Incidental Mutation 'R6216:Pou2f1'
| ID |
503690 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Pou2f1
|
| Ensembl Gene |
ENSMUSG00000026565 |
| Gene Name |
POU domain, class 2, transcription factor 1 |
| Synonyms |
Oct-1z, Oct-1A, Oct-1B, Oct-1C, oct-1, Oct1, 2810482H01Rik, Otf-1, Otf1 |
| MMRRC Submission |
044349-MU
|
| Accession Numbers |
|
| Essential gene? |
Essential
(E-score: 1.000)
|
| Stock # |
R6216 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
1 |
| Chromosomal Location |
165692723-165830247 bp(-) (GRCm39) |
| Type of Mutation |
unclassified |
| DNA Base Change (assembly) |
G to T
at 165707889 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000027850]
[ENSMUST00000069609]
[ENSMUST00000111426]
[ENSMUST00000111427]
[ENSMUST00000111429]
[ENSMUST00000159212]
[ENSMUST00000160260]
[ENSMUST00000160908]
[ENSMUST00000184643]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
unknown
Transcript: ENSMUST00000027850
AA Change: Q511K
|
| SMART Domains |
Protein: ENSMUSP00000027850
Gene: ENSMUSG00000026565
AA Change: Q511K
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
2 |
22 |
N/A |
INTRINSIC |
|
low complexity region
|
94 |
123 |
N/A |
INTRINSIC |
|
low complexity region
|
137 |
152 |
N/A |
INTRINSIC |
|
low complexity region
|
171 |
192 |
N/A |
INTRINSIC |
|
low complexity region
|
199 |
217 |
N/A |
INTRINSIC |
|
POU
|
241 |
315 |
1.55e-52 |
SMART |
|
low complexity region
|
316 |
332 |
N/A |
INTRINSIC |
|
HOX
|
342 |
404 |
2.54e-19 |
SMART |
|
low complexity region
|
422 |
448 |
N/A |
INTRINSIC |
|
low complexity region
|
453 |
520 |
N/A |
INTRINSIC |
|
low complexity region
|
529 |
567 |
N/A |
INTRINSIC |
|
low complexity region
|
675 |
685 |
N/A |
INTRINSIC |
|
low complexity region
|
688 |
705 |
N/A |
INTRINSIC |
|
| Predicted Effect |
unknown
Transcript: ENSMUST00000069609
AA Change: Q563K
|
| SMART Domains |
Protein: ENSMUSP00000064000
Gene: ENSMUSG00000026565
AA Change: Q563K
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
83 |
112 |
N/A |
INTRINSIC |
|
low complexity region
|
130 |
172 |
N/A |
INTRINSIC |
|
low complexity region
|
189 |
204 |
N/A |
INTRINSIC |
|
low complexity region
|
223 |
244 |
N/A |
INTRINSIC |
|
low complexity region
|
251 |
269 |
N/A |
INTRINSIC |
|
POU
|
293 |
367 |
1.55e-52 |
SMART |
|
low complexity region
|
368 |
384 |
N/A |
INTRINSIC |
|
HOX
|
394 |
456 |
2.54e-19 |
SMART |
|
low complexity region
|
474 |
500 |
N/A |
INTRINSIC |
|
low complexity region
|
505 |
572 |
N/A |
INTRINSIC |
|
low complexity region
|
581 |
619 |
N/A |
INTRINSIC |
|
low complexity region
|
727 |
737 |
N/A |
INTRINSIC |
|
low complexity region
|
740 |
757 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000082225
|
| SMART Domains |
Protein: ENSMUSP00000080856
Gene: ENSMUSG00000026565
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
83 |
112 |
N/A |
INTRINSIC |
|
low complexity region
|
130 |
172 |
N/A |
INTRINSIC |
|
