Incidental Mutation 'R6283:Tmem265'
ID 508052
Institutional Source Beutler Lab
Gene Symbol Tmem265
Ensembl Gene ENSMUSG00000106715
Gene Name transmembrane protein 265
Synonyms
MMRRC Submission 044453-MU
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.343) question?
Stock # R6283 (G1)
Quality Score 225.009
Status Validated
Chromosome 7
Chromosomal Location 127160395-127164443 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to G at 127164044 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Glycine at position 86 (V86G)
Ref Sequence ENSEMBL: ENSMUSP00000081611 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000084563] [ENSMUST00000186954] [ENSMUST00000187040] [ENSMUST00000189629] [ENSMUST00000190278] [ENSMUST00000190390]
AlphaFold E9Q8G3
Predicted Effect possibly damaging
Transcript: ENSMUST00000084563
AA Change: V86G

PolyPhen 2 Score 0.891 (Sensitivity: 0.82; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000081611
Gene: ENSMUSG00000106715
AA Change: V86G

DomainStartEndE-ValueType
low complexity region 2 29 N/A INTRINSIC
AT_hook 62 74 4.04e0 SMART
low complexity region 114 134 N/A INTRINSIC
AT_hook 142 154 4.46e-1 SMART
low complexity region 155 166 N/A INTRINSIC
low complexity region 175 202 N/A INTRINSIC
AT_hook 206 218 3.94e-1 SMART
low complexity region 251 262 N/A INTRINSIC
low complexity region 263 273 N/A INTRINSIC
low complexity region 360 396 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000186954
SMART Domains Protein: ENSMUSP00000139536
Gene: ENSMUSG00000053877

DomainStartEndE-ValueType
low complexity region 26 48 N/A INTRINSIC
HSA 125 196 5.4e-25 SMART
low complexity region 257 280 N/A INTRINSIC
low complexity region 283 310 N/A INTRINSIC
low complexity region 322 347 N/A INTRINSIC
low complexity region 396 420 N/A INTRINSIC
low complexity region 480 558 N/A INTRINSIC
low complexity region 577 592 N/A INTRINSIC
DEXDc 626 818 5e-37 SMART
low complexity region 993 1001 N/A INTRINSIC
low complexity region 1027 1042 N/A INTRINSIC
low complexity region 1046 1063 N/A INTRINSIC
low complexity region 1175 1194 N/A INTRINSIC
internal_repeat_1 1202 1245 2.24e-5 PROSPERO
low complexity region 1274 1302 N/A INTRINSIC
low complexity region 1304 1318 N/A INTRINSIC
low complexity region 1335 1353 N/A INTRINSIC
low complexity region 1355 1370 N/A INTRINSIC
low complexity region 1414 1441 N/A INTRINSIC
low complexity region 1452 1466 N/A INTRINSIC
low complexity region 1504 1533 N/A INTRINSIC
internal_repeat_1 1536 1579 2.24e-5 PROSPERO
internal_repeat_2 1537 1559 5.66e-5 PROSPERO
internal_repeat_2 1569 1589 5.66e-5 PROSPERO
low complexity region 1590 1607 N/A INTRINSIC
low complexity region 1609 1627 N/A INTRINSIC
low complexity region 1644 1678 N/A INTRINSIC
low complexity region 1713 1726 N/A INTRINSIC
low complexity region 1828 1840 N/A INTRINSIC
HELICc 1916 1999 1.2e-28 SMART
low complexity region 2058 2078 N/A INTRINSIC
coiled coil region 2166 2201 N/A INTRINSIC
low complexity region 2282 2348 N/A INTRINSIC
low complexity region 2374 2409 N/A INTRINSIC
low complexity region 2588 2600 N/A INTRINSIC
low complexity region 2642 2657 N/A INTRINSIC
low complexity region 2685 2712 N/A INTRINSIC
AT_hook 2745 2757 2.4e-2 SMART
low complexity region 2797 2817 N/A INTRINSIC
AT_hook 2825 2837 2.6e-3 SMART
low complexity region 2838 2849 N/A INTRINSIC
low complexity region 2858 2885 N/A INTRINSIC
AT_hook 2889 2901 2.4e-3 SMART
low complexity region 2934 2945 N/A INTRINSIC
low complexity region 2946 2956 N/A INTRINSIC
low complexity region 3043 3079 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000187040
SMART Domains Protein: ENSMUSP00000140036
Gene: ENSMUSG00000053877

