Incidental Mutation 'R6240:Cdc25a'
ID 505183
Institutional Source Beutler Lab
Gene Symbol Cdc25a
Ensembl Gene ENSMUSG00000032477
Gene Name cell division cycle 25A
Synonyms D9Ertd393e
MMRRC Submission 044364-MU
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # R6240 (G1)
Quality Score 225.009
Status Validated
Chromosome 9
Chromosomal Location 109704647-109722963 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 109713226 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Alanine at position 172 (T172A)
Ref Sequence ENSEMBL: ENSMUSP00000142958 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000094324] [ENSMUST00000198308] [ENSMUST00000198848]
AlphaFold P48964
Predicted Effect probably damaging
Transcript: ENSMUST00000094324
AA Change: T233A

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000091882
Gene: ENSMUSG00000032477
AA Change: T233A

DomainStartEndE-ValueType
Pfam:M-inducer_phosp 85 318 3.6e-69 PFAM
RHOD 356 469 2.6e-25 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000197945
Predicted Effect noncoding transcript
Transcript: ENSMUST00000198219
Predicted Effect probably damaging
Transcript: ENSMUST00000198308
AA Change: T172A

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000142958
Gene: ENSMUSG00000032477
AA Change: T172A

DomainStartEndE-ValueType
Pfam:M-inducer_phosp 24 258 1.2e-88 PFAM
RHOD 295 408 5.97e-25 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000198848
Predicted Effect noncoding transcript
Transcript: ENSMUST00000199353
Predicted Effect unknown
Transcript: ENSMUST00000199787
AA Change: T17A
Meta Mutation Damage Score 0.4184 question?
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.7%
  • 10x: 98.4%
  • 20x: 95.5%
Validation Efficiency 98% (62/63)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] CDC25A is a member of the CDC25 family of phosphatases. CDC25A is required for progression from G1 to the S phase of the cell cycle. It activates the cyclin-dependent kinase CDC2 by removing two phosphate groups. CDC25A is specifically degraded in response to DNA damage, which prevents cells with chromosomal abnormalities from progressing through cell division. CDC25A is an oncogene, although its exact role in oncogenesis has not been demonstrated. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
PHENOTYPE: Homozygotes for a spontaneous mutation exhibit elevated levels of early erythroid progenitor cell cycling but erythropoiesis is normally unaffected. Homozygous deletion of this gene is lethal and male heterozygotes display decreased vertebral trabecular bone. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 62 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930578I06Rik C A 14: 64,223,701 (GRCm39) R25L probably damaging Het
Adamts1 G A 16: 85,599,045 (GRCm39) S185L probably benign Het
Adamts12 A T 15: 11,286,044 (GRCm39) D751V probably benign Het
Adgrg3 A G 8: 95,766,544 (GRCm39) D405G probably benign Het
Ahi1 A G 10: 20,852,980 (GRCm39) D516G probably damaging Het
Ahnak A T 19: 8,990,947 (GRCm39) D4077V probably damaging Het
Arhgef18 G A 8: 3,489,658 (GRCm39) R330Q probably damaging Het
Arid1a A G 4: 133,407,997 (GRCm39) V2170A unknown Het
Asxl3 C T 18: 22,598,565 (GRCm39) L227F probably damaging Het
B3glct A G 5: 149,650,253 (GRCm39) I119V probably benign Het
Brd10 A T 19: 29,694,640 (GRCm39) S1618T probably benign Het
Cad T A 5: 31,230,322 (GRCm39) M1512K probably benign Het
Cdh18 A G 15: 23,227,022 (GRCm39) D161G possibly damaging Het
Clmp A G 9: 40,693,707 (GRCm39) N308S probably damaging Het
Dlg5 A T 14: 24,199,596 (GRCm39) probably null Het
Dscam G A 16: 96,420,702 (GRCm39) T1728M probably damaging Het
E4f1 A G 17: 24,663,556 (GRCm39) S524P possibly damaging Het
Epha5 G C 5: 84,265,438 (GRCm39) A452G probably benign Het
Fzd3 T C 14: 65,447,304 (GRCm39) T542A probably damaging Het
Glyctk A T 9: 106,033,461 (GRCm39) probably null Het
Gm10382 G A 5: 125,466,660 (GRCm39) probably benign Het
Hnmt T A 2: 23,904,281 (GRCm39) M127L probably benign Het
Hoxc10 T A 15: 102,879,265 (GRCm39) W262R probably damaging Het
Icam5 T A 9: 20,944,454 (GRCm39) W52R possibly damaging Het
Jazf1 A T 6: 52,754,537 (GRCm39) C180S probably damaging Het
