Incidental Mutation 'R6226:Agrn'
ID |
504331 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Agrn
|
Ensembl Gene |
ENSMUSG00000041936 |
Gene Name |
agrin |
Synonyms |
Agrin, NMF380, nmf380 |
MMRRC Submission |
044397-MU
|
Accession Numbers |
|
Essential gene? |
Possibly non essential
(E-score: 0.458)
|
Stock # |
R6226 (G1)
|
Quality Score |
225.009 |
Status
|
Not validated
|
Chromosome |
4 |
Chromosomal Location |
156249747-156281945 bp(-) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
A to G
at 156258066 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Serine to Proline
at position 992
(S992P)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000071229
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000071248]
[ENSMUST00000105574]
[ENSMUST00000105575]
[ENSMUST00000180572]
|
AlphaFold |
A2ASQ1 |
Predicted Effect |
probably damaging
Transcript: ENSMUST00000071248
AA Change: S992P
PolyPhen 2
Score 0.965 (Sensitivity: 0.78; Specificity: 0.95)
|
SMART Domains |
Protein: ENSMUSP00000071229 Gene: ENSMUSG00000041936 AA Change: S992P
Domain | Start | End | E-Value | Type |
transmembrane domain
|
25 |
47 |
N/A |
INTRINSIC |
FOLN
|
66 |
91 |
8.25e-6 |
SMART |
KAZAL
|
91 |
137 |
1.22e-17 |
SMART |
FOLN
|
142 |
166 |
7.58e-5 |
SMART |
EGF_like
|
142 |
181 |
7.38e1 |
SMART |
KAZAL
|
166 |
212 |
1.51e-13 |
SMART |
KAZAL
|
241 |
284 |
1.8e-6 |
SMART |
KAZAL
|
310 |
356 |
1.55e-10 |
SMART |
FOLN
|
362 |
384 |
8.25e-6 |
SMART |
KAZAL
|
384 |
429 |
1.14e-17 |
SMART |
KAZAL
|
449 |
494 |
6.43e-17 |
SMART |
FOLN
|
496 |
519 |
2.94e-2 |
SMART |
KAZAL
|
507 |
559 |
8.96e-16 |
SMART |
low complexity region
|
565 |
572 |
N/A |
INTRINSIC |
KAZAL
|
599 |
645 |
1.12e-16 |
SMART |
EGF_Lam
|
688 |
739 |
3.29e-15 |
SMART |
EGF_Lam
|
742 |
786 |
6.7e-7 |
SMART |
FOLN
|
795 |
817 |
1.94e-2 |
SMART |
KAZAL
|
817 |
864 |
3.9e-16 |
SMART |
low complexity region
|
889 |
906 |
N/A |
INTRINSIC |
low complexity region
|
949 |
978 |
N/A |
INTRINSIC |
SEA
|
1014 |
1139 |
5.57e-35 |
SMART |
|
Predicted Effect |
possibly damaging
Transcript: ENSMUST00000105574
AA Change: S992P
PolyPhen 2
Score 0.781 (Sensitivity: 0.85; Specificity: 0.93)
|
SMART Domains |
Protein: ENSMUSP00000101199 Gene: ENSMUSG00000041936 AA Change: S992P
Domain | Start | End | E-Value | Type |
transmembrane domain
|
25 |
47 |
N/A |
INTRINSIC |
FOLN
|
66 |
91 |
8.25e-6 |
SMART |
KAZAL
|
91 |
137 |
1.22e-17 |
SMART |
FOLN
|
142 |
166 |
7.58e-5 |
SMART |
EGF_like
|
142 |
181 |
7.38e1 |
SMART |
KAZAL
|
166 |
212 |
1.51e-13 |
SMART |
KAZAL
|
241 |
284 |
1.8e-6 |
SMART |
KAZAL
|
310 |
356 |
1.55e-10 |
SMART |
FOLN
|
362 |
384 |
8.25e-6 |
SMART |
KAZAL
|
384 |
429 |
1.14e-17 |
SMART |
KAZAL
|
449 |
494 |
6.43e-17 |
SMART |
FOLN
|
496 |
519 |
2.94e-2 |
SMART |
KAZAL
|
507 |
559 |
8.96e-16 |
SMART |
low complexity region
|
565 |
572 |
N/A |
INTRINSIC |
