Incidental Mutation 'R6273:Vmn2r14'
| ID |
507453 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn2r14
|
| Ensembl Gene |
ENSMUSG00000091059 |
| Gene Name |
vomeronasal 2, receptor 14 |
| Synonyms |
EG231591 |
| MMRRC Submission |
044443-MU
|
| Accession Numbers |
|
| Essential gene? |
Possibly non essential
(E-score: 0.469)
|
| Stock # |
R6273 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
5 |
| Chromosomal Location |
109362822-109372488 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to T
at 109369133 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Tryptophan to Arginine
at position 147
(W147R)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000128015
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000170341]
|
| AlphaFold |
E9Q759 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000170341
AA Change: W147R
PolyPhen 2
Score 0.445 (Sensitivity: 0.89; Specificity: 0.90)
|
| SMART Domains |
Protein: ENSMUSP00000128015
Gene: ENSMUSG00000091059
AA Change: W147R
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
26 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
76 |
466 |
8.3e-31 |
PFAM |
|
Pfam:NCD3G
|
507 |
561 |
1.1e-17 |
PFAM |
|
Pfam:7tm_3
|
594 |
829 |
1.2e-55 |
PFAM |
|
| Coding Region Coverage |
- 1x: 99.9%
- 3x: 99.6%
- 10x: 98.0%
- 20x: 94.2%
|
| Validation Efficiency |
98% (78/80) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 78 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 0610040J01Rik |
T |
A |
5: 64,055,561 (GRCm39) |
I99N |
probably damaging |
Het |
| Ank3 |
G |
A |
10: 69,838,395 (GRCm39) |
R1566K |
possibly damaging |
Het |
| Ankrd31 |
A |
G |
13: 96,988,181 (GRCm39) |
I1065V |
possibly damaging |
Het |
| Aox1 |
A |
G |
1: 58,378,831 (GRCm39) |
T1027A |
probably benign |
Het |
| Atm |
G |
A |
9: 53,399,222 (GRCm39) |
P1593L |
probably benign |
Het |
| Atp13a5 |
T |
G |
16: 29,167,555 (GRCm39) |
I132L |
probably benign |
Het |
| BC035044 |
A |
G |
6: 128,867,852 (GRCm39) |
|
probably benign |
Het |
| Cadm3 |
CT |
C |
1: 173,176,691 (GRCm39) |
|
probably benign |
Homo |
| Car3 |
C |
T |
3: 14,936,677 (GRCm39) |
P247S |
probably benign |
Het |
| Ccdc7a |
T |
C |
8: 129,513,819 (GRCm39) |
Y160C |
probably damaging |
Het |
| Cd1d1 |
A |
G |
3: 86,905,564 (GRCm39) |
V143A |
probably benign |
Het |
| Cemip2 |
T |
A |
19: 21,779,369 (GRCm39) |
V393E |
probably damaging |
Het |
| Cog6 |
A |
T |
3: 52,903,473 (GRCm39) |
F142I |
probably damaging |
Het |
| Cracd |
A |
T |
5: 77,005,568 (GRCm39) |
D643V |
unknown |
Het |
| Crhr1 |
T |
G |
11: 104,054,682 (GRCm39) |
N98K |
possibly damaging |
Het |
| Csf1 |
A |
G |
3: 107,656,479 (GRCm39) |
V72A |
probably damaging |
Het |
| Cwc15 |
T |
A |
9: 14,421,537 (GRCm39) |
I201K |
probably benign |
Het |
| Dgka |
T |
C |
10: 128,559,515 (GRCm39) |
K482R |
probably benign |
Het |
| Dnah7b |
T |
C |
1: 46,281,476 (GRCm39) |
S2846P |
possibly damaging |
Het |
| Dst |
T |
A |
1: 34,314,347 (GRCm39) |
I4199N |
probably damaging |
Het |
| Dusp7 |
A |
G |
9: 106,251,095 (GRCm39) |
