Incidental Mutation 'R6282:Cuedc1'
ID 508008
Institutional Source Beutler Lab
Gene Symbol Cuedc1
Ensembl Gene ENSMUSG00000018378
Gene Name CUE domain containing 1
Synonyms C330016O16Rik
MMRRC Submission 044452-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R6282 (G1)
Quality Score 225.009
Status Validated
Chromosome 11
Chromosomal Location 87989972-88084966 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 88074228 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Asparagine to Serine at position 254 (N254S)
Ref Sequence ENSEMBL: ENSMUSP00000120867 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000018522] [ENSMUST00000154812]
AlphaFold Q8R3V6
Predicted Effect probably damaging
Transcript: ENSMUST00000018522
AA Change: N254S

PolyPhen 2 Score 0.996 (Sensitivity: 0.55; Specificity: 0.98)
SMART Domains Protein: ENSMUSP00000018522
Gene: ENSMUSG00000018378
AA Change: N254S

DomainStartEndE-ValueType
low complexity region 6 33 N/A INTRINSIC
CUE 50 92 6.55e-15 SMART
low complexity region 94 110 N/A INTRINSIC
low complexity region 121 136 N/A INTRINSIC
low complexity region 207 222 N/A INTRINSIC
low complexity region 331 340 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000125297
Predicted Effect noncoding transcript
Transcript: ENSMUST00000132377
Predicted Effect noncoding transcript
Transcript: ENSMUST00000133149
Predicted Effect noncoding transcript
Transcript: ENSMUST00000142564
Predicted Effect probably damaging
Transcript: ENSMUST00000154812
AA Change: N254S

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000120867
Gene: ENSMUSG00000018378
AA Change: N254S

