Incidental Mutation 'R6207:Fer1l5'
ID 503165
Institutional Source Beutler Lab
Gene Symbol Fer1l5
Ensembl Gene ENSMUSG00000037432
Gene Name fer-1 like family member 5
Synonyms 4930533C12Rik
MMRRC Submission 044341-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.082) question?
Stock # R6207 (G1)
Quality Score 225.009
Status Not validated
Chromosome 1
Chromosomal Location 36411372-36461191 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 36424241 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Lysine to Arginine at position 285 (K285R)
Ref Sequence ENSEMBL: ENSMUSP00000142130 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000179162]
AlphaFold P0DM40
Predicted Effect probably damaging
Transcript: ENSMUST00000179162
AA Change: K285R

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000142130
Gene: ENSMUSG00000037432
AA Change: K285R

DomainStartEndE-ValueType
C2 1 98 2.74e-4 SMART
C2 168 264 4.29e-6 SMART
FerI 250 323 1.59e-19 SMART
C2 325 422 1.06e-5 SMART
FerA 602 669 6.26e-18 SMART
FerB 691 764 1.38e-37 SMART
internal_repeat_1 781 836 1.77e-5 PROSPERO
internal_repeat_1 852 904 1.77e-5 PROSPERO
DysFC 913 951 1.61e-3 SMART
DysFC 981 1013 4.81e-2 SMART
C2 1078 1222 1.56e0 SMART
Pfam:C2 1248 1329 1e-1 PFAM
low complexity region 1376 1387 N/A INTRINSIC
low complexity region 1459 1470 N/A INTRINSIC
C2 1487 1586 2.21e-8 SMART
C2 1659 1851 5.32e-2 SMART
transmembrane domain 1964 1986 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000202030
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.5%
  • 20x: 98.5%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 71 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930451I11Rik G A 7: 126,430,065 (GRCm39) P69S probably damaging Het
Abca15 A G 7: 119,973,017 (GRCm39) R864G probably benign Het
Acbd5 T C 2: 22,959,490 (GRCm39) C15R possibly damaging Het
Ahctf1 A T 1: 179,604,955 (GRCm39) probably null Het
Ak3 T A 19: 29,000,340 (GRCm39) K190N probably damaging Het
B4galnt3 A T 6: 120,183,575 (GRCm39) probably null Het
Calcrl T C 2: 84,163,874 (GRCm39) H439R probably benign Het
Casp7 T A 19: 56,429,452 (GRCm39) D279E possibly damaging Het
Cckar A G 5: 53,857,186 (GRCm39) V337A probably benign Het
Cep85l T C 10: 53,157,651 (GRCm39) Y684C probably benign Het
Cmtm1 CGGCACGTACTGAAGGTCGCTGACTGGATGGTGTGGCACGTACTGAAGGTCGCTGACTGGATGGTGTGGCACGTACTGAAGGTCGCTGACTGGATGGT CGGCACGTACTGAAGGTCGCTGACTGGATGGTGTGGCACGTACTGAAGGTCGCTGACTGGATGGT 8: 105,036,102 (GRCm39) probably benign Homo
Commd7 T C 2: 153,474,530 (GRCm39) N23S possibly damaging Het
Cpne9 A T 6: 113,271,734 (GRCm39) I365F possibly damaging Het
Dab1 C T 4: 104,588,948 (GRCm39) A524V probably benign Het
Dot1l C T 10: 80,622,277 (GRCm39) A831V probably benign Het
Entrep1 T C 19: 23,950,802 (GRCm39) E593G probably damaging Het
Epcam C A 17: 87,947,864 (GRCm39) N111K probably damaging Het
Etnk1 A G 6: 143,126,524 (GRCm39) Q123R probably damaging Het
Fam170a A T 18: 50,415,017 (GRCm39) E221V probably damaging Het
