Mutagenetix > Incidental Mutation

Incidental Mutation 'R6266:Dnah5'

507032

Institutional Source

Beutler Lab

Gene Symbol

Dnah5

Ensembl Gene

ENSMUSG00000022262

Gene Name

dynein, axonemal, heavy chain 5

Synonyms

Dnahc5, b2b3491Clo, b2b1154Clo, b2b1134Clo, b2b1565Clo, b2b1537Clo, Mdnah5

MMRRC Submission

044378-MU

Accession Numbers

Essential gene?

Probably essential (E-score: 0.791) question?

Stock #

R6266 (G1)

Quality Score

225.009

Status

Not validated

Chromosome

Chromosomal Location

28203898-28472198 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 28335773 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Phenylalanine to Leucine at position 2246 (F2246L)

Ref Sequence

ENSEMBL: ENSMUSP00000069751 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000067048]

AlphaFold

no structure available at present

Predicted Effect

possibly damaging
Transcript: ENSMUST00000067048
AA Change: F2246L

PolyPhen 2 Score 0.665 (Sensitivity: 0.86; Specificity: 0.91)

SMART Domains

Protein: ENSMUSP00000069751
Gene: ENSMUSG00000022262
AA Change: F2246L

Domain	Start	End	E-Value	Type
Pfam:DHC_N1	247	802	2.3e-163	PFAM
low complexity region	1077	1088	N/A	INTRINSIC
low complexity region	1113	1128	N/A	INTRINSIC
Pfam:DHC_N2	1399	1807	2.3e-134	PFAM
AAA	1972	2108	2e-3	SMART
AAA	2251	2424	4.3e-3	SMART
AAA	2579	2777	2.2e-3	SMART
low complexity region	2874	2889	N/A	INTRINSIC
Pfam:AAA_8	2914	3186	3.2e-70	PFAM
Pfam:MT	3198	3546	1e-44	PFAM
Pfam:AAA_9	3567	3792	1.4e-86	PFAM
low complexity region	3889	3899	N/A	INTRINSIC
Pfam:Dynein_heavy	3930	4618	4.4e-246	PFAM

Coding Region Coverage

1x: 99.9%
3x: 99.8%
10x: 98.8%
20x: 96.7%

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a dynein protein, which is part of a microtubule-associated motor protein complex consisting of heavy, light, and intermediate chains. This protein is an axonemal heavy chain dynein. It functions as a force-generating protein with ATPase activity, whereby the release of ADP is thought to produce the force-producing power stroke. Mutations in this gene cause primary ciliary dyskinesia type 3, as well as Kartagener syndrome, which are both diseases due to ciliary defects. [provided by RefSeq, Oct 2009]
PHENOTYPE: Mice homozygous for a disruption in this gene display postnatal lethality, hydrocephalus, respiratory infections, situs inversus and ciliary immotility. [provided by MGI curators]

Allele List at MGI

All alleles(11) : Targeted(2) Gene trapped(1) Transgenic(1) Chemically induced(7)

