Incidental Mutation 'R6290:Olfml2b'
ID 508332
Institutional Source Beutler Lab
Gene Symbol Olfml2b
Ensembl Gene ENSMUSG00000038463
Gene Name olfactomedin-like 2B
Synonyms 4832415H08Rik, 1110018N05Rik, photomedin-2
MMRRC Submission 044460-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R6290 (G1)
Quality Score 225.009
Status Not validated
Chromosome 1
Chromosomal Location 170472101-170510356 bp(+) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) A to T at 170477359 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Lysine to Stop codon at position 165 (K165*)
Ref Sequence ENSEMBL: ENSMUSP00000047291 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000046792]
AlphaFold Q3V1G4
Predicted Effect probably null
Transcript: ENSMUST00000046792
AA Change: K165*
SMART Domains Protein: ENSMUSP00000047291
Gene: ENSMUSG00000038463
AA Change: K165*

DomainStartEndE-ValueType
signal peptide 1 20 N/A INTRINSIC
coiled coil region 41 68 N/A INTRINSIC
coiled coil region 179 213 N/A INTRINSIC
low complexity region 233 238 N/A INTRINSIC
Blast:OLF 254 306 1e-6 BLAST
low complexity region 308 319 N/A INTRINSIC
low complexity region 343 382 N/A INTRINSIC
OLF 492 746 4.76e-61 SMART
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.6%
  • 10x: 98.3%
  • 20x: 95.2%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes an olfactomedin domain-containing protein. Most olfactomedin domain-containing proteins are secreted glycoproteins. [provided by RefSeq, Dec 2016]
Allele List at MGI
Other mutations in this stock
Total: 58 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aim2 T A 1: 173,289,681 (GRCm39) I208N possibly damaging Het
Albfm1 T C 5: 90,740,864 (GRCm39) probably null Het
Ank3 A C 10: 69,827,198 (GRCm39) probably benign Het
Arfgef1 T C 1: 10,259,036 (GRCm39) E687G possibly damaging Het
Ash1l T A 3: 88,890,068 (GRCm39) L649* probably null Het
Atp7b C T 8: 22,510,836 (GRCm39) G437S probably damaging Het
Cep89 G A 7: 35,119,688 (GRCm39) G349D probably damaging Het
Cntn6 T A 6: 104,744,851 (GRCm39) Y315N probably damaging Het
Cspg4b A T 13: 113,456,492 (GRCm39) N846I probably damaging Het
Csrp2 T C 10: 110,767,844 (GRCm39) C10R probably damaging Het
Cux1 T C 5: 136,340,412 (GRCm39) N625D probably damaging Het
Dnah9 T C 11: 65,732,201 (GRCm39) N4235S probably damaging Het
Dpy19l1 A G 9: 24,373,896 (GRCm39) C265R probably damaging Het
Dse A G 10: 34,028,336 (GRCm39) M918T probably benign Het
Duox1 C A 2: 122,164,288 (GRCm39) T916N possibly damaging Het
E130308A19Rik A T 4: 59,691,332 (GRCm39) I389F probably benign Het
Eif2ak1 T A 5: 143,821,617 (GRCm39) V311D probably benign Het
Eps15 T A 4: 109,220,395 (GRCm39) M534K probably benign Het
Gpr182 A T 10: 127,586,893 (GRCm39) F19L probably benign Het
Ifi214 T A 1: 173,356,983 (GRCm39) D40V probably damaging Het
Klhl2 A G 8: 65,264,351 (GRCm39) V121A possibly damaging Het
Klrh1 A G 6: 129,743,658 (GRCm39) Y209H probably benign Het
Mylk T A 16: 34,715,213 (GRCm39) S514T probably benign Het
Myo18b C T 5: 113,013,601 (GRCm39) R785H possibly damaging Het
Naga T G 15: 82,219,057 (GRCm39) D230A possibly damaging Het
Napsa A G 7: 44,230,761 (GRCm39) N70D probably benign Het
Nup210l T A 3: 90,027,216 (GRCm39) Y199* probably null Het
Or1j20 C T 2: 36,760,448 (GRCm39) P290L probably damaging Het
Paxip1 A T 5: 27,970,576 (GRCm39) probably null Het
Pcyox1 T A 6: 86,365,881 (GRCm39) K444N probably benign Het
Pikfyve T A 1: 65,242,084 (GRCm39) probably null Het
Ppp6r3 T C 19: 3,544,011 (GRCm39) I335V probably benign Het
Prkcz A G 4: 155,440,956 (GRCm39) S71P probably damaging Het
Psg19 C T 7: 18,528,014 (GRCm39) R243Q probably benign Het
Ptbp2 A T 3: 119,517,769 (GRCm39) M382K possibly damaging Het
Slc16a14 T A 1: 84,885,106 (GRCm39) I478L probably benign Het
Slc45a1 A T 4: 150,727,096 (GRCm39) N174K probably damaging Het
Slc5a5 G A 8: 71,343,822 (GRCm39) T160I probably damaging Het
Smpdl3b T A 4: 132,465,586 (GRCm39) H278L possibly damaging Het
Sorcs2 C T 5: 36,219,931 (GRCm39) R371H probably damaging Het
Synpo2 A T 3: 122,910,701 (GRCm39) S315T probably damaging Het