KAZAL
|
599 |
645 |
1.12e-16 |
SMART |
EGF_Lam
|
688 |
739 |
3.29e-15 |
SMART |
EGF_Lam
|
742 |
786 |
6.7e-7 |
SMART |
FOLN
|
795 |
817 |
1.94e-2 |
SMART |
KAZAL
|
817 |
864 |
3.9e-16 |
SMART |
low complexity region
|
889 |
906 |
N/A |
INTRINSIC |
low complexity region
|
949 |
978 |
N/A |
INTRINSIC |
SEA
|
1014 |
1136 |
2.26e-35 |
SMART |
low complexity region
|
1142 |
1169 |
N/A |
INTRINSIC |
low complexity region
|
1183 |
1198 |
N/A |
INTRINSIC |
EGF
|
1214 |
1249 |
1.49e-4 |
SMART |
LamG
|
1274 |
1410 |
4e-45 |
SMART |
EGF
|
1434 |
1468 |
2.23e-3 |
SMART |
EGF
|
1473 |
1507 |
7.13e-2 |
SMART |
LamG
|
1542 |
1678 |
6.51e-36 |
SMART |
EGF
|
1699 |
1735 |
4.35e-6 |
SMART |
LamG
|
1771 |
1907 |
5.01e-37 |
SMART |
|
Predicted Effect |
possibly damaging
Transcript: ENSMUST00000105575
AA Change: S992P
PolyPhen 2
Score 0.925 (Sensitivity: 0.81; Specificity: 0.94)
|
SMART Domains |
Protein: ENSMUSP00000101200 Gene: ENSMUSG00000041936 AA Change: S992P
Domain | Start | End | E-Value | Type |
transmembrane domain
|
25 |
47 |
N/A |
INTRINSIC |
FOLN
|
66 |
91 |
8.25e-6 |
SMART |
KAZAL
|
91 |
137 |
1.22e-17 |
SMART |
FOLN
|
142 |
166 |
7.58e-5 |
SMART |
EGF_like
|
142 |
181 |
7.38e1 |
SMART |
KAZAL
|
166 |
212 |
1.51e-13 |
SMART |
KAZAL
|
241 |
284 |
1.8e-6 |
SMART |
KAZAL
|
310 |
356 |
1.55e-10 |
SMART |
FOLN
|
362 |
384 |
8.25e-6 |
SMART |
KAZAL
|
384 |
429 |
1.14e-17 |
SMART |
KAZAL
|
449 |
494 |
6.43e-17 |
SMART |
FOLN
|
496 |
519 |
2.94e-2 |
SMART |
KAZAL
|
507 |
559 |
8.96e-16 |
SMART |
low complexity region
|
565 |
572 |
N/A |
INTRINSIC |
KAZAL
|
599 |
645 |
1.12e-16 |
SMART |
EGF_Lam
|
688 |
739 |
3.29e-15 |
SMART |
EGF_Lam
|
742 |
786 |
6.7e-7 |
SMART |
FOLN
|
795 |
817 |
1.94e-2 |
SMART |
KAZAL
|
817 |
864 |
3.9e-16 |
SMART |
low complexity region
|
889 |
906 |
N/A |
INTRINSIC |
low complexity region
|
949 |
978 |
N/A |
INTRINSIC |
SEA
|
1014 |
1136 |
2.26e-35 |
SMART |
low complexity region
|
1142 |
1169 |
N/A |
INTRINSIC |
low complexity region
|
1183 |
1198 |
N/A |
INTRINSIC |
EGF
|
1214 |
1249 |
1.49e-4 |
SMART |
LamG
|
1274 |
1410 |
4e-45 |
SMART |
EGF
|
1434 |
1468 |
2.23e-3 |
SMART |
EGF
|
1473 |
1507 |
7.13e-2 |
SMART |
LamG
|
1542 |
1682 |
9.2e-36 |
SMART |
EGF
|
1703 |
1739 |
4.35e-6 |
SMART |
LamG
|
1794 |
1930 |
5.01e-37 |
SMART |
|
Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000144749
|
Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000154494
|
Predicted Effect |
possibly damaging
Transcript: ENSMUST00000180572
AA Change: S1099P
PolyPhen 2
Score 0.887 (Sensitivity: 0.82; Specificity: 0.94)
|
SMART Domains |
Protein: ENSMUSP00000137931 Gene: ENSMUSG00000041936 AA Change: S1099P
Domain | Start | End | E-Value | Type |
signal peptide
|
1 |
31 |
N/A |
INTRINSIC |
Pfam:NtA
|
32 |
159 |
5.1e-91 |
PFAM |
FOLN
|
173 |
198 |
8.25e-6 |
SMART |
KAZAL
|
198 |
244 |
1.22e-17 |