low complexity region
|
189 |
204 |
N/A |
INTRINSIC |
|
POU
|
233 |
309 |
4.88e-27 |
SMART |
|
low complexity region
|
310 |
326 |
N/A |
INTRINSIC |
|
HOX
|
336 |
398 |
2.54e-19 |
SMART |
|
low complexity region
|
416 |
442 |
N/A |
INTRINSIC |
|
low complexity region
|
447 |
514 |
N/A |
INTRINSIC |
|
low complexity region
|
523 |
561 |
N/A |
INTRINSIC |
|
| Predicted Effect |
unknown
Transcript: ENSMUST00000111426
AA Change: Q587K
|
| SMART Domains |
Protein: ENSMUSP00000107055
Gene: ENSMUSG00000026565
AA Change: Q587K
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
83 |
112 |
N/A |
INTRINSIC |
|
low complexity region
|
130 |
172 |
N/A |
INTRINSIC |
|
low complexity region
|
189 |
204 |
N/A |
INTRINSIC |
|
low complexity region
|
223 |
244 |
N/A |
INTRINSIC |
|
low complexity region
|
251 |
269 |
N/A |
INTRINSIC |
|
POU
|
293 |
367 |
6.7e-55 |
SMART |
|
low complexity region
|
368 |
384 |
N/A |
INTRINSIC |
|
HOX
|
394 |
456 |
1.3e-21 |
SMART |
|
low complexity region
|
474 |
500 |
N/A |
INTRINSIC |
|
low complexity region
|
531 |
596 |
N/A |
INTRINSIC |
|
low complexity region
|
605 |
643 |
N/A |
INTRINSIC |
|
| Predicted Effect |
unknown
Transcript: ENSMUST00000111427
AA Change: Q587K
|
| SMART Domains |
Protein: ENSMUSP00000107056
Gene: ENSMUSG00000026565
AA Change: Q587K
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
83 |
112 |
N/A |
INTRINSIC |
|
low complexity region
|
130 |
172 |
N/A |
INTRINSIC |
|
low complexity region
|
189 |
204 |
N/A |
INTRINSIC |
|
low complexity region
|
223 |
244 |
N/A |
INTRINSIC |
|
low complexity region
|
251 |
269 |
N/A |
INTRINSIC |
|
POU
|
293 |
367 |
1.55e-52 |
SMART |
|
low complexity region
|
368 |
384 |
N/A |
INTRINSIC |
|
HOX
|
394 |
456 |
2.54e-19 |
SMART |
|
low complexity region
|
474 |
500 |
N/A |
INTRINSIC |
|
low complexity region
|
531 |
596 |
N/A |
INTRINSIC |
|
low complexity region
|
605 |
643 |
N/A |
INTRINSIC |
|
low complexity region
|
751 |
761 |
N/A |
INTRINSIC |
|
low complexity region
|
764 |
781 |
N/A |
INTRINSIC |
|
| Predicted Effect |
unknown
Transcript: ENSMUST00000111429
AA Change: Q551K
|
| SMART Domains |
Protein: ENSMUSP00000107057
Gene: ENSMUSG00000026565
AA Change: Q551K
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
71 |
100 |
N/A |
INTRINSIC |
|
low complexity region
|
118 |
160 |
N/A |
INTRINSIC |
|
low complexity region
|
177 |
192 |
N/A |
INTRINSIC |
|
low complexity region
|
211 |
232 |
N/A |
INTRINSIC |
|
low complexity region
|
239 |
257 |
N/A |
INTRINSIC |
|
POU
|
281 |
355 |
6.7e-55 |
SMART |
|
low complexity region
|
356 |
372 |
N/A |
INTRINSIC |
|
HOX
|
382 |
444 |
1.3e-21 |
SMART |
|
low complexity region
|
462 |
488 |
N/A |
INTRINSIC |
|
low complexity region
|
493 |
560 |
N/A |
INTRINSIC |
|
low complexity region
|
569 |
607 |
N/A |
INTRINSIC |
|
| Predicted Effect |
unknown
Transcript: ENSMUST00000159212
AA Change: Q458K
|
| SMART Domains |
Protein: ENSMUSP00000125371
Gene: ENSMUSG00000026565
