Incidental Mutation 'R6246:Lpo'
ID 505796
Institutional Source Beutler Lab
Gene Symbol Lpo
Ensembl Gene ENSMUSG00000009356
Gene Name lactoperoxidase
Synonyms 5830499B15Rik
MMRRC Submission 044436-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R6246 (G1)
Quality Score 225.009
Status Validated
Chromosome 11
Chromosomal Location 87697254-87716750 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 87713058 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Alanine at position 15 (T15A)
Ref Sequence ENSEMBL: ENSMUSP00000117763 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000103177] [ENSMUST00000136446]
AlphaFold Q5SW46
Predicted Effect unknown
Transcript: ENSMUST00000103177
AA Change: T15A
SMART Domains Protein: ENSMUSP00000099466
Gene: ENSMUSG00000009356
AA Change: T15A

DomainStartEndE-ValueType
signal peptide 1 23 N/A INTRINSIC
Pfam:An_peroxidase 136 682 1.8e-180 PFAM
Predicted Effect unknown
Transcript: ENSMUST00000136446
AA Change: T15A
SMART Domains Protein: ENSMUSP00000117763
Gene: ENSMUSG00000009356
AA Change: T15A

DomainStartEndE-ValueType
signal peptide 1 23 N/A INTRINSIC
PDB:4OEK|A 116 145 4e-7 PDB
SCOP:g1cxp.1 130 145 1e-4 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000157004
Meta Mutation Damage Score 0.0869 question?
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.7%
  • 10x: 98.4%
  • 20x: 95.6%
Validation Efficiency 100% (78/78)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the peroxidase family of proteins. The encoded preproprotein is proteolytically processed to generate the mature enzyme. Following its secretion from salivary, mammary, and other mucosal glands, this enzyme catalyzes the generation of the antimicrobial substance hypothiocyanous acid. This gene is present in a gene cluster on chromosome 17. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed. [provided by RefSeq, Jan 2016]
Allele List at MGI
Other mutations in this stock
Total: 81 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca7 T A 10: 79,850,999 (GRCm39) V2110E probably damaging Het
Acaca C A 11: 84,206,796 (GRCm39) T1552K probably benign Het
Aknad1 A G 3: 108,659,148 (GRCm39) D54G probably damaging Het
Ano1 T C 7: 144,187,462 (GRCm39) T435A possibly damaging Het
Azgp1 A G 5: 137,983,475 (GRCm39) D50G possibly damaging Het
Bbx A G 16: 50,045,023 (GRCm39) S513P probably benign Het
Ccdc85a C T 11: 28,526,897 (GRCm39) S209N probably damaging Het
Cdca2 T A 14: 67,915,277 (GRCm39) R661* probably null Het
Cdhr2 T C 13: 54,867,523 (GRCm39) V451A probably damaging Het
Cenpt C T 8: 106,575,891 (GRCm39) G152S possibly damaging Het
Chd9 A G 8: 91,659,045 (GRCm39) T2A probably damaging Het
Chst14 G A 2: 118,757,482 (GRCm39) C117Y probably damaging Het
Cic C T 7: 24,971,067 (GRCm39) T266M probably damaging Het
Clec12a A T 6: 129,330,733 (GRCm39) N105I possibly damaging Het
Cmah G A 13: 24,650,773 (GRCm39) V525M probably damaging Het
Cplane1 T A 15: 8,239,498 (GRCm39) L1233H probably damaging Het
Cpt1a T C 19: 3,426,550 (GRCm39) L572P probably damaging Het
Crybg2 T C 4: 133,816,657 (GRCm39) L1365P probably damaging Het