SMART |
FOLN
|
249 |
273 |
7.58e-5 |
SMART |
EGF_like
|
249 |
288 |
7.38e1 |
SMART |
KAZAL
|
273 |
319 |
1.51e-13 |
SMART |
KAZAL
|
348 |
391 |
1.8e-6 |
SMART |
KAZAL
|
417 |
463 |
1.55e-10 |
SMART |
FOLN
|
469 |
491 |
8.25e-6 |
SMART |
KAZAL
|
491 |
536 |
1.14e-17 |
SMART |
KAZAL
|
556 |
601 |
6.43e-17 |
SMART |
FOLN
|
603 |
626 |
2.94e-2 |
SMART |
KAZAL
|
614 |
666 |
8.96e-16 |
SMART |
low complexity region
|
672 |
679 |
N/A |
INTRINSIC |
KAZAL
|
706 |
752 |
1.12e-16 |
SMART |
EGF_Lam
|
795 |
846 |
3.29e-15 |
SMART |
EGF_Lam
|
849 |
893 |
6.7e-7 |
SMART |
FOLN
|
902 |
924 |
1.94e-2 |
SMART |
KAZAL
|
924 |
971 |
3.9e-16 |
SMART |
low complexity region
|
996 |
1013 |
N/A |
INTRINSIC |
low complexity region
|
1056 |
1085 |
N/A |
INTRINSIC |
SEA
|
1121 |
1243 |
2.26e-35 |
SMART |
low complexity region
|
1249 |
1276 |
N/A |
INTRINSIC |
low complexity region
|
1290 |
1305 |
N/A |
INTRINSIC |
EGF
|
1321 |
1356 |
1.49e-4 |
SMART |
LamG
|
1381 |
1517 |
4e-45 |
SMART |
EGF
|
1541 |
1575 |
2.23e-3 |
SMART |
EGF
|
1580 |
1614 |
7.13e-2 |
SMART |
LamG
|
1649 |
1785 |
6.51e-36 |
SMART |
EGF
|
1806 |
1842 |
4.35e-6 |
SMART |
LamG
|
1878 |
2014 |
5.01e-37 |
SMART |
|
Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000181062
|
Coding Region Coverage |
- 1x: 99.9%
- 3x: 99.6%
- 10x: 98.3%
- 20x: 95.3%
|
Validation Efficiency |
|
MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes one of several proteins that are critical in the development of the neuromuscular junction (NMJ), as identified in mouse knock-out studies. The encoded protein contains several laminin G, Kazal type serine protease inhibitor, and epidermal growth factor domains. Additional post-translational modifications occur to add glycosaminoglycans and disulfide bonds. In one family with congenital myasthenic syndrome affecting limb-girdle muscles, a mutation in this gene was found. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2015] PHENOTYPE: Nullizygous mice display embryonic failure of NMJ formation, inability to breathe or move and perinatal lethality. Homozygotes for an ENU-induced allele show poor hindlimb motor control, myopathy, muscle atrophy, spasms and fiber-type switching, NMJ disaggregation, camptodactyly and premature death. [provided by MGI curators]
|
Allele List at MGI |
All alleles(12) : Targeted, knock-out(4) Targeted, other(1) Gene trapped(7) |
Other mutations in this stock |
Total: 70 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
Actn2 |
T |
C |
13: 12,293,853 (GRCm39) |
T62A |
probably benign |
Het |
Adam33 |
G |
A |
2: 130,897,530 (GRCm39) |
T265I |
probably damaging |
Het |
Afap1l2 |
T |
C |
19: 56,904,560 (GRCm39) |
T654A |
probably benign |
Het |
Anapc1 |
A |
G |
2: 128,492,292 (GRCm39) |
F939L |
probably damaging |
Het |
Anks1 |
G |
A |
17: 28,276,304 (GRCm39) |
V1016I |
probably benign |
