Incidental Mutation 'R6281:Gpr15'
ID |
507976 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Gpr15
|
Ensembl Gene |
ENSMUSG00000047293 |
Gene Name |
G protein-coupled receptor 15 |
Synonyms |
4933439K08Rik |
MMRRC Submission |
044451-MU
|
Accession Numbers |
|
Essential gene? |
Non essential
(E-score: 0.000)
|
Stock # |
R6281 (G1)
|
Quality Score |
225.009 |
Status
|
Validated
|
Chromosome |
16 |
Chromosomal Location |
58537796-58539433 bp(-) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
A to G
at 58538957 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Phenylalanine to Serine
at position 44
(F44S)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000086731
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000089318]
|
AlphaFold |
Q0VDU3 |
Predicted Effect |
probably damaging
Transcript: ENSMUST00000089318
AA Change: F44S
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
SMART Domains |
Protein: ENSMUSP00000086731 Gene: ENSMUSG00000047293 AA Change: F44S
Domain | Start | End | E-Value | Type |
Pfam:7tm_1
|
50 |
302 |
1.3e-46 |
PFAM |
Pfam:7TM_GPCR_Srv
|
66 |
317 |
7.1e-9 |
PFAM |
|
Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000231342
|
Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000232532
|
Meta Mutation Damage Score |
0.8576 |
Coding Region Coverage |
- 1x: 99.9%
- 3x: 99.7%
- 10x: 98.5%
- 20x: 95.9%
|
Validation Efficiency |
100% (40/40) |
MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a G protein-coupled receptor that acts as a chemokine receptor for human immunodeficiency virus type 1 and 2. The encoded protein localizes to the cell membrane. [provided by RefSeq, Nov 2012] PHENOTYPE: Mice homozygous for a a knock-out allele exhibit impaired regulatory T cell homing in the large intestine mucosa. [provided by MGI curators]
|
Allele List at MGI |
|
Other mutations in this stock |
Total: 40 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
1700018B08Rik |
C |
A |
8: 122,258,620 (GRCm39) |
C166F |
probably damaging |
Het |
Aida |
C |
T |
1: 183,103,145 (GRCm39) |
A237V |
probably damaging |
Het |
Ankib1 |
T |
C |
5: 3,751,965 (GRCm39) |
T692A |
possibly damaging |
Het |
As3mt |
T |
C |
19: 46,713,362 (GRCm39) |
V303A |
possibly damaging |
Het |
Bhlhe40 |
T |
A |
6: 108,641,423 (GRCm39) |
|
probably null |
Het |
Bhmt2 |
G |
A |
13: 93,799,668 (GRCm39) |
P256L |
probably damaging |
Het |
Bpifb1 |
T |
C |
2: 154,048,385 (GRCm39) |
I140T |
probably damaging |
Het |
Cat |
A |
T |
2: 103,302,114 (GRCm39) |
H194Q |
probably damaging |
Het |
Cbfa2t3 |
C |
A |
8: 123,360,148 (GRCm39) |
R466L |
probably damaging |
Het |
Fancm |
T |
C |
12: 65,135,044 (GRCm39) |
V279A |
probably damaging |
Het |
Gabra2 |
T |
C |
5: 71,192,105 (GRCm39) |
T75A |
probably damaging |
Het |
Gm11595 |
G |
A |
11: 99,663,381 (GRCm39) |
R100C |
unknown |
Het |
Gm3512 |
T |
A |
14: 7,159,254 (GRCm38) |
D7V |
possibly damaging |
Het |
Ighv1-72 |
C |
A |
12: 115,722,023 (GRCm39) |
C5F |
probably benign |
Het |
Lilra6 |
A |
G |
7: 3,914,972 (GRCm39) |
L474P |
probably damaging |
Het |
Mboat2 |
T |
C |
12: 25,007,678 (GRCm39) |
V297A |
probably benign |
Het |
Muc2 |
C |
G |
7: 141,306,140 (GRCm39) |
C276W |
probably damaging |
Het |
Ncor1 |
T |
C |
11: 62,264,371 (GRCm39) |
S141G |
possibly damaging |
Het |
Or4k77 |
T |
C |
2: 111,199,894 (GRCm39) |
*306R |
probably null |
Het |
Or5p80 |
T |
G |
7: 108,229,609 (GRCm39) |
S137A |
probably benign |
Het |
Pax5 |
T |
G |
4: 44,691,955 (GRCm39) |
E97A |
probably benign |
Het |
Pcdhga11 |
A |
T |
18: 37,890,426 (GRCm39) |
D478V |
probably damaging |
Het |
Peg10 |
GAT |
GATCAT |
6: 4,756,449 (GRCm39) |
|
probably benign |
Het |
Phf21b |
G |
T |
15: 84,738,946 (GRCm39) |
D38E |
probably benign |
Het |
Ptcd1 |
T |
C |
5: 145,101,881 (GRCm39) |