T407A |
possibly damaging |
Het |
| Eml2 |
G |
A |
7: 18,935,088 (GRCm39) |
V432I |
probably damaging |
Het |
| Fem1a |
T |
C |
17: 56,564,083 (GRCm39) |
Y59H |
possibly damaging |
Het |
| Fetub |
C |
T |
16: 22,751,081 (GRCm39) |
R143C |
probably damaging |
Het |
| Filip1 |
A |
T |
9: 79,723,168 (GRCm39) |
D1150E |
probably benign |
Het |
| Gabra1 |
A |
G |
11: 42,031,138 (GRCm39) |
V264A |
probably damaging |
Het |
| Gm4131 |
T |
C |
14: 62,702,299 (GRCm39) |
E223G |
probably damaging |
Het |
| Gon4l |
T |
C |
3: 88,763,156 (GRCm39) |
V333A |
probably damaging |
Het |
| Gsk3b |
A |
G |
16: 38,028,408 (GRCm39) |
T289A |
probably benign |
Het |
| Hmcn2 |
T |
C |
2: 31,301,846 (GRCm39) |
S2912P |
probably damaging |
Het |
| Htr7 |
A |
T |
19: 36,018,969 (GRCm39) |
|
probably benign |
Het |
| Ibsp |
A |
G |
5: 104,458,167 (GRCm39) |
T235A |
probably benign |
Het |
| Ints13 |
A |
T |
6: 146,467,179 (GRCm39) |
D116E |
probably damaging |
Het |
| Irag1 |
G |
T |
7: 110,470,790 (GRCm39) |
H848N |
probably benign |
Het |
| Kctd19 |
T |
C |
8: 106,112,117 (GRCm39) |
N753S |
probably benign |
Het |
| Mdn1 |
A |
G |
4: 32,715,979 (GRCm39) |
N2054D |
probably benign |
Het |
| Mink1 |
A |
T |
11: 70,502,261 (GRCm39) |
K880* |
probably null |
Het |
| Myo15b |
T |
A |
11: 115,753,625 (GRCm39) |
L824Q |
possibly damaging |
Het |
| Napepld |
T |
C |
5: 21,870,320 (GRCm39) |
E366G |
probably benign |
Het |
| Obscn |
T |
A |
11: 58,967,819 (GRCm39) |
T2662S |
possibly damaging |
Het |
| Or2g7 |
T |
G |
17: 38,378,686 (GRCm39) |
L208R |
probably damaging |
Het |
| Or2n1b |
T |
A |
17: 38,459,833 (GRCm39) |
M118K |
possibly damaging |
Het |
| Or4k52 |
T |
C |
2: 111,611,567 (GRCm39) |
F301L |
probably benign |
Het |
| Or52p1 |
A |
G |
7: 104,267,102 (GRCm39) |
D72G |
probably damaging |
Het |
| Or5b12 |
A |
G |
19: 12,896,764 (GRCm39) |
V303A |
probably benign |
Het |
| Or6d13 |
A |
G |
6: 116,518,277 (GRCm39) |
T288A |
possibly damaging |
Het |
| Pah |
T |
C |
10: 87,412,077 (GRCm39) |
|
probably null |
Het |
| Panx3 |
T |
G |
9: 37,578,725 (GRCm39) |
I85L |
probably benign |
Het |
| Pate4 |
T |
C |
9: 35,519,086 (GRCm39) |
N94D |
probably benign |
Het |
| Pde4d |
A |
G |
13: 110,086,755 (GRCm39) |
M610V |
possibly damaging |
Het |
| Pik3c2b |
T |
C |
1: 132,994,449 (GRCm39) |
S138P |
probably benign |
Het |
| Pkn1 |
T |
C |
8: 84,398,899 (GRCm39) |
N696S |
probably damaging |
Het |
| Plppr2 |
A |
G |
9: 21,855,801 (GRCm39) |
E258G |
probably damaging |
Het |
| Plxnd1 |
A |
T |
6: 115,955,453 (GRCm39) |
M538K |
probably damaging |
Het |
| Prepl |
G |
T |
17: 85,390,696 (GRCm39) |
N87K |
probably benign |
Het |
| Prkag2 |
C |
A |
5: 25,152,534 (GRCm39) |
R190L |
probably damaging |
Het |
| Rara |
A |
G |
11: 98,861,048 (GRCm39) |
T179A |
probably benign |
Het |
| Rfx7 |
A |
G |
9: 72,524,279 (GRCm39) |
K490E |
possibly damaging |
Het |
| Rgsl1 |
C |
T |
1: 153,703,211 (GRCm39) |
V147M |
possibly damaging |
Het |
| Rph3a |
A |
G |
5: 121,083,485 (GRCm39) |
I595T |
possibly damaging |