DomainStartEndE-ValueType
low complexity region 26 48 N/A INTRINSIC
HSA 125 196 5.4e-25 SMART
low complexity region 257 280 N/A INTRINSIC
low complexity region 283 310 N/A INTRINSIC
low complexity region 322 347 N/A INTRINSIC
low complexity region 396 420 N/A INTRINSIC
low complexity region 480 558 N/A INTRINSIC
low complexity region 577 592 N/A INTRINSIC
DEXDc 626 818 5e-37 SMART
low complexity region 993 1001 N/A INTRINSIC
low complexity region 1027 1042 N/A INTRINSIC
low complexity region 1046 1063 N/A INTRINSIC
low complexity region 1120 1143 N/A INTRINSIC
low complexity region 1150 1178 N/A INTRINSIC
low complexity region 1277 1305 N/A INTRINSIC
low complexity region 1332 1351 N/A INTRINSIC
internal_repeat_1 1359 1402 1.78e-5 PROSPERO
low complexity region 1431 1459 N/A INTRINSIC
low complexity region 1461 1475 N/A INTRINSIC
low complexity region 1492 1510 N/A INTRINSIC
low complexity region 1512 1527 N/A INTRINSIC
low complexity region 1571 1598 N/A INTRINSIC
low complexity region 1609 1623 N/A INTRINSIC
low complexity region 1661 1690 N/A INTRINSIC
internal_repeat_1 1693 1736 1.78e-5 PROSPERO
internal_repeat_2 1694 1716 4.56e-5 PROSPERO
internal_repeat_2 1726 1746 4.56e-5 PROSPERO
low complexity region 1747 1764 N/A INTRINSIC
low complexity region 1766 1784 N/A INTRINSIC
low complexity region 1801 1835 N/A INTRINSIC
low complexity region 1870 1883 N/A INTRINSIC
low complexity region 1985 1997 N/A INTRINSIC
HELICc 2073 2156 1.2e-28 SMART
low complexity region 2215 2235 N/A INTRINSIC
coiled coil region 2323 2358 N/A INTRINSIC
low complexity region 2439 2505 N/A INTRINSIC
low complexity region 2531 2566 N/A INTRINSIC
low complexity region 2745 2757 N/A INTRINSIC
low complexity region 2799 2814 N/A INTRINSIC
low complexity region 2842 2869 N/A INTRINSIC
AT_hook 2902 2914 2.4e-2 SMART
low complexity region 2954 2974 N/A INTRINSIC
AT_hook 2982 2994 2.6e-3 SMART
low complexity region 2995 3006 N/A INTRINSIC
low complexity region 3015 3042 N/A INTRINSIC
AT_hook 3046 3058 2.4e-3 SMART
low complexity region 3091 3102 N/A INTRINSIC
low complexity region 3103 3113 N/A INTRINSIC
low complexity region 3200 3236 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000189629
SMART Domains Protein: ENSMUSP00000139644
Gene: ENSMUSG00000107023

DomainStartEndE-ValueType
low complexity region 7 29 N/A INTRINSIC
HSA 106 177 5.4e-25 SMART
low complexity region 238 261 N/A INTRINSIC
low complexity region 264 291 N/A INTRINSIC
low complexity region 303 328 N/A INTRINSIC
low complexity region 377 401 N/A INTRINSIC
low complexity region 461 539 N/A INTRINSIC
low complexity region 558 573 N/A INTRINSIC
DEXDc 607 799 5e-37 SMART
low complexity region 974 982 N/A INTRINSIC
low complexity region 1008 1023 N/A INTRINSIC
low complexity region 1027 1044 N/A INTRINSIC
low complexity region 1156 1175 N/A INTRINSIC
internal_repeat_1 1183 1226 2e-5 PROSPERO
low complexity region 1255 1283 N/A INTRINSIC
low complexity region 1285 1299 N/A INTRINSIC
low complexity region 1316 1334 N/A INTRINSIC
low complexity region 1336 1351 N/A INTRINSIC
low complexity region 1395 1422 N/A INTRINSIC
low complexity region 1433 1447 N/A INTRINSIC
low complexity region 1485 1514 N/A INTRINSIC
internal_repeat_1 1517 1560 2e-5 PROSPERO
internal_repeat_2 1518 1540 5.08e-5 PROSPERO
internal_repeat_2 1550 1570 5.08e-5 PROSPERO
low complexity region 1571 1588 N/A INTRINSIC
low complexity region 1590 1608 N/A INTRINSIC
low complexity region 1625 1659 N/A INTRINSIC
low complexity region 1694 1707 N/A INTRINSIC
low complexity region 1809 1821 N/A INTRINSIC
HELICc 1897 1980 1.2e-28 SMART
low complexity region 2039 2059 N/A INTRINSIC
coiled coil region 2147 2182 N/A INTRINSIC
low complexity region 2263 2329 N/A INTRINSIC
low complexity region 2355 2390 N/A INTRINSIC
low complexity region 2569 2581 N/A INTRINSIC
low complexity region 2623 2638 N/A INTRINSIC
low complexity region 2666 2693 N/A INTRINSIC
AT_hook 2726 2738 2.4e-2 SMART
low complexity region 2778 2798 N/A INTRINSIC
AT_hook 2806 2818 2.6e-3 SMART
low complexity region 2819 2830 N/A INTRINSIC
low complexity region 2839 2866 N/A INTRINSIC
AT_hook 2870 2882 2.4e-3 SMART
low complexity region 2915 2926 N/A INTRINSIC
low complexity region 2927 2937 N/A INTRINSIC
low complexity region 3024 3060 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000190278
SMART Domains Protein: ENSMUSP00000144111
Gene: ENSMUSG00000106715

