Incidental Mutation 'IGL01140:Trmt10a'
ID 50795
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Trmt10a
Ensembl Gene ENSMUSG00000004127
Gene Name tRNA methyltransferase 10A
Synonyms 3110023L08Rik, Rg9mtd2
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # IGL01140
Quality Score
Status
Chromosome 3
Chromosomal Location 137849214-137865582 bp(+) (GRCm39)
Type of Mutation splice site
DNA Base Change (assembly) G to A at 137862459 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000125749 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000040321] [ENSMUST00000162864]
AlphaFold no structure available at present
Predicted Effect probably benign
Transcript: ENSMUST00000040321
SMART Domains Protein: ENSMUSP00000042082
Gene: ENSMUSG00000004127

DomainStartEndE-ValueType
low complexity region 44 82 N/A INTRINSIC
Pfam:tRNA_m1G_MT 111 277 3.7e-52 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000161791
Predicted Effect probably benign
Transcript: ENSMUST00000162864
SMART Domains Protein: ENSMUSP00000125749
Gene: ENSMUSG00000004127

DomainStartEndE-ValueType
low complexity region 44 82 N/A INTRINSIC
Pfam:tRNA_m1G_MT 111 277 2.7e-33 PFAM
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a protein that belongs to the tRNA (Guanine-1)-methyltransferase family. A similar gene in yeast modifies several different tRNA species. Mutations in this gene are associated with microcephaly, short stature, and impaired glucose metabolism. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit increased circulating magnesium level. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 43 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Afm A G 5: 90,672,726 (GRCm39) E187G probably damaging Het
Asap2 T C 12: 21,256,317 (GRCm39) V205A probably damaging Het
Atg16l1 A G 1: 87,702,575 (GRCm39) I279V probably benign Het
Atp2b2 C T 6: 113,766,932 (GRCm39) V436I possibly damaging Het
Cald1 T A 6: 34,739,196 (GRCm39) S640T possibly damaging Het
Cdc23 A G 18: 34,769,385 (GRCm39) Y460H probably benign Het
Cenpk T A 13: 104,372,742 (GRCm39) probably benign Het
Ctss A G 3: 95,446,036 (GRCm39) E52G probably damaging Het
Cuzd1 A T 7: 130,913,523 (GRCm39) C365S probably damaging Het
Cyp2c55 T C 19: 39,007,093 (GRCm39) L163P probably benign Het
Cyp4f37 T C 17: 32,848,027 (GRCm39) S182P probably benign Het
Flt4 G T 11: 49,525,770 (GRCm39) E740* probably null Het
Galntl6 T A 8: 58,411,356 (GRCm39) R291S probably damaging Het
Hydin G A 8: 111,124,694 (GRCm39) V568I probably benign Het
Ift70a1 A G 2: 75,810,259 (GRCm39) V608A probably benign Het
Kcnab3 A G 11: 69,220,705 (GRCm39) K145R probably benign Het
Lama1 T C 17: 68,109,928 (GRCm39) V2183A probably benign Het
Lrmda C T 14: 22,646,585 (GRCm39) A75V possibly damaging Het
Mbtd1 A G 11: 93,815,258 (GRCm39) E282G probably damaging Het
Muc19 A T 15: 91,783,593 (GRCm39) noncoding transcript Het
Mug1 A G 6: 121,859,693 (GRCm39) T1231A probably benign Het
Nkpd1 A G 7: 19,257,387 (GRCm39) T389A possibly damaging Het
Nudt19 A G 7: 35,247,336 (GRCm39) *358Q probably null Het
Nup160 G T 2: 90,530,909 (GRCm39) M522I possibly damaging Het
Obsl1 T A 1: 75,466,400 (GRCm39) probably benign Het
Or4m1 T A 14: 50,557,732 (GRCm39) I187F probably damaging Het
Or5ak24 T C 2: 85,260,484 (GRCm39) T230A probably benign Het
Or5b119 G A 19: 13,457,151 (GRCm39) T137I possibly damaging Het
Osbpl10 C T 9: 115,005,070 (GRCm39) P341S probably benign Het
Papola C A 12: 105,775,856 (GRCm39) C7* probably null Het
Pld1 C A 3: 28,132,386 (GRCm39) L525I probably benign Het
Prom2 T C 2: 127,373,125 (GRCm39) probably benign Het
Psmb5 G A 14: 54,855,264 (GRCm39) T62I possibly damaging Het
Sag A G 1: 87,751,086 (GRCm39) E184G probably benign Het
Slc16a10 T C 10: 39,952,921 (GRCm39) Y191C probably damaging Het
Slc22a22 T C 15: 57,126,734 (GRCm39) T93A probably damaging Het
Ssx2ip A G 3: 146,133,598 (GRCm39) Y231C probably benign Het
Trib1 A G 15: 59,523,476 (GRCm39) Y170C probably damaging Het
Troap G T 15: 98,980,027 (GRCm39) Q402H probably damaging Het
Vmn2r70 G A 7: 85,214,379 (GRCm39) Q258* probably null Het
Zfp128 A G 7: 12,624,949 (GRCm39) Y439C probably benign Het
Zmym1 A G 4: 126,943,435 (GRCm39) F318L probably damaging Het
Zswim2 A G 2: 83,745,672 (GRCm39) S589P probably benign Het
Other mutations in Trmt10a
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00562:Trmt10a APN 3 137,853,177 (GRCm39) missense probably damaging 0.97
IGL00563:Trmt10a APN 3 137,853,177 (GRCm39) missense probably damaging 0.97
IGL00771:Trmt10a APN 3 137,856,216 (GRCm39) missense probably benign 0.08
IGL02869:Trmt10a APN 3 137,857,945 (GRCm39) splice site probably null
R0898:Trmt10a UTSW 3 137,855,279 (GRCm39) missense probably damaging 1.00
R0975:Trmt10a UTSW 3 137,862,570 (GRCm39) missense probably benign 0.41
R1511:Trmt10a UTSW 3 137,857,945 (GRCm39) splice site probably null
R1872:Trmt10a UTSW 3 137,862,481 (GRCm39) missense probably damaging 1.00
R4856:Trmt10a UTSW 3 137,854,146 (GRCm39) nonsense probably null
R4880:Trmt10a UTSW 3 137,857,972 (GRCm39) missense possibly damaging 0.64
R4886:Trmt10a UTSW 3 137,854,146 (GRCm39) nonsense probably null
R5399:Trmt10a UTSW 3 137,853,265 (GRCm39) missense probably damaging 0.97
R5516:Trmt10a UTSW 3 137,857,957 (GRCm39) missense possibly damaging 0.91
R5994:Trmt10a UTSW 3 137,862,475 (GRCm39) missense probably damaging 1.00
R7272:Trmt10a UTSW 3 137,860,527 (GRCm39) missense probably damaging 1.00
X0028:Trmt10a UTSW 3 137,860,556 (GRCm39) missense probably damaging 1.00
Posted On 2013-06-21