Het |
| Rsf1 |
CG |
CGACGGCGGTG |
7: 97,229,115 (GRCm39) |
|
probably benign |
Homo |
| Slc35e2 |
C |
T |
4: 155,694,483 (GRCm39) |
P10L |
probably benign |
Het |
| Slc8a2 |
T |
C |
7: 15,879,259 (GRCm39) |
F582L |
possibly damaging |
Het |
| Sprr2e |
A |
G |
3: 92,260,171 (GRCm39) |
M1V |
probably null |
Het |
| Steap1 |
T |
A |
5: 5,790,827 (GRCm39) |
R40S |
possibly damaging |
Het |
| Tbc1d2 |
C |
T |
4: 46,629,912 (GRCm39) |
G252R |
probably benign |
Het |
| Thsd7a |
A |
T |
6: 12,408,835 (GRCm39) |
V729E |
probably damaging |
Het |
| Tmprss13 |
A |
G |
9: 45,256,630 (GRCm39) |
Y525C |
probably damaging |
Het |
| Tnik |
A |
T |
3: 28,631,649 (GRCm39) |
H383L |
possibly damaging |
Het |
| Vars1 |
T |
C |
17: 35,232,719 (GRCm39) |
L881S |
probably damaging |
Het |
| Vmn1r201 |
A |
C |
13: 22,659,385 (GRCm39) |
S200R |
probably damaging |
Het |
| Vmn2r130 |
A |
T |
17: 23,295,759 (GRCm39) |
H643L |
probably benign |
Het |
| Vps53 |
T |
C |
11: 75,992,844 (GRCm39) |
E367G |
probably benign |
Het |
| Xab2 |
C |
T |
8: 3,661,822 (GRCm39) |
G544S |
probably damaging |
Het |
| Ythdf3 |
T |
A |
3: 16,259,020 (GRCm39) |
V400E |
possibly damaging |
Het |
| Zfand5 |
C |
T |
19: 21,257,060 (GRCm39) |
P147S |
probably benign |
Het |
| Zfp768 |
A |
T |
7: 126,944,319 (GRCm39) |
|
probably null |
Het |
| Zswim8 |
A |
G |
14: 20,763,521 (GRCm39) |
M423V |
probably benign |
Het |
|
| Other mutations in Vmn2r14 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01472:Vmn2r14
|
APN |
5 |
109,364,180 (GRCm39) |
nonsense |
probably null |
|
|
IGL01504:Vmn2r14
|
APN |
5 |
109,369,285 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL01828:Vmn2r14
|
APN |
5 |
109,372,443 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
IGL02093:Vmn2r14
|
APN |
5 |
109,368,275 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
IGL02103:Vmn2r14
|
APN |
5 |
109,372,349 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL02123:Vmn2r14
|
APN |
5 |
109,367,933 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02145:Vmn2r14
|
APN |
5 |
109,368,454 (GRCm39) |
nonsense |
probably null |
|
|
IGL02676:Vmn2r14
|
APN |
5 |
109,367,882 (GRCm39) |
missense |
probably benign |
0.03 |
|
IGL02720:Vmn2r14
|
APN |
5 |
109,369,305 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02877:Vmn2r14
|
APN |
5 |
109,368,054 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02974:Vmn2r14
|
APN |
5 |
109,369,292 (GRCm39) |
missense |
possibly damaging |
0.55 |
|
IGL03151:Vmn2r14
|
APN |
5 |
109,364,260 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03297:Vmn2r14
|
APN |
5 |
109,363,973 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03386:Vmn2r14
|
APN |
5 |
109,368,350 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
IGL03394:Vmn2r14
|
APN |
5 |
109,367,702 (GRCm39) |
missense |
probably null |
0.83 |
|
ANU74:Vmn2r14
|
UTSW |
5 |
109,366,910 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0316:Vmn2r14
|
UTSW |
5 |
109,366,762 (GRCm39) |
missense |
probably benign |
0.07 |
|
R0755:Vmn2r14