AA Change: Q458K
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
71 |
100 |
N/A |
INTRINSIC |
|
low complexity region
|
118 |
160 |
N/A |
INTRINSIC |
|
low complexity region
|
177 |
192 |
N/A |
INTRINSIC |
|
low complexity region
|
211 |
232 |
N/A |
INTRINSIC |
|
low complexity region
|
239 |
257 |
N/A |
INTRINSIC |
|
POU
|
281 |
355 |
1.55e-52 |
SMART |
|
low complexity region
|
356 |
372 |
N/A |
INTRINSIC |
|
HOX
|
382 |
444 |
2.54e-19 |
SMART |
|
low complexity region
|
462 |
488 |
N/A |
INTRINSIC |
|
low complexity region
|
493 |
560 |
N/A |
INTRINSIC |
|
low complexity region
|
569 |
607 |
N/A |
INTRINSIC |
|
low complexity region
|
715 |
725 |
N/A |
INTRINSIC |
|
low complexity region
|
728 |
745 |
N/A |
INTRINSIC |
|
| Predicted Effect |
unknown
Transcript: ENSMUST00000160260
AA Change: Q598K
|
| SMART Domains |
Protein: ENSMUSP00000124738
Gene: ENSMUSG00000026565
AA Change: Q598K
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
2 |
22 |
N/A |
INTRINSIC |
|
low complexity region
|
94 |
123 |
N/A |
INTRINSIC |
|
low complexity region
|
141 |
183 |
N/A |
INTRINSIC |
|
low complexity region
|
200 |
215 |
N/A |
INTRINSIC |
|
low complexity region
|
234 |
255 |
N/A |
INTRINSIC |
|
low complexity region
|
262 |
280 |
N/A |
INTRINSIC |
|
POU
|
304 |
378 |
1.55e-52 |
SMART |
|
low complexity region
|
379 |
395 |
N/A |
INTRINSIC |
|
HOX
|
405 |
467 |
2.54e-19 |
SMART |
|
low complexity region
|
485 |
511 |
N/A |
INTRINSIC |
|
low complexity region
|
542 |
607 |
N/A |
INTRINSIC |
|
low complexity region
|
616 |
654 |
N/A |
INTRINSIC |
|
low complexity region
|
762 |
772 |
N/A |
INTRINSIC |
|
low complexity region
|
775 |
792 |
N/A |
INTRINSIC |
|
| Predicted Effect |
unknown
Transcript: ENSMUST00000160908
AA Change: Q574K
|
| SMART Domains |
Protein: ENSMUSP00000125444
Gene: ENSMUSG00000026565
AA Change: Q574K
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
2 |
22 |
N/A |
INTRINSIC |
|
low complexity region
|
94 |
123 |
N/A |
INTRINSIC |
|
low complexity region
|
141 |
183 |
N/A |
INTRINSIC |
|
low complexity region
|
200 |
215 |
N/A |
INTRINSIC |
|
low complexity region
|
234 |
255 |
N/A |
INTRINSIC |
|
low complexity region
|
262 |
280 |
N/A |
INTRINSIC |
|
POU
|
304 |
378 |
1.55e-52 |
SMART |
|
low complexity region
|
379 |
395 |
N/A |
INTRINSIC |
|
HOX
|
405 |
467 |
2.54e-19 |
SMART |
|
low complexity region
|
485 |
511 |
N/A |
INTRINSIC |
|
low complexity region
|
516 |
583 |
N/A |
INTRINSIC |
|
low complexity region
|
592 |
630 |
N/A |
INTRINSIC |
|
low complexity region
|
738 |
748 |
N/A |
INTRINSIC |
|
low complexity region
|
751 |
768 |
N/A |
INTRINSIC |
|
| Predicted Effect |
unknown
Transcript: ENSMUST00000184643
AA Change: Q551K
|
| SMART Domains |
Protein: ENSMUSP00000138962
Gene: ENSMUSG00000026565
AA Change: Q551K
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
71 |
100 |
N/A |
INTRINSIC |
|
low complexity region
|
118 |
160 |
N/A |
