Incidental Mutation 'R6217:Exosc10'
ID 503772
Institutional Source Beutler Lab
Gene Symbol Exosc10
Ensembl Gene ENSMUSG00000017264
Gene Name exosome component 10
Synonyms PM-Scl, Pmscl2, p2, p3, p4, RRP6, PM/Scl-100
MMRRC Submission 044350-MU
Accession Numbers
Essential gene? Probably essential (E-score: 0.971) question?
Stock # R6217 (G1)
Quality Score 225.009
Status Validated
Chromosome 4
Chromosomal Location 148642886-148666858 bp(+) (GRCm39)
Type of Mutation splice site
DNA Base Change (assembly) A to G at 148666768 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000075401 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000017408] [ENSMUST00000076022] [ENSMUST00000097781]
AlphaFold P56960
Predicted Effect probably null
Transcript: ENSMUST00000017408
SMART Domains Protein: ENSMUSP00000017408
Gene: ENSMUSG00000017264

DomainStartEndE-ValueType
Pfam:PMC2NT 44 133 2.7e-26 PFAM
low complexity region 219 230 N/A INTRINSIC
35EXOc 288 456 7.84e-53 SMART
HRDC 503 583 8.24e-25 SMART
low complexity region 745 760 N/A INTRINSIC
coiled coil region 769 800 N/A INTRINSIC
Predicted Effect probably null
Transcript: ENSMUST00000076022
SMART Domains Protein: ENSMUSP00000075401
Gene: ENSMUSG00000017264

DomainStartEndE-ValueType
Pfam:PMC2NT 43 134 5.1e-30 PFAM
low complexity region 219 230 N/A INTRINSIC
35EXOc 288 456 7.84e-53 SMART
HRDC 503 583 8.24e-25 SMART
low complexity region 720 735 N/A INTRINSIC
coiled coil region 744 775 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000097781
SMART Domains Protein: ENSMUSP00000095388
Gene: ENSMUSG00000017264

DomainStartEndE-ValueType
Pfam:PMC2NT 43 134 1.4e-30 PFAM
low complexity region 219 230 N/A INTRINSIC
35EXOc 288 456 7.84e-53 SMART
HRDC 503 583 8.24e-25 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000138492
Predicted Effect noncoding transcript
Transcript: ENSMUST00000173154
Predicted Effect noncoding transcript
Transcript: ENSMUST00000173892
Meta Mutation Damage Score 0.9756 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.4%
  • 20x: 98.2%
Validation Efficiency 97% (59/61)
MGI Phenotype PHENOTYPE: Mice homozygous for a conditional allele appear phenotypically normal. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 60 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abraxas2 G A 7: 132,476,694 (GRCm39) A145T probably damaging Het
Adamts20 T C 15: 94,236,596 (GRCm39) D808G probably benign Het
Ankdd1a C T 9: 65,415,343 (GRCm39) A227T possibly damaging Het
Arsk T A 13: 76,239,935 (GRCm39) Q46L unknown Het
Asnsd1 A G 1: 53,387,187 (GRCm39) F147L probably benign Het
Atp5f1a T A 18: 77,869,056 (GRCm39) S427T probably benign Het
Atp6v1b2 A C 8: 69,562,530 (GRCm39) probably null Het
AU021092 T A 16: 5,030,050 (GRCm39) T322S possibly damaging Het
Bcl7c A T 7: 127,307,698 (GRCm39) M1K probably null Het
Cacna1i T C 15: 80,273,333 (GRCm39) V1673A probably damaging Het
Ccdc146 A T 5: 21,522,900 (GRCm39) probably null Het
Cdc7 A G 5: 107,120,660 (GRCm39) D122G probably damaging Het
Cfap46 CCTTCTTCT CCTTCT 7: 139,218,816 (GRCm39) probably benign Het
Chd3 T A 11: 69,236,361 (GRCm39) Q1950L probably damaging Het
Cutc T C 19: 43,748,436 (GRCm39) L111S probably damaging Het