K146R |
probably benign |
Het |
Rad23a |
A |
T |
8: 85,564,739 (GRCm39) |
M166K |
probably damaging |
Het |
Rfc4 |
A |
T |
16: 22,936,816 (GRCm39) |
|
probably null |
Het |
Slc17a3 |
T |
A |
13: 24,040,782 (GRCm39) |
I336N |
probably benign |
Het |
Slc2a12 |
T |
A |
10: 22,541,219 (GRCm39) |
M358K |
probably damaging |
Het |
Stk31 |
T |
G |
6: 49,446,114 (GRCm39) |
M939R |
possibly damaging |
Het |
Tecrl |
T |
A |
5: 83,442,453 (GRCm39) |
T167S |
probably damaging |
Het |
Tfap2d |
G |
C |
1: 19,174,702 (GRCm39) |
G52R |
probably benign |
Het |
Ttn |
C |
T |
2: 76,772,172 (GRCm39) |
V2577M |
probably damaging |
Het |
Uox |
C |
T |
3: 146,330,332 (GRCm39) |
R163* |
probably null |
Het |
Vezt |
G |
A |
10: 93,809,808 (GRCm39) |
R578C |
probably benign |
Het |
Vmn2r111 |
T |
C |
17: 22,778,032 (GRCm39) |
N549S |
possibly damaging |
Het |
Vwa3b |
T |
A |
1: 37,163,063 (GRCm39) |
L562Q |
probably damaging |
Het |
Zfyve27 |
T |
A |
19: 42,171,194 (GRCm39) |
N127K |
probably damaging |
Het |
Znfx1 |
A |
G |
2: 166,897,805 (GRCm39) |
F373S |
probably damaging |
Het |
Zswim8 |
G |
A |
14: 20,764,708 (GRCm39) |
V693I |
probably benign |
Het |
|
Other mutations in Gpr15 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL00473:Gpr15
|
APN |
16 |
58,538,441 (GRCm39) |
missense |
probably damaging |
0.99 |
IGL02616:Gpr15
|
APN |
16 |
58,538,567 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL03381:Gpr15
|
APN |
16 |
58,538,339 (GRCm39) |
missense |
probably damaging |
1.00 |
PIT4418001:Gpr15
|
UTSW |
16 |
58,538,313 (GRCm39) |
missense |
probably benign |
0.13 |
R1484:Gpr15
|
UTSW |
16 |
58,538,937 (GRCm39) |
missense |
probably damaging |
1.00 |
R1775:Gpr15
|
UTSW |
16 |
58,538,921 (GRCm39) |
missense |
probably benign |
0.05 |
R1959:Gpr15
|
UTSW |
16 |
58,538,370 (GRCm39) |
missense |
probably benign |
0.03 |
R1961:Gpr15
|
UTSW |
16 |
58,538,370 (GRCm39) |
missense |
probably benign |
0.03 |
R2127:Gpr15
|
UTSW |
16 |
58,538,618 (GRCm39) |
missense |
possibly damaging |
0.67 |
R3825:Gpr15
|
UTSW |
16 |
58,538,723 (GRCm39) |
missense |
probably damaging |
1.00 |
R4957:Gpr15
|
UTSW |
16 |
58,538,537 (GRCm39) |
missense |
probably damaging |
0.99 |
R5098:Gpr15
|
UTSW |
16 |
58,538,890 (GRCm39) |
missense |
probably damaging |
1.00 |
R5180:Gpr15
|
UTSW |
16 |
58,538,248 (GRCm39) |
missense |
probably benign |
0.07 |
R5668:Gpr15
|
UTSW |
16 |
58,538,013 (GRCm39) |
missense |
probably damaging |
1.00 |
R6104:Gpr15
|
UTSW |
16 |
58,538,339 (GRCm39) |
missense |
probably damaging |
1.00 |
R6921:Gpr15
|
UTSW |
16 |
58,538,144 (GRCm39) |
missense |
probably benign |
0.00 |
R6980:Gpr15
|
UTSW |
16 |
58,539,105 (GRCm39) |
start gained |
probably benign |
|
R6981:Gpr15
|
UTSW |
16 |
58,538,548 (GRCm39) |
missense |
probably benign |
0.44 |
R7252:Gpr15
|
UTSW |
16 |
58,538,760 (GRCm39) |
missense |
probably damaging |
1.00 |
R7643:Gpr15
|
UTSW |
16 |
58,538,179 (GRCm39) |
nonsense |
probably null |
|
R7680:Gpr15
|
UTSW |
16 |
58,538,328 (GRCm39) |
missense |
probably damaging |
1.00 |
R7844:Gpr15
|
UTSW |
16 |
58,538,873 (GRCm39) |
missense |
probably damaging |
1.00 |
R7954:Gpr15
|
UTSW |
16 |
58,539,047 (GRCm39) |
missense |
probably benign |
0.00 |
R8100:Gpr15
|
UTSW |
16 |
58,538,076 (GRCm39) |
missense |
probably benign |
0.00 |
R8372:Gpr15
|
UTSW |
16 |
58,538,850 (GRCm39) |
missense |
probably benign |
0.09 |
R9414:Gpr15
|
UTSW |
16 |
58,538,516 (GRCm39) |
missense |
probably benign |
0.03 |
R9729:Gpr15
|
UTSW |
16 |
58,538,249 (GRCm39) |
missense |
possibly damaging |
0.70 |
|
Predicted Primers |
PCR Primer
(F):5'- GGAAAGAGCCAGTCCTCCATAG -3'
(R):5'- GGTGTACATCAAGACGCTCC -3'
Sequencing Primer
(F):5'- AGTCCTCCATAGTCCTAGAGAGG -3'
(R):5'- GTACATCAAGACGCTCCCTTGG -3'
|
Posted On |
2018-03-15 |