Incidental Mutation 'R6259:Or56b35'
ID 506554
Institutional Source Beutler Lab
Gene Symbol Or56b35
Ensembl Gene ENSMUSG00000073907
Gene Name olfactory receptor family 56 subfamily B member 35
Synonyms Olfr689, MOR40-3, GA_x6K02T2PBJ9-7942985-7943947
MMRRC Submission 044376-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.054) question?
Stock # R6259 (G1)
Quality Score 225.009
Status Validated
Chromosome 7
Chromosomal Location 104963213-104964175 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 104963264 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Phenylalanine at position 18 (I18F)
Ref Sequence ENSEMBL: ENSMUSP00000151049 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000098153] [ENSMUST00000215413]
AlphaFold Q8VG18
Predicted Effect probably benign
Transcript: ENSMUST00000098153
AA Change: I18F

PolyPhen 2 Score 0.008 (Sensitivity: 0.96; Specificity: 0.76)
SMART Domains Protein: ENSMUSP00000095756
Gene: ENSMUSG00000073907
AA Change: I18F

DomainStartEndE-ValueType
Pfam:7tm_4 36 313 4.3e-74 PFAM
Pfam:7TM_GPCR_Srsx 40 311 3.9e-8 PFAM
Pfam:7tm_1 46 296 1.6e-15 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000215413
AA Change: I18F

