Incidental Mutation 'R6272:Or5w20'
ID 507379
Institutional Source Beutler Lab
Gene Symbol Or5w20
Ensembl Gene ENSMUSG00000048197
Gene Name olfactory receptor family 5 subfamily W member 20
Synonyms Olfr1153, MOR177-7, GA_x6K02T2Q125-49395950-49396882
MMRRC Submission 044442-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.186) question?
Stock # R6272 (G1)
Quality Score 225.009
Status Validated
Chromosome 2
Chromosomal Location 87726521-87727477 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to A at 87727001 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Isoleucine at position 153 (V153I)
Ref Sequence ENSEMBL: ENSMUSP00000150945 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000052300] [ENSMUST00000215017] [ENSMUST00000215862] [ENSMUST00000217436]
AlphaFold A2AVC0
Predicted Effect probably benign
Transcript: ENSMUST00000052300
AA Change: V161I

PolyPhen 2 Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)
SMART Domains Protein: ENSMUSP00000057839
Gene: ENSMUSG00000048197
AA Change: V161I

DomainStartEndE-ValueType
Pfam:7tm_4 38 315 4.9e-45 PFAM
Pfam:7tm_1 48 297 5.9e-17 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000215017
Predicted Effect probably benign
Transcript: ENSMUST00000215862
Predicted Effect probably benign
Transcript: ENSMUST00000217436
AA Change: V153I

