Incidental Mutation 'R6254:Mtcl1'
| ID |
506026 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Mtcl1
|
| Ensembl Gene |
ENSMUSG00000052105 |
| Gene Name |
microtubule crosslinking factor 1 |
| Synonyms |
1110012J17Rik, Soga2, t8219b25 |
| MMRRC Submission |
044371-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.126)
|
| Stock # |
R6254 (G1)
|
| Quality Score |
170.009 |
|
Status
|
Validated
|
| Chromosome |
17 |
| Chromosomal Location |
66643977-66756745 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
C to T
at 66665129 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Arginine to Histidine
at position 1142
(R1142H)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000094894
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000086693]
[ENSMUST00000097291]
[ENSMUST00000145347]
[ENSMUST00000177034]
|
| AlphaFold |
Q3UHU5 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000086693
AA Change: R1142H
PolyPhen 2
Score 0.019 (Sensitivity: 0.95; Specificity: 0.80)
|
| SMART Domains |
Protein: ENSMUSP00000083899
Gene: ENSMUSG00000052105
AA Change: R1142H
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
23 |
42 |
N/A |
INTRINSIC |
|
low complexity region
|
54 |
98 |
N/A |
INTRINSIC |
|
low complexity region
|
99 |
120 |
N/A |
INTRINSIC |
|
low complexity region
|
127 |
132 |
N/A |
INTRINSIC |
|
low complexity region
|
166 |
183 |
N/A |
INTRINSIC |
|
low complexity region
|
240 |
259 |
N/A |
INTRINSIC |
|
low complexity region
|
273 |
290 |
N/A |
INTRINSIC |
|
SCOP:d1fxkc_
|
332 |
466 |
3e-7 |
SMART |
|
Blast:BRLZ
|
339 |
362 |
1e-5 |
BLAST |
|
Pfam:DUF3166
|
493 |
587 |
1.8e-34 |
PFAM |
|
Pfam:DUF3166
|
622 |
714 |
3.8e-39 |
PFAM |
|
low complexity region
|
843 |
859 |
N/A |
INTRINSIC |
|
low complexity region
|
896 |
910 |
N/A |
INTRINSIC |
|
low complexity region
|
962 |
973 |
N/A |
INTRINSIC |
|
low complexity region
|
1049 |
1062 |
N/A |
INTRINSIC |
|
coiled coil region
|
1120 |
1159 |
N/A |
INTRINSIC |
|
Pfam:DUF4482
|
1220 |
1344 |
3e-40 |
PFAM |
|
low complexity region
|
1464 |
1476 |
N/A |
INTRINSIC |
|
low complexity region
|
1672 |
1681 |
N/A |
INTRINSIC |
|
low complexity region
|
1912 |
1924 |
N/A |
INTRINSIC |
|
low complexity region
|
1931 |
1943 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000097291
AA Change: R1142H
PolyPhen 2
Score 0.019 (Sensitivity: 0.95; Specificity: 0.80)
|
| SMART Domains |
Protein: ENSMUSP00000094894
Gene: ENSMUSG00000052105
AA Change: R1142H
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
23 |
42 |
N/A |
INTRINSIC |
|
low complexity region
|
54 |
98 |
N/A |
INTRINSIC |
|
low complexity region
|
99 |
120 |
N/A |
INTRINSIC |
|
low complexity region
|
127 |
132 |
N/A |
INTRINSIC |
|
low complexity region
|
166 |
183 |
N/A |
INTRINSIC |
|
low complexity region
|
240 |
259 |
N/A |
INTRINSIC |
|
low complexity region
|
273 |
290 |
N/A |
INTRINSIC |
|
SCOP:d1fxkc_
|
332 |
466 |
3e-7 |
SMART |
|
Blast:BRLZ
|
339 |
362 |
1e-5 |
BLAST |
|
Pfam:DUF3166
|
492 |
588 |
1.8e-43 |
PFAM |
|
Pfam:DUF3166
|
621 |
716 |
5e-19 |
PFAM |
|
low complexity region
|
843 |
859 |
N/A |
INTRINSIC |
|
low complexity region
|
896 |
910 |
N/A |
INTRINSIC |
|
low complexity region
|
962 |
973 |
