Incidental Mutation 'R6223:Cdc25a'
ID 504149
Institutional Source Beutler Lab
Gene Symbol Cdc25a
Ensembl Gene ENSMUSG00000032477
Gene Name cell division cycle 25A
Synonyms D9Ertd393e
MMRRC Submission 044354-MU
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # R6223 (G1)
Quality Score 225.009
Status Not validated
Chromosome 9
Chromosomal Location 109704647-109722963 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to A at 109718842 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Proline to Threonine at position 409 (P409T)
Ref Sequence ENSEMBL: ENSMUSP00000091882 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000094324] [ENSMUST00000198308]
AlphaFold P48964
Predicted Effect possibly damaging
Transcript: ENSMUST00000094324
AA Change: P409T

PolyPhen 2 Score 0.851 (Sensitivity: 0.83; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000091882
Gene: ENSMUSG00000032477
AA Change: P409T

DomainStartEndE-ValueType
Pfam:M-inducer_phosp 85 318 3.6e-69 PFAM
RHOD 356 469 2.6e-25 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000184522
Predicted Effect noncoding transcript
Transcript: ENSMUST00000197945
Predicted Effect noncoding transcript
Transcript: ENSMUST00000198219
Predicted Effect possibly damaging
Transcript: ENSMUST00000198308
AA Change: P348T

PolyPhen 2 Score 0.723 (Sensitivity: 0.86; Specificity: 0.92)
SMART Domains Protein: ENSMUSP00000142958
Gene: ENSMUSG00000032477
AA Change: P348T