Dab1 C T 4: 104,588,948 (GRCm39) A524V probably benign Het
Dlg1 G A 16: 31,484,468 (GRCm39) S32N probably benign Het
Dnah14 T C 1: 181,508,453 (GRCm39) I1877T probably benign Het
Duox1 G T 2: 122,157,655 (GRCm39) G594C probably damaging Het
Eci2 T C 13: 35,174,181 (GRCm39) N127D probably damaging Het
Ecpas A G 4: 58,811,365 (GRCm39) probably null Het
Fat4 T C 3: 38,945,870 (GRCm39) S1588P probably damaging Het
Fer1l4 T A 2: 155,866,902 (GRCm39) I1489F probably damaging Het
Flrt3 A G 2: 140,501,721 (GRCm39) Y636H probably damaging Het
Frmd5 T A 2: 121,381,529 (GRCm39) H62L possibly damaging Het
Gm6309 A T 5: 146,107,050 (GRCm39) Y99N probably damaging Het
Gm8225 T C 17: 26,762,652 (GRCm39) V281A probably benign Het
Grep1 C A 17: 23,929,465 (GRCm39) G315* probably null Het
Grsf1 A G 5: 88,810,451 (GRCm39) L353P possibly damaging Het
Gtf2a1l A G 17: 88,978,975 (GRCm39) R58G probably benign Het
Guf1 G A 5: 69,715,898 (GRCm39) G113R probably damaging Het
Hfe A T 13: 23,892,212 (GRCm39) F51I probably damaging Het
Hibch T C 1: 52,943,801 (GRCm39) S250P probably damaging Het
Il1rap T A 16: 26,533,631 (GRCm39) M509K probably benign Het
Il4ra T C 7: 125,175,577 (GRCm39) V595A probably benign Het
Ints11 A G 4: 155,972,546 (GRCm39) T460A probably benign Het
Itprid1 A T 6: 55,944,657 (GRCm39) K459N probably damaging Het
Kdm5a G A 6: 120,408,871 (GRCm39) G1518E probably damaging Het
Khsrp T C 17: 57,332,324 (GRCm39) D289G possibly damaging Het
Kif14 C T 1: 136,404,162 (GRCm39) Q29* probably null Het
Krt72 T C 15: 101,689,372 (GRCm39) K320R probably damaging Het
Lcmt2 A G 2: 120,970,870 (GRCm39) L71P probably damaging Het
Lmo7 A T 14: 102,156,136 (GRCm39) D1037V probably damaging Het
Mia3 G T 1: 183,126,720 (GRCm39) T7N probably damaging Het
Muc16 A T 9: 18,488,363 (GRCm39) probably null Het
Mup9 T A 4: 60,375,809 (GRCm39) Y29F probably damaging Het
Nisch T C 14: 30,894,516 (GRCm39) D1105G probably damaging Het
Odad1 A G 7: 45,585,788 (GRCm39) I116V probably damaging Het
Oip5 T C 2: 119,446,101 (GRCm39) T136A probably benign Het
Or2a52 G A 6: 43,144,436 (GRCm39) probably null Het
Osbpl10 C A 9: 115,055,842 (GRCm39) N532K probably benign Het
P2ry12 C T 3: 59,124,950 (GRCm39) V242I probably benign Het
Pdhx A T 2: 102,877,137 (GRCm39) C26S probably damaging Het
Pgk2 A T 17: 40,518,315 (GRCm39) I371K probably damaging Het
Phyhip T C 14: 70,704,495 (GRCm39) V238A probably damaging Het
Pla2g4a G A 1: 149,748,338 (GRCm39) T282I probably damaging Het
Pld5 A T 1: 175,791,475 (GRCm39) C448* probably null Het
Plk1 T A 7: 121,768,659 (GRCm39) I553N probably damaging Het
Ppp1r13l T A 7: 19,103,783 (GRCm39) I88K probably benign Het
Rad54l2 A G 9: 106,577,692 (GRCm39) probably null Het
Septin7 A G 9: 25,218,817 (GRCm39) E428G probably benign Het
Serpina3j G A 12: 104,283,706 (GRCm39) G268D probably damaging Het
Smc2 A T 4: 52,460,289 (GRCm39) D555V probably damaging Het
Spag16 A T 1: 69,962,980 (GRCm39) I376F probably benign Het
Spag6 G A 2: 18,703,906 (GRCm39) probably null Het
Tecta T C 9: 42,289,204 (GRCm39) I454V probably benign Het
Tlcd3b T A 7: 126,426,668 (GRCm39) F30L probably damaging Het