N/A |
INTRINSIC |
|
low complexity region
|
1049 |
1062 |
N/A |
INTRINSIC |
|
coiled coil region
|
1120 |
1159 |
N/A |
INTRINSIC |
|
Pfam:DUF4482
|
1220 |
1392 |
3.9e-49 |
PFAM |
|
low complexity region
|
1464 |
1476 |
N/A |
INTRINSIC |
|
low complexity region
|
1672 |
1681 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000134139
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000142154
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000143420
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000144492
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000145347
AA Change: R693H
PolyPhen 2
Score 0.013 (Sensitivity: 0.96; Specificity: 0.78)
|
| SMART Domains |
Protein: ENSMUSP00000121387
Gene: ENSMUSG00000052105
AA Change: R693H
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:DUF3166
|
43 |
139 |
9.1e-44 |
PFAM |
|
Pfam:DUF3166
|
172 |
267 |
2.5e-19 |
PFAM |
|
low complexity region
|
394 |
410 |
N/A |
INTRINSIC |
|
low complexity region
|
447 |
461 |
N/A |
INTRINSIC |
|
low complexity region
|
513 |
524 |
N/A |
INTRINSIC |
|
low complexity region
|
600 |
613 |
N/A |
INTRINSIC |
|
coiled coil region
|
671 |
710 |
N/A |
INTRINSIC |
|
Pfam:DUF4482
|
771 |
910 |
4.6e-49 |
PFAM |
|
low complexity region
|
1015 |
1027 |
N/A |
INTRINSIC |
|
low complexity region
|
1223 |
1232 |
N/A |
INTRINSIC |
|
low complexity region
|
1463 |
1475 |
N/A |
INTRINSIC |
|
low complexity region
|
1482 |
1494 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000177034
AA Change: R831H
PolyPhen 2
Score 0.007 (Sensitivity: 0.96; Specificity: 0.75)
|
| SMART Domains |
Protein: ENSMUSP00000135690
Gene: ENSMUSG00000052105
AA Change: R831H
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:DUF3166
|
140 |
236 |
1.5e-43 |
PFAM |
|
Pfam:DUF3166
|
269 |
364 |
4e-19 |
PFAM |
|
low complexity region
|
491 |
507 |
N/A |
INTRINSIC |
|
low complexity region
|
544 |
558 |
N/A |
INTRINSIC |
|
low complexity region
|
610 |
621 |
N/A |
INTRINSIC |
|
coiled coil region
|
642 |
674 |
N/A |
INTRINSIC |
|
low complexity region
|
738 |
751 |
N/A |
INTRINSIC |
|
coiled coil region
|
809 |
848 |
N/A |
INTRINSIC |
|
Pfam:DUF4482
|
909 |
1042 |
4e-49 |
PFAM |
|
low complexity region
|
1161 |
1173 |
N/A |
INTRINSIC |
|
low complexity region
|
1369 |
1378 |
N/A |
INTRINSIC |
|
| Meta Mutation Damage Score |
0.0629 |
| Coding Region Coverage |
- 1x: 99.9%
- 3x: 99.6%
- 10x: 98.2%
- 20x: 94.4%
|
| Validation Efficiency |
100% (82/82) |
| MGI Phenotype |
PHENOTYPE: Global or Purkinje cell-specific homozygous knockout affects Purkinje cell axon and dendrite morphology, resulting in abnormal motor function. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 82 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Adam6b |
A |
T |
12: 113,453,190 (GRCm39) |
L2F |
probably damaging |
Het |
| Ank2 |
T |
A |
3: 126,735,453 (GRCm39) |
|
probably benign |
Het |
| Anpep |
T |
G |
7: 79,488,981 (GRCm39) |
D369A |
probably damaging |
Het |
| App |
T |
C |
16: 84,775,065 (GRCm39) |
E599G |
probably damaging |
Het |
| Asphd1 |
C |
T |
7: 126,548,040 (GRCm39) |
V88I |
probably benign |
Het |
| Atad5 |
A |
T |
11: 80,018,215 (GRCm39) |
I1389F |
probably damaging |
Het |
| Blm |