Het |
Ankzf1 |
A |
G |
1: 75,173,238 (GRCm39) |
T401A |
probably benign |
Het |
Atad1 |
G |
T |
19: 32,678,987 (GRCm39) |
D105E |
probably benign |
Het |
Carmil2 |
A |
G |
8: 106,415,664 (GRCm39) |
T313A |
possibly damaging |
Het |
Cdk15 |
T |
C |
1: 59,304,792 (GRCm39) |
V131A |
probably damaging |
Het |
Cldnd1 |
A |
T |
16: 58,551,663 (GRCm39) |
|
probably null |
Het |
Col16a1 |
A |
T |
4: 129,948,882 (GRCm39) |
|
probably benign |
Het |
Cts3 |
T |
A |
13: 61,716,535 (GRCm39) |
I34L |
probably benign |
Het |
Dnah7b |
A |
C |
1: 46,165,828 (GRCm39) |
K498Q |
probably benign |
Het |
Dnase2b |
A |
G |
3: 146,290,318 (GRCm39) |
Y218H |
probably benign |
Het |
Dsg2 |
T |
A |
18: 20,712,506 (GRCm39) |
V170D |
probably damaging |
Het |
Dst |
T |
C |
1: 34,309,955 (GRCm39) |
V1543A |
probably damaging |
Het |
Ell3 |
A |
T |
2: 121,272,258 (GRCm39) |
I72K |
probably damaging |
Het |
Fank1 |
A |
G |
7: 133,463,927 (GRCm39) |
Y41C |
probably benign |
Het |
Foxd3 |
T |
C |
4: 99,545,261 (GRCm39) |
Y134H |
probably damaging |
Het |
Frmd6 |
A |
G |
12: 70,910,685 (GRCm39) |
|
probably benign |
Het |
Gale |
A |
G |
4: 135,692,916 (GRCm39) |
E53G |
possibly damaging |
Het |
Glis3 |
A |
G |
19: 28,294,702 (GRCm39) |
S699P |
probably damaging |
Het |
Gm12830 |
T |
A |
4: 114,702,246 (GRCm39) |
M136K |
unknown |
Het |
Grik3 |
T |
C |
4: 125,553,582 (GRCm39) |
V438A |
probably benign |
Het |
Gsap |
A |
G |
5: 21,422,429 (GRCm39) |
N133D |
probably damaging |
Het |
Gsg1 |
T |
A |
6: 135,217,110 (GRCm39) |
D239V |
probably damaging |
Het |
H2-T10 |
A |
T |
17: 36,431,975 (GRCm39) |
W23R |
probably damaging |
Het |
Itgae |
A |
G |
11: 73,031,583 (GRCm39) |
T1100A |
probably benign |
Het |
Kcnh7 |
A |
T |
2: 62,607,903 (GRCm39) |
F559L |
probably damaging |
Het |
Kdm5b |
G |
T |
1: 134,536,616 (GRCm39) |
R612L |
probably damaging |
Het |
Lrrc74a |
T |
A |
12: 86,795,231 (GRCm39) |
N253K |
possibly damaging |
Het |
Mcm3ap |
A |
G |
10: 76,351,540 (GRCm39) |
H1961R |
possibly damaging |
Het |
Ncam1 |
C |
T |
9: 49,476,304 (GRCm39) |
E262K |
probably benign |
Het |
Nckap1 |
A |
G |
2: 80,339,125 (GRCm39) |
S968P |
possibly damaging |
Het |
Nkapd1 |
T |
C |
9: 50,519,070 (GRCm39) |
T181A |
possibly damaging |
Het |
Nr2f2 |
T |
G |
7: 70,009,744 (GRCm39) |
S112R |
probably benign |
Het |
Nup93 |
T |
C |
8: 95,013,165 (GRCm39) |
W137R |
probably damaging |
Het |
Or10ag53 |
A |
G |
2: 87,082,736 (GRCm39) |
S152G |
probably benign |
Het |
Or2t26 |
A |
G |
11: 49,039,660 (GRCm39) |
D192G |
possibly damaging |
Het |
Or4a78 |
A |
T |
2: 89,497,333 (GRCm39) |
L299H |
probably damaging |
Het |
Or52n1 |
A |
T |
7: 104,383,243 (GRCm39) |
F109L |
probably damaging |
Het |
Or8b12 |
T |
A |
9: 37,657,433 (GRCm39) |
M1K |
probably null |
Het |
Or8b55 |
T |
C |
9: 38,727,666 (GRCm39) |
I289T |
probably damaging |
Het |
Otogl |
A |