Other mutations in this stock

Total: 57 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Akr1c12	T	C	13: 4,320,206 (GRCm39)	T295A	probably benign	Het
Aldh2	C	A	5: 121,706,997 (GRCm39)	V217L	probably damaging	Het
Arap3	G	A	18: 38,123,844 (GRCm39)	R392C	probably damaging	Het
Aurkaip1	T	G	4: 155,916,977 (GRCm39)	L75R	probably damaging	Het
Blm	C	A	7: 80,149,688 (GRCm39)	K640N	probably benign	Het
Brap	A	T	5: 121,823,328 (GRCm39)	T487S	probably benign	Het
Ccser2	G	A	14: 36,601,632 (GRCm39)	P276L	probably damaging	Het
Cdc42bpg	A	G	19: 6,361,503 (GRCm39)	E343G	probably damaging	Het
Cecr2	A	G	6: 120,738,647 (GRCm39)	S1097G	probably benign	Het
D7Ertd443e	A	T	7: 133,951,514 (GRCm39)	V53D	probably damaging	Het
Ddx3y	G	A	Y: 1,266,635 (GRCm39)	T274I	probably damaging	Homo
Dock3	T	A	9: 106,841,952 (GRCm39)	H959L	probably damaging	Het
Dpy19l1	A	G	9: 24,350,442 (GRCm39)	S406P	probably damaging	Het
Efcab8	T	C	2: 153,625,688 (GRCm39)	L116P	probably damaging	Het
Efnb2	T	C	8: 8,710,524 (GRCm39)	I31V	probably benign	Het
Fbxl12	A	T	9: 20,549,911 (GRCm39)	L271Q	probably damaging	Het
Fmn1	T	A	2: 113,426,683 (GRCm39)	N1133K	probably damaging	Het
Frmpd2	T	C	14: 33,287,864 (GRCm39)	S1219P	probably benign	Het
Gm7298	A	T	6: 121,759,663 (GRCm39)	R1187S	probably damaging	Het
H6pd	T	C	4: 150,080,414 (GRCm39)	I136V	probably benign	Het
Hyal2	A	G	9: 107,447,914 (GRCm39)	N189S	probably benign	Het
Jmjd1c	C	T	10: 67,085,439 (GRCm39)	P2410S	probably damaging	Het
Larp1	A	G	11: 57,933,089 (GRCm39)	D231G	probably damaging	Het
Lilra5	T	A	7: 4,244,927 (GRCm39)	S233T	possibly damaging	Het
Lrrc43	T	C	5: 123,641,340 (GRCm39)	F508S	probably damaging	Het
Marchf4	T	C	1: 72,491,647 (GRCm39)	Y208C	probably damaging	Het
Mtarc2	T	C	1: 184,566,140 (GRCm39)	R85G	probably damaging	Het
Nr1h2	A	T	7: 44,201,476 (GRCm39)	C45*	probably null	Het
Or10ag2	T	A	2: 87,249,350 (GRCm39)	S319R	probably benign	Het
Or2n1e	A	G	17: 38,586,039 (GRCm39)	I126V	probably benign	Het
Ppp2r5d	G	T	17: 46,996,629 (GRCm39)		probably null	Het
Prpf40a	A	T	2: 53,046,639 (GRCm39)	S324T	probably benign	Het
Psmb7	T	C	2: 38,530,199 (GRCm39)	D94G	probably damaging	Het
Psmd11	A	G	11: 80,336,767 (GRCm39)	T140A	probably benign	Het
Pygm	T	C	19: 6,448,169 (GRCm39)	I737T	probably damaging	Het
Rbp3	G	A	14: 33,676,418 (GRCm39)	R122H	probably benign	Het
Relch	T	G	1: 105,659,007 (GRCm39)		probably null	Het
Rrp8	T	C	7: 105,385,596 (GRCm39)	E3G	probably damaging	Het
Sacm1l	T	C	9: 123,371,485 (GRCm39)	S37P	probably damaging	Het
Slc12a3	A	G	8: 95,085,099 (GRCm39)	R939G	possibly damaging	Het
Slc20a1	T	C	2: 129,051,814 (GRCm39)	S608P	possibly damaging	Het
Sntg1	T	C	1: 8,624,953 (GRCm39)	Q281R	possibly damaging	Het
Spata31d1e	C	T	13: 59,890,126 (GRCm39)	V147I	probably benign	Het
Tefm	A	G	11: 80,028,814 (GRCm39)	L194P	probably damaging	Het
Terf2ip	T	A	8: 112,738,547 (GRCm39)	V145E	probably damaging	Het
Tmem231	T	A	8: 112,641,897 (GRCm39)	E219V	probably null	Het
Tmx3	T	A	18: 90,555,334 (GRCm39)		probably null	Het
Tns3	G	A	11: 8,442,987 (GRCm39)	P459S	probably damaging	Het
Trav13d-1	T	A	14: 53,089,220 (GRCm39)	S76R	probably benign	Het
Trp63	A	G	16: 25,681,210 (GRCm39)	N254S	probably damaging	Het
Tsen34	A	G	7: 3,696,984 (GRCm39)		probably benign	Het
Unc13d	A	G	11: 115,959,064 (GRCm39)	V701A	probably damaging	Het
Usp36	A	G	11: 118,159,411 (GRCm39)	S513P	probably damaging	Het
Uspl1	T	A	5: 149,141,176 (GRCm39)	S392T	probably damaging	Het
Vmn2r102	T	A	17: 19,899,007 (GRCm39)	C450S	probably benign	Het
Zfp128	T	C	7: 12,624,897 (GRCm39)	Y422H	possibly damaging	Het
Zkscan7	C	T	9: 122,724,299 (GRCm39)	Q423*	probably null	Het