T |
C |
7: 80,130,090 (GRCm39) |
N950S |
probably benign |
Het |
| Bsn |
A |
T |
9: 107,989,065 (GRCm39) |
M2229K |
probably damaging |
Het |
| Cacna2d2 |
A |
G |
9: 107,386,415 (GRCm39) |
M181V |
probably benign |
Het |
| Cadps2 |
T |
A |
6: 23,329,162 (GRCm39) |
|
probably null |
Het |
| Cdh1 |
T |
A |
8: 107,390,430 (GRCm39) |
V590D |
probably damaging |
Het |
| Cdk5rap2 |
G |
A |
4: 70,282,269 (GRCm39) |
T160M |
probably damaging |
Het |
| Cfap97d2 |
A |
G |
8: 13,756,043 (GRCm39) |
D26G |
possibly damaging |
Het |
| Cfhr4 |
A |
G |
1: 139,682,128 (GRCm39) |
I156T |
probably damaging |
Het |
| Chrna5 |
A |
G |
9: 54,913,740 (GRCm39) |
M325V |
probably benign |
Het |
| Clca3a2 |
A |
G |
3: 144,507,895 (GRCm39) |
I116T |
probably benign |
Het |
| Cyp2c23 |
T |
C |
19: 43,993,902 (GRCm39) |
K488R |
probably benign |
Het |
| Edil3 |
T |
A |
13: 89,467,848 (GRCm39) |
I451N |
probably damaging |
Het |
| Exph5 |
T |
G |
9: 53,284,010 (GRCm39) |
S364A |
possibly damaging |
Het |
| Fam98c |
A |
G |
7: 28,853,942 (GRCm39) |
S209P |
probably damaging |
Het |
| Fat3 |
G |
A |
9: 15,907,441 (GRCm39) |
L2854F |
probably benign |
Het |
| Fbxo38 |
T |
C |
18: 62,638,571 (GRCm39) |
|
probably null |
Het |
| Fermt2 |
T |
C |
14: 45,713,516 (GRCm39) |
D205G |
probably damaging |
Het |
| Fmnl1 |
G |
A |
11: 103,087,141 (GRCm39) |
|
probably benign |
Het |
| Fn3k |
A |
G |
11: 121,325,894 (GRCm39) |
E27G |
probably damaging |
Het |
| Foxj2 |
A |
G |
6: 122,815,098 (GRCm39) |
H378R |
probably damaging |
Het |
| Fubp1 |
A |
G |
3: 151,938,045 (GRCm39) |
K140E |
possibly damaging |
Het |
| Gm7694 |
A |
T |
1: 170,130,103 (GRCm39) |
C98* |
probably null |
Het |
| Golgb1 |
T |
C |
16: 36,734,340 (GRCm39) |
S1196P |
probably damaging |
Het |
| Gpm6a |
G |
A |
8: 55,500,431 (GRCm39) |
|
probably null |
Het |
| Hltf |
T |
A |
3: 20,117,993 (GRCm39) |
N80K |
possibly damaging |
Het |
| Il1rap |
G |
A |
16: 26,514,020 (GRCm39) |
R251H |
probably benign |
Het |
| Ipo7 |
T |
A |
7: 109,648,267 (GRCm39) |
D688E |
probably benign |
Het |
| Itgal |
T |
A |
7: 126,924,375 (GRCm39) |
N897K |
probably damaging |
Het |
| Itsn2 |
A |
G |
12: 4,674,982 (GRCm39) |
|
probably null |
Het |
| Kcnk13 |
A |
G |
12: 99,931,631 (GRCm39) |
|
probably benign |
Het |
| Kdm7a |
A |
G |
6: 39,147,203 (GRCm39) |
L248P |
probably damaging |
Het |
| Kmt2c |
T |
C |
5: 25,554,872 (GRCm39) |
E1254G |
possibly damaging |
Het |
| Ldah |
G |
A |
12: 8,325,912 (GRCm39) |
|
probably benign |
Het |
| Lingo1 |
T |
A |
9: 56,527,371 (GRCm39) |
D406V |
possibly damaging |
Het |
| Lratd2 |
A |
G |
15: 60,695,650 (GRCm39) |
I32T |
probably damaging |
Het |
| Lrriq1 |
A |
T |
10: 103,051,312 (GRCm39) |
V480E |
probably benign |
Het |
| Mtmr3 |
G |
A |
11: 4,447,381 (GRCm39) |
Q360* |
probably null |
Het |
| Muc6 |
T |
C |
7: 141,237,380 (GRCm39) |
N252S |
probably benign |
Het |
| Naa20 |
T |
C |
2: 145,745,240 (GRCm39) |
L4P |
probably damaging |
Het |
| Neb |
T |
A |
2: 52,112,973 (GRCm39) |
I4274L |
probably benign |
Het |
| Noa1 |
A |
T |
5: 77,457,516 (GRCm39) |
F130I |
probably benign |
Het |
| Nrg4 |
G |
T |
9: 55,143,796 (GRCm39) |
H87N |
possibly damaging |
Het |
| Or51ai2 |
T |
A |
7: 103,586,741 (GRCm39) |