DomainStartEndE-ValueType
Pfam:M-inducer_phosp 24 258 1.2e-88 PFAM
RHOD 295 408 5.97e-25 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000199353
Predicted Effect unknown
Transcript: ENSMUST00000199787
AA Change: P193T
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.7%
  • 10x: 98.4%
  • 20x: 95.6%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] CDC25A is a member of the CDC25 family of phosphatases. CDC25A is required for progression from G1 to the S phase of the cell cycle. It activates the cyclin-dependent kinase CDC2 by removing two phosphate groups. CDC25A is specifically degraded in response to DNA damage, which prevents cells with chromosomal abnormalities from progressing through cell division. CDC25A is an oncogene, although its exact role in oncogenesis has not been demonstrated. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
PHENOTYPE: Homozygotes for a spontaneous mutation exhibit elevated levels of early erythroid progenitor cell cycling but erythropoiesis is normally unaffected. Homozygous deletion of this gene is lethal and male heterozygotes display decreased vertebral trabecular bone. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 60 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
6820408C15Rik A C 2: 152,269,873 (GRCm39) R8S probably benign Het
Abca8b A G 11: 109,868,672 (GRCm39) V164A probably benign Het
Acadm C A 3: 153,644,186 (GRCm39) probably null Het
Ap3b2 G A 7: 81,123,210 (GRCm39) R435* probably null Het
Art2b A G 7: 101,229,158 (GRCm39) F247S possibly damaging Het
C1rb T A 6: 124,551,539 (GRCm39) D216E probably benign Het
Casz1 C A 4: 149,017,840 (GRCm39) D90E probably damaging Het
Ccdc13 A G 9: 121,627,975 (GRCm39) probably benign Het
Cidea A C 18: 67,491,809 (GRCm39) K23T possibly damaging Het
Clspn T A 4: 126,479,961 (GRCm39) D1101E probably damaging Het
Col10a1 A T 10: 34,271,183 (GRCm39) D385V probably damaging Het
Crat C T 2: 30,297,042 (GRCm39) V304I probably benign Het
Cyp2d26 A T 15: 82,675,918 (GRCm39) W265R probably benign Het
Dock8 A T 19: 25,138,416 (GRCm39) Y1247F probably benign Het
Dync2i1 T C 12: 116,221,078 (GRCm39) D11G possibly damaging Het
Eed A G 7: 89,605,495 (GRCm39) Y365H probably damaging Het
Fabp5 T A 3: 10,080,170 (GRCm39) F73L probably benign Het
Fbn1 C T 2: 125,254,591 (GRCm39) C224Y possibly damaging Het
Ggcx T C 6: 72,406,588 (GRCm39) F684L probably damaging Het
Glrp1 G A 1: 88,431,164 (GRCm39) Q69* probably null Het
Gm29797 T C 2: 181,300,850 (GRCm39) V115A possibly damaging Het
Gtf3c1 C T 7: 125,275,797 (GRCm39) R543K probably benign Het
Ifih1 T C 2: 62,428,603 (GRCm39) I891V probably benign Het
Ifnar2 C T 16: 91,184,876 (GRCm39) T89M probably damaging Het
Kat6a C A 8: 23,430,442 (GRCm39) N1932K unknown Het
Mgat5 A T 1: 127,310,716 (GRCm39) D210V possibly damaging Het
Mmel1 A G 4: 154,956,159 (GRCm39) probably null Het
Myh3 G T 11: 66,988,843 (GRCm39) V1499L probably benign Het
Ncan A C 8: 70,562,604 (GRCm39) D551E probably benign Het
Nol11 G T 11: 107,062,442 (GRCm39) T598K possibly damaging Het
Olfml3 G A 3: 103,643,776 (GRCm39) R202W probably damaging Het
Or2w4 G A 13: 21,795,536 (GRCm39) T201I probably benign Het
Or4e2 A G 14: 52,688,136 (GRCm39) R89G probably benign Het
Pcdh9 T C 14: 93,253,169 (GRCm39) K1131E probably benign Het
Pcolce A G 5: 137,603,561 (GRCm39) M424T probably damaging Het
Pi16 C A 17: 29,546,413 (GRCm39) S397* probably null Het
Pi4ka A T 16: 17,175,435 (GRCm39) Y464* probably null Het
Pik3c2b T A 1: 132,998,095 (GRCm39) L324M probably damaging Het
Prdm2 T C 4: 142,868,777 (GRCm39) N179S probably benign Het
Prss56 C T 1: 87,113,134 (GRCm39) P183S probably benign Het
Prx T G 7: 27,216,261 (GRCm39) M393R probably damaging Het
Qpctl T C 7: 18,877,134 (GRCm39) D328G probably damaging Het
Qser1 A G 2: 104,617,993 (GRCm39) S940P probably benign Het
Rchy1 G A 5: 92,105,826 (GRCm39) R41W probably damaging Het
Scp2d1 T C 2: 144,665,868 (GRCm39) I69T possibly damaging Het
Sirpb1a A G 3: 15,444,086 (GRCm39) V388A probably benign Het
Ssu2 G T 6: 112,353,409 (GRCm39) C238* probably null Het
Stub1 C T 17: 26,051,787 (GRCm39) G14D probably damaging Het
Tab1 T A 15: 80,032,464 (GRCm39) C24S probably damaging Het
Tdrd1 T C 19: 56,854,282 (GRCm39) V1076A probably damaging Het
Tex10 T C 4: 48,468,525 (GRCm39) R134G probably damaging Het
Tg T A 15: 66,579,771 (GRCm39) N1525K probably benign Het
Tll2 G A 19: 41,124,391 (GRCm39) T208I possibly damaging Het
Tmem232 T C 17: 65,807,191 (GRCm39) M1V probably null Het
Ttc7b A G 12: 100,353,368 (GRCm39) probably null Het
Ubb A G 11: 62,443,351 (GRCm39) E127G possibly damaging Het
Ulk2 A T 11: 61,678,330 (GRCm39) Y796* probably null Het
Vdac2 G A 14: 21,895,246 (GRCm39) G265R possibly damaging Het
Vmn2r45 A T 7: 8,486,301 (GRCm39) V329E probably benign Het
Zbtb47 G A 9: 121,592,853 (GRCm39) R391Q possibly damaging Het
Other mutations in Cdc25a
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01658:Cdc25a APN 9 109,705,194 (GRCm39) splice site probably null
IGL01761:Cdc25a APN 9 109,720,933 (GRCm39) intron probably benign
IGL02808:Cdc25a APN 9 109,712,667 (GRCm39) splice site probably null
IGL03241:Cdc25a APN 9 109,713,267 (GRCm39) splice site probably null
P4748:Cdc25a UTSW 9 109,713,176 (GRCm39) splice site probably benign
R1472:Cdc25a UTSW 9 109,705,157 (GRCm39) missense probably benign 0.00
R1571:Cdc25a UTSW 9 109,710,614 (GRCm39) missense possibly damaging 0.56
R1598:Cdc25a UTSW 9 109,708,961 (GRCm39) frame shift probably null
R4135:Cdc25a UTSW 9 109,710,585 (GRCm39) missense possibly damaging 0.62
R4301:Cdc25a UTSW 9 109,718,810 (GRCm39) missense probably benign 0.23
R4386:Cdc25a UTSW 9 109,718,801 (GRCm39) missense probably damaging 1.00
R5074:Cdc25a UTSW 9 109,713,208 (GRCm39) missense possibly damaging 0.46
R5171:Cdc25a UTSW 9 109,706,229 (GRCm39) missense probably benign 0.25
R5896:Cdc25a UTSW 9 109,713,433 (GRCm39) missense probably benign 0.00
R5928:Cdc25a UTSW 9 109,718,861 (GRCm39) missense probably damaging 1.00
R6240:Cdc25a UTSW 9 109,713,226 (GRCm39) missense probably damaging 1.00
R6440:Cdc25a UTSW 9 109,710,566 (GRCm39) missense probably benign
R6854:Cdc25a UTSW 9 109,708,995 (GRCm39) missense probably damaging 1.00
R7219:Cdc25a UTSW 9 109,718,154 (GRCm39) missense probably damaging 0.99
R7980:Cdc25a UTSW 9 109,708,949 (GRCm39) missense probably damaging 1.00
R8506:Cdc25a UTSW 9 109,720,820 (GRCm39) missense probably damaging 0.99
R8790:Cdc25a UTSW 9 109,716,416 (GRCm39) critical splice donor site probably null
R8807:Cdc25a UTSW 9 109,708,303 (GRCm39) missense probably benign 0.01
Predicted Primers PCR Primer
(F):5'- TGGCCTACAGAGAAAGCCTC -3'
(R):5'- GTTTCCACAAAAGCCATGTATACAC -3'

Sequencing Primer
(F):5'- CTCACTGACATAACAGGCAGGTG -3'
(R):5'- TGTGTAGACTGGAGCAGCACTG -3'
Posted On 2018-02-28