Other mutations in Dnah5

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00226:Dnah5	APN	15	28,272,488 (GRCm39)	missense	probably benign
IGL00331:Dnah5	APN	15	28,421,766 (GRCm39)	missense	probably damaging	1.00
IGL00519:Dnah5	APN	15	28,444,364 (GRCm39)	missense	probably benign	0.10
IGL00537:Dnah5	APN	15	28,458,848 (GRCm39)	critical splice donor site	probably null
IGL01102:Dnah5	APN	15	28,410,149 (GRCm39)	critical splice donor site	probably null
IGL01126:Dnah5	APN	15	28,302,545 (GRCm39)	missense	possibly damaging	0.85
IGL01154:Dnah5	APN	15	28,458,802 (GRCm39)	missense	possibly damaging	0.75
IGL01349:Dnah5	APN	15	28,295,059 (GRCm39)	splice site	probably benign
IGL01353:Dnah5	APN	15	28,233,418 (GRCm39)	missense	probably benign	0.00
IGL01372:Dnah5	APN	15	28,230,636 (GRCm39)	missense	probably benign	0.00
IGL01390:Dnah5	APN	15	28,411,686 (GRCm39)	missense	probably benign	0.00
IGL01446:Dnah5	APN	15	28,326,815 (GRCm39)	missense	probably damaging	1.00
IGL01472:Dnah5	APN	15	28,331,872 (GRCm39)	missense	probably damaging	1.00
IGL01485:Dnah5	APN	15	28,331,872 (GRCm39)	missense	probably damaging	1.00
IGL01568:Dnah5	APN	15	28,229,798 (GRCm39)	missense	probably benign	0.01
IGL01592:Dnah5	APN	15	28,236,783 (GRCm39)	missense	probably benign	0.01
IGL01594:Dnah5	APN	15	28,311,480 (GRCm39)	missense	possibly damaging	0.87
IGL01677:Dnah5	APN	15	28,367,928 (GRCm39)	missense	probably damaging	1.00
IGL01845:Dnah5	APN	15	28,449,315 (GRCm39)	missense	probably benign	0.06
IGL01904:Dnah5	APN	15	28,307,510 (GRCm39)	missense	probably benign	0.09
IGL01913:Dnah5	APN	15	28,313,899 (GRCm39)	missense	possibly damaging	0.50
IGL01950:Dnah5	APN	15	28,290,435 (GRCm39)	missense	probably null	1.00
IGL01963:Dnah5	APN	15	28,370,682 (GRCm39)	missense	probably benign	0.12
IGL02008:Dnah5	APN	15	28,343,698 (GRCm39)	missense	probably damaging	0.98
IGL02088:Dnah5	APN	15	28,459,264 (GRCm39)	critical splice acceptor site	probably null
IGL02090:Dnah5	APN	15	28,240,187 (GRCm39)	splice site	probably benign
IGL02114:Dnah5	APN	15	28,397,270 (GRCm39)	missense	probably damaging	0.97
IGL02135:Dnah5	APN	15	28,248,031 (GRCm39)	missense	possibly damaging	0.50
IGL02232:Dnah5	APN	15	28,299,386 (GRCm39)	missense	probably damaging	1.00
IGL02386:Dnah5	APN	15	28,340,527 (GRCm39)	missense	probably damaging	1.00
IGL02475:Dnah5	APN	15	28,219,296 (GRCm39)	missense	probably benign	0.09
IGL02626:Dnah5	APN	15	28,307,422 (GRCm39)	missense	possibly damaging	0.94
IGL02650:Dnah5	APN	15	28,289,193 (GRCm39)	splice site	probably benign
IGL02651:Dnah5	APN	15	28,350,768 (GRCm39)	missense	probably benign	0.05
IGL02652:Dnah5	APN	15	28,366,333 (GRCm39)	missense	probably damaging	0.99
IGL02670:Dnah5	APN	15	28,409,442 (GRCm39)	missense	probably damaging	1.00
IGL02697:Dnah5	APN	15	28,445,289 (GRCm39)	missense	probably benign	0.00
IGL02721:Dnah5	APN	15	28,234,389 (GRCm39)	critical splice acceptor site	probably null
IGL02858:Dnah5	APN	15	28,453,358 (GRCm39)	missense	possibly damaging	0.65
IGL02859:Dnah5	APN	15	28,383,771 (GRCm39)	missense	probably benign	0.01
IGL02945:Dnah5	APN	15	28,270,572 (GRCm39)	missense	probably benign	0.00
IGL02949:Dnah5	APN	15	28,272,331 (GRCm39)	missense	probably benign	0.32
IGL02971:Dnah5	APN	15	28,384,607 (GRCm39)	missense	probably damaging	1.00
IGL03017:Dnah5	APN	15	28,340,471 (GRCm39)	missense	possibly damaging	0.93
IGL03177:Dnah5	APN	15	28,295,545 (GRCm39)	missense	probably damaging	0.97
IGL03212:Dnah5	APN	15	28,290,309 (GRCm39)	missense	probably benign	0.08
IGL03224:Dnah5	APN	15	28,459,300 (GRCm39)	missense	probably damaging	1.00
IGL03231:Dnah5	APN	15	28,311,294 (GRCm39)	missense	probably damaging	1.00
IGL03273:Dnah5	APN	15	28,458,795 (GRCm39)	missense	probably damaging	0.98
IGL03294:Dnah5	APN	15	28,233,441 (GRCm39)	critical splice donor site	probably null
IGL03331:Dnah5	APN	15	28,420,086 (GRCm39)	missense	probably damaging	1.00