H51Q |
probably benign |
Het |
| Or5m12 |
T |
A |
2: 85,734,849 (GRCm39) |
Y183F |
probably damaging |
Het |
| P3h3 |
C |
T |
6: 124,822,564 (GRCm39) |
E536K |
probably damaging |
Het |
| Pcdhb11 |
T |
C |
18: 37,554,771 (GRCm39) |
S34P |
probably damaging |
Het |
| Pik3r1 |
T |
C |
13: 101,825,914 (GRCm39) |
T71A |
possibly damaging |
Het |
| Plaur |
T |
A |
7: 24,166,225 (GRCm39) |
C99S |
possibly damaging |
Het |
| Plekha5 |
G |
A |
6: 140,532,162 (GRCm39) |
G501E |
probably damaging |
Het |
| Plxnd1 |
C |
T |
6: 115,954,921 (GRCm39) |
V614M |
probably benign |
Het |
| Ppp2r3d |
T |
C |
9: 101,025,786 (GRCm39) |
D307G |
possibly damaging |
Het |
| Prl3d3 |
C |
T |
13: 27,341,453 (GRCm39) |
S28F |
possibly damaging |
Het |
| Prpf40a |
T |
C |
2: 53,047,927 (GRCm39) |
M197V |
probably benign |
Het |
| Ptk7 |
C |
A |
17: 46,883,568 (GRCm39) |
Q832H |
probably damaging |
Het |
| Qser1 |
T |
C |
2: 104,620,435 (GRCm39) |
S126G |
probably benign |
Het |
| Rab3ip |
A |
T |
10: 116,751,772 (GRCm39) |
C332S |
probably damaging |
Het |
| Raly |
C |
A |
2: 154,699,286 (GRCm39) |
T30K |
probably damaging |
Het |
| Rbp2 |
G |
T |
9: 98,372,700 (GRCm39) |
S13I |
probably benign |
Het |
| Rps6ka1 |
C |
T |
4: 133,594,535 (GRCm39) |
M159I |
possibly damaging |
Het |
| Rufy3 |
C |
T |
5: 88,732,168 (GRCm39) |
T57I |
probably benign |
Het |
| Samd4 |
A |
G |
14: 47,254,088 (GRCm39) |
D184G |
probably damaging |
Het |
| Slc35f3 |
T |
C |
8: 127,047,833 (GRCm39) |
C58R |
possibly damaging |
Het |
| Smarca4 |
T |
C |
9: 21,611,173 (GRCm39) |
I1467T |
probably damaging |
Het |
| Spag17 |
T |
G |
3: 99,972,901 (GRCm39) |
I1371S |
probably benign |
Het |
| Sptan1 |
T |
C |
2: 29,897,561 (GRCm39) |
L1228P |
possibly damaging |
Het |
| Stk31 |
C |
T |
6: 49,398,631 (GRCm39) |
A344V |
probably benign |
Het |
| Supt16 |
A |
G |
14: 52,408,291 (GRCm39) |
W885R |
probably damaging |
Het |
| Tdrd9 |
T |
A |
12: 111,992,334 (GRCm39) |
|
probably null |
Het |
| Tmod1 |
A |
G |
4: 46,078,469 (GRCm39) |
|
probably null |
Het |
| Tnfsf13 |
A |
C |
11: 69,575,309 (GRCm39) |
|
probably null |
Het |
| Trim75 |
C |
A |
8: 65,436,094 (GRCm39) |
E119* |
probably null |
Het |
| Wdr6 |
T |
C |
9: 108,452,110 (GRCm39) |
Y591C |
probably damaging |
Het |
| Wdr86 |
C |
T |
5: 24,923,281 (GRCm39) |
R137H |
probably benign |
Het |
| Ythdf1 |
T |
A |
2: 180,552,943 (GRCm39) |
Y424F |
probably damaging |
Het |
| Zfp984 |
G |
T |
4: 147,840,643 (GRCm39) |
S69R |
possibly damaging |
Het |
| Zyg11a |
A |
G |
4: 108,038,991 (GRCm39) |
F743L |
probably damaging |
Het |
|
| Other mutations in Mtcl1 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00092:Mtcl1
|
APN |
17 |
66,651,314 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01774:Mtcl1
|
APN |
17 |
66,692,880 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01918:Mtcl1
|
APN |
17 |
66,675,263 (GRCm39) |
missense |
possibly damaging |
0.47 |
|
IGL02000:Mtcl1
|
APN |
17 |
66,661,185 (GRCm39) |
missense |
probably benign |
0.19 |
|
IGL02074:Mtcl1
|
APN |
17 |
66,673,463 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
IGL02338:Mtcl1
|
APN |
17 |
66,686,965 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02597:Mtcl1
