Mutagenetix > Incidental Mutation

Incidental Mutation 'R6290:Vmn2r115'

508385

Institutional Source

Beutler Lab

Gene Symbol

Vmn2r115

Ensembl Gene

ENSMUSG00000091076

Gene Name

vomeronasal 2, receptor 115

Synonyms

V2Rp4, EG638102

MMRRC Submission

044460-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.084) question?

Stock #

R6290 (G1)

Quality Score

217.468

Status

Not validated

Chromosome

Chromosomal Location

23562951-23579102 bp(+) (GRCm39)

Type of Mutation

small deletion (1 aa in frame mutation)

DNA Base Change (assembly)

ATCTTCT to ATCT at 23578962 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000131447 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000168175]

AlphaFold

E9Q0E7

Predicted Effect

probably benign
Transcript: ENSMUST00000168175

SMART Domains

Protein: ENSMUSP00000131447
Gene: ENSMUSG00000091076

Domain	Start	End	E-Value	Type
signal peptide	1	18	N/A	INTRINSIC
Pfam:ANF_receptor	73	471	1.4e-28	PFAM
Pfam:NCD3G	512	565	2.9e-20	PFAM
Pfam:7tm_3	598	833	5e-55	PFAM

Meta Mutation Damage Score

0.0898

Coding Region Coverage

1x: 99.9%
3x: 99.6%
10x: 98.3%
20x: 95.2%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 58 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Aim2	T	A	1: 173,289,681 (GRCm39)	I208N	possibly damaging	Het
Albfm1	T	C	5: 90,740,864 (GRCm39)		probably null	Het
Ank3	A	C	10: 69,827,198 (GRCm39)		probably benign	Het
Arfgef1	T	C	1: 10,259,036 (GRCm39)	E687G	possibly damaging	Het
Ash1l	T	A	3: 88,890,068 (GRCm39)	L649*	probably null	Het
Atp7b	C	T	8: 22,510,836 (GRCm39)	G437S	probably damaging	Het
Cep89	G	A	7: 35,119,688 (GRCm39)	G349D	probably damaging	Het
Cntn6	T	A	6: 104,744,851 (GRCm39)	Y315N	probably damaging	Het
Cspg4b	A	T	13: 113,456,492 (GRCm39)	N846I	probably damaging	Het
Csrp2	T	C	10: 110,767,844 (GRCm39)	C10R	probably damaging	Het
Cux1	T	C	5: 136,340,412 (GRCm39)	N625D	probably damaging	Het
Dnah9	T	C	11: 65,732,201 (GRCm39)	N4235S	probably damaging	Het
Dpy19l1	A	G	9: 24,373,896 (GRCm39)	C265R	probably damaging	Het
Dse	A	G	10: 34,028,336 (GRCm39)	M918T	probably benign	Het
Duox1	C	A	2: 122,164,288 (GRCm39)	T916N	possibly damaging	Het
E130308A19Rik	A	T	4: 59,691,332 (GRCm39)	I389F	probably benign	Het
Eif2ak1	T	A	5: 143,821,617 (GRCm39)	V311D	probably benign	Het
Eps15	T	A	4: 109,220,395 (GRCm39)	M534K	probably benign	Het
Gpr182	A	T	10: 127,586,893 (GRCm39)	F19L	probably benign	Het
Ifi214	T	A	1: 173,356,983 (GRCm39)	D40V	probably damaging	Het
Klhl2	A	G	8: 65,264,351 (GRCm39)	V121A	possibly damaging	Het
Klrh1	A	G	6: 129,743,658 (GRCm39)	Y209H	probably benign	Het
Mylk	T	A	16: 34,715,213 (GRCm39)	S514T	probably benign	Het
Myo18b	C	T	5: 113,013,601 (GRCm39)	R785H	possibly damaging	Het
Naga	T	G	15: 82,219,057 (GRCm39)	D230A	possibly damaging	Het
Napsa	A	G	7: 44,230,761 (GRCm39)	N70D	probably benign	Het
Nup210l	T	A	3: 90,027,216 (GRCm39)	Y199*	probably null	Het
Olfml2b	A	T	1: 170,477,359 (GRCm39)	K165*	probably null	Het
Or1j20	C	T	2: 36,760,448 (GRCm39)	P290L	probably damaging	Het
Paxip1	A	T	5: 27,970,576 (GRCm39)		probably null	Het
Pcyox1	T	A	6: 86,365,881 (GRCm39)	K444N	probably benign	Het
Pikfyve	T	A	1: 65,242,084 (GRCm39)		probably null	Het
Ppp6r3	T	C	19: 3,544,011 (GRCm39)	I335V	probably benign	Het
Prkcz	A	G	4: 155,440,956 (GRCm39)	S71P	probably damaging	Het
Psg19	C	T	7: 18,528,014 (GRCm39)	R243Q	probably benign	Het
Ptbp2	A	T	3: 119,517,769 (GRCm39)	M382K	possibly damaging	Het
Slc16a14	T	A	1: 84,885,106 (GRCm39)	I478L	probably benign	Het
Slc45a1	A	T	4: 150,727,096 (GRCm39)	N174K	probably damaging	Het
Slc5a5	G	A	8: 71,343,822 (GRCm39)	T160I	probably damaging	Het
Smpdl3b	T	A	4: 132,465,586 (GRCm39)	H278L	possibly damaging	Het
Sorcs2	C	T	5: 36,219,931 (GRCm39)	R371H	probably damaging	Het
Synpo2	A	T	3: 122,910,701 (GRCm39)	S315T	probably damaging	Het
Taok3	A	G	5: 117,342,433 (GRCm39)	Y137C	probably damaging	Het
Tapbpl	T	C	6: 125,207,679 (GRCm39)	D49G	probably benign	Het
Tbr1	T	C	2: 61,635,394 (GRCm39)	S115P	probably benign	Het
Trim67	C	T	8: 125,549,918 (GRCm39)	T516I	probably benign	Het
Trrap	T	A	5: 144,741,828 (GRCm39)	L1351Q	probably damaging	Het
Tsc2	A	G	17: 24,815,884 (GRCm39)	I166T	probably benign	Het
Tspan8	T	A	10: 115,663,729 (GRCm39)	C22S	probably damaging	Het
Tyro3	T	C	2: 119,647,321 (GRCm39)	S813P	probably benign	Het
U2af2	G	T	7: 5,078,683 (GRCm39)	V421L	probably benign	Het
Vmn1r77	T	C	7: 11,775,736 (GRCm39)	S103P	probably damaging	Het
Vmn2r1	T	A	3: 64,012,873 (GRCm39)	D911E	probably benign	Het
Vmn2r56	A	T	7: 12,428,809 (GRCm39)	C486S	probably damaging	Het
Vwa8	A	G	14: 79,331,772 (GRCm39)		probably null	Het
Xirp1	T	G	9: 119,847,791 (GRCm39)	E364A	probably benign	Het
Zbp1	T	C	2: 173,057,634 (GRCm39)	E99G	probably damaging	Het
Zfp385b	C	A	2: 77,280,612 (GRCm39)	V109F	possibly damaging	Het