|
UTSW |
5 |
109,364,226 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R1219:Vmn2r14
|
UTSW |
5 |
109,372,440 (GRCm39) |
missense |
probably benign |
0.17 |
|
R1321:Vmn2r14
|
UTSW |
5 |
109,364,117 (GRCm39) |
missense |
probably benign |
0.08 |
|
R1465:Vmn2r14
|
UTSW |
5 |
109,368,195 (GRCm39) |
missense |
possibly damaging |
0.47 |
|
R1465:Vmn2r14
|
UTSW |
5 |
109,368,195 (GRCm39) |
missense |
possibly damaging |
0.47 |
|
R1509:Vmn2r14
|
UTSW |
5 |
109,363,862 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1551:Vmn2r14
|
UTSW |
5 |
109,369,283 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1628:Vmn2r14
|
UTSW |
5 |
109,367,838 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1668:Vmn2r14
|
UTSW |
5 |
109,366,913 (GRCm39) |
nonsense |
probably null |
|
|
R2013:Vmn2r14
|
UTSW |
5 |
109,369,109 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2201:Vmn2r14
|
UTSW |
5 |
109,366,698 (GRCm39) |
splice site |
probably null |
|
|
R2417:Vmn2r14
|
UTSW |
5 |
109,372,329 (GRCm39) |
missense |
probably benign |
0.00 |
|
R3029:Vmn2r14
|
UTSW |
5 |
109,363,776 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3120:Vmn2r14
|
UTSW |
5 |
109,372,431 (GRCm39) |
missense |
probably null |
0.00 |
|
R3729:Vmn2r14
|
UTSW |
5 |
109,364,095 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3762:Vmn2r14
|
UTSW |
5 |
109,368,033 (GRCm39) |
missense |
probably benign |
0.02 |
|
R3943:Vmn2r14
|
UTSW |
5 |
109,363,930 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3944:Vmn2r14
|
UTSW |
5 |
109,363,930 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4222:Vmn2r14
|
UTSW |
5 |
109,364,149 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4224:Vmn2r14
|
UTSW |
5 |
109,364,149 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4239:Vmn2r14
|
UTSW |
5 |
109,364,277 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R4240:Vmn2r14
|
UTSW |
5 |
109,364,277 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R4782:Vmn2r14
|
UTSW |
5 |
109,369,370 (GRCm39) |
missense |
probably benign |
0.01 |
|
R4832:Vmn2r14
|
UTSW |
5 |
109,363,976 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4884:Vmn2r14
|
UTSW |
5 |
109,369,384 (GRCm39) |
splice site |
probably null |
|
|
R4896:Vmn2r14
|
UTSW |
5 |
109,368,246 (GRCm39) |
missense |
probably benign |
0.19 |
|
R5004:Vmn2r14
|
UTSW |
5 |
109,368,246 (GRCm39) |
missense |
probably benign |
0.19 |
|
R5117:Vmn2r14
|
UTSW |
5 |
109,363,961 (GRCm39) |
missense |
probably benign |
0.16 |
|
R5285:Vmn2r14
|
UTSW |
5 |
109,365,442 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R5413:Vmn2r14
|
UTSW |
5 |
109,369,154 (GRCm39) |
missense |
probably benign |
0.29 |
|
R5569:Vmn2r14
|
UTSW |
5 |
109,368,261 (GRCm39) |
missense |
probably benign |
0.44 |
|
R5701:Vmn2r14
|
UTSW |
5 |
109,367,816 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5726:Vmn2r14
|
UTSW |
5 |
109,365,486 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R5763:Vmn2r14
|
UTSW |
5 |
109,363,724 (GRCm39) |
missense |
possibly damaging |
0.49 |