|
APN |
17 |
66,645,016 (GRCm39) |
missense |
probably benign |
|
|
IGL03034:Mtcl1
|
APN |
17 |
66,651,193 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03120:Mtcl1
|
APN |
17 |
66,686,378 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL03184:Mtcl1
|
APN |
17 |
66,661,209 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL03240:Mtcl1
|
APN |
17 |
66,645,014 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03294:Mtcl1
|
APN |
17 |
66,645,014 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03332:Mtcl1
|
APN |
17 |
66,645,014 (GRCm39) |
missense |
probably damaging |
1.00 |
|
PIT4378001:Mtcl1
|
UTSW |
17 |
66,745,274 (GRCm39) |
missense |
probably damaging |
1.00 |
|
PIT4520001:Mtcl1
|
UTSW |
17 |
66,692,907 (GRCm39) |
missense |
possibly damaging |
0.48 |
|
R0110:Mtcl1
|
UTSW |
17 |
66,665,109 (GRCm39) |
missense |
possibly damaging |
0.51 |
|
R0113:Mtcl1
|
UTSW |
17 |
66,661,237 (GRCm39) |
missense |
possibly damaging |
0.52 |
|
R0321:Mtcl1
|
UTSW |
17 |
66,686,426 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0366:Mtcl1
|
UTSW |
17 |
66,645,124 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0629:Mtcl1
|
UTSW |
17 |
66,645,137 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R1466:Mtcl1
|
UTSW |
17 |
66,687,430 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1466:Mtcl1
|
UTSW |
17 |
66,687,430 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1467:Mtcl1
|
UTSW |
17 |
66,755,322 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1467:Mtcl1
|
UTSW |
17 |
66,755,322 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1471:Mtcl1
|
UTSW |
17 |
66,686,143 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R1650:Mtcl1
|
UTSW |
17 |
66,692,871 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1754:Mtcl1
|
UTSW |
17 |
66,687,178 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1855:Mtcl1
|
UTSW |
17 |
66,686,509 (GRCm39) |
missense |
probably benign |
|
|
R1882:Mtcl1
|
UTSW |
17 |
66,686,315 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1935:Mtcl1
|
UTSW |
17 |
66,686,409 (GRCm39) |
missense |
probably benign |
0.10 |
|
R2063:Mtcl1
|
UTSW |
17 |
66,653,350 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2132:Mtcl1
|
UTSW |
17 |
66,650,618 (GRCm39) |
missense |
probably benign |
0.04 |
|
R2197:Mtcl1
|
UTSW |
17 |
66,673,427 (GRCm39) |
missense |
probably benign |
|
|
R3196:Mtcl1
|
UTSW |
17 |
66,650,829 (GRCm39) |
missense |
probably benign |
0.07 |
|
R3877:Mtcl1
|
UTSW |
17 |
66,649,949 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4116:Mtcl1
|
UTSW |
17 |
66,673,476 (GRCm39) |
missense |
probably benign |
|
|
R4204:Mtcl1
|
UTSW |
17 |
66,745,256 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4373:Mtcl1
|
UTSW |
17 |
66,687,074 (GRCm39) |
missense |
probably benign |
0.05 |
|
R4396:Mtcl1
|
UTSW |
17 |
66,651,220 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4591:Mtcl1
|
UTSW |
17 |
66,655,506 (GRCm39) |
missense |
probably benign |
0.07 |
|
R4610:Mtcl1
|
UTSW |
17 |
66,684,882 (GRCm39) |
missense |
probably benign |
0.04 |
|
R4681:Mtcl1
|
UTSW |
17 |
66,756,139 (GRCm39) |
missense |
unknown |
|
|
R4922:Mtcl1
|
UTSW |
17 |
66,655,474 (GRCm39) |
missense |