Fbl T C 7: 27,874,278 (GRCm39) S88P possibly damaging Het
Fbxo36 T A 1: 84,874,251 (GRCm39) Y82* probably null Het
Foxn3 G T 12: 99,162,569 (GRCm39) T444K probably damaging Het
Gak C T 5: 108,772,895 (GRCm39) probably null Het
Gprc6a T C 10: 51,502,931 (GRCm39) I311V probably benign Het
Hrg T C 16: 22,773,288 (GRCm39) probably null Het
Htatip2 G A 7: 49,420,567 (GRCm39) V138I probably benign Het
Ighv1-4 A T 12: 114,451,142 (GRCm39) probably benign Het
Kcnq2 T C 2: 180,755,026 (GRCm39) M174V possibly damaging Het
Krt39 G T 11: 99,412,041 (GRCm39) P15Q probably damaging Het
L1td1 G A 4: 98,625,655 (GRCm39) D617N possibly damaging Het
Lgalsl T A 11: 20,779,382 (GRCm39) K88* probably null Het
Lims1 A T 10: 58,230,386 (GRCm39) K49M possibly damaging Het
Man2a1 T C 17: 65,020,600 (GRCm39) V792A probably benign Het
Mcm2 G T 6: 88,862,844 (GRCm39) D749E probably benign Het
Mdga1 G A 17: 30,057,491 (GRCm39) T775M probably damaging Het
Myb A G 10: 21,021,221 (GRCm39) S403P probably benign Het
Nek6 T C 2: 38,447,846 (GRCm39) S37P possibly damaging Het
Or10d1b T C 9: 39,613,606 (GRCm39) H153R probably benign Het
Or14c46 A C 7: 85,918,968 (GRCm39) F10V probably damaging Het
Or52a33 A G 7: 103,289,209 (GRCm39) V46A probably benign Het
Or56b2j G A 7: 104,352,818 (GRCm39) V15M probably damaging Het
Peg10 GAT GATCAT 6: 4,756,449 (GRCm39) probably benign Het
Prpf40a T C 2: 53,047,927 (GRCm39) M197V probably benign Het
Prune2 T A 19: 17,095,480 (GRCm39) I328N probably damaging Het
Psap T A 10: 60,136,317 (GRCm39) C484S probably damaging Het
Pus1 T C 5: 110,925,580 (GRCm39) D80G probably benign Het
Rasa3 T C 8: 13,648,251 (GRCm39) T138A possibly damaging Het
Scaf1 G T 7: 44,657,047 (GRCm39) probably benign Het
Skap1 T A 11: 96,594,959 (GRCm39) Y143* probably null Het
Slc22a20 A G 19: 6,035,969 (GRCm39) L67P probably damaging Het
Slc25a17 T C 15: 81,213,265 (GRCm39) Y146C probably damaging Het
Slfn4 C T 11: 83,079,951 (GRCm39) T154I possibly damaging Het
Snai1 T A 2: 167,380,229 (GRCm39) V7D probably damaging Het
Snrnp200 T A 2: 127,052,655 (GRCm39) M84K probably benign Het
Spop G T 11: 95,362,063 (GRCm39) K31N possibly damaging Het
Surf1 T C 2: 26,804,819 (GRCm39) T145A probably benign Het
Tbkbp1 T C 11: 97,037,165 (GRCm39) E278G probably damaging Het
Thumpd2 G A 17: 81,363,266 (GRCm39) A67V probably damaging Het
Timd4 A T 11: 46,706,353 (GRCm39) M52L probably damaging Het
Trav16 A T 14: 53,981,045 (GRCm39) N78I probably damaging Het
Tspan12 T C 6: 21,799,907 (GRCm39) T147A probably damaging Het
Tulp1 A T 17: 28,577,651 (GRCm39) probably benign Het
Ubqlnl A T 7: 103,797,915 (GRCm39) N527K possibly damaging Het
Ubr4 G A 4: 139,148,559 (GRCm39) C1681Y probably damaging Het
Unc13c T C 9: 73,665,910 (GRCm39) K1037E possibly damaging Het
Vmn2r111 T C 17: 22,778,032 (GRCm39) N549S possibly damaging Het
Vmn2r4 G A 3: 64,313,926 (GRCm39) H352Y probably damaging Het
Vmn2r61 A T 7: 41,909,616 (GRCm39) H47L probably benign Het