Cyp2j6 A G 4: 96,406,398 (GRCm39) F458L probably damaging Het
Ddhd1 T C 14: 45,856,971 (GRCm39) probably null Het
Dstyk T C 1: 132,387,677 (GRCm39) S804P probably damaging Het
Ech1 A G 7: 28,531,261 (GRCm39) D283G possibly damaging Het
Fancg A C 4: 43,010,084 (GRCm39) V5G probably benign Het
Fbxo11 A G 17: 88,316,332 (GRCm39) V394A probably benign Het
Fcmr C T 1: 130,806,060 (GRCm39) R339W probably damaging Het
Fhip2b T C 14: 70,829,198 (GRCm39) probably null Het
Fsip2 T A 2: 82,818,762 (GRCm39) L4832M possibly damaging Het
Gab1 A G 8: 81,518,237 (GRCm39) V125A possibly damaging Het
Gabrr1 A T 4: 33,149,026 (GRCm39) probably null Het
Gon4l T C 3: 88,799,968 (GRCm39) V871A possibly damaging Het
Hspg2 A G 4: 137,267,559 (GRCm39) T2056A probably damaging Het
Lrrc3 T A 10: 77,736,843 (GRCm39) T198S probably benign Het
Lsamp A T 16: 41,954,675 (GRCm39) E174V possibly damaging Het
Ltbr C T 6: 125,284,417 (GRCm39) V342M probably damaging Het
Muc16 A T 9: 18,566,742 (GRCm39) S1926T unknown Het
Ntn1 C A 11: 68,104,158 (GRCm39) V497F possibly damaging Het
Or2ag18 A T 7: 106,405,279 (GRCm39) L130Q probably damaging Het
Or5k17 T C 16: 58,746,877 (GRCm39) D19G probably benign Het
Or8g22 A T 9: 38,958,039 (GRCm39) *270R probably null Het
Osmr T C 15: 6,853,047 (GRCm39) Y615C probably damaging Het
Pcdhgb2 T C 18: 37,823,054 (GRCm39) V15A possibly damaging Het
Pkd2l2 A G 18: 34,547,733 (GRCm39) N162S probably benign Het
Ppp1r12a G A 10: 108,076,045 (GRCm39) probably null Het
Prss59 G A 6: 40,903,019 (GRCm39) P118S possibly damaging Het
Prtg C T 9: 72,812,076 (GRCm39) P899S probably damaging Het
Ptprn A T 1: 75,224,810 (GRCm39) S912R probably damaging Het
Rex2 A G 4: 147,141,931 (GRCm39) T140A possibly damaging Het
Ryr2 T G 13: 11,848,964 (GRCm39) D339A probably damaging Het
Sf3b1 C T 1: 55,046,677 (GRCm39) R289H probably damaging Het
Slc17a9 A G 2: 180,379,455 (GRCm39) D309G probably benign Het
Slc4a10 A G 2: 62,134,295 (GRCm39) R1004G probably benign Het
Sprr2f A T 3: 92,273,366 (GRCm39) Q55L unknown Het
Syne1 C T 10: 5,243,761 (GRCm39) G2801D probably benign Het
Tenm3 A T 8: 48,746,700 (GRCm39) V1026D probably damaging Het
Ticam1 A T 17: 56,577,730 (GRCm39) I455N probably damaging Het
Tmem161b A G 13: 84,399,363 (GRCm39) I6M possibly damaging Het
Ubn1 A G 16: 4,895,096 (GRCm39) E714G probably damaging Het
Ush2a T G 1: 188,475,651 (GRCm39) probably null Het
Usp19 G A 9: 108,377,343 (GRCm39) V874M probably damaging Het
Vmn2r106 T C 17: 20,488,501 (GRCm39) T633A probably benign Het
Vmn2r75 A T 7: 85,815,375 (GRCm39) probably benign Het
Zfyve27 T C 19: 42,178,016 (GRCm39) V386A probably damaging Het
Zscan20 A T 4: 128,498,327 (GRCm39) W24R probably damaging Het
Other mutations in Exosc10
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01400:Exosc10 APN 4 148,649,728 (GRCm39) missense probably damaging 1.00
IGL01591:Exosc10 APN 4 148,647,344 (GRCm39) unclassified probably benign
IGL01990:Exosc10 APN 4 148,650,867 (GRCm39) missense possibly damaging 0.83
IGL02137:Exosc10 APN 4 148,645,590 (GRCm39) missense probably damaging 0.97
IGL02186:Exosc10 APN 4 148,649,755 (GRCm39) missense probably damaging 0.96
