Incidental Mutation 'R6258:Zfp1007'
ID 506466
Institutional Source Beutler Lab
Gene Symbol Zfp1007
Ensembl Gene ENSMUSG00000072763
Gene Name zinc finger protein 1007
Synonyms 5430403G16Rik, ENSMUSG00000072763
MMRRC Submission 044375-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.105) question?
Stock # R6258 (G1)
Quality Score 186.009
Status Validated
Chromosome 5
Chromosomal Location 109822409-109838700 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 109824433 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Histidine to Arginine at position 339 (H339R)
Ref Sequence ENSEMBL: ENSMUSP00000090395 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000092720]
AlphaFold D3Z5L4
Predicted Effect probably benign
Transcript: ENSMUST00000092720
AA Change: H339R

PolyPhen 2 Score 0.006 (Sensitivity: 0.97; Specificity: 0.75)
SMART Domains Protein: ENSMUSP00000090395
Gene: ENSMUSG00000072763
AA Change: H339R

DomainStartEndE-ValueType
KRAB 4 60 2.47e-14 SMART
ZnF_C2H2 131 153 3.39e-3 SMART
ZnF_C2H2 159 181 3.95e-4 SMART
ZnF_C2H2 187 209 3.95e-4 SMART
ZnF_C2H2 215 237 1.12e-3 SMART
ZnF_C2H2 243 265 4.01e-5 SMART
ZnF_C2H2 271 293 7.78e-3 SMART
ZnF_C2H2 299 321 2.61e-4 SMART
ZnF_C2H2 327 349 1.36e-2 SMART
ZnF_C2H2 355 377 7.37e-4 SMART
ZnF_C2H2 383 405 1.3e-4 SMART
ZnF_C2H2 411 433 3.69e-4 SMART
ZnF_C2H2 439 461 4.3e-5 SMART
ZnF_C2H2 467 489 2.57e-3 SMART
ZnF_C2H2 495 517 2.61e-4 SMART
ZnF_C2H2 523 545 2.05e-2 SMART
ZnF_C2H2 551 573 5.59e-4 SMART
ZnF_C2H2 579 601 1.58e-3 SMART
ZnF_C2H2 607 629 9.08e-4 SMART
ZnF_C2H2 635 657 3.44e-4 SMART
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.7%
  • 10x: 98.5%
  • 20x: 95.7%
Validation Efficiency 99% (74/75)
Allele List at MGI
Other mutations in this stock
Total: 76 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adamtsl3 T C 7: 82,178,191 (GRCm39) probably null Het
Alms1 A T 6: 85,605,717 (GRCm39) K2456* probably null Het
Alppl2 A T 1: 87,016,184 (GRCm39) M225K probably damaging Het
AU041133 A G 10: 81,986,992 (GRCm39) E215G probably damaging Het
Carmil3 T A 14: 55,737,889 (GRCm39) L815Q probably damaging Het
Casr A G 16: 36,337,971 (GRCm39) C60R probably damaging Het
Cdc7 A G 5: 107,117,093 (GRCm39) K84E probably damaging Het
Cdc73 G A 1: 143,567,211 (GRCm39) T104I probably benign Het
Clcc1 G A 3: 108,580,624 (GRCm39) V313I possibly damaging Het
Cntn3 A G 6: 102,254,178 (GRCm39) probably null Het
Crocc2 A G 1: 93,141,360 (GRCm39) K1171R possibly damaging Het
Ctsa T C 2: 164,676,281 (GRCm39) V86A probably damaging Het
Cyp2s1 ACAGCAGCAGCAGCAGCAGCAGCAG ACAGCAGCAGCAGCAGCAGCAG 7: 25,515,867 (GRCm39) probably benign Het
Dab1 C T 4: 104,588,948 (GRCm39) A524V probably benign Het
Dnah17 C A 11: 118,017,148 (GRCm39) W197C probably damaging Het
Dnah17 A T 11: 118,017,150 (GRCm39) W197R probably damaging Het
Dnah17 C T 11: 118,017,149 (GRCm39) W197* probably null Het