DomainStartEndE-ValueType
transmembrane domain 33 55 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000190390
SMART Domains Protein: ENSMUSP00000139399
Gene: ENSMUSG00000053877

DomainStartEndE-ValueType
low complexity region 26 48 N/A INTRINSIC
HSA 125 196 5.4e-25 SMART
low complexity region 257 280 N/A INTRINSIC
low complexity region 283 310 N/A INTRINSIC
low complexity region 322 347 N/A INTRINSIC
low complexity region 396 420 N/A INTRINSIC
low complexity region 480 558 N/A INTRINSIC
low complexity region 577 592 N/A INTRINSIC
DEXDc 626 818 5e-37 SMART
low complexity region 993 1001 N/A INTRINSIC
low complexity region 1027 1042 N/A INTRINSIC
low complexity region 1046 1063 N/A INTRINSIC
low complexity region 1120 1143 N/A INTRINSIC
low complexity region 1150 1178 N/A INTRINSIC
low complexity region 1271 1290 N/A INTRINSIC
internal_repeat_1 1298 1341 2.01e-5 PROSPERO
low complexity region 1370 1398 N/A INTRINSIC
low complexity region 1400 1414 N/A INTRINSIC
low complexity region 1431 1449 N/A INTRINSIC
low complexity region 1451 1466 N/A INTRINSIC
low complexity region 1510 1537 N/A INTRINSIC
low complexity region 1548 1562 N/A INTRINSIC
low complexity region 1600 1629 N/A INTRINSIC
internal_repeat_1 1632 1675 2.01e-5 PROSPERO
internal_repeat_2 1633 1655 5.11e-5 PROSPERO
internal_repeat_2 1665 1685 5.11e-5 PROSPERO
low complexity region 1686 1703 N/A INTRINSIC
low complexity region 1705 1723 N/A INTRINSIC
low complexity region 1740 1774 N/A INTRINSIC
low complexity region 1809 1822 N/A INTRINSIC
low complexity region 1924 1936 N/A INTRINSIC
HELICc 2012 2095 1.2e-28 SMART
low complexity region 2154 2174 N/A INTRINSIC
coiled coil region 2262 2297 N/A INTRINSIC
low complexity region 2378 2444 N/A INTRINSIC
low complexity region 2470 2505 N/A INTRINSIC
low complexity region 2684 2696 N/A INTRINSIC
low complexity region 2738 2753 N/A INTRINSIC
low complexity region 2781 2808 N/A INTRINSIC
AT_hook 2841 2853 2.4e-2 SMART
low complexity region 2893 2913 N/A INTRINSIC
AT_hook 2921 2933 2.6e-3 SMART
low complexity region 2934 2945 N/A INTRINSIC
low complexity region 2954 2981 N/A INTRINSIC
AT_hook 2985 2997 2.4e-3 SMART
low complexity region 3030 3041 N/A INTRINSIC
low complexity region 3042 3052 N/A INTRINSIC
low complexity region 3139 3175 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000190938
Predicted Effect probably benign
Transcript: ENSMUST00000206825
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.6%
  • 10x: 98.0%
  • 20x: 94.1%
Validation Efficiency 100% (59/59)
Allele List at MGI
Other mutations in this stock
Total: 58 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acsf3 C A 8: 123,512,694 (GRCm39) R372S probably damaging Het
Adamts20 A G 15: 94,249,602 (GRCm39) S472P probably benign Het
Bhlhe40 T C 6: 108,641,992 (GRCm39) L312P probably damaging Het
Ccdc180 A G 4: 45,902,486 (GRCm39) E305G possibly damaging Het
Ccdc83 T A 7: 89,885,615 (GRCm39) R257* probably null Het
Cd209e G A 8: 3,899,212 (GRCm39) Q167* probably null Het
Cd300e G A 11: 114,945,380 (GRCm39) T138I probably benign Het
Ces2c A T 8: 105,576,331 (GRCm39) M115L probably benign Het
Cfap61 T A 2: 145,971,022 (GRCm39) probably null Het
Chd1l G A 3: 97,494,483 (GRCm39) A399V probably damaging Het