IGL03337:Dnah5	APN	15	28,290,287 (GRCm39)	missense	probably benign	0.10
IGL03367:Dnah5	APN	15	28,234,473 (GRCm39)	missense	possibly damaging	0.95
Firtel	UTSW	15	28,448,513 (GRCm39)	missense	possibly damaging	0.95
lowbar	UTSW	15	28,311,279 (GRCm39)	splice site	probably null
notherone	UTSW	15	28,340,552 (GRCm39)	missense	probably benign	0.13
scheffler	UTSW	15	28,438,237 (GRCm39)	splice site	probably benign
IGL02837:Dnah5	UTSW	15	28,269,546 (GRCm39)	missense	probably benign
P0008:Dnah5	UTSW	15	28,302,533 (GRCm39)	missense	probably damaging	1.00
P0014:Dnah5	UTSW	15	28,403,619 (GRCm39)	missense	probably damaging	1.00
PIT4687001:Dnah5	UTSW	15	28,383,723 (GRCm39)	missense	probably damaging	0.98
R0030:Dnah5	UTSW	15	28,451,663 (GRCm39)	missense	probably benign	0.34
R0087:Dnah5	UTSW	15	28,350,759 (GRCm39)	missense	probably damaging	1.00
R0099:Dnah5	UTSW	15	28,240,080 (GRCm39)	missense	probably damaging	1.00
R0102:Dnah5	UTSW	15	28,245,897 (GRCm39)	splice site	probably benign
R0102:Dnah5	UTSW	15	28,245,897 (GRCm39)	splice site	probably benign
R0104:Dnah5	UTSW	15	28,453,499 (GRCm39)	missense	possibly damaging	0.88
R0112:Dnah5	UTSW	15	28,263,825 (GRCm39)	missense	probably benign	0.00
R0122:Dnah5	UTSW	15	28,378,509 (GRCm39)	missense	probably damaging	1.00
R0126:Dnah5	UTSW	15	28,246,465 (GRCm39)	missense	probably benign	0.00
R0127:Dnah5	UTSW	15	28,295,071 (GRCm39)	missense	probably damaging	1.00
R0233:Dnah5	UTSW	15	28,333,216 (GRCm39)	missense	probably damaging	1.00
R0310:Dnah5	UTSW	15	28,299,256 (GRCm39)	missense	probably benign	0.19
R0386:Dnah5	UTSW	15	28,383,727 (GRCm39)	missense	probably damaging	1.00
R0421:Dnah5	UTSW	15	28,229,687 (GRCm39)	missense	possibly damaging	0.79
R0481:Dnah5	UTSW	15	28,383,745 (GRCm39)	missense	probably benign	0.31
R0514:Dnah5	UTSW	15	28,366,467 (GRCm39)	missense	probably damaging	1.00
R0609:Dnah5	UTSW	15	28,327,925 (GRCm39)	missense	probably benign
R0720:Dnah5	UTSW	15	28,314,007 (GRCm39)	missense	probably null	0.98
R0731:Dnah5	UTSW	15	28,311,289 (GRCm39)	missense	possibly damaging	0.78
R0747:Dnah5	UTSW	15	28,444,333 (GRCm39)	missense	possibly damaging	0.64
R0747:Dnah5	UTSW	15	28,444,332 (GRCm39)	missense	probably damaging	0.99
R0766:Dnah5	UTSW	15	28,448,633 (GRCm39)	missense	probably null	0.89
R0849:Dnah5	UTSW	15	28,263,745 (GRCm39)	missense	probably damaging	0.96
R1034:Dnah5	UTSW	15	28,302,617 (GRCm39)	missense	probably damaging	1.00
R1084:Dnah5	UTSW	15	28,343,598 (GRCm39)	missense	probably benign	0.01
R1148:Dnah5	UTSW	15	28,421,836 (GRCm39)	missense	probably damaging	1.00
R1148:Dnah5	UTSW	15	28,421,836 (GRCm39)	missense	probably damaging	1.00
R1200:Dnah5	UTSW	15	28,246,403 (GRCm39)	missense	possibly damaging	0.88
R1208:Dnah5	UTSW	15	28,327,877 (GRCm39)	missense	probably damaging	1.00
R1208:Dnah5	UTSW	15	28,327,877 (GRCm39)	missense	probably damaging	1.00
R1269:Dnah5	UTSW	15	28,238,657 (GRCm39)	missense	probably damaging	1.00
R1373:Dnah5	UTSW	15	28,314,064 (GRCm39)	splice site	probably benign
R1401:Dnah5	UTSW	15	28,402,059 (GRCm39)	missense	probably damaging	1.00
R1413:Dnah5	UTSW	15	28,370,555 (GRCm39)	missense	probably benign
R1430:Dnah5	UTSW	15	28,346,003 (GRCm39)	missense	probably benign	0.37
R1457:Dnah5	UTSW	15	28,403,688 (GRCm39)	critical splice donor site	probably null
R1468:Dnah5	UTSW	15	28,230,609 (GRCm39)	nonsense	probably null
R1468:Dnah5	UTSW	15	28,230,609 (GRCm39)	nonsense	probably null
R1560:Dnah5	UTSW	15	28,420,149 (GRCm39)	missense	probably damaging	1.00
R1568:Dnah5	UTSW	15	28,409,323 (GRCm39)	missense	probably damaging	0.98
R1574:Dnah5	UTSW	15	28,252,569 (GRCm39)	missense	probably benign	0.00
R1574:Dnah5	UTSW	15	28,252,569 (GRCm39)	missense	probably benign	0.00
R1603:Dnah5	UTSW	15	28,449,326 (GRCm39)	missense	probably benign	0.09
R1603:Dnah5	UTSW	15	28,295,131 (GRCm39)	splice site	probably benign
R1673:Dnah5	UTSW	15	28,290,294 (GRCm39)	missense	probably benign