Egflam T A 15: 7,263,773 (GRCm39) T726S probably damaging Het
Eml2 T G 7: 18,913,289 (GRCm39) probably null Het
Ercc6 T A 14: 32,279,813 (GRCm39) D609E probably benign Het
Erg C A 16: 95,181,100 (GRCm39) R147L probably damaging Het
Faiml T C 9: 99,114,513 (GRCm39) I125M possibly damaging Het
Fbxo41 A T 6: 85,455,537 (GRCm39) L549H probably damaging Het
Fbxw2 A T 2: 34,702,825 (GRCm39) probably null Het
Fgd6 T A 10: 93,880,161 (GRCm39) N338K probably benign Het
Gaa C A 11: 119,171,997 (GRCm39) A700D probably benign Het
Gm32742 T A 9: 51,068,862 (GRCm39) I200F probably damaging Het
Gm4924 T G 10: 82,213,307 (GRCm39) probably benign Het
Gm8369 G A 19: 11,488,973 (GRCm39) A87T possibly damaging Het
H2-M10.1 T A 17: 36,634,994 (GRCm39) I304F unknown Het
Ighv5-8 A G 12: 113,618,611 (GRCm39) T9A possibly damaging Het
Itgb4 C T 11: 115,874,983 (GRCm39) R447W probably benign Het
Jakmip1 G T 5: 37,299,104 (GRCm39) E775* probably null Het
Klhl40 T C 9: 121,607,026 (GRCm39) F62S probably damaging Het
Krtcap3 A T 5: 31,409,572 (GRCm39) R84W probably damaging Het
Lgr6 C T 1: 134,921,748 (GRCm39) A199T probably damaging Het
Lins1 T C 7: 66,360,496 (GRCm39) probably null Het
Magi3 A G 3: 103,996,912 (GRCm39) L211P probably damaging Het
Map2k5 T A 9: 63,124,647 (GRCm39) I359F probably benign Het
Map4k5 C A 12: 69,878,336 (GRCm39) R355L probably benign Het
Mef2c T A 13: 83,801,057 (GRCm39) D252E probably damaging Het
Methig1 T C 15: 100,251,422 (GRCm39) V111A possibly damaging Het
Mical3 A T 6: 120,985,991 (GRCm39) L150Q probably damaging Het
Nf1 A T 11: 79,456,581 (GRCm39) probably null Het
Nisch T A 14: 30,899,085 (GRCm39) probably benign Het
Or4f15 C T 2: 111,814,396 (GRCm39) V8I probably benign Het
Or5p61 T C 7: 107,758,181 (GRCm39) N300D probably damaging Het
Pcdhb12 T C 18: 37,569,892 (GRCm39) V346A probably benign Het
Pde7b T C 10: 20,316,546 (GRCm39) D168G possibly damaging Het
Pdzrn4 A T 15: 92,655,562 (GRCm39) E485V probably damaging Het
Pla2g4a A G 1: 149,733,238 (GRCm39) S504P probably benign Het
Plin2 G T 4: 86,575,526 (GRCm39) A341D probably damaging Het
Psma8 A G 18: 14,854,324 (GRCm39) D68G probably damaging Het
Rcor3 G A 1: 191,808,559 (GRCm39) H207Y probably benign Het
Rptn C G 3: 93,305,437 (GRCm39) H923Q possibly damaging Het
Ryr3 A G 2: 112,490,449 (GRCm39) F3795S probably damaging Het
Samm50 C G 15: 84,084,512 (GRCm39) P150A probably damaging Het
Samm50 C A 15: 84,084,513 (GRCm39) P150H probably damaging Het
Slc28a2b A T 2: 122,353,963 (GRCm39) I530F probably damaging Het
Slc6a18 A T 13: 73,818,164 (GRCm39) C284* probably null Het
Smc3 T A 19: 53,616,162 (GRCm39) probably null Het
Snrnp200 G A 2: 127,060,343 (GRCm39) G529D possibly damaging Het
Sord T A 2: 122,089,613 (GRCm39) probably null Het
Spdl1 T A 11: 34,710,713 (GRCm39) N345I probably damaging Het