INTRINSIC |
|
low complexity region
|
177 |
192 |
N/A |
INTRINSIC |
|
low complexity region
|
211 |
232 |
N/A |
INTRINSIC |
|
low complexity region
|
239 |
257 |
N/A |
INTRINSIC |
|
POU
|
281 |
355 |
6.7e-55 |
SMART |
|
low complexity region
|
356 |
372 |
N/A |
INTRINSIC |
|
HOX
|
382 |
444 |
1.3e-21 |
SMART |
|
low complexity region
|
462 |
488 |
N/A |
INTRINSIC |
|
low complexity region
|
493 |
560 |
N/A |
INTRINSIC |
|
low complexity region
|
569 |
607 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000162411
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000184799
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000176004
|
| SMART Domains |
Protein: ENSMUSP00000135153
Gene: ENSMUSG00000026565
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
3 |
41 |
N/A |
INTRINSIC |
|
low complexity region
|
149 |
159 |
N/A |
INTRINSIC |
|
low complexity region
|
162 |
179 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000194366
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000176942
|
| SMART Domains |
Protein: ENSMUSP00000135052
Gene: ENSMUSG00000026565
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
65 |
94 |
N/A |
INTRINSIC |
|
low complexity region
|
112 |
154 |
N/A |
INTRINSIC |
|
low complexity region
|
171 |
186 |
N/A |
INTRINSIC |
|
low complexity region
|
205 |
226 |
N/A |
INTRINSIC |
|
low complexity region
|
233 |
251 |
N/A |
INTRINSIC |
|
POU
|
275 |
349 |
1.55e-52 |
SMART |
|
low complexity region
|
350 |
366 |
N/A |
INTRINSIC |
|
HOX
|
376 |
438 |
2.54e-19 |
SMART |
|
low complexity region
|
456 |
482 |
N/A |
INTRINSIC |
|
low complexity region
|
487 |
554 |
N/A |
INTRINSIC |
|
low complexity region
|
563 |
601 |
N/A |
INTRINSIC |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.5%
- 20x: 98.5%
|
| Validation Efficiency |
97% (67/69) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The OCT1 transcription factor was among the first identified members of the POU transcription factor family (summarized by Sturm et al., 1993 [PubMed 8314572]). Members of this family contain the POU domain, a 160-amino acid region necessary for DNA binding to the octameric sequence ATGCAAAT.[supplied by OMIM, Jul 2010]
PHENOTYPE: Homozygous mutation of this gene results in prenatal lethality, with earlier lethality on either a 129/Sv or C57BL/6 background than a mixed 129/Sv and C57BL/6 background. Embryos show decreased erythropoiesis and partial penetrance of small lens size. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 70 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 1700017B05Rik |
T |
C |
9: 57,164,910 (GRCm39) |
D488G |
probably benign |
Het |
| Adgrv1 |
C |
A |
13: 81,672,590 (GRCm39) |
|
probably null |
Het |
| Afg3l2 |
G |
T |
18: 67,554,329 (GRCm39) |
L458M |
probably damaging |
Het |
| Alkbh3 |
G |
A |
2: 93,838,881 (GRCm39) |
|
probably benign |
Het |
| Ankrd22 |
A |
T |
19: 34,101,569 (GRCm39) |
|
probably null |
Het |
| Anks1b |