PolyPhen 2 Score 0.008 (Sensitivity: 0.96; Specificity: 0.76)
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.7%
  • 10x: 98.5%
  • 20x: 96.0%
Validation Efficiency 99% (74/75)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 77 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
5730507C01Rik C A 12: 18,584,120 (GRCm39) N393K probably benign Het
Acap3 A T 4: 155,980,575 (GRCm39) I19F possibly damaging Het
Acsbg3 A G 17: 57,184,513 (GRCm39) Y96C probably benign Het
Adamts5 C T 16: 85,696,641 (GRCm39) R172H probably benign Het
Adgra3 A G 5: 50,156,483 (GRCm39) F416L possibly damaging Het
Amy1 T C 3: 113,363,059 (GRCm39) D96G possibly damaging Het
Ank2 A G 3: 126,810,635 (GRCm39) S484P probably benign Het
Arsa A G 15: 89,359,724 (GRCm39) C68R probably damaging Het
Asprv1 A G 6: 86,605,361 (GRCm39) Y69C probably benign Het
Ass1 A G 2: 31,378,654 (GRCm39) E162G possibly damaging Het
Atf7 G T 15: 102,455,673 (GRCm39) N230K probably damaging Het
Atp10b A G 11: 43,092,065 (GRCm39) M367V probably benign Het
Atp11b A G 3: 35,861,050 (GRCm39) Y179C probably damaging Het
BC004004 A T 17: 29,517,686 (GRCm39) Q300L possibly damaging Het
Bglap3 A T 3: 88,276,067 (GRCm39) I95N probably damaging Het
Cacna1h T C 17: 25,616,630 (GRCm39) probably null Het
Caskin2 C T 11: 115,691,279 (GRCm39) G1141D probably damaging Het
Clcn4 G A 7: 7,294,529 (GRCm39) R351W possibly damaging Het
Col11a1 T C 3: 113,932,096 (GRCm39) C89R probably benign Het
Csrp1 T G 1: 135,667,252 (GRCm39) probably null Het
Cwf19l2 T C 9: 3,458,879 (GRCm39) I776T probably damaging Het
Cyp2b19 A T 7: 26,470,817 (GRCm39) Q486L possibly damaging Het
Cyp2j9 T A 4: 96,472,243 (GRCm39) Y165F probably benign Het
Dab1 C T 4: 104,588,948 (GRCm39) A524V probably benign Het
Dennd1c G A 17: 57,374,104 (GRCm39) R522C probably damaging Het
Dmgdh T C 13: 93,888,816 (GRCm39) V818A probably benign Het
Dst T A 1: 34,221,477 (GRCm39) V2427E probably benign Het
Duox1 C T 2: 122,175,264 (GRCm39) T1354M probably benign Het
Ehbp1 A G 11: 22,235,684 (GRCm39) probably benign Het
Epc2 T A 2: 49,378,866 (GRCm39) probably null Het
Eya2 T C 2: 165,558,019 (GRCm39) V205A probably benign Het
Fat4 A G 3: 39,061,395 (GRCm39) H4326R probably benign Het
Gaa C A 11: 119,171,997 (GRCm39) A700D probably benign Het
Gm10100 G T 10: 77,562,498 (GRCm39) C60F possibly damaging Het
Hhip T A 8: 80,699,033 (GRCm39) R678W probably damaging Het
Il21r T A 7: 125,229,891 (GRCm39) I266K possibly damaging Het
Itgb4 C T 11: 115,874,983 (GRCm39) R447W probably benign Het
Kif26b T C 1: 178,744,970 (GRCm39) S1689P probably damaging Het
L3mbtl2 A G 15: 81,566,128 (GRCm39) E317G probably damaging Het
Lgr6 C T 1: 134,921,748 (GRCm39) A199T probably damaging Het
Lratd1 T A 12: 14,200,646 (GRCm39) D27V probably damaging Het
Lrr1 A G 12: 69,221,589 (GRCm39) N244D probably damaging Het
Lrrk2 A T 15: 91,586,450 (GRCm39) H422L probably benign Het
Map4k5 A G 12: 69,899,514 (GRCm39) S46P probably damaging Het
Ngf A G 3: 102,417,113 (GRCm39) probably benign Het
Nploc4 T C 11: 120,276,691 (GRCm39) I452V probably benign Het
Oas1d T A 5: 121,057,244 (GRCm39) Y283* probably null Het
Or52h1 A T 7: 103,829,261 (GRCm39) M118K possibly damaging Het
Or5b109 A G 19: 13,211,785 (GRCm39) H57R probably damaging Het
Or5l13 T C 2: 87,779,779 (GRCm39) N266S probably benign Het
Pdzrn4 A T 15: 92,655,562 (GRCm39) E485V probably damaging Het
Peg3 A G 7: 6,712,810 (GRCm39) V804A probably damaging Het
Piezo2 T A 18: 63,250,749 (GRCm39) Y450F possibly damaging Het
Pprc1 T A 19: 46,052,849 (GRCm39) V789E probably damaging Het
Prcc A G 3: 87,769,454 (GRCm39) M436T possibly damaging Het
Prepl A T 17: 85,377,859 (GRCm39) V507D probably damaging Het
Rag1 T A 2: 101,474,797 (GRCm39) N115I possibly damaging Het
Rap1gap T C 4: 137,409,068 (GRCm39) probably null Het
Reln A C 5: 22,265,331 (GRCm39) F454V probably damaging Het
Slc39a11 A T 11: 113,354,780 (GRCm39) S150T probably benign Het
Slc45a1 T A 4: 150,722,817 (GRCm39) I356F possibly damaging Het
Snrnp200 G A 2: 127,060,343 (GRCm39) G529D possibly damaging Het
Stkld1 A T 2: 26,839,393 (GRCm39) D353V possibly damaging Het
Susd2 T C 10: 75,473,880 (GRCm39) S572G probably damaging Het
Synrg T A 11: 83,899,484 (GRCm39) D563E probably damaging Het
Tmem131 C T 1: 36,858,209 (GRCm39) V713I probably benign Het
Tnfrsf8 A G 4: 145,004,094 (GRCm39) probably null Het
Trim26 C T 17: 37,167,110 (GRCm39) A267V probably benign Het
Trpm1 T G 7: 63,918,226 (GRCm39) F522C possibly damaging Het
Uggt1 T C 1: 36,273,997 (GRCm39) I29V probably benign Het
Unc5d C T 8: 29,156,820 (GRCm39) M808I probably benign Het
Vmn2r108 T A 17: 20,683,371 (GRCm39) D611V possibly damaging Het
Vps13a A C 19: 16,664,534 (GRCm39) Y1436* probably null Het
Wdfy3 C T 5: 102,020,831 (GRCm39) R2491Q possibly damaging Het
Zfp518a G T 19: 40,901,225 (GRCm39) V385F probably benign Het
Zfp541 C T 7: 15,829,451 (GRCm39) A1222V probably benign Het
Zfp709 TCGACG TCG 8: 72,644,552 (GRCm39) probably benign Het
Other mutations in Or56b35
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01862:Or56b35 APN 7 104,963,439 (GRCm39) missense probably damaging 0.99
R0320:Or56b35 UTSW 7 104,963,861 (GRCm39) missense probably benign 0.24
R0533:Or56b35 UTSW 7 104,963,579 (GRCm39) missense probably benign 0.05
R3499:Or56b35 UTSW 7 104,963,607 (GRCm39) missense probably damaging 1.00
R5326:Or56b35 UTSW 7 104,963,646 (GRCm39) missense probably damaging 1.00
R5424:Or56b35 UTSW 7 104,963,778 (GRCm39) missense possibly damaging 0.96
R5595:Or56b35 UTSW 7 104,963,213 (GRCm39) start codon destroyed probably benign
R5905:Or56b35 UTSW 7 104,964,158 (GRCm39) missense probably benign
R6139:Or56b35 UTSW 7 104,963,453 (GRCm39) missense probably damaging 0.99
R6230:Or56b35 UTSW 7 104,963,289 (GRCm39) missense possibly damaging 0.59
R7471:Or56b35 UTSW 7 104,963,712 (GRCm39) missense probably damaging 1.00
R7747:Or56b35 UTSW 7 104,963,654 (GRCm39) missense probably damaging 0.99
R9282:Or56b35 UTSW 7 104,963,781 (GRCm39) missense probably benign
R9769:Or56b35 UTSW 7 104,963,933 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- GTTCAAAAGACCACAAGATTATGGG -3'
(R):5'- TGGTCTTGGCATCAAACCAC -3'

Sequencing Primer
(F):5'- TGGGTGAGACCTATATCACTACC -3'
(R):5'- CCACAAGATGGCCAGTATTTTGG -3'
Posted On 2018-03-15