Taok3 A G 5: 117,342,433 (GRCm39) Y137C probably damaging Het
Tapbpl T C 6: 125,207,679 (GRCm39) D49G probably benign Het
Tbr1 T C 2: 61,635,394 (GRCm39) S115P probably benign Het
Trim67 C T 8: 125,549,918 (GRCm39) T516I probably benign Het
Trrap T A 5: 144,741,828 (GRCm39) L1351Q probably damaging Het
Tsc2 A G 17: 24,815,884 (GRCm39) I166T probably benign Het
Tspan8 T A 10: 115,663,729 (GRCm39) C22S probably damaging Het
Tyro3 T C 2: 119,647,321 (GRCm39) S813P probably benign Het
U2af2 G T 7: 5,078,683 (GRCm39) V421L probably benign Het
Vmn1r77 T C 7: 11,775,736 (GRCm39) S103P probably damaging Het
Vmn2r1 T A 3: 64,012,873 (GRCm39) D911E probably benign Het
Vmn2r115 ATCTTCT ATCT 17: 23,578,962 (GRCm39) probably benign Het
Vmn2r56 A T 7: 12,428,809 (GRCm39) C486S probably damaging Het
Vwa8 A G 14: 79,331,772 (GRCm39) probably null Het
Xirp1 T G 9: 119,847,791 (GRCm39) E364A probably benign Het
Zbp1 T C 2: 173,057,634 (GRCm39) E99G probably damaging Het
Zfp385b C A 2: 77,280,612 (GRCm39) V109F possibly damaging Het
Other mutations in Olfml2b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00422:Olfml2b APN 1 170,496,635 (GRCm39) missense probably damaging 0.96
IGL01871:Olfml2b APN 1 170,489,924 (GRCm39) splice site probably benign
IGL02475:Olfml2b APN 1 170,509,743 (GRCm39) missense probably damaging 1.00
IGL02657:Olfml2b APN 1 170,508,645 (GRCm39) missense probably benign 0.00
IGL03375:Olfml2b APN 1 170,477,401 (GRCm39) missense probably benign 0.35
PIT4280001:Olfml2b UTSW 1 170,475,305 (GRCm39) missense probably damaging 1.00
R0040:Olfml2b UTSW 1 170,496,320 (GRCm39) missense probably benign 0.00
R0194:Olfml2b UTSW 1 170,508,684 (GRCm39) missense possibly damaging 0.89
R0834:Olfml2b UTSW 1 170,475,413 (GRCm39) missense probably benign 0.00
R1218:Olfml2b UTSW 1 170,477,351 (GRCm39) missense probably damaging 1.00
R1386:Olfml2b UTSW 1 170,508,731 (GRCm39) missense probably damaging 0.97
R1420:Olfml2b UTSW 1 170,496,596 (GRCm39) missense probably benign 0.01
R1699:Olfml2b UTSW 1 170,472,642 (GRCm39) missense possibly damaging 0.89
R1730:Olfml2b UTSW 1 170,509,358 (GRCm39) missense probably damaging 1.00
R1755:Olfml2b UTSW 1 170,509,346 (GRCm39) missense probably damaging 1.00
R1869:Olfml2b UTSW 1 170,496,812 (GRCm39) missense probably damaging 0.96
R2295:Olfml2b UTSW 1 170,490,107 (GRCm39) splice site probably benign
R2394:Olfml2b UTSW 1 170,477,319 (GRCm39) missense possibly damaging 0.82
R3784:Olfml2b UTSW 1 170,509,551 (GRCm39) missense probably damaging 0.96
R4523:Olfml2b UTSW 1 170,496,791 (GRCm39) missense probably benign
R4611:Olfml2b UTSW 1 170,472,516 (GRCm39) missense probably damaging 0.99
R4900:Olfml2b UTSW 1 170,489,947 (GRCm39) missense probably damaging 1.00
R5201:Olfml2b UTSW 1 170,496,433 (GRCm39) missense probably benign
R5245:Olfml2b UTSW 1 170,496,443 (GRCm39) missense probably benign
R5268:Olfml2b UTSW 1 170,477,330 (GRCm39) missense probably damaging 1.00
R5283:Olfml2b UTSW 1 170,508,758 (GRCm39) nonsense probably null
R5348:Olfml2b UTSW 1 170,489,995 (GRCm39) missense probably benign 0.02
R5408:Olfml2b UTSW 1 170,472,545 (GRCm39) missense probably damaging 1.00
R5673:Olfml2b UTSW 1 170,509,698 (GRCm39) missense probably damaging 1.00
R5758:Olfml2b UTSW 1 170,496,833 (GRCm39) critical splice donor site probably null
R5893:Olfml2b UTSW 1 170,490,042 (GRCm39) missense probably benign
R6380:Olfml2b UTSW 1 170,496,800 (GRCm39) missense probably benign 0.00
R6778:Olfml2b UTSW 1 170,472,639 (GRCm39) missense probably damaging 1.00
R7155:Olfml2b UTSW 1 170,494,354 (GRCm39) missense probably benign 0.01
R7538:Olfml2b UTSW 1 170,477,402 (GRCm39) missense possibly damaging 0.79
R8354:Olfml2b UTSW 1 170,509,793 (GRCm39) missense possibly damaging 0.96
R8377:Olfml2b UTSW 1 170,496,353 (GRCm39) missense probably damaging 0.99
R8792:Olfml2b UTSW 1 170,508,669 (GRCm39) missense possibly damaging 0.68
Predicted Primers PCR Primer
(F):5'- ACAGATGTGCTTCTGAGGCC -3'
(R):5'- CAACTGTTTGGGCACAAGAG -3'

Sequencing Primer
(F):5'- GAGGCCACCTCTCAATTCCTGG -3'
(R):5'- AGCTAGATGCCAGTCAATAGC -3'
Posted On 2018-03-15