Sucnr1 T C 3: 59,993,778 (GRCm39) L102P probably damaging Het
Tbc1d9 T C 8: 83,937,145 (GRCm39) W76R probably damaging Het
Tcerg1 T A 18: 42,686,530 (GRCm39) Y696N probably damaging Het
Thsd7b A G 1: 129,595,655 (GRCm39) T492A probably benign Het
Trdmt1 T A 2: 13,524,870 (GRCm39) Q195L probably benign Het
Ubr3 A G 2: 69,813,208 (GRCm39) probably null Het
Ung A T 5: 114,275,361 (GRCm39) Y250F probably benign Het
Vezf1 A G 11: 87,972,326 (GRCm39) N229S probably damaging Het
Wdfy3 C T 5: 102,020,831 (GRCm39) R2491Q possibly damaging Het
Wdr97 C A 15: 76,239,895 (GRCm39) S277* probably null Het
Zfp709 TCGACG TCG 8: 72,644,552 (GRCm39) probably benign Het
Zscan4-ps1 C A 7: 10,799,829 (GRCm39) E353D probably benign Het
Other mutations in Zfp1007
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01653:Zfp1007 APN 5 109,825,182 (GRCm39) nonsense probably null
IGL02547:Zfp1007 APN 5 109,826,628 (GRCm39) critical splice donor site probably null
IGL02589:Zfp1007 APN 5 109,826,386 (GRCm39) missense possibly damaging 0.95
BB007:Zfp1007 UTSW 5 109,823,622 (GRCm39) nonsense probably null
BB017:Zfp1007 UTSW 5 109,823,622 (GRCm39) nonsense probably null
R0363:Zfp1007 UTSW 5 109,824,754 (GRCm39) missense probably benign 0.03
R0628:Zfp1007 UTSW 5 109,826,442 (GRCm39) critical splice acceptor site probably null
R2858:Zfp1007 UTSW 5 109,823,819 (GRCm39) missense probably benign 0.02
R4914:Zfp1007 UTSW 5 109,826,396 (GRCm39) missense probably damaging 1.00
R4945:Zfp1007 UTSW 5 109,824,941 (GRCm39) missense possibly damaging 0.60
R5444:Zfp1007 UTSW 5 109,823,502 (GRCm39) nonsense probably null
R6000:Zfp1007 UTSW 5 109,824,730 (GRCm39) missense probably benign 0.19
R6389:Zfp1007 UTSW 5 109,823,885 (GRCm39) missense possibly damaging 0.84
R6945:Zfp1007 UTSW 5 109,824,711 (GRCm39) missense probably benign 0.25
R7225:Zfp1007 UTSW 5 109,825,015 (GRCm39) missense possibly damaging 0.69
R7581:Zfp1007 UTSW 5 109,838,654 (GRCm39) start gained probably benign
R7810:Zfp1007 UTSW 5 109,825,170 (GRCm39) nonsense probably null
R7930:Zfp1007 UTSW 5 109,823,622 (GRCm39) nonsense probably null
R8821:Zfp1007 UTSW 5 109,824,174 (GRCm39) missense probably benign 0.00
R8825:Zfp1007 UTSW 5 109,826,746 (GRCm39) missense probably damaging 1.00
R8831:Zfp1007 UTSW 5 109,824,174 (GRCm39) missense probably benign 0.00
R9179:Zfp1007 UTSW 5 109,823,708 (GRCm39) missense probably damaging 1.00
R9429:Zfp1007 UTSW 5 109,824,334 (GRCm39) nonsense probably null
R9486:Zfp1007 UTSW 5 109,824,062 (GRCm39) nonsense probably null
R9496:Zfp1007 UTSW 5 109,823,924 (GRCm39) missense probably damaging 0.98
R9525:Zfp1007 UTSW 5 109,824,846 (GRCm39) missense
Predicted Primers PCR Primer
(F):5'- AGCATTGCGTACAAAGGCT -3'
(R):5'- GTACGCAATGCTAGTCTCCAA -3'

Sequencing Primer
(F):5'- TGCGTACAAAGGCTTTACCG -3'
(R):5'- AGCAATGTGGTAAAGCCTTTGCC -3'
Posted On 2018-03-15