Incidental Mutation 'R6211:Or9i1'
ID 503482
Institutional Source Beutler Lab
Gene Symbol Or9i1
Ensembl Gene ENSMUSG00000056858
Gene Name olfactory receptor family 9 subfamily I member 1
Synonyms GA_x6K02T2RE5P-4193992-4194942, Olfr1502, MOR211-1
Accession Numbers
Essential gene? Probably non essential (E-score: 0.171) question?
Stock # R6211 (G1)
Quality Score 225.009
Status Validated
Chromosome 19
Chromosomal Location 13839159-13840109 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 13839938 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Methionine at position 260 (I260M)
Ref Sequence ENSEMBL: ENSMUSP00000073843 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000074221]
AlphaFold Q8VG66
Predicted Effect probably benign
Transcript: ENSMUST00000074221
AA Change: I260M

PolyPhen 2 Score 0.008 (Sensitivity: 0.96; Specificity: 0.76)
SMART Domains Protein: ENSMUSP00000073843
Gene: ENSMUSG00000056858
AA Change: I260M

DomainStartEndE-ValueType
Pfam:7tm_4 31 307 7.1e-43 PFAM
Pfam:7tm_1 41 290 1.6e-17 PFAM
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.2%
  • 20x: 97.6%
Validation Efficiency 100% (54/54)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 55 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acin1 A T 14: 54,881,503 (GRCm39) W391R probably damaging Het
Arl6ip1 A T 7: 117,726,473 (GRCm39) S18R probably benign Het
Armc3 G A 2: 19,301,614 (GRCm39) probably null Het
Ccdc162 G T 10: 41,506,141 (GRCm39) S883* probably null Het
Cd300lg A G 11: 101,944,995 (GRCm39) M358V possibly damaging Het
Cdh23 A G 10: 60,246,600 (GRCm39) V949A possibly damaging Het
Cenpo C T 12: 4,266,733 (GRCm39) S126N probably benign Het
Chd3 A T 11: 69,243,503 (GRCm39) D1366E probably damaging Het
Chd4 A G 6: 125,078,248 (GRCm39) E169G possibly damaging Het
Clec1b A G 6: 129,378,440 (GRCm39) T24A possibly damaging Het
Clhc1 A G 11: 29,528,145 (GRCm39) I558V probably damaging Het
Col5a2 T A 1: 45,415,826 (GRCm39) R1440S probably damaging Het
Cops3 A G 11: 59,708,727 (GRCm39) probably benign Het
Cxcr4 A G 1: 128,517,187 (GRCm39) V158A probably damaging Het
Dnah7a A G 1: 53,458,795 (GRCm39) M3781T probably damaging Het
Dnai7 C T 6: 145,146,217 (GRCm39) R95Q probably damaging Het
Elovl5 C A 9: 77,888,784 (GRCm39) T217K probably damaging Het
Fbln7 G T 2: 128,737,260 (GRCm39) M358I probably damaging Het
Fbxl13 C T 5: 21,689,019 (GRCm39) R763Q possibly damaging Het
Gabrr3 C A 16: 59,268,471 (GRCm39) N361K probably benign Het
Garre1 A T 7: 33,938,429 (GRCm39) H1035Q possibly damaging Het
Gbp7 A G 3: 142,251,754 (GRCm39) M534V probably benign Het
Hcar2 G A 5: 124,003,017 (GRCm39) T162I probably benign Het
Hdc A T 2: 126,435,897 (GRCm39) L658Q probably damaging Het
Hivep3 A G 4: 119,955,602 (GRCm39) Y1306C probably damaging Het
Homer3 C T 8: 70,738,174 (GRCm39) R49C probably damaging Het
Hspa4 C T 11: 53,153,766 (GRCm39) E702K probably benign Het
Iqgap3 A G 3: 87,998,822 (GRCm39) N308D probably benign Het
Itga8 G A 2: 12,198,320 (GRCm39) T555M probably damaging Het
Lrfn5 G T 12: 61,886,256 (GRCm39) V15L probably benign Het
Lrrk1 T C 7: 65,952,458 (GRCm39) K493E possibly damaging Het
