Incidental Mutation 'R6207:Vmn2r61'
| ID |
503192 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn2r61
|
| Ensembl Gene |
ENSMUSG00000090967 |
| Gene Name |
vomeronasal 2, receptor 61 |
| Synonyms |
Gprc2a-rs2, Casr-rs2, EG637873 |
| MMRRC Submission |
044341-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.099)
|
| Stock # |
R6207 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Not validated
|
| Chromosome |
7 |
| Chromosomal Location |
41909477-41950179 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to T
at 41909616 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Histidine to Leucine
at position 47
(H47L)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000129576
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000166131]
|
| AlphaFold |
L7N2B8 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000166131
AA Change: H47L
PolyPhen 2
Score 0.007 (Sensitivity: 0.96; Specificity: 0.75)
|
| SMART Domains |
Protein: ENSMUSP00000129576
Gene: ENSMUSG00000090967
AA Change: H47L
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
18 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
77 |
471 |
4e-42 |
PFAM |
|
Pfam:NCD3G
|
514 |
567 |
1.9e-21 |
PFAM |
|
Pfam:7tm_3
|
600 |
835 |
6.2e-52 |
PFAM |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000206486
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.5%
- 20x: 98.5%
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 71 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 4930451I11Rik |
G |
A |
7: 126,430,065 (GRCm39) |
P69S |
probably damaging |
Het |
| Abca15 |
A |
G |
7: 119,973,017 (GRCm39) |
R864G |
probably benign |
Het |
| Acbd5 |
T |
C |
2: 22,959,490 (GRCm39) |
C15R |
possibly damaging |
Het |
| Ahctf1 |
A |
T |
1: 179,604,955 (GRCm39) |
|
probably null |
Het |
| Ak3 |
T |
A |
19: 29,000,340 (GRCm39) |
K190N |
probably damaging |
Het |
| B4galnt3 |
A |
T |
6: 120,183,575 (GRCm39) |
|
probably null |
Het |
| Calcrl |
T |
C |
2: 84,163,874 (GRCm39) |
H439R |
probably benign |
Het |
| Casp7 |
T |
A |
19: 56,429,452 (GRCm39) |
D279E |
possibly damaging |
Het |
| Cckar |
A |
G |
5: 53,857,186 (GRCm39) |
V337A |
probably benign |
Het |
| Cep85l |
T |
C |
10: 53,157,651 (GRCm39) |
Y684C |
probably benign |
Het |
| Cmtm1 |
CGGCACGTACTGAAGGTCGCTGACTGGATGGTGTGGCACGTACTGAAGGTCGCTGACTGGATGGTGTGGCACGTACTGAAGGTCGCTGACTGGATGGT |
CGGCACGTACTGAAGGTCGCTGACTGGATGGTGTGGCACGTACTGAAGGTCGCTGACTGGATGGT |
8: 105,036,102 (GRCm39) |
|
probably benign |
Homo |
| Commd7 |
T |
C |
2: 153,474,530 (GRCm39) |
N23S |
possibly damaging |
Het |
| Cpne9 |
A |
T |
6: 113,271,734 (GRCm39) |
I365F |
possibly damaging |
Het |
| Dab1 |
C |
T |
4: 104,588,948 (GRCm39) |
A524V |
probably benign |
Het |
| Dot1l |
C |
T |
10: 80,622,277 (GRCm39) |
A831V |
probably benign |
Het |
| Entrep1 |
T |
C |
19: 23,950,802 (GRCm39) |
E593G |
probably damaging |
Het |
| Epcam |
C |
A |
17: 87,947,864 (GRCm39) |
N111K |
probably damaging |
Het |
| Etnk1 |
A |
G |
6: 143,126,524 (GRCm39) |
Q123R |
probably damaging |
Het |
| Fam170a |
A |
T |
18: 50,415,017 (GRCm39) |
E221V |
probably damaging |
Het |
| Fbl |
T |
C |
7: 27,874,278 (GRCm39) |
S88P |
possibly damaging |
Het |
| Fbxo36 |
T |
A |
1: 84,874,251 (GRCm39) |
Y82* |
probably null |
Het |
| Fer1l5 |
A |
G |
1: 36,424,241 (GRCm39) |
K285R |
probably damaging |
Het |
| Foxn3 |
G |
T |
12: 99,162,569 (GRCm39) |
T444K |
probably damaging |
Het |
| Gak |
C |
T |
5: 108,772,895 (GRCm39) |
|
probably null |
Het |
| Gprc6a |
T |
C |
10: 51,502,931 (GRCm39) |
I311V |
probably benign |
Het |
| Hrg |
T |
C |
16: 22,773,288 (GRCm39) |
|
probably null |
Het |
| Htatip2 |
G |
A |
7: 49,420,567 (GRCm39) |
V138I |
probably benign |
Het |
| Ighv1-4 |