PolyPhen 2 Score 0.005 (Sensitivity: 0.97; Specificity: 0.74)
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.6%
  • 10x: 98.2%
  • 20x: 95.3%
Validation Efficiency 98% (55/56)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 59 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adgra3 A T 5: 50,166,791 (GRCm39) M187K possibly damaging Het
Adgrg3 A G 8: 95,762,889 (GRCm39) I189V noncoding transcript Het
Ampd1 A G 3: 102,992,699 (GRCm39) K147R possibly damaging Het
Apbb2 T C 5: 66,468,415 (GRCm39) T561A probably damaging Het
Arfgef3 A T 10: 18,522,711 (GRCm39) D438E probably benign Het
Atxn1 T A 13: 45,721,238 (GRCm39) Q219L possibly damaging Het
AW551984 A T 9: 39,509,333 (GRCm39) D269E probably benign Het
Cryab A G 9: 50,665,825 (GRCm39) K72R possibly damaging Het
Dbn1 G A 13: 55,622,917 (GRCm39) A522V probably benign Het
Dip2a A T 10: 76,122,241 (GRCm39) *158R probably null Het
Edrf1 C T 7: 133,239,537 (GRCm39) probably benign Het
Ern2 A T 7: 121,775,869 (GRCm39) D408E probably benign Het
F830016B08Rik T C 18: 60,433,150 (GRCm39) S78P probably damaging Het
Fah C A 7: 84,244,753 (GRCm39) G137C probably damaging Het
Foxd3 A G 4: 99,544,977 (GRCm39) D39G probably damaging Het
Gprin3 G A 6: 59,330,316 (GRCm39) Q664* probably null Het
H2-Ob T C 17: 34,461,618 (GRCm39) I119T probably benign Het
H3c6 A T 13: 23,746,400 (GRCm39) V47E probably damaging Het
Hmgcll1 G A 9: 76,037,627 (GRCm39) G174R probably damaging Het
Kbtbd11 T A 8: 15,079,118 (GRCm39) C572* probably null Het
Kynu A T 2: 43,525,001 (GRCm39) N315Y probably benign Het
Map1lc3b G A 8: 122,323,429 (GRCm39) E100K probably benign Het
Matn2 T A 15: 34,355,753 (GRCm39) Q33L possibly damaging Het
Mettl8 T C 2: 70,806,419 (GRCm39) probably null Het
Neto1 A T 18: 86,512,940 (GRCm39) N312Y probably damaging Het
Nhsl1 A G 10: 18,400,253 (GRCm39) D493G probably benign Het
Nup210l A G 3: 90,077,331 (GRCm39) E889G possibly damaging Het
Or13l2 A G 3: 97,318,207 (GRCm39) F97L probably benign Het
Or14c42-ps1 A G 7: 86,211,081 (GRCm39) Y47C unknown Het
Or2y13 C A 11: 49,414,953 (GRCm39) S134R possibly damaging Het
Or5ac25 A C 16: 59,181,948 (GRCm39) M211R possibly damaging Het
Or6k2 C T 1: 173,986,741 (GRCm39) T134I probably benign Het
Or8g4 A T 9: 39,661,816 (GRCm39) M45L probably benign Het
Otx1 C A 11: 21,947,037 (GRCm39) A91S probably damaging Het
Phc2 A G 4: 128,603,440 (GRCm39) Y190C probably damaging Het
Platr25 T C 13: 62,820,811 (GRCm39) T347A possibly damaging Het
Plec T C 15: 76,059,053 (GRCm39) E3655G probably damaging Het
Plekhg3 A T 12: 76,623,619 (GRCm39) Q954L probably benign Het
Pnpla1 G A 17: 29,100,342 (GRCm39) G403E probably benign Het
Prdm4 G A 10: 85,743,694 (GRCm39) T187I possibly damaging Het
Prg4 T C 1: 150,330,517 (GRCm39) probably benign Het
Prpf18 G A 2: 4,638,258 (GRCm39) R312W probably damaging Het
Rnf213 T A 11: 119,305,374 (GRCm39) V535D probably damaging Het
Rtcb A T 10: 85,791,638 (GRCm39) N39K probably damaging Het
Slc4a3 G A 1: 75,531,341 (GRCm39) probably null Het
Szt2 A C 4: 118,231,487 (GRCm39) probably benign Het
Tasor2 C T 13: 3,631,891 (GRCm39) R870H possibly damaging Het
Tfap2e A T 4: 126,615,657 (GRCm39) V259D probably damaging Het
Trav19 A G 14: 54,083,255 (GRCm39) D110G probably damaging Het
Ttc17 A C 2: 94,189,100 (GRCm39) C749W probably damaging Het
Ttc8 A G 12: 98,948,753 (GRCm39) K490E possibly damaging Het
Ube4b A G 4: 149,471,590 (GRCm39) S99P probably damaging Het
Ubqln3 C T 7: 103,791,385 (GRCm39) R235H probably damaging Het
Vmn2r61 A T 7: 41,949,242 (GRCm39) D554V probably damaging Het
Vmn2r70 A T 7: 85,208,194 (GRCm39) V761E probably damaging Het
Vmn2r97 T C 17: 19,167,861 (GRCm39) I705T possibly damaging Het
Wwox G A 8: 115,215,692 (GRCm39) C155Y probably damaging Het
Zfp451 T C 1: 33,842,325 (GRCm39) probably benign Het
Zfp582 C T 7: 6,356,844 (GRCm39) P219L probably damaging Het
Other mutations in Or5w20
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01075:Or5w20 APN 2 87,727,265 (GRCm39) missense probably benign 0.00
IGL02024:Or5w20 APN 2 87,727,243 (GRCm39) missense possibly damaging 0.81
IGL02219:Or5w20 APN 2 87,727,317 (GRCm39) missense possibly damaging 0.93
IGL02693:Or5w20 APN 2 87,726,877 (GRCm39) missense probably damaging 1.00
R0121:Or5w20 UTSW 2 87,727,434 (GRCm39) missense possibly damaging 0.93
R0315:Or5w20 UTSW 2 87,727,410 (GRCm39) missense probably damaging 1.00
R0446:Or5w20 UTSW 2 87,727,199 (GRCm39) missense possibly damaging 0.51
R0472:Or5w20 UTSW 2 87,726,837 (GRCm39) missense possibly damaging 0.47
R0720:Or5w20 UTSW 2 87,727,013 (GRCm39) missense probably benign 0.31
R1579:Or5w20 UTSW 2 87,727,286 (GRCm39) missense probably benign 0.05
R1968:Or5w20 UTSW 2 87,727,383 (GRCm39) missense probably damaging 1.00
R3909:Or5w20 UTSW 2 87,727,293 (GRCm39) splice site probably null
R4936:Or5w20 UTSW 2 87,727,157 (GRCm39) missense probably benign 0.06
R5520:Or5w20 UTSW 2 87,726,753 (GRCm39) unclassified probably benign
R5585:Or5w20 UTSW 2 87,727,019 (GRCm39) missense possibly damaging 0.54
R6176:Or5w20 UTSW 2 87,727,280 (GRCm39) missense probably benign 0.18
R6451:Or5w20 UTSW 2 87,726,935 (GRCm39) missense probably damaging 1.00
R7312:Or5w20 UTSW 2 87,726,755 (GRCm39) missense possibly damaging 0.54
R7350:Or5w20 UTSW 2 87,726,753 (GRCm39) unclassified probably benign
R8060:Or5w20 UTSW 2 87,727,317 (GRCm39) missense probably damaging 1.00
R8752:Or5w20 UTSW 2 87,726,591 (GRCm39) missense possibly damaging 0.66
R9474:Or5w20 UTSW 2 87,726,693 (GRCm39) missense probably benign 0.00
R9710:Or5w20 UTSW 2 87,726,902 (GRCm39) missense probably damaging 1.00
Z1088:Or5w20 UTSW 2 87,726,977 (GRCm39) missense probably benign 0.05
Predicted Primers PCR Primer
(F):5'- GCAGTTGGACCCAAGATGTTG -3'
(R):5'- ATGGTGCTCAGCTCAATAAACCC -3'

Sequencing Primer
(F):5'- TGGTGGGCCTTATATTCAAGAAC -3'
(R):5'- GTGCTCAGCTCAATAAACCCAAATAG -3'
Posted On 2018-03-15