A |
G |
10: 90,096,618 (GRCm39) |
D425G |
probably damaging |
Het |
| Arid2 |
A |
G |
15: 96,254,790 (GRCm39) |
D212G |
probably benign |
Het |
| Bbx |
A |
T |
16: 50,071,751 (GRCm39) |
S225T |
probably benign |
Het |
| Bivm |
T |
A |
1: 44,166,028 (GRCm39) |
|
probably null |
Het |
| Bpifb3 |
A |
G |
2: 153,767,773 (GRCm39) |
Y282C |
probably benign |
Het |
| Cacna1h |
A |
T |
17: 25,597,793 (GRCm39) |
I1767N |
probably damaging |
Het |
| Ccdc28a |
G |
T |
10: 18,100,719 (GRCm39) |
S36* |
probably null |
Het |
| Ccser2 |
A |
G |
14: 36,662,465 (GRCm39) |
S240P |
probably damaging |
Het |
| Ceacam1 |
A |
T |
7: 25,171,421 (GRCm39) |
S348T |
probably benign |
Het |
| Ddx49 |
C |
T |
8: 70,749,934 (GRCm39) |
G161D |
probably damaging |
Het |
| Dhx16 |
A |
G |
17: 36,193,864 (GRCm39) |
E353G |
possibly damaging |
Het |
| Dnaaf6rt |
A |
T |
1: 31,262,432 (GRCm39) |
D138V |
probably damaging |
Het |
| Etv2 |
A |
G |
7: 30,334,036 (GRCm39) |
|
probably null |
Het |
| Extl1 |
T |
C |
4: 134,090,441 (GRCm39) |
T345A |
probably benign |
Het |
| Fam163a |
A |
T |
1: 155,954,741 (GRCm39) |
S137T |
probably benign |
Het |
| Fermt2 |
A |
T |
14: 45,697,338 (GRCm39) |
M671K |
possibly damaging |
Het |
| Fsd1l |
T |
C |
4: 53,694,742 (GRCm39) |
C388R |
probably damaging |
Het |
| Galnt18 |
A |
C |
7: 111,112,757 (GRCm39) |
V470G |
probably benign |
Het |
| Grin2b |
T |
A |
6: 135,749,397 (GRCm39) |
I602F |
probably damaging |
Het |
| Gucy1b1 |
G |
T |
3: 81,954,020 (GRCm39) |
|
probably null |
Het |
| Hace1 |
T |
C |
10: 45,494,643 (GRCm39) |
V151A |
probably benign |
Het |
| Hadhb |
T |
A |
5: 30,379,929 (GRCm39) |
D258E |
probably benign |
Het |
| Heatr1 |
C |
T |
13: 12,447,545 (GRCm39) |
T1746I |
probably benign |
Het |
| Hrnr |
T |
C |
3: 93,239,469 (GRCm39) |
S3236P |
unknown |
Het |
| Kcnd1 |
G |
C |
X: 7,690,148 (GRCm39) |
A23P |
probably damaging |
Homo |
| Kiz |
C |
A |
2: 146,731,417 (GRCm39) |
D302E |
probably damaging |
Het |
| Kng2 |
A |
T |
16: 22,806,343 (GRCm39) |
W619R |
probably damaging |
Het |
| Mfap3l |
C |
A |
8: 61,124,841 (GRCm39) |
T361K |
probably damaging |
Het |
| Mlec |
T |
C |
5: 115,288,376 (GRCm39) |
H160R |
probably benign |
Het |
| Myo16 |
T |
C |
8: 10,365,494 (GRCm39) |
L89P |
probably benign |
Het |
| Neb |
T |
C |
2: 52,114,564 (GRCm39) |
I4232V |
probably benign |
Het |
| Nf1 |
A |
G |
11: 79,302,433 (GRCm39) |
I334V |
possibly damaging |
Het |
| Nipbl |
A |
C |
15: 8,347,867 (GRCm39) |
F1942V |
probably damaging |
Het |
| Or2ag17 |
A |
T |
7: 106,389,665 (GRCm39) |
I181N |
probably benign |
Het |
| Or4a70 |
C |
A |
2: 89,324,066 (GRCm39) |
V197F |
probably damaging |
Het |
| Or4c11c |
T |
C |
2: 88,661,655 (GRCm39) |
S65P |
probably damaging |
Het |
| Or51a10 |
A |
G |
7: 103,698,902 (GRCm39) |
Y220H |
probably damaging |
Het |
| Pabpc2 |
G |
T |
18: 39,907,772 (GRCm39) |
A346S |
probably damaging |
Het |
| Paxip1 |
T |
C |
5: 27,971,171 (GRCm39) |
T393A |