A |
T |
12: 114,451,142 (GRCm39) |
|
probably benign |
Het |
| Kcnq2 |
T |
C |
2: 180,755,026 (GRCm39) |
M174V |
possibly damaging |
Het |
| Krt39 |
G |
T |
11: 99,412,041 (GRCm39) |
P15Q |
probably damaging |
Het |
| L1td1 |
G |
A |
4: 98,625,655 (GRCm39) |
D617N |
possibly damaging |
Het |
| Lgalsl |
T |
A |
11: 20,779,382 (GRCm39) |
K88* |
probably null |
Het |
| Lims1 |
A |
T |
10: 58,230,386 (GRCm39) |
K49M |
possibly damaging |
Het |
| Man2a1 |
T |
C |
17: 65,020,600 (GRCm39) |
V792A |
probably benign |
Het |
| Mcm2 |
G |
T |
6: 88,862,844 (GRCm39) |
D749E |
probably benign |
Het |
| Mdga1 |
G |
A |
17: 30,057,491 (GRCm39) |
T775M |
probably damaging |
Het |
| Myb |
A |
G |
10: 21,021,221 (GRCm39) |
S403P |
probably benign |
Het |
| Nek6 |
T |
C |
2: 38,447,846 (GRCm39) |
S37P |
possibly damaging |
Het |
| Or10d1b |
T |
C |
9: 39,613,606 (GRCm39) |
H153R |
probably benign |
Het |
| Or14c46 |
A |
C |
7: 85,918,968 (GRCm39) |
F10V |
probably damaging |
Het |
| Or52a33 |
A |
G |
7: 103,289,209 (GRCm39) |
V46A |
probably benign |
Het |
| Or56b2j |
G |
A |
7: 104,352,818 (GRCm39) |
V15M |
probably damaging |
Het |
| Peg10 |
GAT |
GATCAT |
6: 4,756,449 (GRCm39) |
|
probably benign |
Het |
| Prpf40a |
T |
C |
2: 53,047,927 (GRCm39) |
M197V |
probably benign |
Het |
| Prune2 |
T |
A |
19: 17,095,480 (GRCm39) |
I328N |
probably damaging |
Het |
| Psap |
T |
A |
10: 60,136,317 (GRCm39) |
C484S |
probably damaging |
Het |
| Pus1 |
T |
C |
5: 110,925,580 (GRCm39) |
D80G |
probably benign |
Het |
| Rasa3 |
T |
C |
8: 13,648,251 (GRCm39) |
T138A |
possibly damaging |
Het |
| Scaf1 |
G |
T |
7: 44,657,047 (GRCm39) |
|
probably benign |
Het |
| Skap1 |
T |
A |
11: 96,594,959 (GRCm39) |
Y143* |
probably null |
Het |
| Slc22a20 |
A |
G |
19: 6,035,969 (GRCm39) |
L67P |
probably damaging |
Het |
| Slc25a17 |
T |
C |
15: 81,213,265 (GRCm39) |
Y146C |
probably damaging |
Het |
| Slfn4 |
C |
T |
11: 83,079,951 (GRCm39) |
T154I |
possibly damaging |
Het |
| Snai1 |
T |
A |
2: 167,380,229 (GRCm39) |
V7D |
probably damaging |
Het |
| Snrnp200 |
T |
A |
2: 127,052,655 (GRCm39) |
M84K |
probably benign |
Het |
| Spop |
G |
T |
11: 95,362,063 (GRCm39) |
K31N |
possibly damaging |
Het |
| Surf1 |
T |
C |
2: 26,804,819 (GRCm39) |
T145A |
probably benign |
Het |
| Tbkbp1 |
T |
C |
11: 97,037,165 (GRCm39) |
E278G |
probably damaging |
Het |
| Thumpd2 |
G |
A |
17: 81,363,266 (GRCm39) |
A67V |
probably damaging |
Het |
| Timd4 |
A |
T |
11: 46,706,353 (GRCm39) |
M52L |
probably damaging |
Het |
| Trav16 |
A |
T |
14: 53,981,045 (GRCm39) |
N78I |
probably damaging |
Het |
| Tspan12 |
T |
C |
6: 21,799,907 (GRCm39) |
T147A |
probably damaging |
Het |
| Tulp1 |
A |
T |
17: 28,577,651 (GRCm39) |
|
probably benign |
Het |
| Ubqlnl |
A |
T |
7: 103,797,915 (GRCm39) |
N527K |
possibly damaging |
Het |
| Ubr4 |
G |
A |
4: 139,148,559 (GRCm39) |
C1681Y |
probably damaging |
Het |
| Unc13c |
T |
C |
9: 73,665,910 (GRCm39) |
K1037E |
possibly damaging |
Het |
| Vmn2r111 |
T |
C |
17: 22,778,032 (GRCm39) |
N549S |
possibly damaging |
Het |
| Vmn2r4 |
G |
A |
3: 64,313,926 (GRCm39) |
H352Y |
probably damaging |
Het |
| Vwa5a |
A |
G |
9: 38,633,968 (GRCm39) |
E57G |
probably damaging |
Het |
| Zfp180 |
A |
T |
7: 23,804,510 (GRCm39) |
R310* |
probably null |
Het |
| Zfp672 |
T |
C |
11: 58,208,349 (GRCm39) |
|
probably benign |
Het |
|
| Other mutations in Vmn2r61 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00158:Vmn2r61
|
APN |
7 |
41,950,175 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
IGL00824:Vmn2r61
|
APN |
7 |
41,916,438 (GRCm39) |
missense |
probably benign |
0.03 |
|
IGL00903:Vmn2r61
|
APN |
7 |
41,949,935 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01125:Vmn2r61