R1755:Dnah5	UTSW	15	28,326,782 (GRCm39)	missense	probably damaging	0.99
R1785:Dnah5	UTSW	15	28,313,932 (GRCm39)	missense	probably damaging	1.00
R1786:Dnah5	UTSW	15	28,313,932 (GRCm39)	missense	probably damaging	1.00
R1789:Dnah5	UTSW	15	28,270,572 (GRCm39)	missense	probably benign	0.00
R1817:Dnah5	UTSW	15	28,246,546 (GRCm39)	nonsense	probably null
R1819:Dnah5	UTSW	15	28,246,546 (GRCm39)	nonsense	probably null
R1834:Dnah5	UTSW	15	28,409,270 (GRCm39)	missense	probably benign	0.00
R1855:Dnah5	UTSW	15	28,411,815 (GRCm39)	missense	possibly damaging	0.88
R1870:Dnah5	UTSW	15	28,331,859 (GRCm39)	nonsense	probably null
R1871:Dnah5	UTSW	15	28,331,859 (GRCm39)	nonsense	probably null
R1987:Dnah5	UTSW	15	28,343,737 (GRCm39)	missense	probably damaging	0.99
R1988:Dnah5	UTSW	15	28,343,737 (GRCm39)	missense	probably damaging	0.99
R1989:Dnah5	UTSW	15	28,343,737 (GRCm39)	missense	probably damaging	0.99
R2062:Dnah5	UTSW	15	28,366,416 (GRCm39)	missense	probably damaging	1.00
R2069:Dnah5	UTSW	15	28,312,534 (GRCm39)	splice site	probably null
R2121:Dnah5	UTSW	15	28,297,151 (GRCm39)	splice site	probably benign
R2128:Dnah5	UTSW	15	28,408,467 (GRCm39)	missense	probably benign	0.00
R2129:Dnah5	UTSW	15	28,408,467 (GRCm39)	missense	probably benign	0.00
R2151:Dnah5	UTSW	15	28,444,237 (GRCm39)	missense	probably damaging	1.00
R2159:Dnah5	UTSW	15	28,252,691 (GRCm39)	missense	probably benign	0.00
R2207:Dnah5	UTSW	15	28,343,817 (GRCm39)	missense	probably benign	0.11
R2231:Dnah5	UTSW	15	28,408,563 (GRCm39)	critical splice donor site	probably null
R2232:Dnah5	UTSW	15	28,408,563 (GRCm39)	critical splice donor site	probably null
R2282:Dnah5	UTSW	15	28,327,448 (GRCm39)	missense	probably damaging	0.99
R2305:Dnah5	UTSW	15	28,387,913 (GRCm39)	missense	probably benign	0.25
R2339:Dnah5	UTSW	15	28,314,028 (GRCm39)	missense	probably benign	0.00
R2437:Dnah5	UTSW	15	28,307,537 (GRCm39)	critical splice donor site	probably null
R2696:Dnah5	UTSW	15	28,278,722 (GRCm39)	missense	probably benign	0.00
R3156:Dnah5	UTSW	15	28,438,237 (GRCm39)	splice site	probably benign
R3431:Dnah5	UTSW	15	28,295,413 (GRCm39)	missense	probably benign	0.20
R3700:Dnah5	UTSW	15	28,387,937 (GRCm39)	missense	possibly damaging	0.72
R3724:Dnah5	UTSW	15	28,270,566 (GRCm39)	missense	probably benign	0.08
R3732:Dnah5	UTSW	15	28,409,268 (GRCm39)	missense	possibly damaging	0.64
R3872:Dnah5	UTSW	15	28,411,656 (GRCm39)	missense	possibly damaging	0.50
R4063:Dnah5	UTSW	15	28,421,144 (GRCm39)	missense	probably damaging	0.98
R4072:Dnah5	UTSW	15	28,340,444 (GRCm39)	nonsense	probably null
R4075:Dnah5	UTSW	15	28,293,937 (GRCm39)	missense	probably benign
R4245:Dnah5	UTSW	15	28,219,335 (GRCm39)	missense	probably benign
R4254:Dnah5	UTSW	15	28,438,248 (GRCm39)	missense	probably benign	0.07
R4255:Dnah5	UTSW	15	28,438,248 (GRCm39)	missense	probably benign	0.07
R4392:Dnah5	UTSW	15	28,289,375 (GRCm39)	missense	probably benign	0.19
R4552:Dnah5	UTSW	15	28,397,300 (GRCm39)	missense	probably benign	0.19
R4574:Dnah5	UTSW	15	28,367,909 (GRCm39)	missense	probably benign	0.05
R4577:Dnah5	UTSW	15	28,289,396 (GRCm39)	missense	probably benign	0.06
R4587:Dnah5	UTSW	15	28,304,745 (GRCm39)	missense	probably damaging	1.00
R4631:Dnah5	UTSW	15	28,420,140 (GRCm39)	missense	probably damaging	1.00
R4631:Dnah5	UTSW	15	28,402,099 (GRCm39)	missense	probably damaging	1.00
R4676:Dnah5	UTSW	15	28,295,406 (GRCm39)	missense	possibly damaging	0.65
R4707:Dnah5	UTSW	15	28,372,521 (GRCm39)	missense	probably damaging	0.97
R4754:Dnah5	UTSW	15	28,421,101 (GRCm39)	splice site	probably null
R4767:Dnah5	UTSW	15	28,270,620 (GRCm39)	missense	probably benign	0.02
R4857:Dnah5	UTSW	15	28,345,953 (GRCm39)	missense	probably benign	0.00
R4883:Dnah5	UTSW	15	28,343,784 (GRCm39)	missense	probably benign	0.00
R4889:Dnah5	UTSW	15	28,235,938 (GRCm39)	missense	probably benign	0.01
R4946:Dnah5	UTSW	15	28,388,050 (GRCm39)	missense	probably damaging	1.00
