Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01065:Slc25a24'

50689

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Slc25a24

Ensembl Gene

ENSMUSG00000040322

Gene Name

solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 24

Synonyms

2610016M12Rik

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL01065

Quality Score

Status

Chromosome

Chromosomal Location

109030465-109075725 bp(+) (GRCm39)

Type of Mutation

unclassified

DNA Base Change (assembly)

G to A at 109065967 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000143109 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000029477] [ENSMUST00000140786]

AlphaFold

Q8BMD8

Predicted Effect

probably benign
Transcript: ENSMUST00000029477

SMART Domains

Protein: ENSMUSP00000029477
Gene: ENSMUSG00000040322

Domain	Start	End	E-Value	Type
EFh	23	51	3.08e-2	SMART
EFh	59	87	1.32e-1	SMART
EFh	90	118	1.65e-2	SMART
Blast:EFh	126	154	7e-9	BLAST
Pfam:Mito_carr	190	281	2.1e-27	PFAM
Pfam:Mito_carr	282	374	8.1e-27	PFAM
Pfam:Mito_carr	380	473	4.8e-22	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000140786

SMART Domains

Protein: ENSMUSP00000143109
Gene: ENSMUSG00000040322

Domain	Start	End	E-Value	Type
EFh	23	51	1.5e-4	SMART
EFh	59	87	6.3e-4	SMART

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a carrier protein that transports ATP-Mg exchanging it for phosphate. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012]

Allele List at MGI

Other mutations in this stock

Total: 42 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1110038F14Rik	G	A	15: 76,834,475 (GRCm39)	V124I	probably damaging	Het
Aen	G	A	7: 78,557,050 (GRCm39)	M299I	probably damaging	Het
Apob	A	G	12: 8,053,299 (GRCm39)	Y1247C	probably damaging	Het
Atg16l1	A	T	1: 87,713,653 (GRCm39)	N401I	probably damaging	Het
Bcam	T	C	7: 19,490,724 (GRCm39)	H591R	probably benign	Het
Bcat1	T	C	6: 144,946,015 (GRCm39)	S446G	possibly damaging	Het
C2cd5	A	G	6: 143,024,005 (GRCm39)	S262P	probably damaging	Het
Clrn1	T	C	3: 58,792,446 (GRCm39)	K6E	probably damaging	Het
D17H6S53E	A	T	17: 35,346,259 (GRCm39)	K57*	probably null	Het
Dennd1a	T	A	2: 37,734,917 (GRCm39)	I17F	probably benign	Het
Depdc7	A	C	2: 104,552,426 (GRCm39)	Y460*	probably null	Het
Disp3	T	C	4: 148,345,640 (GRCm39)	Y400C	probably damaging	Het
Edem3	T	C	1: 151,653,302 (GRCm39)	Y203H	probably damaging	Het
Fbxl5	A	G	5: 43,902,676 (GRCm39)	C679R	probably damaging	Het
Fhad1	T	C	4: 141,632,923 (GRCm39)	T1194A	probably benign	Het
Garin4	T	C	1: 190,895,224 (GRCm39)	D473G	probably benign	Het
Gipc2	A	G	3: 151,808,294 (GRCm39)	L253P	possibly damaging	Het
Gpr26	T	C	7: 131,569,230 (GRCm39)	Y192H	probably damaging	Het
Hoxb6	A	G	11: 96,191,635 (GRCm39)	T186A	probably damaging	Het
Kif24	A	G	4: 41,423,639 (GRCm39)		probably benign	Het
Lonp1	T	C	17: 56,922,500 (GRCm39)		probably benign	Het
Lrp1	A	G	10: 127,410,907 (GRCm39)	I1427T	probably benign	Het
Lrp2	C	T	2: 69,299,780 (GRCm39)	E3091K	possibly damaging	Het
Lzts1	T	C	8: 69,588,744 (GRCm39)	N404S	probably benign	Het
Map3k4	A	T	17: 12,451,877 (GRCm39)	D1470E	probably damaging	Het
Med30	A	T	15: 52,584,456 (GRCm39)	N125Y	probably benign	Het
Mgam	G	A	6: 40,639,644 (GRCm39)		probably null	Het
Mrps33	G	A	6: 39,779,447 (GRCm39)	R83*	probably null	Het
Notch3	A	T	17: 32,365,390 (GRCm39)	Y1107*	probably null	Het
Rc3h2	T	A	2: 37,267,856 (GRCm39)		probably benign	Het
Rev1	T	C	1: 38,138,090 (GRCm39)	E65G	possibly damaging	Het
Rgl1	T	C	1: 152,394,893 (GRCm39)	N760S	probably damaging	Het
Slc16a4	T	C	3: 107,210,416 (GRCm39)	I362T	possibly damaging	Het
Slc2a4	G	T	11: 69,836,782 (GRCm39)		probably benign	Het
Slc39a13	T	A	2: 90,894,051 (GRCm39)	I256F	probably damaging	Het
Spdya	A	T	17: 71,863,320 (GRCm39)	N23I	possibly damaging	Het
Srpra	T	A	9: 35,124,734 (GRCm39)	W112R	probably damaging	Het
Tbc1d4	A	C	14: 101,686,629 (GRCm39)		probably benign	Het
Ttc39d	G	A	17: 80,523,703 (GRCm39)	G121R	probably damaging	Het
Tuba3a	C	T	6: 125,259,920 (GRCm39)	V9M	possibly damaging	Het
Upf2	A	G	2: 5,966,111 (GRCm39)	K244E	unknown	Het
Usp39	T	C	6: 72,316,958 (GRCm39)	Y141C	probably damaging	Het