Cic C T 7: 24,985,459 (GRCm39) S301L probably damaging Het
Cks2 A G 13: 51,799,495 (GRCm39) H16R probably benign Het
Copa A T 1: 171,946,415 (GRCm39) H953L possibly damaging Het
Ctdsp2 T C 10: 126,831,749 (GRCm39) V145A possibly damaging Het
Cyp2j13 A G 4: 95,945,074 (GRCm39) V377A possibly damaging Het
Dhx57 A G 17: 80,582,234 (GRCm39) V404A probably benign Het
Dock2 T C 11: 34,598,152 (GRCm39) S340G probably damaging Het
Ggps1 A G 13: 14,232,379 (GRCm39) probably null Het
Gm10549 C A 18: 33,597,358 (GRCm39) probably benign Het
Gm11444 T C 11: 85,737,617 (GRCm39) probably null Het
Grina A G 15: 76,132,751 (GRCm39) T173A possibly damaging Het
Hcrtr1 G A 4: 130,029,133 (GRCm39) T223I probably benign Het
Igsf10 T A 3: 59,226,870 (GRCm39) T2268S probably damaging Het
Inhca G A 9: 103,159,834 (GRCm39) R14* probably null Het
Ino80d C T 1: 63,101,285 (GRCm39) R447Q probably damaging Het
Inpp4b C T 8: 82,497,462 (GRCm39) T94M probably damaging Het
Itga2 A G 13: 115,005,786 (GRCm39) Y465H probably damaging Het
Knl1 A G 2: 118,900,767 (GRCm39) T823A probably damaging Het
Krtap4-16 A G 11: 99,741,861 (GRCm39) S180P unknown Het
Ldc1 A G 4: 130,115,534 (GRCm39) S5P probably benign Het
Lpar6 A T 14: 73,476,297 (GRCm39) D86V probably damaging Het
Muc5ac C A 7: 141,370,601 (GRCm39) C2500* probably null Het
Mzf1 T C 7: 12,787,296 (GRCm39) probably benign Het
Or4f58 A C 2: 111,851,605 (GRCm39) M198R possibly damaging Het
Or5d46 T A 2: 88,170,002 (GRCm39) I31N probably benign Het
Or5m3 G T 2: 85,838,443 (GRCm39) V108L possibly damaging Het
Or7a36 T C 10: 78,820,113 (GRCm39) V163A probably benign Het
Otogl T G 10: 107,626,361 (GRCm39) E1501A probably damaging Het
Pcdh10 T A 3: 45,335,989 (GRCm39) S768T possibly damaging Het
Pcnx2 G T 8: 126,604,325 (GRCm39) Q644K probably damaging Het
Pdzd9 T A 7: 120,259,449 (GRCm39) I180F possibly damaging Het
Pinx1 A C 14: 64,115,621 (GRCm39) N152T probably benign Het
Prr14l T C 5: 32,987,608 (GRCm39) E629G probably benign Het
Qpctl T A 7: 18,882,345 (GRCm39) I104F probably benign Het
Rabep1 C T 11: 70,808,505 (GRCm39) A444V probably damaging Het
Rnf150 A G 8: 83,717,183 (GRCm39) Y230C probably damaging Het
Slc25a27 A C 17: 43,968,621 (GRCm39) V152G probably damaging Het
Swt1 A G 1: 151,260,084 (GRCm39) S772P possibly damaging Het
Tenm4 A G 7: 96,523,701 (GRCm39) T1711A probably benign Het
Tfap2d G C 1: 19,174,702 (GRCm39) G52R probably benign Het
Trpm8 C T 1: 88,276,054 (GRCm39) H551Y probably benign Het
Ttc6 T G 12: 57,749,048 (GRCm39) Y1327D possibly damaging Het
Uevld G T 7: 46,587,729 (GRCm39) Q324K possibly damaging Het
Vmn2r111 T C 17: 22,778,032 (GRCm39) N549S possibly damaging Het
Vmn2r73 C T 7: 85,521,049 (GRCm39) M306I probably benign Het
Vmn2r93 T A 17: 18,524,366 (GRCm39) M120K probably benign Het
Zfp804b T A 5: 6,819,908 (GRCm39) I1016F probably benign Het
Zfp90 T C 8: 107,152,026 (GRCm39) C580R probably damaging Het
Other mutations in Tmem265
AlleleSourceChrCoordTypePredicted EffectPPH Score
R7395:Tmem265 UTSW 7 127,164,039 (GRCm39) missense
Predicted Primers PCR Primer
(F):5'- TGTGAGCTAACTGTGGCCAG -3'
(R):5'- GGCAACATTCTTCCAGACAGG -3'

Sequencing Primer
(F):5'- CTTTGTATTGCAGATGAGCCAAG -3'
(R):5'- TCCAGACAGGAAGAACCACG -3'
Posted On 2018-03-15