R4946:Dnah5	UTSW	15	28,326,703 (GRCm39)	missense	probably damaging	0.96
R4947:Dnah5	UTSW	15	28,272,518 (GRCm39)	missense	probably benign
R5033:Dnah5	UTSW	15	28,421,824 (GRCm39)	missense	probably damaging	0.96
R5164:Dnah5	UTSW	15	28,408,438 (GRCm39)	missense	probably benign	0.00
R5175:Dnah5	UTSW	15	28,448,550 (GRCm39)	missense	probably damaging	1.00
R5182:Dnah5	UTSW	15	28,311,424 (GRCm39)	missense	probably damaging	0.99
R5187:Dnah5	UTSW	15	28,272,318 (GRCm39)	missense	probably benign	0.41
R5272:Dnah5	UTSW	15	28,350,811 (GRCm39)	missense	probably benign
R5308:Dnah5	UTSW	15	28,229,797 (GRCm39)	missense	possibly damaging	0.80
R5310:Dnah5	UTSW	15	28,311,474 (GRCm39)	missense	probably damaging	1.00
R5322:Dnah5	UTSW	15	28,384,390 (GRCm39)	missense	probably benign	0.41
R5398:Dnah5	UTSW	15	28,293,872 (GRCm39)	missense	probably benign
R5596:Dnah5	UTSW	15	28,343,754 (GRCm39)	missense	probably damaging	1.00
R5603:Dnah5	UTSW	15	28,420,078 (GRCm39)	missense	probably damaging	1.00
R5619:Dnah5	UTSW	15	28,302,581 (GRCm39)	missense	probably damaging	1.00
R5656:Dnah5	UTSW	15	28,421,210 (GRCm39)	missense	probably benign	0.03
R5741:Dnah5	UTSW	15	28,246,513 (GRCm39)	missense	probably benign	0.11
R5754:Dnah5	UTSW	15	28,402,014 (GRCm39)	missense	probably benign	0.01
R5763:Dnah5	UTSW	15	28,311,298 (GRCm39)	missense	probably damaging	1.00
R5824:Dnah5	UTSW	15	28,313,967 (GRCm39)	missense	probably benign	0.00
R5836:Dnah5	UTSW	15	28,383,738 (GRCm39)	missense	probably damaging	1.00
R5838:Dnah5	UTSW	15	28,290,341 (GRCm39)	missense	probably benign	0.00
R5864:Dnah5	UTSW	15	28,297,159 (GRCm39)	missense	possibly damaging	0.83
R5895:Dnah5	UTSW	15	28,234,599 (GRCm39)	splice site	probably null
R5896:Dnah5	UTSW	15	28,272,206 (GRCm39)	missense	probably benign
R5899:Dnah5	UTSW	15	28,448,513 (GRCm39)	missense	possibly damaging	0.95
R5905:Dnah5	UTSW	15	28,387,979 (GRCm39)	missense	probably damaging	1.00
R5924:Dnah5	UTSW	15	28,307,473 (GRCm39)	missense	probably benign	0.41
R5927:Dnah5	UTSW	15	28,335,864 (GRCm39)	missense	probably benign	0.00
R5929:Dnah5	UTSW	15	28,311,354 (GRCm39)	missense	probably damaging	1.00
R5929:Dnah5	UTSW	15	28,311,353 (GRCm39)	missense	probably benign	0.01
R5931:Dnah5	UTSW	15	28,453,425 (GRCm39)	missense	probably damaging	0.99
R5964:Dnah5	UTSW	15	28,458,730 (GRCm39)	missense	possibly damaging	0.49
R5975:Dnah5	UTSW	15	28,234,428 (GRCm39)	missense	probably damaging	1.00
R5993:Dnah5	UTSW	15	28,299,372 (GRCm39)	missense	probably benign	0.09
R6016:Dnah5	UTSW	15	28,328,030 (GRCm39)	missense	probably damaging	1.00
R6028:Dnah5	UTSW	15	28,387,979 (GRCm39)	missense	probably damaging	1.00
R6065:Dnah5	UTSW	15	28,230,614 (GRCm39)	missense	possibly damaging	0.47
R6117:Dnah5	UTSW	15	28,270,566 (GRCm39)	missense	probably damaging	0.99
R6143:Dnah5	UTSW	15	28,233,377 (GRCm39)	missense	probably benign	0.05
R6146:Dnah5	UTSW	15	28,459,331 (GRCm39)	missense	probably benign
R6154:Dnah5	UTSW	15	28,204,177 (GRCm39)	missense	probably benign	0.15
R6164:Dnah5	UTSW	15	28,378,489 (GRCm39)	missense	probably benign	0.08
R6321:Dnah5	UTSW	15	28,372,557 (GRCm39)	missense	probably damaging	0.99
R6349:Dnah5	UTSW	15	28,238,657 (GRCm39)	missense	probably damaging	1.00
R6431:Dnah5	UTSW	15	28,349,970 (GRCm39)	missense	possibly damaging	0.52
R6467:Dnah5	UTSW	15	28,438,329 (GRCm39)	missense	probably benign	0.10
R6564:Dnah5	UTSW	15	28,367,891 (GRCm39)	missense	probably benign
R6607:Dnah5	UTSW	15	28,445,346 (GRCm39)	missense	possibly damaging	0.95
R6619:Dnah5	UTSW	15	28,409,266 (GRCm39)	missense	probably benign	0.03
R6633:Dnah5	UTSW	15	28,293,933 (GRCm39)	missense	probably benign	0.27
R6647:Dnah5	UTSW	15	28,403,633 (GRCm39)	missense	probably benign	0.02
R6782:Dnah5	UTSW	15	28,449,302 (GRCm39)	missense	possibly damaging	0.89
R6797:Dnah5	UTSW	15	28,233,384 (GRCm39)	nonsense	probably null
R6797:Dnah5	UTSW	15	28,451,609 (GRCm39)	missense	probably damaging	1.00
R6831:Dnah5	UTSW	15	28,411,661 (GRCm39)	missense	possibly damaging	0.88