Lyzl6 A G 11: 103,525,889 (GRCm39) I77T probably damaging Het
Mavs G T 2: 131,082,311 (GRCm39) R65L probably damaging Het
Mdn1 T G 4: 32,696,269 (GRCm39) D1217E probably benign Het
Or12d13 A T 17: 37,647,599 (GRCm39) F175I possibly damaging Het
Or52h1 A T 7: 103,828,954 (GRCm39) Y220* probably null Het
Otof C A 5: 30,529,244 (GRCm39) V1762L probably damaging Het
Pcdha12 T C 18: 37,153,374 (GRCm39) L31P probably damaging Het
Pxk C A 14: 8,163,952 (GRCm38) P515T probably damaging Het
Qrich2 A T 11: 116,344,368 (GRCm39) D1759E probably benign Het
Rps6ka1 A T 4: 133,596,617 (GRCm39) F33Y probably damaging Het
Rxfp2 G A 5: 149,967,591 (GRCm39) probably null Het
Slc23a4 A T 6: 34,933,896 (GRCm39) I202N probably damaging Het
Slc24a5 A T 2: 124,930,171 (GRCm39) I491F probably benign Het
Slco1a1 T A 6: 141,854,775 (GRCm39) K625N probably benign Het
Snx31 A G 15: 36,547,030 (GRCm39) V51A probably damaging Het
Sox6 G T 7: 115,400,697 (GRCm39) H48Q probably damaging Het
Tas2r109 A T 6: 132,957,587 (GRCm39) Y114* probably null Het
Tbc1d2 C T 4: 46,629,912 (GRCm39) G252R probably benign Het
Timm13 A C 10: 80,736,314 (GRCm39) probably null Het
Tpsb2 G A 17: 25,586,737 (GRCm39) A250T possibly damaging Het
Trpm6 T C 19: 18,760,492 (GRCm39) I131T probably damaging Het
Vars2 A T 17: 35,976,554 (GRCm39) probably null Het
Vmn2r35 T A 7: 7,789,527 (GRCm39) I737F probably damaging Het
Wdr46 C A 17: 34,163,459 (GRCm39) T339K probably damaging Het
Other mutations in Or9i1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00094:Or9i1 APN 19 13,839,150 (GRCm39) unclassified probably benign
IGL01061:Or9i1 APN 19 13,840,069 (GRCm39) missense possibly damaging 0.94
IGL01534:Or9i1 APN 19 13,839,283 (GRCm39) missense probably damaging 1.00
IGL02017:Or9i1 APN 19 13,839,595 (GRCm39) missense possibly damaging 0.58
IGL02039:Or9i1 APN 19 13,840,083 (GRCm39) nonsense probably null
IGL02173:Or9i1 APN 19 13,839,378 (GRCm39) missense probably benign 0.00
IGL02219:Or9i1 APN 19 13,839,187 (GRCm39) missense probably damaging 1.00
IGL02475:Or9i1 APN 19 13,839,663 (GRCm39) missense probably damaging 1.00
IGL02604:Or9i1 APN 19 13,839,170 (GRCm39) missense probably benign 0.01
R0012:Or9i1 UTSW 19 13,839,187 (GRCm39) missense probably damaging 0.98
R0594:Or9i1 UTSW 19 13,839,643 (GRCm39) missense probably benign 0.04
R2184:Or9i1 UTSW 19 13,839,399 (GRCm39) missense probably benign 0.02
R2518:Or9i1 UTSW 19 13,839,673 (GRCm39) missense probably damaging 1.00
R5541:Or9i1 UTSW 19 13,839,328 (GRCm39) missense probably benign
R5587:Or9i1 UTSW 19 13,839,940 (GRCm39) missense probably damaging 1.00
R6351:Or9i1 UTSW 19 13,839,186 (GRCm39) missense probably benign 0.04
R7575:Or9i1 UTSW 19 13,839,381 (GRCm39) missense probably damaging 1.00
R8425:Or9i1 UTSW 19 13,839,849 (GRCm39) missense probably benign 0.00
R9545:Or9i1 UTSW 19 13,839,217 (GRCm39) missense possibly damaging 0.94
Predicted Primers PCR Primer
(F):5'- AAGCTGGCCTGTAGTGACAC -3'
(R):5'- CCTCACTCAGTGTTGTGTGC -3'

Sequencing Primer
(F):5'- GGCCTGTAGTGACACAACAAATATTG -3'
(R):5'- CAGTGTTGTGTGCATTGGGAAAC -3'
Posted On 2018-02-27