Kcnk2 A G 1: 188,975,179 (GRCm39) W286R probably damaging Het
Kcnmb2 C T 3: 32,236,045 (GRCm39) S98F probably damaging Het
Mob3a C G 10: 80,525,698 (GRCm39) E204D possibly damaging Het
Morc3 C G 16: 93,659,572 (GRCm39) H459D probably damaging Het
Mroh2b A T 15: 4,964,126 (GRCm39) N876I probably benign Het
Myo16 A T 8: 10,420,930 (GRCm39) T257S probably damaging Het
Nat1 A T 8: 67,944,354 (GRCm39) R243S possibly damaging Het
Nudt9 T C 5: 104,194,955 (GRCm39) V17A probably benign Het
Or13p8 A G 4: 118,583,668 (GRCm39) S75G probably benign Het
Or4c111 A G 2: 88,843,970 (GRCm39) I146T probably benign Het
Or4c11c A G 2: 88,661,707 (GRCm39) D82G probably benign Het
Or4m1 A G 14: 50,558,043 (GRCm39) V83A probably benign Het
Or6c70 C A 10: 129,710,546 (GRCm39) V27L probably benign Het
Pcdh7 T C 5: 57,878,704 (GRCm39) L753P probably damaging Het
Pcf11 T A 7: 92,295,710 (GRCm39) E1446D probably damaging Het
Pepd A G 7: 34,721,176 (GRCm39) I267V probably benign Het
Plk2 T A 13: 110,536,008 (GRCm39) Y571N probably damaging Het
Plk2 T A 13: 110,536,568 (GRCm39) V620E probably damaging Het
Prag1 T C 8: 36,570,506 (GRCm39) L363P probably benign Het
Psmd3 A G 11: 98,584,479 (GRCm39) T387A probably damaging Het
Ptgs1 G A 2: 36,127,297 (GRCm39) C61Y probably damaging Het
Rab18 T C 18: 6,784,635 (GRCm39) Y109H probably benign Het
Robo2 G A 16: 73,779,027 (GRCm39) P358L probably damaging Het
Smarcc2 C T 10: 128,323,893 (GRCm39) probably benign Het
Spata31e4 G A 13: 50,855,453 (GRCm39) D364N probably damaging Het
Srgap1 A G 10: 121,883,061 (GRCm39) I13T probably benign Het
Tcf12 T A 9: 71,851,298 (GRCm39) K110* probably null Het
Tdrd1 T C 19: 56,829,767 (GRCm39) S214P probably benign Het
Tdrd3 T A 14: 87,743,322 (GRCm39) N417K probably damaging Het
Tmem255b A G 8: 13,504,216 (GRCm39) Y136C probably damaging Het
Tmem63c A T 12: 87,123,179 (GRCm39) I448F possibly damaging Het
Tnpo1 T C 13: 99,000,337 (GRCm39) I335M probably damaging Het
Vmn1r1 T C 1: 181,985,186 (GRCm39) T160A probably damaging Het
Vmn1r203 A G 13: 22,708,899 (GRCm39) N227D possibly damaging Het
Vmn2r6 T A 3: 64,464,226 (GRCm39) S203C probably damaging Het
Zfp628 A G 7: 4,922,848 (GRCm39) T357A possibly damaging Het
Zfp872 A G 9: 22,111,180 (GRCm39) K220E probably damaging Het
Other mutations in Cdc25a
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01658:Cdc25a APN 9 109,705,194 (GRCm39) splice site probably null
IGL01761:Cdc25a APN 9 109,720,933 (GRCm39) intron probably benign
IGL02808:Cdc25a APN 9 109,712,667 (GRCm39) splice site probably null
IGL03241:Cdc25a APN 9 109,713,267 (GRCm39) splice site probably null
P4748:Cdc25a UTSW 9 109,713,176 (GRCm39) splice site probably benign
R1472:Cdc25a UTSW 9 109,705,157 (GRCm39) missense probably benign 0.00
R1571:Cdc25a UTSW 9 109,710,614 (GRCm39) missense possibly damaging 0.56
R1598:Cdc25a UTSW 9 109,708,961 (GRCm39) frame shift probably null
R4135:Cdc25a UTSW 9 109,710,585 (GRCm39) missense possibly damaging 0.62
R4301:Cdc25a UTSW 9 109,718,810 (GRCm39) missense probably benign 0.23
R4386:Cdc25a UTSW 9 109,718,801 (GRCm39) missense probably damaging 1.00
R5074:Cdc25a UTSW 9 109,713,208 (GRCm39) missense possibly damaging 0.46
R5171:Cdc25a UTSW 9 109,706,229 (GRCm39) missense probably benign 0.25
R5896:Cdc25a UTSW 9 109,713,433 (GRCm39) missense probably benign 0.00
R5928:Cdc25a UTSW 9 109,718,861 (GRCm39) missense probably damaging 1.00
R6223:Cdc25a UTSW 9 109,718,842 (GRCm39) missense possibly damaging 0.85
R6440:Cdc25a UTSW 9 109,710,566 (GRCm39) missense probably benign
R6854:Cdc25a UTSW 9 109,708,995 (GRCm39) missense probably damaging 1.00
R7219:Cdc25a UTSW 9 109,718,154 (GRCm39) missense probably damaging 0.99
R7980:Cdc25a UTSW 9 109,708,949 (GRCm39) missense probably damaging 1.00
R8506:Cdc25a UTSW 9 109,720,820 (GRCm39) missense probably damaging 0.99
R8790:Cdc25a UTSW 9 109,716,416 (GRCm39) critical splice donor site probably null
R8807:Cdc25a UTSW 9 109,708,303 (GRCm39) missense probably benign 0.01
Predicted Primers PCR Primer
(F):5'- TCAGGATGCTAGCCAAACACAG -3'
(R):5'- TTAGGGTCAGAGACAGGTCCAAC -3'

Sequencing Primer
(F):5'- TGCTAGCCAAACACAGTAAGACTCTG -3'
(R):5'- CTTTGTTTAGTGGCTCAGC -3'
Posted On 2018-02-28