|
APN |
7 |
41,909,550 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01393:Vmn2r61
|
APN |
7 |
41,916,258 (GRCm39) |
missense |
probably benign |
0.08 |
|
IGL01712:Vmn2r61
|
APN |
7 |
41,909,661 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL01822:Vmn2r61
|
APN |
7 |
41,950,130 (GRCm39) |
missense |
probably benign |
0.18 |
|
IGL01835:Vmn2r61
|
APN |
7 |
41,950,015 (GRCm39) |
missense |
probably benign |
0.12 |
|
IGL01844:Vmn2r61
|
APN |
7 |
41,909,639 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01953:Vmn2r61
|
APN |
7 |
41,949,613 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02032:Vmn2r61
|
APN |
7 |
41,949,466 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02054:Vmn2r61
|
APN |
7 |
41,926,158 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL02569:Vmn2r61
|
APN |
7 |
41,926,070 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02697:Vmn2r61
|
APN |
7 |
41,924,892 (GRCm39) |
missense |
possibly damaging |
0.55 |
|
IGL02958:Vmn2r61
|
APN |
7 |
41,949,361 (GRCm39) |
missense |
probably benign |
|
|
IGL03290:Vmn2r61
|
APN |
7 |
41,915,408 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL03337:Vmn2r61
|
APN |
7 |
41,916,509 (GRCm39) |
missense |
possibly damaging |
0.58 |
|
IGL03369:Vmn2r61
|
APN |
7 |
41,909,517 (GRCm39) |
missense |
probably benign |
|
|
IGL03402:Vmn2r61
|
APN |
7 |
41,909,679 (GRCm39) |
missense |
probably benign |
|
|
R0026:Vmn2r61
|
UTSW |
7 |
41,924,898 (GRCm39) |
missense |
possibly damaging |
0.64 |
|
R0319:Vmn2r61
|
UTSW |
7 |
41,949,941 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0433:Vmn2r61
|
UTSW |
7 |
41,915,335 (GRCm39) |
missense |
probably benign |
0.02 |
|
R0555:Vmn2r61
|
UTSW |
7 |
41,915,442 (GRCm39) |
missense |
probably benign |
0.02 |
|
R0691:Vmn2r61
|
UTSW |
7 |
41,949,844 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1701:Vmn2r61
|
UTSW |
7 |
41,949,935 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1718:Vmn2r61
|
UTSW |
7 |
41,950,121 (GRCm39) |
missense |
probably benign |
|
|
R1835:Vmn2r61
|
UTSW |
7 |
41,916,076 (GRCm39) |
nonsense |
probably null |
|
|
R1920:Vmn2r61
|
UTSW |
7 |
41,949,710 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R2069:Vmn2r61
|
UTSW |
7 |
41,949,425 (GRCm39) |
missense |
probably benign |
0.06 |
|
R2326:Vmn2r61
|
UTSW |
7 |
41,916,287 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2402:Vmn2r61
|
UTSW |
7 |
41,949,529 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R3103:Vmn2r61
|
UTSW |
7 |
41,916,067 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R3107:Vmn2r61
|
UTSW |
7 |
41,916,491 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R4426:Vmn2r61
|
UTSW |
7 |
41,950,159 (GRCm39) |
missense |
probably benign |
|
|
R4426:Vmn2r61
|
UTSW |
7 |
41,950,157 (GRCm39) |
missense |
probably benign |
|
|
R4484:Vmn2r61
|
UTSW |
7 |
41,950,120 (GRCm39) |
missense |
probably benign |
|
|
R4748:Vmn2r61
|
UTSW |
7 |
41,916,565 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R4835:Vmn2r61
|
UTSW |
7 |
41,916,459 (GRCm39) |
missense |
possibly damaging |
0.52 |
|
R4863:Vmn2r61
|
UTSW |
7 |
41,950,132 (GRCm39) |
missense |
probably benign |
0.03 |
|
R4923:Vmn2r61
|
UTSW |
7 |
41,916,520 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4968:Vmn2r61
|
UTSW |
7 |
41,949,478 (GRCm39) |
missense |
probably benign |
0.14 |
|
R5114:Vmn2r61
|
UTSW |
7 |
41,949,953 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R5297:Vmn2r61
|
UTSW |
7 |
41,909,646 (GRCm39) |
missense |
probably benign |
|
|
R5497:Vmn2r61
|
UTSW |
7 |
41,924,906 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R5508:Vmn2r61
|
UTSW |
7 |
41,916,242 (GRCm39) |
missense |
possibly damaging |