R6849:Dnah5	UTSW	15	28,278,770 (GRCm39)	missense	probably benign	0.14
R6871:Dnah5	UTSW	15	28,229,786 (GRCm39)	missense	probably benign	0.32
R6936:Dnah5	UTSW	15	28,409,414 (GRCm39)	missense	probably damaging	1.00
R6943:Dnah5	UTSW	15	28,235,866 (GRCm39)	missense	probably damaging	1.00
R7030:Dnah5	UTSW	15	28,333,208 (GRCm39)	missense	probably benign	0.00
R7030:Dnah5	UTSW	15	28,238,738 (GRCm39)	missense	probably benign
R7032:Dnah5	UTSW	15	28,326,796 (GRCm39)	missense	probably damaging	1.00
R7063:Dnah5	UTSW	15	28,233,394 (GRCm39)	missense	probably benign	0.00
R7094:Dnah5	UTSW	15	28,453,482 (GRCm39)	missense	probably damaging	0.98
R7097:Dnah5	UTSW	15	28,453,410 (GRCm39)	missense	probably benign	0.00
R7126:Dnah5	UTSW	15	28,349,983 (GRCm39)	missense	probably benign	0.03
R7153:Dnah5	UTSW	15	28,365,668 (GRCm39)	splice site	probably null
R7209:Dnah5	UTSW	15	28,459,371 (GRCm39)	missense	possibly damaging	0.71
R7276:Dnah5	UTSW	15	28,367,984 (GRCm39)	missense	probably damaging	1.00
R7320:Dnah5	UTSW	15	28,270,616 (GRCm39)	missense	probably null	0.33
R7350:Dnah5	UTSW	15	28,235,965 (GRCm39)	critical splice donor site	probably null
R7380:Dnah5	UTSW	15	28,370,524 (GRCm39)	missense	probably damaging	1.00
R7438:Dnah5	UTSW	15	28,347,098 (GRCm39)	missense	probably damaging	0.99
R7499:Dnah5	UTSW	15	28,302,596 (GRCm39)	missense	probably damaging	1.00
R7513:Dnah5	UTSW	15	28,370,561 (GRCm39)	missense	probably benign
R7519:Dnah5	UTSW	15	28,390,629 (GRCm39)	missense	probably damaging	0.98
R7524:Dnah5	UTSW	15	28,297,212 (GRCm39)	missense	possibly damaging	0.50
R7556:Dnah5	UTSW	15	28,290,389 (GRCm39)	missense	probably null	0.43
R7570:Dnah5	UTSW	15	28,347,098 (GRCm39)	missense	probably damaging	1.00
R7585:Dnah5	UTSW	15	28,402,014 (GRCm39)	missense	probably benign	0.09
R7642:Dnah5	UTSW	15	28,248,125 (GRCm39)	critical splice donor site	probably null
R7670:Dnah5	UTSW	15	28,246,378 (GRCm39)	splice site	probably null
R7763:Dnah5	UTSW	15	28,314,001 (GRCm39)	missense	probably damaging	1.00
R7821:Dnah5	UTSW	15	28,411,678 (GRCm39)	missense	possibly damaging	0.89
R7826:Dnah5	UTSW	15	28,367,958 (GRCm39)	missense	probably damaging	1.00
R7872:Dnah5	UTSW	15	28,245,830 (GRCm39)	missense	probably damaging	0.99
R7889:Dnah5	UTSW	15	28,448,560 (GRCm39)	nonsense	probably null
R7919:Dnah5	UTSW	15	28,350,742 (GRCm39)	missense	probably damaging	1.00
R7920:Dnah5	UTSW	15	28,453,368 (GRCm39)	missense	probably benign	0.00
R7936:Dnah5	UTSW	15	28,345,983 (GRCm39)	missense	possibly damaging	0.64
R7996:Dnah5	UTSW	15	28,409,323 (GRCm39)	missense	probably damaging	0.98
R8063:Dnah5	UTSW	15	28,230,729 (GRCm39)	missense	probably benign
R8084:Dnah5	UTSW	15	28,388,099 (GRCm39)	missense	probably damaging	1.00
R8105:Dnah5	UTSW	15	28,372,548 (GRCm39)	missense	probably benign
R8114:Dnah5	UTSW	15	28,240,122 (GRCm39)	missense	probably benign	0.01
R8142:Dnah5	UTSW	15	28,384,519 (GRCm39)	missense	probably benign	0.36
R8153:Dnah5	UTSW	15	28,384,576 (GRCm39)	missense	probably damaging	1.00
R8161:Dnah5	UTSW	15	28,350,850 (GRCm39)	missense	possibly damaging	0.79
R8174:Dnah5	UTSW	15	28,311,279 (GRCm39)	splice site	probably null
R8187:Dnah5	UTSW	15	28,384,355 (GRCm39)	missense	probably damaging	1.00
R8194:Dnah5	UTSW	15	28,453,414 (GRCm39)	missense	probably damaging	0.99
R8280:Dnah5	UTSW	15	28,408,538 (GRCm39)	missense	probably benign	0.01
R8291:Dnah5	UTSW	15	28,263,743 (GRCm39)	missense	probably benign	0.03
R8324:Dnah5	UTSW	15	28,347,011 (GRCm39)	missense	probably damaging	1.00
R8347:Dnah5	UTSW	15	28,236,812 (GRCm39)	missense	possibly damaging	0.90
R8356:Dnah5	UTSW	15	28,444,313 (GRCm39)	missense	probably benign	0.03
R8356:Dnah5	UTSW	15	28,444,469 (GRCm39)	missense	probably null	0.02
R8361:Dnah5	UTSW	15	28,331,956 (GRCm39)	missense	probably damaging	0.98
R8375:Dnah5	UTSW	15	28,327,489 (GRCm39)	missense	probably benign	0.00