Tm9sf1 C T 14: 55,873,827 (GRCm39) R557H probably damaging Het
Traf5 C T 1: 191,754,853 (GRCm39) E28K probably damaging Het
Trav23 G A 14: 54,214,885 (GRCm39) E33K probably damaging Het
Trim32 T C 4: 65,532,801 (GRCm39) S453P probably damaging Het
Tssk1 A G 16: 17,713,303 (GRCm39) T363A probably benign Het
Txnrd3 A G 6: 89,628,523 (GRCm39) N88S probably benign Het
Unc13b A G 4: 43,216,246 (GRCm39) S182G probably benign Het
Vmn2r89 A T 14: 51,693,503 (GRCm39) R284S probably damaging Het
Zbtb14 A G 17: 69,694,478 (GRCm39) T59A possibly damaging Het
Zcchc2 T A 1: 105,957,796 (GRCm39) S756T possibly damaging Het
Zfp709 TCGACG TCG 8: 72,644,552 (GRCm39) probably benign Het
Other mutations in Lpo
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01483:Lpo APN 11 87,711,964 (GRCm39) missense probably benign 0.43
IGL01833:Lpo APN 11 87,698,159 (GRCm39) missense possibly damaging 0.81
IGL02413:Lpo APN 11 87,697,732 (GRCm39) missense possibly damaging 0.87
IGL02706:Lpo APN 11 87,708,599 (GRCm39) missense probably benign 0.02
IGL02865:Lpo APN 11 87,697,803 (GRCm39) missense possibly damaging 0.80
IGL02939:Lpo APN 11 87,706,004 (GRCm39) missense possibly damaging 0.85
R1072:Lpo UTSW 11 87,709,260 (GRCm39) missense probably damaging 1.00
R1169:Lpo UTSW 11 87,708,143 (GRCm39) missense possibly damaging 0.58
R1667:Lpo UTSW 11 87,698,067 (GRCm39) unclassified probably benign
R1719:Lpo UTSW 11 87,700,018 (GRCm39) splice site probably null
R2133:Lpo UTSW 11 87,711,956 (GRCm39) missense probably benign 0.17
R2871:Lpo UTSW 11 87,707,350 (GRCm39) missense possibly damaging 0.51
R2871:Lpo UTSW 11 87,707,350 (GRCm39) missense possibly damaging 0.51
R4382:Lpo UTSW 11 87,713,027 (GRCm39) missense probably benign 0.14
R4657:Lpo UTSW 11 87,705,173 (GRCm39) missense probably damaging 1.00
R4936:Lpo UTSW 11 87,701,166 (GRCm39) missense probably benign 0.02
R4969:Lpo UTSW 11 87,697,751 (GRCm39) missense probably benign 0.09
R5368:Lpo UTSW 11 87,711,895 (GRCm39) missense possibly damaging 0.61
R5536:Lpo UTSW 11 87,707,389 (GRCm39) missense probably damaging 1.00
R6556:Lpo UTSW 11 87,708,589 (GRCm39) nonsense probably null
R6817:Lpo UTSW 11 87,700,067 (GRCm39) missense probably benign
R7024:Lpo UTSW 11 87,707,269 (GRCm39) missense probably damaging 1.00
R7203:Lpo UTSW 11 87,700,077 (GRCm39) missense possibly damaging 0.75
R7206:Lpo UTSW 11 87,698,249 (GRCm39) missense probably damaging 1.00
R8355:Lpo UTSW 11 87,705,114 (GRCm39) missense probably damaging 1.00
R8455:Lpo UTSW 11 87,705,114 (GRCm39) missense probably damaging 1.00
R8693:Lpo UTSW 11 87,700,066 (GRCm39) missense probably benign 0.04
R8848:Lpo UTSW 11 87,708,603 (GRCm39) missense probably benign 0.00
R8891:Lpo UTSW 11 87,697,848 (GRCm39) missense probably benign 0.08
R8989:Lpo UTSW 11 87,708,660 (GRCm39) missense probably benign 0.00
RF010:Lpo UTSW 11 87,711,928 (GRCm39) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- TGAGCAGTGTCCCTTTGGAG -3'
(R):5'- CCAGCCTGTGAATACTGTGAG -3'

Sequencing Primer
(F):5'- CAAACAGGCTTTGCAGATCTG -3'
(R):5'- AGTTTGTATAGCTAGGGCATCTAAG -3'
Posted On 2018-02-28