IGL02412:Exosc10 APN 4 148,652,849 (GRCm39) missense probably benign 0.15
IGL02880:Exosc10 APN 4 148,660,640 (GRCm39) missense probably damaging 1.00
R0172:Exosc10 UTSW 4 148,649,814 (GRCm39) missense probably benign 0.02
R0267:Exosc10 UTSW 4 148,647,213 (GRCm39) missense probably damaging 1.00
R0592:Exosc10 UTSW 4 148,665,570 (GRCm39) missense probably benign
R1122:Exosc10 UTSW 4 148,650,821 (GRCm39) missense possibly damaging 0.86
R1218:Exosc10 UTSW 4 148,654,858 (GRCm39) missense probably damaging 1.00
R1498:Exosc10 UTSW 4 148,666,243 (GRCm39) missense possibly damaging 0.66
R1591:Exosc10 UTSW 4 148,652,840 (GRCm39) missense probably benign 0.04
R1719:Exosc10 UTSW 4 148,652,960 (GRCm39) missense probably damaging 1.00
R1760:Exosc10 UTSW 4 148,662,926 (GRCm39) nonsense probably null
R3727:Exosc10 UTSW 4 148,649,734 (GRCm39) missense probably damaging 1.00
R3842:Exosc10 UTSW 4 148,648,322 (GRCm39) nonsense probably null
R3876:Exosc10 UTSW 4 148,657,376 (GRCm39) missense probably benign 0.00
R4476:Exosc10 UTSW 4 148,649,781 (GRCm39) missense probably damaging 0.98
R4750:Exosc10 UTSW 4 148,646,851 (GRCm39) missense possibly damaging 0.69
R5306:Exosc10 UTSW 4 148,646,849 (GRCm39) missense probably benign 0.13
R5438:Exosc10 UTSW 4 148,650,799 (GRCm39) nonsense probably null
R5835:Exosc10 UTSW 4 148,649,844 (GRCm39) missense probably damaging 1.00
R5925:Exosc10 UTSW 4 148,657,819 (GRCm39) missense probably benign 0.01
R6116:Exosc10 UTSW 4 148,657,810 (GRCm39) missense probably benign 0.08
R6365:Exosc10 UTSW 4 148,645,562 (GRCm39) missense probably benign 0.13
R6495:Exosc10 UTSW 4 148,647,329 (GRCm39) missense probably benign 0.45
R6498:Exosc10 UTSW 4 148,657,795 (GRCm39) missense probably benign
R6772:Exosc10 UTSW 4 148,665,591 (GRCm39) missense probably damaging 1.00
R7297:Exosc10 UTSW 4 148,664,834 (GRCm39) missense probably damaging 1.00
R7523:Exosc10 UTSW 4 148,648,299 (GRCm39) critical splice acceptor site probably null
R7698:Exosc10 UTSW 4 148,642,955 (GRCm39) missense probably benign
R7967:Exosc10 UTSW 4 148,649,121 (GRCm39) missense probably damaging 1.00
R8225:Exosc10 UTSW 4 148,649,661 (GRCm39) missense possibly damaging 0.86
R8477:Exosc10 UTSW 4 148,649,847 (GRCm39) missense possibly damaging 0.71
R8510:Exosc10 UTSW 4 148,648,646 (GRCm39) missense probably damaging 1.00
R8825:Exosc10 UTSW 4 148,653,159 (GRCm39) critical splice donor site probably null
R8826:Exosc10 UTSW 4 148,653,159 (GRCm39) critical splice donor site probably null
R9080:Exosc10 UTSW 4 148,649,121 (GRCm39) missense probably damaging 1.00
R9104:Exosc10 UTSW 4 148,664,859 (GRCm39) missense probably benign 0.03
R9159:Exosc10 UTSW 4 148,663,916 (GRCm39) critical splice donor site probably null
R9188:Exosc10 UTSW 4 148,643,017 (GRCm39) missense probably damaging 0.96
R9337:Exosc10 UTSW 4 148,665,588 (GRCm39) missense probably damaging 1.00
R9696:Exosc10 UTSW 4 148,649,704 (GRCm39) missense probably damaging 1.00
Z1177:Exosc10 UTSW 4 148,649,843 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- GCAGAACCTGTCAGGAATCAG -3'
(R):5'- GGTTTCTGGTCAGCCTCTTCAG -3'

Sequencing Primer
(F):5'- CTGTCAGGAATCAGGACAGGCC -3'
(R):5'- GTTTCTCTCCTATTCTCTGAACAAAC -3'
Posted On 2018-02-27