0.52 |
|
R5587:Vmn2r61
|
UTSW |
7 |
41,949,911 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5615:Vmn2r61
|
UTSW |
7 |
41,949,917 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5615:Vmn2r61
|
UTSW |
7 |
41,916,677 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5782:Vmn2r61
|
UTSW |
7 |
41,949,253 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6136:Vmn2r61
|
UTSW |
7 |
41,916,455 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6265:Vmn2r61
|
UTSW |
7 |
41,915,915 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6272:Vmn2r61
|
UTSW |
7 |
41,949,242 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6355:Vmn2r61
|
UTSW |
7 |
41,916,659 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6469:Vmn2r61
|
UTSW |
7 |
41,915,283 (GRCm39) |
nonsense |
probably null |
|
|
R6554:Vmn2r61
|
UTSW |
7 |
41,926,139 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6699:Vmn2r61
|
UTSW |
7 |
41,949,580 (GRCm39) |
missense |
probably benign |
|
|
R6768:Vmn2r61
|
UTSW |
7 |
41,949,748 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6824:Vmn2r61
|
UTSW |
7 |
41,949,403 (GRCm39) |
missense |
probably benign |
0.10 |
|
R6930:Vmn2r61
|
UTSW |
7 |
41,949,364 (GRCm39) |
missense |
probably benign |
0.02 |
|
R7053:Vmn2r61
|
UTSW |
7 |
41,916,557 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R7238:Vmn2r61
|
UTSW |
7 |
41,916,629 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R7332:Vmn2r61
|
UTSW |
7 |
41,909,534 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7359:Vmn2r61
|
UTSW |
7 |
41,915,407 (GRCm39) |
missense |
probably benign |
0.11 |
|
R7553:Vmn2r61
|
UTSW |
7 |
41,916,205 (GRCm39) |
missense |
not run |
|
|
R7710:Vmn2r61
|
UTSW |
7 |
41,916,472 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7732:Vmn2r61
|
UTSW |
7 |
41,916,097 (GRCm39) |
missense |
probably benign |
|
|
R7839:Vmn2r61
|
UTSW |
7 |
41,916,032 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R7916:Vmn2r61
|
UTSW |
7 |
41,949,935 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8026:Vmn2r61
|
UTSW |
7 |
41,916,141 (GRCm39) |
missense |
probably benign |
0.02 |
|
R8440:Vmn2r61
|
UTSW |
7 |
41,916,080 (GRCm39) |
missense |
probably benign |
0.02 |
|
R8499:Vmn2r61
|
UTSW |
7 |
41,949,700 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8771:Vmn2r61
|
UTSW |
7 |
41,916,194 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8847:Vmn2r61
|
UTSW |
7 |
41,950,010 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8986:Vmn2r61
|
UTSW |
7 |
41,915,325 (GRCm39) |
nonsense |
probably null |
|
|
R9290:Vmn2r61
|
UTSW |
7 |
41,915,385 (GRCm39) |
missense |
probably benign |
0.27 |
|
R9311:Vmn2r61
|
UTSW |
7 |
41,950,092 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R9324:Vmn2r61
|
UTSW |
7 |
41,916,619 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9476:Vmn2r61
|
UTSW |
7 |
41,949,593 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9521:Vmn2r61
|
UTSW |
7 |
41,916,626 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9619:Vmn2r61
|
UTSW |
7 |
41,926,136 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R9729:Vmn2r61
|
UTSW |
7 |
41,949,917 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1088:Vmn2r61
|
UTSW |
7 |
41,949,388 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
Z1176:Vmn2r61
|
UTSW |
7 |
41,916,166 (GRCm39) |
missense |
probably benign |
0.00 |
|
Z1176:Vmn2r61
|
UTSW |
7 |
41,909,585 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
| Predicted Primers |
PCR Primer
(F):5'- TCCATCAGTCCTATGGCTGG -3'
(R):5'- TGGTGTTACATGCATGACAAAG -3'
Sequencing Primer
(F):5'- GCTGGGCAGGTGTATACATTAATAG -3'
(R):5'- CCTTTTACAGAGGAAAAGAAGTCAAC -3'
|
| Posted On |
2018-02-27 |
Incidental Mutation