unknown |
Het |
| Pcdhgb5 |
A |
T |
18: 37,864,981 (GRCm39) |
T259S |
probably benign |
Het |
| Pfkp |
A |
T |
13: 6,669,224 (GRCm39) |
L253H |
probably benign |
Het |
| Piezo1 |
T |
C |
8: 123,215,869 (GRCm39) |
D1428G |
probably benign |
Het |
| Pkd1l2 |
T |
G |
8: 117,808,209 (GRCm39) |
D105A |
probably damaging |
Het |
| Ppfia4 |
T |
C |
1: 134,256,921 (GRCm39) |
E100G |
probably damaging |
Het |
| Ppp1r15a |
G |
T |
7: 45,173,446 (GRCm39) |
T454K |
probably damaging |
Het |
| Prpsap1 |
A |
T |
11: 116,362,239 (GRCm39) |
I381N |
probably damaging |
Het |
| Ptx3 |
T |
A |
3: 66,132,265 (GRCm39) |
V262E |
probably damaging |
Het |
| Rab21 |
A |
T |
10: 115,130,831 (GRCm39) |
H158Q |
probably benign |
Het |
| Rasa2 |
A |
G |
9: 96,426,357 (GRCm39) |
S830P |
probably damaging |
Het |
| Rdh1 |
G |
A |
10: 127,600,622 (GRCm39) |
S215N |
probably benign |
Het |
| Rhot1 |
G |
A |
11: 80,141,885 (GRCm39) |
R463H |
probably benign |
Het |
| Rsf1 |
CG |
CGACGGCGGGG |
7: 97,229,115 (GRCm39) |
|
probably benign |
Het |
| Sart3 |
C |
T |
5: 113,881,267 (GRCm39) |
A938T |
probably benign |
Het |
| Selenom |
A |
T |
11: 3,464,915 (GRCm39) |
|
probably benign |
Het |
| Selenop |
T |
C |
15: 3,308,947 (GRCm39) |
C300R |
probably damaging |
Het |
| Skint1 |
T |
A |
4: 111,878,679 (GRCm39) |
S204T |
probably benign |
Het |
| Ss18l1 |
A |
G |
2: 179,703,706 (GRCm39) |
N313S |
unknown |
Het |
| Sycp2l |
A |
G |
13: 41,295,200 (GRCm39) |
D289G |
probably damaging |
Het |
| Terf1 |
C |
T |
1: 15,889,221 (GRCm39) |
H188Y |
probably benign |
Het |
| Tmem116 |
C |
T |
5: 121,629,171 (GRCm39) |
T188M |
probably benign |
Het |
| Trdn |
A |
G |
10: 33,181,065 (GRCm39) |
T357A |
probably damaging |
Het |
| Trip11 |
A |
C |
12: 101,856,859 (GRCm39) |
M401R |
probably benign |
Het |
| Ubald2 |
A |
C |
11: 116,325,211 (GRCm39) |
D26A |
probably benign |
Het |
| Ube2w |
C |
G |
1: 16,689,508 (GRCm39) |
|
probably benign |
Het |
| Vmn2r101 |
T |
A |
17: 19,811,267 (GRCm39) |
S450R |
probably benign |
Het |
|
| Other mutations in Pou2f1 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00090:Pou2f1
|
APN |
1 |
165,729,867 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00392:Pou2f1
|
APN |
1 |
165,724,159 (GRCm39) |
splice site |
probably benign |
|
|
IGL01627:Pou2f1
|
APN |
1 |
165,708,002 (GRCm39) |
unclassified |
probably benign |
|
|
IGL01707:Pou2f1
|
APN |
1 |
165,742,685 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL02735:Pou2f1
|
APN |
1 |
165,703,396 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02740:Pou2f1
|
APN |
1 |
165,710,685 (GRCm39) |
nonsense |
probably null |
|
|
IGL03117:Pou2f1
|
APN |
1 |
165,762,382 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL03272:Pou2f1
|
APN |
1 |
165,724,049 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R0021:Pou2f1
|
UTSW |
1 |
165,703,587 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1437:Pou2f1
|
UTSW |
1 |
