW	1	87,984,009 (GRCm39)	missense	probably damaging	0.98
R4799:Ugt1a10	UTSW	1	88,143,650 (GRCm39)	intron	probably benign
R4910:Ugt1a10	UTSW	1	88,142,845 (GRCm39)	missense	probably damaging	1.00
R4915:Ugt1a10	UTSW	1	87,983,646 (GRCm39)	missense	probably damaging	1.00
R5110:Ugt1a10	UTSW	1	87,983,974 (GRCm39)	splice site	probably null
R5168:Ugt1a10	UTSW	1	87,983,531 (GRCm39)	missense	probably benign	0.01
R5329:Ugt1a10	UTSW	1	88,143,976 (GRCm39)	missense	probably damaging	1.00
R5373:Ugt1a10	UTSW	1	87,983,632 (GRCm39)	missense	probably damaging	0.98
R5374:Ugt1a10	UTSW	1	87,983,632 (GRCm39)	missense	probably damaging	0.98
R5615:Ugt1a10	UTSW	1	88,143,880 (GRCm39)	small deletion	probably benign
R6498:Ugt1a10	UTSW	1	88,143,862 (GRCm39)	missense	probably damaging	1.00
R6727:Ugt1a10	UTSW	1	87,983,979 (GRCm39)	splice site	probably null
R6809:Ugt1a10	UTSW	1	87,983,647 (GRCm39)	missense	probably damaging	0.98
R6924:Ugt1a10	UTSW	1	87,983,379 (GRCm39)	missense	probably damaging	0.99
R6967:Ugt1a10	UTSW	1	88,142,845 (GRCm39)	missense	probably damaging	1.00
R7913:Ugt1a10	UTSW	1	87,983,477 (GRCm39)	missense	probably benign	0.00
R9165:Ugt1a10	UTSW	1	87,983,509 (GRCm39)	missense	probably benign	0.00
R9264:Ugt1a10	UTSW	1	87,983,393 (GRCm39)	missense	possibly damaging	0.62
R9475:Ugt1a10	UTSW	1	88,143,982 (GRCm39)	missense	probably damaging	1.00
S24628:Ugt1a10	UTSW	1	88,143,880 (GRCm39)	small deletion	probably benign
X0013:Ugt1a10	UTSW	1	88,143,976 (GRCm39)	missense	probably damaging	1.00
Z1088:Ugt1a10	UTSW	1	87,983,564 (GRCm39)	missense	probably benign	0.20
Z1190:Ugt1a10	UTSW	1	88,143,880 (GRCm39)	small deletion	probably benign

Posted On

2013-06-21