Other mutations in Slc25a24

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00709:Slc25a24	APN	3	109,066,670 (GRCm39)	missense	probably damaging	1.00
IGL01769:Slc25a24	APN	3	109,056,816 (GRCm39)	missense	probably damaging	0.99
IGL02803:Slc25a24	APN	3	109,062,387 (GRCm39)	missense	probably damaging	0.99
IGL03349:Slc25a24	APN	3	109,056,865 (GRCm39)	missense	possibly damaging	0.67
R0318:Slc25a24	UTSW	3	109,064,316 (GRCm39)	missense	probably benign	0.00
R0448:Slc25a24	UTSW	3	109,064,332 (GRCm39)	splice site	probably benign
R1554:Slc25a24	UTSW	3	109,043,586 (GRCm39)	missense	probably benign	0.02
R1564:Slc25a24	UTSW	3	109,070,819 (GRCm39)	missense	probably damaging	1.00
R1935:Slc25a24	UTSW	3	109,043,581 (GRCm39)	missense	probably damaging	1.00
R1936:Slc25a24	UTSW	3	109,043,581 (GRCm39)	missense	probably damaging	1.00
R4936:Slc25a24	UTSW	3	109,070,864 (GRCm39)	missense	probably damaging	0.98
R5299:Slc25a24	UTSW	3	109,073,668 (GRCm39)	missense	probably benign	0.03
R6480:Slc25a24	UTSW	3	109,043,617 (GRCm39)	missense	probably damaging	1.00
R6748:Slc25a24	UTSW	3	109,056,823 (GRCm39)	missense	possibly damaging	0.67
R7269:Slc25a24	UTSW	3	109,065,960 (GRCm39)	missense	probably null	0.99
R7483:Slc25a24	UTSW	3	109,066,751 (GRCm39)	missense	probably damaging	1.00
R8362:Slc25a24	UTSW	3	109,065,878 (GRCm39)	missense	possibly damaging	0.86
R9017:Slc25a24	UTSW	3	109,062,395 (GRCm39)	missense	possibly damaging	0.91
R9022:Slc25a24	UTSW	3	109,070,757 (GRCm39)	missense	probably benign	0.06
R9178:Slc25a24	UTSW	3	109,064,268 (GRCm39)	missense	possibly damaging	0.92
R9258:Slc25a24	UTSW	3	109,066,751 (GRCm39)	missense	probably damaging	1.00

Posted On

2013-06-21