Incidental Mutation 'IGL01150:Ptges'
ID 50650
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Ptges
Ensembl Gene ENSMUSG00000050737
Gene Name prostaglandin E synthase
Synonyms D2Ertd369e, mPGES, mPGES-1, 2410099E23Rik
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # IGL01150
Quality Score
Status
Chromosome 2
Chromosomal Location 30779483-30793309 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to T at 30782720 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Arginine to Serine at position 111 (R111S)
Ref Sequence ENSEMBL: ENSMUSP00000099916 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000102852]
AlphaFold Q9JM51
Predicted Effect noncoding transcript
Transcript: ENSMUST00000056046
SMART Domains Protein: ENSMUSP00000054679
Gene: ENSMUSG00000050737

DomainStartEndE-ValueType
Pfam:MAPEG 13 129 9.6e-22 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000102852
AA Change: R111S

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000099916
Gene: ENSMUSG00000050737
AA Change: R111S

DomainStartEndE-ValueType
Pfam:MAPEG 17 147 1e-26 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000126588
Predicted Effect noncoding transcript
Transcript: ENSMUST00000132244
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a glutathione-dependent prostaglandin E synthase. The expression of this gene has been shown to be induced by proinflammatory cytokine interleukin 1 beta (IL1B). Its expression can also be induced by tumor suppressor protein TP53, and may be involved in TP53 induced apoptosis. Knockout studies in mice suggest that this gene may contribute to the pathogenesis of collagen-induced arthritis and mediate acute pain during inflammatory responses. [provided by RefSeq, Jul 2008]
PHENOTYPE: Homozygous null mice are fertile and display a decreased inflammatory response. Mice homozygous for a conditional allele activated in the vascular smooth muscle, endothelial or myeloid cells exhibit altered response to vascular injury. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 40 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcb1a A G 5: 8,752,550 (GRCm39) D507G possibly damaging Het
Actl6a A G 3: 32,766,313 (GRCm39) I60V probably benign Het
Adra2c T C 5: 35,438,485 (GRCm39) F419S probably damaging Het
Afap1l2 T C 19: 56,918,618 (GRCm39) Y105C probably damaging Het
Arid4b C T 13: 14,369,959 (GRCm39) Q1152* probably null Het
Arsj A G 3: 126,232,433 (GRCm39) D393G probably benign Het
Avp T C 2: 130,422,593 (GRCm39) probably benign Het
Cacna2d3 C T 14: 28,905,598 (GRCm39) V390I possibly damaging Het
Ccdc25 T A 14: 66,097,651 (GRCm39) M195K possibly damaging Het
Cdhr2 T A 13: 54,878,931 (GRCm39) S979T probably benign Het
Cog2 T C 8: 125,269,630 (GRCm39) F390S possibly damaging Het
Dennd5b A G 6: 148,969,583 (GRCm39) V290A probably benign Het
Ebf1 T C 11: 44,759,927 (GRCm39) L188P probably damaging Het
Galt T C 4: 41,757,786 (GRCm39) probably benign Het
Gm12830 C T 4: 114,702,261 (GRCm39) T141I unknown Het
Herc2 T A 7: 55,830,881 (GRCm39) W2965R probably damaging Het
Hrg A G 16: 22,777,909 (GRCm39) probably null Het
Ighv8-5 T C 12: 115,031,194 (GRCm39) Y115C probably damaging Het
Igkv12-89 A G 6: 68,812,127 (GRCm39) V14A probably benign Het
Nav2 A C 7: 49,102,269 (GRCm39) T295P probably benign Het
Niban1 T C 1: 151,593,472 (GRCm39) V719A probably benign Het
Nrg1 G A 8: 32,407,903 (GRCm39) T110I probably damaging Het
Or4c31 T C 2: 88,292,419 (GRCm39) V264A possibly damaging Het
Or51h1 A C 7: 102,308,699 (GRCm39) K224Q probably benign Het
Or7g29 A T 9: 19,286,535 (GRCm39) I214N probably damaging Het
Pclo T C 5: 14,726,926 (GRCm39) probably benign Het
Polg2 T C 11: 106,668,258 (GRCm39) probably null Het
Rbbp4 T C 4: 129,216,668 (GRCm39) probably benign Het
Rundc3a T C 11: 102,284,602 (GRCm39) V34A probably benign Het
Scn3a C A 2: 65,327,709 (GRCm39) probably null Het
Sec14l3 T C 11: 4,026,238 (GRCm39) probably benign Het
Strip1 C T 3: 107,534,047 (GRCm39) probably null Het
Svep1 T A 4: 58,070,302 (GRCm39) I2495F probably benign Het
Syne1 A G 10: 5,393,154 (GRCm39) S71P probably damaging Het
Tedc1 C T 12: 113,126,808 (GRCm39) R357* probably null Het
Tmem161b C T 13: 84,440,526 (GRCm39) R133* probably null Het
Tnnc2 A T 2: 164,619,753 (GRCm39) I71N probably damaging Het
Vps13d T C 4: 144,875,845 (GRCm39) N1554S probably benign Het
Wfdc3 A T 2: 164,574,123 (GRCm39) probably benign Het
Zfp648 A T 1: 154,081,110 (GRCm39) H423L probably damaging Het
Other mutations in Ptges
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02737:Ptges APN 2 30,782,698 (GRCm39) missense probably damaging 1.00
R0352:Ptges UTSW 2 30,793,144 (GRCm39) nonsense probably null
R2164:Ptges UTSW 2 30,782,708 (GRCm39) missense probably benign 0.31
R2496:Ptges UTSW 2 30,782,722 (GRCm39) missense possibly damaging 0.89
R2497:Ptges UTSW 2 30,782,722 (GRCm39) missense possibly damaging 0.89
R4832:Ptges UTSW 2 30,793,232 (GRCm39) utr 5 prime probably benign
R6703:Ptges UTSW 2 30,793,133 (GRCm39) missense possibly damaging 0.80
R7155:Ptges UTSW 2 30,782,816 (GRCm39) missense probably benign 0.07
R7601:Ptges UTSW 2 30,782,809 (GRCm39) missense probably benign 0.02
Posted On 2013-06-21