probably benign |
0.29 |
|
R4992:Mtcl1
|
UTSW |
17 |
66,649,834 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5169:Mtcl1
|
UTSW |
17 |
66,650,818 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5542:Mtcl1
|
UTSW |
17 |
66,691,354 (GRCm39) |
intron |
probably benign |
|
|
R5804:Mtcl1
|
UTSW |
17 |
66,650,132 (GRCm39) |
missense |
probably benign |
0.03 |
|
R5998:Mtcl1
|
UTSW |
17 |
66,675,275 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6163:Mtcl1
|
UTSW |
17 |
66,686,326 (GRCm39) |
missense |
probably benign |
0.10 |
|
R6191:Mtcl1
|
UTSW |
17 |
66,650,521 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6260:Mtcl1
|
UTSW |
17 |
66,650,536 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6524:Mtcl1
|
UTSW |
17 |
66,655,280 (GRCm39) |
missense |
probably benign |
0.15 |
|
R6884:Mtcl1
|
UTSW |
17 |
66,745,197 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7199:Mtcl1
|
UTSW |
17 |
66,647,534 (GRCm39) |
missense |
probably benign |
0.13 |
|
R7431:Mtcl1
|
UTSW |
17 |
66,649,901 (GRCm39) |
nonsense |
probably null |
|
|
R7479:Mtcl1
|
UTSW |
17 |
66,686,485 (GRCm39) |
missense |
probably benign |
|
|
R7564:Mtcl1
|
UTSW |
17 |
66,678,322 (GRCm39) |
missense |
probably benign |
|
|
R7608:Mtcl1
|
UTSW |
17 |
66,650,300 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R7691:Mtcl1
|
UTSW |
17 |
66,687,352 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7847:Mtcl1
|
UTSW |
17 |
66,651,328 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R7908:Mtcl1
|
UTSW |
17 |
66,678,325 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R8262:Mtcl1
|
UTSW |
17 |
66,650,653 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8324:Mtcl1
|
UTSW |
17 |
66,743,212 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8477:Mtcl1
|
UTSW |
17 |
66,684,942 (GRCm39) |
missense |
probably benign |
0.10 |
|
R8927:Mtcl1
|
UTSW |
17 |
66,755,628 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8928:Mtcl1
|
UTSW |
17 |
66,755,628 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9016:Mtcl1
|
UTSW |
17 |
66,651,062 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9048:Mtcl1
|
UTSW |
17 |
66,678,331 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9059:Mtcl1
|
UTSW |
17 |
66,650,606 (GRCm39) |
missense |
probably benign |
0.04 |
|
R9221:Mtcl1
|
UTSW |
17 |
66,650,879 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9327:Mtcl1
|
UTSW |
17 |
66,645,130 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R9398:Mtcl1
|
UTSW |
17 |
66,755,462 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R9762:Mtcl1
|
UTSW |
17 |
66,673,347 (GRCm39) |
missense |
probably benign |
0.00 |
|
X0065:Mtcl1
|
UTSW |
17 |
66,686,602 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1088:Mtcl1
|
UTSW |
17 |
66,650,723 (GRCm39) |
missense |
probably benign |
0.20 |
|
Z1176:Mtcl1
|
UTSW |
17 |
66,686,455 (GRCm39) |
missense |
probably benign |
0.01 |
|
Z1177:Mtcl1
|
UTSW |
17 |
66,651,290 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- GAGAACCTACCTGTGCCTCTTC -3'
(R):5'- GACCATCTTGCCTCTATTCAGAG -3'
Sequencing Primer
(F):5'- ACCCATCCTGGATAGGGTAG -3'
(R):5'- CTCTATTCAGAGGTCGGAGGC -3'
|
| Posted On |
2018-02-28 |
Incidental Mutation