T |
10: 107,607,067 (GRCm39) |
Y2105* |
probably null |
Het |
Pibf1 |
A |
G |
14: 99,338,555 (GRCm39) |
S24G |
probably damaging |
Het |
Pitx2 |
C |
T |
3: 129,009,491 (GRCm39) |
R130W |
probably damaging |
Het |
Pkd1l1 |
T |
C |
11: 8,851,287 (GRCm39) |
N715S |
probably benign |
Het |
Pou6f2 |
A |
T |
13: 18,303,739 (GRCm39) |
I123N |
possibly damaging |
Het |
Prss29 |
T |
A |
17: 25,539,513 (GRCm39) |
H35Q |
possibly damaging |
Het |
Ptpn21 |
A |
G |
12: 98,646,375 (GRCm39) |
F1028L |
probably benign |
Het |
Ptpn21 |
A |
T |
12: 98,681,431 (GRCm39) |
Y68N |
probably damaging |
Het |
Ptprk |
A |
G |
10: 28,440,099 (GRCm39) |
T856A |
probably benign |
Het |
Rnd2 |
C |
T |
11: 101,359,825 (GRCm39) |
L57F |
probably damaging |
Het |
Rpl22l1 |
A |
G |
3: 28,860,676 (GRCm39) |
T13A |
possibly damaging |
Het |
Rptn |
C |
G |
3: 93,305,437 (GRCm39) |
H923Q |
possibly damaging |
Het |
Sec14l5 |
G |
A |
16: 4,994,429 (GRCm39) |
V408I |
probably damaging |
Het |
Serpina5 |
T |
C |
12: 104,068,037 (GRCm39) |
S33P |
possibly damaging |
Het |
Sgip1 |
A |
G |
4: 102,823,392 (GRCm39) |
N524S |
probably damaging |
Het |
Shkbp1 |
C |
A |
7: 27,051,405 (GRCm39) |
R218M |
probably null |
Het |
Sorcs1 |
T |
A |
19: 50,169,852 (GRCm39) |
I970F |
probably damaging |
Het |
Spg11 |
A |
G |
2: 121,918,743 (GRCm39) |
V962A |
possibly damaging |
Het |
Sptbn1 |
A |
G |
11: 30,086,054 (GRCm39) |
M1205T |
probably damaging |
Het |
Sufu |
G |
A |
19: 46,462,093 (GRCm39) |
V369M |
probably damaging |
Het |
Tmem98 |
T |
C |
11: 80,712,220 (GRCm39) |
F219S |
probably benign |
Het |
Trim27 |
T |
C |
13: 21,365,086 (GRCm39) |
|
probably benign |
Het |
Trim43b |
T |
C |
9: 88,973,328 (GRCm39) |
E135G |
possibly damaging |
Het |
Ube2m |
A |
G |
7: 12,769,815 (GRCm39) |
V110A |
probably damaging |
Het |
Ugt2b36 |
A |
G |
5: 87,239,989 (GRCm39) |
V132A |
probably damaging |
Het |
Usp36 |
A |
T |
11: 118,168,100 (GRCm39) |
S86T |
probably damaging |
Het |
Zfp941 |
A |
T |
7: 140,392,398 (GRCm39) |
D320E |
probably benign |
Het |
|
Other mutations in Agrn |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL00479:Agrn
|
APN |
4 |
156,255,029 (GRCm39) |
splice site |
probably benign |
|
IGL00811:Agrn
|
APN |
4 |
156,253,231 (GRCm39) |
missense |
possibly damaging |
0.70 |
IGL01066:Agrn
|
APN |
4 |
156,261,800 (GRCm39) |
missense |
probably benign |
0.00 |
IGL01412:Agrn
|
APN |
4 |
156,255,491 (GRCm39) |
splice site |
probably benign |
|
IGL01414:Agrn
|
APN |
4 |
156,279,696 (GRCm39) |
splice site |
probably null |
|
IGL02075:Agrn
|
APN |
4 |
156,254,667 (GRCm39) |
missense |
probably benign |
0.40 |
IGL02609:Agrn
|
APN |
4 |
156,259,680 (GRCm39) |
splice site |
probably benign |
|
IGL02669:Agrn
|
APN |
4 |
156,259,018 (GRCm39) |
splice site |
probably benign |
|
IGL02671:Agrn
|
APN |
4 |
156,259,018 (GRCm39) |
splice site |