Vwa5a A G 9: 38,633,968 (GRCm39) E57G probably damaging Het
Zfp180 A T 7: 23,804,510 (GRCm39) R310* probably null Het
Zfp672 T C 11: 58,208,349 (GRCm39) probably benign Het
Other mutations in Fer1l5
AlleleSourceChrCoordTypePredicted EffectPPH Score
PIT4151001:Fer1l5 UTSW 1 36,450,728 (GRCm39) missense probably benign 0.27
R5580:Fer1l5 UTSW 1 36,424,539 (GRCm39) nonsense probably null
R5848:Fer1l5 UTSW 1 36,428,016 (GRCm39) missense probably benign 0.39
R5930:Fer1l5 UTSW 1 36,424,254 (GRCm39) nonsense probably null
R6193:Fer1l5 UTSW 1 36,448,517 (GRCm39) missense probably benign 0.20
R6195:Fer1l5 UTSW 1 36,414,367 (GRCm39) splice site probably null
R6233:Fer1l5 UTSW 1 36,414,367 (GRCm39) splice site probably null
R6349:Fer1l5 UTSW 1 36,450,355 (GRCm39) missense probably damaging 0.96
R6478:Fer1l5 UTSW 1 36,441,612 (GRCm39) missense probably damaging 1.00
R6514:Fer1l5 UTSW 1 36,442,697 (GRCm39) missense probably benign 0.01
R6611:Fer1l5 UTSW 1 36,445,735 (GRCm39) missense probably benign 0.01
R6634:Fer1l5 UTSW 1 36,450,466 (GRCm39) missense probably damaging 0.99
R6733:Fer1l5 UTSW 1 36,447,753 (GRCm39) critical splice donor site probably null
R6816:Fer1l5 UTSW 1 36,445,591 (GRCm39) missense possibly damaging 0.60
R7225:Fer1l5 UTSW 1 36,460,033 (GRCm39) missense possibly damaging 0.90
R7316:Fer1l5 UTSW 1 36,457,197 (GRCm39) missense probably benign 0.41
R7455:Fer1l5 UTSW 1 36,428,064 (GRCm39) missense probably benign 0.00
R7473:Fer1l5 UTSW 1 36,460,689 (GRCm39) missense possibly damaging 0.53
R7702:Fer1l5 UTSW 1 36,459,775 (GRCm39) nonsense probably null
R7714:Fer1l5 UTSW 1 36,440,558 (GRCm39) missense probably damaging 1.00
R7872:Fer1l5 UTSW 1 36,460,967 (GRCm39) missense probably benign 0.00
R7881:Fer1l5 UTSW 1 36,446,117 (GRCm39) missense not run
R7984:Fer1l5 UTSW 1 36,447,702 (GRCm39) missense possibly damaging 0.68
R8326:Fer1l5 UTSW 1 36,415,841 (GRCm39) missense probably benign 0.04
R8523:Fer1l5 UTSW 1 36,426,271 (GRCm39) missense probably benign 0.27
R8528:Fer1l5 UTSW 1 36,456,855 (GRCm39) missense possibly damaging 0.91
R8975:Fer1l5 UTSW 1 36,456,897 (GRCm39) missense probably benign 0.13
R9011:Fer1l5 UTSW 1 36,441,601 (GRCm39) missense probably damaging 0.96
R9084:Fer1l5 UTSW 1 36,429,619 (GRCm39) missense probably benign 0.00
R9140:Fer1l5 UTSW 1 36,460,047 (GRCm39) intron probably benign
R9180:Fer1l5 UTSW 1 36,449,999 (GRCm39) missense probably null 1.00
R9312:Fer1l5 UTSW 1 36,460,248 (GRCm39) missense probably damaging 1.00
R9510:Fer1l5 UTSW 1 36,442,662 (GRCm39) missense probably damaging 0.97
R9655:Fer1l5 UTSW 1 36,460,696 (GRCm39) missense probably benign 0.40
Z1176:Fer1l5 UTSW 1 36,429,644 (GRCm39) nonsense probably null
Z1177:Fer1l5 UTSW 1 36,448,275 (GRCm39) missense probably benign 0.03
Predicted Primers PCR Primer
(F):5'- TGCATGTGAGACACCACTTG -3'
(R):5'- CCCGACTTTCCATGTGATGCAG -3'

Sequencing Primer
(F):5'- CCCTGTTTTCCCTGGAAACAAAGG -3'
(R):5'- CATGTGATGCAGGGAGAGC -3'
Posted On 2018-02-27