R8474:Dnah5	UTSW	15	28,247,978 (GRCm39)	missense	probably benign	0.00
R8481:Dnah5	UTSW	15	28,419,941 (GRCm39)	missense	probably benign	0.00
R8494:Dnah5	UTSW	15	28,345,977 (GRCm39)	missense	probably benign	0.32
R8495:Dnah5	UTSW	15	28,409,414 (GRCm39)	missense	probably damaging	0.97
R8519:Dnah5	UTSW	15	28,299,245 (GRCm39)	missense	probably benign	0.07
R8683:Dnah5	UTSW	15	28,289,367 (GRCm39)	missense	probably benign	0.00
R8739:Dnah5	UTSW	15	28,346,006 (GRCm39)	missense	probably benign	0.01
R8752:Dnah5	UTSW	15	28,290,365 (GRCm39)	missense	probably benign	0.00
R8784:Dnah5	UTSW	15	28,388,097 (GRCm39)	missense	probably benign	0.16
R8813:Dnah5	UTSW	15	28,229,719 (GRCm39)	missense	probably damaging	1.00
R8862:Dnah5	UTSW	15	28,459,502 (GRCm39)	splice site	probably benign
R8873:Dnah5	UTSW	15	28,219,334 (GRCm39)	missense	probably benign
R8885:Dnah5	UTSW	15	28,327,886 (GRCm39)	missense	probably damaging	1.00
R8901:Dnah5	UTSW	15	28,365,715 (GRCm39)	missense	possibly damaging	0.76
R9025:Dnah5	UTSW	15	28,409,412 (GRCm39)	missense	probably damaging	1.00
R9037:Dnah5	UTSW	15	28,248,104 (GRCm39)	missense	probably benign	0.05
R9057:Dnah5	UTSW	15	28,391,014 (GRCm39)	missense	probably damaging	1.00
R9059:Dnah5	UTSW	15	28,245,812 (GRCm39)	missense	probably benign
R9065:Dnah5	UTSW	15	28,293,936 (GRCm39)	missense	probably benign	0.09
R9098:Dnah5	UTSW	15	28,420,107 (GRCm39)	missense
R9118:Dnah5	UTSW	15	28,401,994 (GRCm39)	frame shift	probably null
R9149:Dnah5	UTSW	15	28,387,914 (GRCm39)	missense	probably benign	0.00
R9184:Dnah5	UTSW	15	28,340,552 (GRCm39)	missense	probably benign	0.13
R9205:Dnah5	UTSW	15	28,448,480 (GRCm39)	missense	possibly damaging	0.88
R9297:Dnah5	UTSW	15	28,204,054 (GRCm39)	start gained	probably benign
R9302:Dnah5	UTSW	15	28,240,032 (GRCm39)	missense	probably benign	0.03
R9310:Dnah5	UTSW	15	28,448,579 (GRCm39)	missense	probably damaging	1.00
R9318:Dnah5	UTSW	15	28,204,054 (GRCm39)	start gained	probably benign
R9405:Dnah5	UTSW	15	28,272,306 (GRCm39)	missense	probably benign
R9424:Dnah5	UTSW	15	28,272,286 (GRCm39)	missense	probably benign	0.01
R9467:Dnah5	UTSW	15	28,366,293 (GRCm39)	missense	possibly damaging	0.94
R9469:Dnah5	UTSW	15	28,421,146 (GRCm39)	missense	probably benign	0.06
R9548:Dnah5	UTSW	15	28,328,025 (GRCm39)	missense	possibly damaging	0.79
R9564:Dnah5	UTSW	15	28,290,422 (GRCm39)	missense	probably benign	0.04
R9576:Dnah5	UTSW	15	28,272,286 (GRCm39)	missense	probably benign	0.01
R9593:Dnah5	UTSW	15	28,236,774 (GRCm39)	missense	probably benign
R9644:Dnah5	UTSW	15	28,230,650 (GRCm39)	missense	probably damaging	0.98
R9655:Dnah5	UTSW	15	28,242,900 (GRCm39)	missense	probably benign
R9657:Dnah5	UTSW	15	28,410,089 (GRCm39)	missense	probably damaging	1.00
R9704:Dnah5	UTSW	15	28,247,965 (GRCm39)	missense	probably benign	0.00
R9797:Dnah5	UTSW	15	28,233,316 (GRCm39)	missense	probably benign	0.34
RF009:Dnah5	UTSW	15	28,204,165 (GRCm39)	missense	probably benign	0.00
X0011:Dnah5	UTSW	15	28,408,527 (GRCm39)	missense	probably benign	0.16
X0018:Dnah5	UTSW	15	28,269,500 (GRCm39)	missense	probably benign	0.00
X0022:Dnah5	UTSW	15	28,270,557 (GRCm39)	missense	probably benign	0.01
X0023:Dnah5	UTSW	15	28,384,454 (GRCm39)	missense	probably damaging	0.99
X0028:Dnah5	UTSW	15	28,470,623 (GRCm39)	missense	probably damaging	1.00
Z1088:Dnah5	UTSW	15	28,366,503 (GRCm39)	missense	probably null	0.10
Z1088:Dnah5	UTSW	15	28,384,376 (GRCm39)	missense	probably damaging	1.00
Z1177:Dnah5	UTSW	15	28,295,457 (GRCm39)	missense	probably damaging	0.98
Z1177:Dnah5	UTSW	15	28,270,549 (GRCm39)	missense	probably benign	0.00
Z1177:Dnah5	UTSW	15	28,270,500 (GRCm39)	missense	probably benign	0.32
Z1177:Dnah5	UTSW	15	28,387,909 (GRCm39)	missense	possibly damaging	0.72

Predicted Primers

PCR Primer
(F):5'- ACTCCCGGGTCTCTATTGTG -3'
(R):5'- AAACACGTGTTTGTCTCTCTGC -3'

Sequencing Primer
(F):5'- GGGTCTCTATTGTGCAGTCATCC -3'
(R):5'- GCCTTCCTGTCTCTTCTTGAG -3'

Posted On

2018-03-15