probably benign |
|
IGL02672:Agrn
|
APN |
4 |
156,259,018 (GRCm39) |
splice site |
probably benign |
|
IGL02674:Agrn
|
APN |
4 |
156,259,018 (GRCm39) |
splice site |
probably benign |
|
IGL02724:Agrn
|
APN |
4 |
156,257,264 (GRCm39) |
nonsense |
probably null |
|
IGL02804:Agrn
|
APN |
4 |
156,258,512 (GRCm39) |
missense |
probably benign |
0.00 |
IGL02986:Agrn
|
APN |
4 |
156,263,311 (GRCm39) |
missense |
possibly damaging |
0.84 |
IGL03160:Agrn
|
APN |
4 |
156,254,820 (GRCm39) |
missense |
probably damaging |
0.98 |
BB004:Agrn
|
UTSW |
4 |
156,257,266 (GRCm39) |
missense |
probably damaging |
0.99 |
BB014:Agrn
|
UTSW |
4 |
156,257,266 (GRCm39) |
missense |
probably damaging |
0.99 |
F6893:Agrn
|
UTSW |
4 |
156,258,636 (GRCm39) |
missense |
probably benign |
|
R0092:Agrn
|
UTSW |
4 |
156,263,410 (GRCm39) |
missense |
probably damaging |
1.00 |
R0100:Agrn
|
UTSW |
4 |
156,259,415 (GRCm39) |
missense |
probably damaging |
1.00 |
R0100:Agrn
|
UTSW |
4 |
156,259,415 (GRCm39) |
missense |
probably damaging |
1.00 |
R0482:Agrn
|
UTSW |
4 |
156,258,012 (GRCm39) |
missense |
probably damaging |
0.98 |
R0531:Agrn
|
UTSW |
4 |
156,263,891 (GRCm39) |
missense |
probably benign |
0.38 |
R0536:Agrn
|
UTSW |
4 |
156,264,010 (GRCm39) |
missense |
probably benign |
0.01 |
R0690:Agrn
|
UTSW |
4 |
156,258,910 (GRCm39) |
missense |
probably damaging |
1.00 |
R0750:Agrn
|
UTSW |
4 |
156,251,394 (GRCm39) |
nonsense |
probably null |
|
R1079:Agrn
|
UTSW |
4 |
156,261,682 (GRCm39) |
missense |
probably damaging |
1.00 |
R1199:Agrn
|
UTSW |
4 |
156,256,756 (GRCm39) |
missense |
probably benign |
0.00 |
R1222:Agrn
|
UTSW |
4 |
156,261,842 (GRCm39) |
missense |
probably damaging |
0.99 |
R1534:Agrn
|
UTSW |
4 |
156,261,141 (GRCm39) |
missense |
probably damaging |
1.00 |
R1587:Agrn
|
UTSW |
4 |
156,263,897 (GRCm39) |
missense |
probably damaging |
0.99 |
R1625:Agrn
|
UTSW |
4 |
156,257,317 (GRCm39) |
missense |
probably damaging |
1.00 |
R1698:Agrn
|
UTSW |
4 |
156,251,015 (GRCm39) |
missense |
probably benign |
0.03 |
R1717:Agrn
|
UTSW |
4 |
156,250,976 (GRCm39) |
frame shift |
probably null |
|
R1718:Agrn
|
UTSW |
4 |
156,250,976 (GRCm39) |
frame shift |
probably null |
|
R1721:Agrn
|
UTSW |
4 |
156,259,630 (GRCm39) |
nonsense |
probably null |
|
R1765:Agrn
|
UTSW |
4 |
156,261,284 (GRCm39) |
nonsense |
probably null |
|
R1840:Agrn
|
UTSW |
4 |
156,251,872 (GRCm39) |
missense |
probably damaging |
1.00 |
R1865:Agrn
|
UTSW |
4 |
156,250,976 (GRCm39) |
frame shift |
probably null |
|
R2105:Agrn
|
UTSW |
4 |
156,261,756 (GRCm39) |
nonsense |
probably null |
|
R2265:Agrn
|
UTSW |
4 |
156,263,675 (GRCm39) |
missense |
probably damaging |
0.99 |
R2266:Agrn
|
UTSW |
4 |
156,263,675 (GRCm39) |
missense |
probably damaging |
0.99 |
R2269:Agrn
|
UTSW |
4 |
156,263,675 (GRCm39) |
missense |
probably damaging |
0.99 |
R2382:Agrn
|
