Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01086:Or5w18'

50459

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Or5w18

Ensembl Gene

ENSMUSG00000068815

Gene Name

olfactory receptor family 5 subfamily W member 18

Synonyms

MOR177-14, Olfr1143, GA_x6K02T2Q125-49303473-49304405

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.153) question?

Stock #

IGL01086

Quality Score

Status

Chromosome

Chromosomal Location

87632735-87633679 bp(+) (GRCm39)

Type of Mutation

nonsense

DNA Base Change (assembly)

T to A at 87633544 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Tyrosine to Stop codon at position 266 (Y266*)

Ref Sequence

ENSEMBL: ENSMUSP00000107194 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000090708] [ENSMUST00000099852] [ENSMUST00000111568]

AlphaFold

Q8VEU8

Predicted Effect

probably null
Transcript: ENSMUST00000090708
AA Change: Y270*

SMART Domains

Protein: ENSMUSP00000088210
Gene: ENSMUSG00000068815
AA Change: Y270*

Domain	Start	End	E-Value	Type
Pfam:7tm_4	35	312	2.6e-45	PFAM
Pfam:7tm_1	45	294	5.8e-20	PFAM

Predicted Effect

probably null
Transcript: ENSMUST00000099852
AA Change: Y266*

SMART Domains

Protein: ENSMUSP00000097438
Gene: ENSMUSG00000068815
AA Change: Y266*

Domain	Start	End	E-Value	Type
Pfam:7tm_4	31	307	2e-41	PFAM
Pfam:7tm_1	41	290	4.3e-14	PFAM

Predicted Effect

probably null
Transcript: ENSMUST00000111568
AA Change: Y266*

SMART Domains

Protein: ENSMUSP00000107194
Gene: ENSMUSG00000068815
AA Change: Y266*

Domain	Start	End	E-Value	Type
Pfam:7tm_4	31	308	1.5e-44	PFAM
Pfam:7tm_1	41	290	2.8e-16	PFAM

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 36 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1700016H13Rik	T	A	5: 103,796,729 (GRCm39)	R104S	probably damaging	Het
Aen	G	A	7: 78,557,050 (GRCm39)	M299I	probably damaging	Het
Aim2	A	G	1: 173,282,999 (GRCm39)	Y27C	probably damaging	Het
Apol7b	T	C	15: 77,308,114 (GRCm39)	E127G	probably damaging	Het
Atp10a	T	C	7: 58,474,066 (GRCm39)	F1118L	probably damaging	Het
Cacna1e	T	C	1: 154,347,347 (GRCm39)	D940G	probably benign	Het
Cfap206	C	T	4: 34,721,562 (GRCm39)	S162N	probably damaging	Het
Clip4	G	A	17: 72,131,789 (GRCm39)	V376I	probably benign	Het
Cmklr2	T	C	1: 63,222,650 (GRCm39)	E195G	probably benign	Het
Coro6	C	A	11: 77,357,374 (GRCm39)	C194*	probably null	Het
Crebbp	T	C	16: 3,997,416 (GRCm39)	M223V	probably benign	Het
Dkk4	T	A	8: 23,116,857 (GRCm39)	C157S	probably damaging	Het
Dnah14	T	C	1: 181,579,611 (GRCm39)	L3048S	probably benign	Het
Dscaml1	T	C	9: 45,613,960 (GRCm39)		probably benign	Het
Gria2	T	C	3: 80,599,688 (GRCm39)	Y732C	probably damaging	Het
Igkv4-59	T	C	6: 69,415,707 (GRCm39)	I7V	probably benign	Het
Lamc3	T	C	2: 31,788,488 (GRCm39)	F216S	probably damaging	Het
Lcn6	T	C	2: 25,570,792 (GRCm39)	F61L	probably benign	Het
Nup205	T	A	6: 35,185,871 (GRCm39)		probably benign	Het
Otof	C	T	5: 30,533,617 (GRCm39)		probably null	Het
Pik3c2b	T	C	1: 133,019,356 (GRCm39)	C1035R	probably damaging	Het
Pla1a	T	C	16: 38,227,984 (GRCm39)	N298D	probably benign	Het
Poteg	T	A	8: 27,963,648 (GRCm39)		probably benign	Het
Pwp1	T	C	10: 85,715,757 (GRCm39)		probably null	Het
Scel	A	G	14: 103,849,827 (GRCm39)	I631V	probably benign	Het
Scn3a	T	A	2: 65,300,503 (GRCm39)	M1288L	probably benign	Het
Serpina11	T	A	12: 103,952,329 (GRCm39)	D147V	probably damaging	Het
Shroom3	T	A	5: 93,096,311 (GRCm39)	C1266S	probably benign	Het
Slc12a7	A	G	13: 73,962,962 (GRCm39)	Y1054C	probably damaging	Het
Srms	A	G	2: 180,854,216 (GRCm39)	V117A	probably damaging	Het
Tmem161b	T	C	13: 84,370,541 (GRCm39)		probably benign	Het
Tmem94	A	T	11: 115,681,110 (GRCm39)	T158S	probably benign	Het
Tomm40l	T	C	1: 171,047,878 (GRCm39)		probably null	Het
Traf6	A	G	2: 101,515,128 (GRCm39)	I95V	probably benign	Het
Ttc13	A	G	8: 125,402,085 (GRCm39)	I686T	probably damaging	Het
Zmat2	C	T	18: 36,929,163 (GRCm39)	H104Y	probably damaging	Het

Other mutations in Or5w18

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01670:Or5w18	APN	2	87,633,224 (GRCm39)	missense	probably benign	0.10
IGL02503:Or5w18	APN	2	87,632,864 (GRCm39)	missense	probably benign	0.01
R0316:Or5w18	UTSW	2	87,633,525 (GRCm39)	missense	probably damaging	0.98
R1381:Or5w18	UTSW	2	87,633,480 (GRCm39)	missense	probably damaging	1.00
R1496:Or5w18	UTSW	2	87,633,212 (GRCm39)	missense	probably benign	0.00
R1753:Or5w18	UTSW	2	87,633,106 (GRCm39)	missense	probably benign	0.06
R2013:Or5w18	UTSW	2	87,632,847 (GRCm39)	missense	probably damaging	0.97
R2370:Or5w18	UTSW	2	87,633,159 (GRCm39)	missense	probably benign	0.35
R3810:Or5w18	UTSW	2	87,633,396 (GRCm39)	missense	possibly damaging	0.90
R3812:Or5w18	UTSW	2	87,633,396 (GRCm39)	missense	possibly damaging	0.90
R3909:Or5w18	UTSW	2	87,633,031 (GRCm39)	missense	probably benign
R4227:Or5w18	UTSW	2	87,633,219 (GRCm39)	missense	probably damaging	0.97
R5753:Or5w18	UTSW	2	87,633,596 (GRCm39)	missense	probably benign	0.05
R6516:Or5w18	UTSW	2	87,633,114 (GRCm39)	missense	possibly damaging	0.81
R9101:Or5w18	UTSW	2	87,632,924 (GRCm39)	missense	probably damaging	1.00
R9144:Or5w18	UTSW	2	87,633,482 (GRCm39)	missense	probably benign	0.02
Z1177:Or5w18	UTSW	2	87,633,572 (GRCm39)	missense	probably damaging	1.00

Posted On

2013-06-21