165,719,399 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R2171:Pou2f1
|
UTSW |
1 |
165,707,925 (GRCm39) |
unclassified |
probably benign |
|
|
R3722:Pou2f1
|
UTSW |
1 |
165,722,538 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3789:Pou2f1
|
UTSW |
1 |
165,722,538 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3790:Pou2f1
|
UTSW |
1 |
165,722,538 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3901:Pou2f1
|
UTSW |
1 |
165,722,538 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4225:Pou2f1
|
UTSW |
1 |
165,738,889 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
R4459:Pou2f1
|
UTSW |
1 |
165,722,575 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4460:Pou2f1
|
UTSW |
1 |
165,722,575 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4573:Pou2f1
|
UTSW |
1 |
165,740,830 (GRCm39) |
missense |
probably benign |
0.29 |
|
R4820:Pou2f1
|
UTSW |
1 |
165,719,517 (GRCm39) |
intron |
probably benign |
|
|
R4838:Pou2f1
|
UTSW |
1 |
165,744,492 (GRCm39) |
missense |
probably null |
1.00 |
|
R5579:Pou2f1
|
UTSW |
1 |
165,742,731 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5856:Pou2f1
|
UTSW |
1 |
165,742,699 (GRCm39) |
missense |
probably benign |
0.14 |
|
R5951:Pou2f1
|
UTSW |
1 |
165,710,625 (GRCm39) |
unclassified |
probably benign |
|
|
R6128:Pou2f1
|
UTSW |
1 |
165,703,056 (GRCm39) |
unclassified |
probably benign |
|
|
R6145:Pou2f1
|
UTSW |
1 |
165,703,002 (GRCm39) |
unclassified |
probably benign |
|
|
R6971:Pou2f1
|
UTSW |
1 |
165,759,258 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R7052:Pou2f1
|
UTSW |
1 |
165,742,684 (GRCm39) |
missense |
possibly damaging |
0.59 |
|
R7403:Pou2f1
|
UTSW |
1 |
165,738,955 (GRCm39) |
missense |
unknown |
|
|
R7404:Pou2f1
|
UTSW |
1 |
165,738,955 (GRCm39) |
missense |
unknown |
|
|
R7741:Pou2f1
|
UTSW |
1 |
165,703,444 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8011:Pou2f1
|
UTSW |
1 |
165,722,472 (GRCm39) |
critical splice donor site |
probably null |
|
|
R8478:Pou2f1
|
UTSW |
1 |
165,759,287 (GRCm39) |
start codon destroyed |
probably null |
|
|
R8804:Pou2f1
|
UTSW |
1 |
165,708,039 (GRCm39) |
missense |
unknown |
|
|
R8892:Pou2f1
|
UTSW |
1 |
165,708,027 (GRCm39) |
missense |
unknown |
|
|
R9126:Pou2f1
|
UTSW |
1 |
165,722,603 (GRCm39) |
missense |
unknown |
|
|
R9151:Pou2f1
|
UTSW |
1 |
165,703,640 (GRCm39) |
intron |
probably benign |
|
|
R9469:Pou2f1
|
UTSW |
1 |
165,740,830 (GRCm39) |
missense |
probably benign |
0.29 |
|
R9665:Pou2f1
|
UTSW |
1 |
165,703,600 (GRCm39) |
missense |
probably damaging |
0.99 |
|
RF012:Pou2f1
|
UTSW |
1 |
165,740,800 (GRCm39) |
missense |
unknown |
|
|
X0022:Pou2f1
|
UTSW |
1 |
165,724,025 (GRCm39) |
nonsense |
probably null |
|
|
| Predicted Primers |
PCR Primer
(F):5'- CTTACCCAGCAGCAAACTGTG -3'
(R):5'- TCCAAACCCATTTACAGGAGG -3'
Sequencing Primer
(F):5'- CAAACTGTGAGGGTGCCATG -3'
(R):5'- GGAGGCCATCTTCTAACTCAG -3'
|
| Posted On |
2018-02-27 |
Incidental Mutation