UTSW |
4 |
156,260,973 (GRCm39) |
missense |
probably damaging |
0.97 |
R2497:Agrn
|
UTSW |
4 |
156,258,268 (GRCm39) |
missense |
probably benign |
0.28 |
R2509:Agrn
|
UTSW |
4 |
156,250,881 (GRCm39) |
splice site |
probably null |
|
R2510:Agrn
|
UTSW |
4 |
156,250,881 (GRCm39) |
splice site |
probably null |
|
R2511:Agrn
|
UTSW |
4 |
156,250,881 (GRCm39) |
splice site |
probably null |
|
R2994:Agrn
|
UTSW |
4 |
156,251,785 (GRCm39) |
missense |
possibly damaging |
0.79 |
R3824:Agrn
|
UTSW |
4 |
156,253,759 (GRCm39) |
missense |
probably damaging |
1.00 |
R4736:Agrn
|
UTSW |
4 |
156,256,858 (GRCm39) |
missense |
probably benign |
0.38 |
R4755:Agrn
|
UTSW |
4 |
156,257,979 (GRCm39) |
intron |
probably benign |
|
R4853:Agrn
|
UTSW |
4 |
156,270,007 (GRCm39) |
critical splice donor site |
probably null |
|
R4878:Agrn
|
UTSW |
4 |
156,255,302 (GRCm39) |
missense |
probably damaging |
1.00 |
R5117:Agrn
|
UTSW |
4 |
156,270,010 (GRCm39) |
missense |
probably benign |
0.30 |
R5228:Agrn
|
UTSW |
4 |
156,251,403 (GRCm39) |
missense |
probably damaging |
1.00 |
R5236:Agrn
|
UTSW |
4 |
156,263,315 (GRCm39) |
missense |
possibly damaging |
0.93 |
R5269:Agrn
|
UTSW |
4 |
156,253,447 (GRCm39) |
missense |
probably benign |
0.10 |
R5282:Agrn
|
UTSW |
4 |
156,257,492 (GRCm39) |
missense |
probably damaging |
1.00 |
R5449:Agrn
|
UTSW |
4 |
156,251,737 (GRCm39) |
critical splice donor site |
probably null |
|
R5560:Agrn
|
UTSW |
4 |
156,262,954 (GRCm39) |
missense |
probably damaging |
0.99 |
R5668:Agrn
|
UTSW |
4 |
156,251,770 (GRCm39) |
missense |
probably damaging |
0.97 |
R5725:Agrn
|
UTSW |
4 |
156,258,332 (GRCm39) |
missense |
probably benign |
0.25 |
R5967:Agrn
|
UTSW |
4 |
156,259,560 (GRCm39) |
missense |
probably damaging |
1.00 |
R6338:Agrn
|
UTSW |
4 |
156,255,042 (GRCm39) |
missense |
probably benign |
0.17 |
R6351:Agrn
|
UTSW |
4 |
156,263,891 (GRCm39) |
missense |
probably benign |
0.00 |
R6437:Agrn
|
UTSW |
4 |
156,261,235 (GRCm39) |
missense |
probably damaging |
0.96 |
R6490:Agrn
|
UTSW |
4 |
156,251,819 (GRCm39) |
nonsense |
probably null |
|
R6909:Agrn
|
UTSW |
4 |
156,261,464 (GRCm39) |
missense |
possibly damaging |
0.90 |
R7110:Agrn
|
UTSW |
4 |
156,263,332 (GRCm39) |
missense |
possibly damaging |
0.88 |
R7123:Agrn
|
UTSW |
4 |
156,257,297 (GRCm39) |
missense |
probably benign |
|
R7163:Agrn
|
UTSW |
4 |
156,262,966 (GRCm39) |
missense |
probably damaging |
1.00 |
R7180:Agrn
|
UTSW |
4 |
156,256,296 (GRCm39) |
missense |
probably benign |
0.00 |
R7251:Agrn
|
UTSW |
4 |
156,259,063 (GRCm39) |
missense |
probably damaging |
1.00 |
R7289:Agrn
|
UTSW |
4 |
156,263,389 (GRCm39) |
missense |
probably damaging |
1.00 |
R7335:Agrn
|
UTSW |
4 |
156,260,989 (GRCm39) |
missense |
probably damaging |
1.00 |
R7336:Agrn
|
UTSW |
4 |
156,259,371 (GRCm39) |
nonsense |
probably null |
|
R7406:Agrn
|