DomainStartEndE-ValueType
low complexity region 6 33 N/A INTRINSIC
CUE 50 92 6.55e-15 SMART
low complexity region 94 110 N/A INTRINSIC
low complexity region 121 136 N/A INTRINSIC
low complexity region 207 222 N/A INTRINSIC
Meta Mutation Damage Score 0.3863 question?
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.7%
  • 10x: 98.6%
  • 20x: 96.3%
Validation Efficiency 98% (45/46)
Allele List at MGI
Other mutations in this stock
Total: 45 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700001O22Rik A T 2: 30,690,781 (GRCm39) L185Q possibly damaging Het
Abca6 A T 11: 110,099,650 (GRCm39) C966S probably damaging Het
Atp13a4 A T 16: 29,252,822 (GRCm39) I708N probably benign Het
Axin1 C G 17: 26,362,011 (GRCm39) D118E probably damaging Het
Bace2 A T 16: 97,216,297 (GRCm39) I297F probably damaging Het
Ccdc30 T A 4: 119,181,214 (GRCm39) D649V probably damaging Het
Cd180 G A 13: 102,830,265 (GRCm39) A20T possibly damaging Het
Cdk18 T C 1: 132,047,758 (GRCm39) D112G probably damaging Het
Dnah7a T C 1: 53,542,760 (GRCm39) H2470R probably damaging Het
Drap1 G A 19: 5,474,464 (GRCm39) probably null Het
Fbxo5 T A 10: 5,751,216 (GRCm39) K257M probably damaging Het
Gm11595 G A 11: 99,663,381 (GRCm39) R100C unknown Het
Gm12790 A G 4: 101,824,713 (GRCm39) V185A possibly damaging Het
Gm7361 A G 5: 26,465,411 (GRCm39) N136S probably benign Het
Il10ra C A 9: 45,171,703 (GRCm39) C255F probably damaging Het
Insyn2b A G 11: 34,352,819 (GRCm39) D287G possibly damaging Het
Itgam A T 7: 127,684,114 (GRCm39) T340S probably benign Het
Ktn1 A T 14: 47,901,428 (GRCm39) N62I probably damaging Het
Ldb2 A G 5: 44,690,007 (GRCm39) L204P probably damaging Het
Map2k4 T C 11: 65,597,842 (GRCm39) T90A possibly damaging Het
Mettl3 A T 14: 52,535,428 (GRCm39) D287E probably benign Het
Mier2 A G 10: 79,380,576 (GRCm39) F278S probably damaging Het
Mis18bp1 A G 12: 65,195,937 (GRCm39) M609T probably benign Het
Myo1d A T 11: 80,448,338 (GRCm39) V929D probably damaging Het
Naprt A T 15: 75,763,828 (GRCm39) M364K probably benign Het
Nod2 T A 8: 89,397,088 (GRCm39) C833S probably benign Het
Nrip3 C T 7: 109,362,686 (GRCm39) probably null Het
Ntsr2 A G 12: 16,708,426 (GRCm39) Y320C probably damaging Het
Or14j8 G A 17: 38,263,315 (GRCm39) S200F possibly damaging Het
Or4p7 C A 2: 88,221,877 (GRCm39) C95* probably null Het
Or51h1 G A 7: 102,308,854 (GRCm39) M275I probably benign Het
Osbpl3 A T 6: 50,325,063 (GRCm39) probably null Het
Pcdhb3 C T 18: 37,434,699 (GRCm39) R222C probably damaging Het
Pik3cd G T 4: 149,744,200 (GRCm39) R184S probably benign Het
Pramel32 T C 4: 88,548,291 (GRCm39) E38G probably damaging Het
Rad50 A T 11: 53,560,597 (GRCm39) probably null Het
Rad51ap2 A T 12: 11,507,560 (GRCm39) H494L probably benign Het
Rbm25 T C 12: 83,722,863 (GRCm39) M762T probably damaging Het
Sars1 G T 3: 108,335,590 (GRCm39) S338* probably null Het
Usp35 T C 7: 96,975,155 (GRCm39) E6G probably damaging Het
Vash2 T C 1: 190,692,422 (GRCm39) Y251C probably benign Het
Vmn2r111 T C 17: 22,778,032 (GRCm39) N549S possibly damaging Het
Wdr20 T A 12: 110,763,443 (GRCm39) probably benign Het
Wfdc1 G A 8: 120,406,146 (GRCm39) C87Y probably damaging Het
Zfp985 T A 4: 147,667,805 (GRCm39) H224Q probably benign Het
Other mutations in Cuedc1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01129:Cuedc1 APN 11 88,074,080 (GRCm39) missense possibly damaging 0.56
IGL02103:Cuedc1 APN 11 88,079,625 (GRCm39) missense probably damaging 0.99
IGL02325:Cuedc1 APN 11 88,060,999 (GRCm39) missense probably null 1.00
IGL03001:Cuedc1 APN 11 88,073,315 (GRCm39) missense probably benign 0.02
IGL03245:Cuedc1 APN 11 88,068,088 (GRCm39) splice site probably benign
R0242:Cuedc1 UTSW 11 88,075,447 (GRCm39) splice site probably benign
R0511:Cuedc1 UTSW 11 88,074,231 (GRCm39) missense probably damaging 1.00
R1013:Cuedc1 UTSW 11 88,078,853 (GRCm39) missense possibly damaging 0.68
R1382:Cuedc1 UTSW 11 88,068,189 (GRCm39) missense probably benign 0.08
R2004:Cuedc1 UTSW 11 88,068,216 (GRCm39) missense probably damaging 1.00
R5320:Cuedc1 UTSW 11 88,068,136 (GRCm39) missense probably damaging 1.00
R5381:Cuedc1 UTSW 11 88,078,812 (GRCm39) splice site probably null
R5782:Cuedc1 UTSW 11 88,060,858 (GRCm39) missense probably damaging 1.00
R6918:Cuedc1 UTSW 11 88,077,899 (GRCm39) missense probably benign 0.00
R7329:Cuedc1 UTSW 11 88,060,692 (GRCm39) missense unknown
R7985:Cuedc1 UTSW 11 88,073,342 (GRCm39) missense probably benign 0.16
R8289:Cuedc1 UTSW 11 88,073,381 (GRCm39) missense probably benign
R9632:Cuedc1 UTSW 11 88,060,955 (GRCm39) missense possibly damaging 0.92
Predicted Primers PCR Primer
(F):5'- TGCGCATACAGCTGTACATGG -3'
(R):5'- AAACCCGGAGCTCCTGAATG -3'

Sequencing Primer
(F):5'- CGCATACAGCTGTACATGGATTTAAG -3'
(R):5'- GAGCTCCTGAATGACCCAG -3'
Posted On 2018-03-15