Incidental Mutation 'R6286:Or6c7'
ID 508239
Institutional Source Beutler Lab
Gene Symbol Or6c7
Ensembl Gene ENSMUSG00000111273
Gene Name olfactory receptor family 6 subfamily C member 7
Synonyms MOR111-13, Olfr789-ps1, MOR111-9P, Olfr789, GA_x6K02T2PULF-11165842-11166815
MMRRC Submission 044456-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.096) question?
Stock # R6286 (G1)
Quality Score 174.009
Status Validated
Chromosome 10
Chromosomal Location 129322881-129323819 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 129323497 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Leucine to Proline at position 206 (L206P)
Ref Sequence ENSEMBL: ENSMUSP00000151052 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000213236] [ENSMUST00000213992]
AlphaFold A0A1L1SV77
Predicted Effect probably damaging
Transcript: ENSMUST00000213236
AA Change: L206P

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Predicted Effect probably damaging
Transcript: ENSMUST00000213992
AA Change: L206P

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Meta Mutation Damage Score 0.6467 question?
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.7%
  • 10x: 98.4%
  • 20x: 95.7%
Validation Efficiency 98% (40/41)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 40 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Alk T A 17: 72,187,842 (GRCm39) M1300L probably damaging Het
C3 A T 17: 57,531,118 (GRCm39) I356N probably damaging Het
Cntnap5b T A 1: 100,182,798 (GRCm39) S276T possibly damaging Het
Cts7 C T 13: 61,500,584 (GRCm39) G321E probably damaging Het
Cyp11a1 G A 9: 57,924,701 (GRCm39) probably benign Het
Ddx4 T C 13: 112,750,269 (GRCm39) T421A probably damaging Het
Dnttip2 A G 3: 122,078,049 (GRCm39) T694A probably damaging Het
Eif3b G T 5: 140,405,566 (GRCm39) D151Y probably damaging Het
Fhad1 T A 4: 141,648,209 (GRCm39) E219V probably damaging Het
Gdf2 C T 14: 33,667,057 (GRCm39) R260C probably damaging Het
Gm14295 T C 2: 176,501,361 (GRCm39) Y284H possibly damaging Het
Gm45861 A G 8: 28,019,619 (GRCm39) T745A unknown Het
Grin2a G A 16: 9,579,639 (GRCm39) T208I possibly damaging Het
Ide T A 19: 37,255,409 (GRCm39) Y798F unknown Het
Llgl1 G A 11: 60,600,358 (GRCm39) G569D probably damaging Het
Mrpl9 G C 3: 94,351,097 (GRCm39) E92D probably benign Het
Muc16 T A 9: 18,555,685 (GRCm39) H3536L unknown Het
Nasp T C 4: 116,461,985 (GRCm39) Y526C probably damaging Het
Nfx1 A G 4: 40,986,728 (GRCm39) N404D probably damaging Het
Nsrp1 A G 11: 76,940,269 (GRCm39) I112T probably damaging Het
Or8b8 A T 9: 37,809,074 (GRCm39) I125F probably damaging Het
Oxsr1 A G 9: 119,093,948 (GRCm39) V235A probably damaging Het
Pamr1 C T 2: 102,471,293 (GRCm39) Q539* probably null Het
Pramel20 T A 4: 143,297,796 (GRCm39) V72D probably benign Het
Ptpn4 A G 1: 119,649,592 (GRCm39) probably null Het
Ranbp2 C T 10: 58,315,394 (GRCm39) A2038V probably benign Het
Rsf1 G GACGGCGGCA 7: 97,229,116 (GRCm39) probably benign Homo
Septin5 A G 16: 18,442,127 (GRCm39) V253A probably damaging Het
Skic3 T C 13: 76,291,359 (GRCm39) L993P probably damaging Het
Slc22a13 C A 9: 119,037,778 (GRCm39) E117* probably null Het
Slc9c1 T C 16: 45,398,194 (GRCm39) I653T probably benign Het
Slco6c1 T A 1: 97,053,445 (GRCm39) H152L possibly damaging Het
Sp2 A C 11: 96,852,372 (GRCm39) V184G probably benign Het
Taok1 T A 11: 77,444,599 (GRCm39) H492L probably benign Het
Tas2r110 G A 6: 132,845,490 (GRCm39) D174N probably benign Het
Trim24 G A 6: 37,896,426 (GRCm39) probably null Het
Ttn G A 2: 76,581,321 (GRCm39) R21445* probably null Het
Ttn A G 2: 76,605,967 (GRCm39) Y16502H probably damaging Het
Vmn2r84 A C 10: 130,226,737 (GRCm39) M367R possibly damaging Het
Zfp46 T C 4: 136,018,320 (GRCm39) S385P probably damaging Het
Other mutations in Or6c7
AlleleSourceChrCoordTypePredicted EffectPPH Score
R6154:Or6c7 UTSW 10 129,323,545 (GRCm39) missense probably damaging 1.00
R6961:Or6c7 UTSW 10 129,323,331 (GRCm39) missense probably damaging 0.99
R7007:Or6c7 UTSW 10 129,323,277 (GRCm39) missense probably damaging 0.96
R9097:Or6c7 UTSW 10 129,323,647 (GRCm39) missense possibly damaging 0.93
R9146:Or6c7 UTSW 10 129,323,392 (GRCm39) missense possibly damaging 0.61
Predicted Primers PCR Primer
(F):5'- AGGGTTCCTAAACATCTTCCCAC -3'
(R):5'- TGGATTCATCATAGGAGCCACAG -3'

Sequencing Primer
(F):5'- AAACATCTTCCCACCTGTCATTC -3'
(R):5'- GAGAATAGCTACTCCTTTGGTCAG -3'
Posted On 2018-03-15