UTSW |
4 |
156,256,758 (GRCm39) |
missense |
possibly damaging |
0.93 |
R7460:Agrn
|
UTSW |
4 |
156,258,881 (GRCm39) |
missense |
probably damaging |
0.98 |
R7531:Agrn
|
UTSW |
4 |
156,254,261 (GRCm39) |
missense |
probably damaging |
1.00 |
R7585:Agrn
|
UTSW |
4 |
156,255,131 (GRCm39) |
missense |
probably benign |
0.08 |
R7646:Agrn
|
UTSW |
4 |
156,279,811 (GRCm39) |
missense |
probably damaging |
0.99 |
R7652:Agrn
|
UTSW |
4 |
156,253,675 (GRCm39) |
critical splice donor site |
probably null |
|
R7714:Agrn
|
UTSW |
4 |
156,279,854 (GRCm39) |
missense |
probably damaging |
1.00 |
R7751:Agrn
|
UTSW |
4 |
156,260,886 (GRCm39) |
missense |
probably damaging |
1.00 |
R7852:Agrn
|
UTSW |
4 |
156,253,514 (GRCm39) |
missense |
probably benign |
0.01 |
R7927:Agrn
|
UTSW |
4 |
156,257,266 (GRCm39) |
missense |
probably damaging |
0.99 |
R8039:Agrn
|
UTSW |
4 |
156,253,468 (GRCm39) |
missense |
probably benign |
0.12 |
R8056:Agrn
|
UTSW |
4 |
156,254,868 (GRCm39) |
missense |
probably benign |
|
R8061:Agrn
|
UTSW |
4 |
156,263,411 (GRCm39) |
missense |
probably damaging |
1.00 |
R8158:Agrn
|
UTSW |
4 |
156,258,346 (GRCm39) |
missense |
probably benign |
|
R8159:Agrn
|
UTSW |
4 |
156,256,825 (GRCm39) |
missense |
probably benign |
0.27 |
R8325:Agrn
|
UTSW |
4 |
156,258,119 (GRCm39) |
missense |
probably benign |
0.01 |
R8338:Agrn
|
UTSW |
4 |
156,253,018 (GRCm39) |
missense |
probably benign |
0.01 |
R8739:Agrn
|
UTSW |
4 |
156,257,045 (GRCm39) |
missense |
probably benign |
|
R8956:Agrn
|
UTSW |
4 |
156,250,995 (GRCm39) |
missense |
probably damaging |
0.99 |
R9094:Agrn
|
UTSW |
4 |
156,253,264 (GRCm39) |
missense |
probably benign |
0.01 |
R9112:Agrn
|
UTSW |
4 |
156,261,514 (GRCm39) |
missense |
probably damaging |
1.00 |
R9384:Agrn
|
UTSW |
4 |
156,257,106 (GRCm39) |
missense |
probably damaging |
1.00 |
R9472:Agrn
|
UTSW |
4 |
156,254,841 (GRCm39) |
missense |
|
|
R9619:Agrn
|
UTSW |
4 |
156,258,490 (GRCm39) |
missense |
probably benign |
0.00 |
R9629:Agrn
|
UTSW |
4 |
156,257,094 (GRCm39) |
nonsense |
probably null |
|
R9732:Agrn
|
UTSW |
4 |
156,258,446 (GRCm39) |
missense |
probably benign |
0.13 |
R9749:Agrn
|
UTSW |
4 |
156,258,114 (GRCm39) |
missense |
probably benign |
0.02 |
R9757:Agrn
|
UTSW |
4 |
156,261,235 (GRCm39) |
missense |
probably benign |
0.03 |
R9792:Agrn
|
UTSW |
4 |
156,261,129 (GRCm39) |
missense |
probably benign |
0.09 |
R9793:Agrn
|
UTSW |
4 |
156,261,129 (GRCm39) |
missense |
probably benign |
0.09 |
Z1177:Agrn
|
UTSW |
4 |
156,264,033 (GRCm39) |
missense |
possibly damaging |
0.95 |
Z1177:Agrn
|
UTSW |
4 |
156,256,001 (GRCm39) |
nonsense |
probably null |
|
|
Predicted Primers |
PCR Primer
(F):5'- GTGCTGGAGCCAGAATACCATAAC -3'
(R):5'- TTCAGGGAATCTGGCAGCAC -3'
Sequencing Primer
(F):5'- AACCTTATACCAACCTGCTGCCTG -3'
(R):5'- CAGTGGCGATGAGGAGCTC -3'
|
Posted On |
2018-02-28 |