|
R5872:Vmn2r14
|
UTSW |
5 |
109,369,222 (GRCm39) |
missense |
probably benign |
|
|
R5985:Vmn2r14
|
UTSW |
5 |
109,368,082 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R6268:Vmn2r14
|
UTSW |
5 |
109,369,283 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R6409:Vmn2r14
|
UTSW |
5 |
109,364,096 (GRCm39) |
missense |
probably benign |
0.09 |
|
R6944:Vmn2r14
|
UTSW |
5 |
109,364,140 (GRCm39) |
missense |
probably benign |
0.06 |
|
R6944:Vmn2r14
|
UTSW |
5 |
109,363,925 (GRCm39) |
missense |
probably benign |
0.22 |
|
R7608:Vmn2r14
|
UTSW |
5 |
109,369,276 (GRCm39) |
missense |
probably benign |
0.03 |
|
R7740:Vmn2r14
|
UTSW |
5 |
109,368,324 (GRCm39) |
missense |
probably benign |
0.41 |
|
R7768:Vmn2r14
|
UTSW |
5 |
109,368,086 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7804:Vmn2r14
|
UTSW |
5 |
109,368,324 (GRCm39) |
missense |
probably benign |
0.41 |
|
R7872:Vmn2r14
|
UTSW |
5 |
109,369,219 (GRCm39) |
missense |
probably benign |
0.02 |
|
R7993:Vmn2r14
|
UTSW |
5 |
109,363,862 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8006:Vmn2r14
|
UTSW |
5 |
109,368,324 (GRCm39) |
missense |
probably benign |
0.41 |
|
R8007:Vmn2r14
|
UTSW |
5 |
109,368,324 (GRCm39) |
missense |
probably benign |
0.41 |
|
R8187:Vmn2r14
|
UTSW |
5 |
109,368,420 (GRCm39) |
missense |
probably benign |
0.03 |
|
R8369:Vmn2r14
|
UTSW |
5 |
109,369,342 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8463:Vmn2r14
|
UTSW |
5 |
109,369,340 (GRCm39) |
missense |
probably benign |
0.30 |
|
R8968:Vmn2r14
|
UTSW |
5 |
109,365,533 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9008:Vmn2r14
|
UTSW |
5 |
109,367,893 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9030:Vmn2r14
|
UTSW |
5 |
109,368,054 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9039:Vmn2r14
|
UTSW |
5 |
109,367,902 (GRCm39) |
nonsense |
probably null |
|
|
R9150:Vmn2r14
|
UTSW |
5 |
109,367,783 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9164:Vmn2r14
|
UTSW |
5 |
109,364,087 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9216:Vmn2r14
|
UTSW |
5 |
109,369,112 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9225:Vmn2r14
|
UTSW |
5 |
109,369,288 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9245:Vmn2r14
|
UTSW |
5 |
109,368,176 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R9342:Vmn2r14
|
UTSW |
5 |
109,368,428 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9472:Vmn2r14
|
UTSW |
5 |
109,367,962 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9678:Vmn2r14
|
UTSW |
5 |
109,364,041 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9774:Vmn2r14
|
UTSW |
5 |
109,369,126 (GRCm39) |
missense |
probably benign |
0.07 |
|
Z1177:Vmn2r14
|
UTSW |
5 |
109,367,741 (GRCm39) |
missense |
probably benign |
0.33 |
|
| Predicted Primers |
PCR Primer
(F):5'- TCTTGTAGGCACATGTAAATGGAC -3'
(R):5'- GTAATCTAGTTCAAGGTTGGCATTC -3'
Sequencing Primer
(F):5'- GAGTTCAATTCCCAGTAACCATGTGG -3'
(R):5'- CCAGCAAGAAGACATGAGTTTTTCC -3'
|
| Posted On |
2018-03-15 |
Incidental Mutation