Other mutations in Vmn2r115

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00990:Vmn2r115	APN	17	23,575,934 (GRCm39)	missense	probably benign	0.00
IGL00990:Vmn2r115	APN	17	23,565,345 (GRCm39)	nonsense	probably null
IGL00990:Vmn2r115	APN	17	23,578,371 (GRCm39)	missense	probably damaging	1.00
IGL00990:Vmn2r115	APN	17	23,565,135 (GRCm39)	missense	probably benign	0.03
IGL00990:Vmn2r115	APN	17	23,565,252 (GRCm39)	missense	probably benign	0.14
IGL00990:Vmn2r115	APN	17	23,565,313 (GRCm39)	missense	probably damaging	1.00
IGL00990:Vmn2r115	APN	17	23,578,323 (GRCm39)	missense	probably benign	0.22
IGL00990:Vmn2r115	APN	17	23,565,150 (GRCm39)	missense	probably benign	0.00
IGL00990:Vmn2r115	APN	17	23,565,180 (GRCm39)	missense	possibly damaging	0.90
IGL00990:Vmn2r115	APN	17	23,567,008 (GRCm39)	nonsense	probably null
IGL00990:Vmn2r115	APN	17	23,578,798 (GRCm39)	missense	probably damaging	1.00
IGL00990:Vmn2r115	APN	17	23,578,753 (GRCm39)	missense	probably damaging	1.00
IGL00990:Vmn2r115	APN	17	23,565,238 (GRCm39)	missense	probably benign	0.19
IGL00990:Vmn2r115	APN	17	23,565,346 (GRCm39)	missense	probably benign	0.30
IGL01073:Vmn2r115	APN	17	23,564,971 (GRCm39)	missense	probably benign	0.12
IGL01101:Vmn2r115	APN	17	23,564,971 (GRCm39)	missense	probably benign	0.12
IGL01300:Vmn2r115	APN	17	23,578,755 (GRCm39)	missense	probably damaging	1.00
IGL01415:Vmn2r115	APN	17	23,578,755 (GRCm39)	missense	probably damaging	1.00
IGL02309:Vmn2r115	APN	17	23,564,113 (GRCm39)	missense	probably benign	0.01
IGL02863:Vmn2r115	APN	17	23,578,257 (GRCm39)	missense	probably damaging	0.97
R0023:Vmn2r115	UTSW	17	23,565,252 (GRCm39)	missense	probably benign	0.14
R0197:Vmn2r115	UTSW	17	23,578,755 (GRCm39)	missense	probably damaging	1.00
R0361:Vmn2r115	UTSW	17	23,564,196 (GRCm39)	missense	probably benign	0.11
R0601:Vmn2r115	UTSW	17	23,579,074 (GRCm39)	missense	probably null	0.51
R0676:Vmn2r115	UTSW	17	23,565,238 (GRCm39)	missense	probably benign	0.19
R0685:Vmn2r115	UTSW	17	23,578,249 (GRCm39)	missense	probably benign
R0865:Vmn2r115	UTSW	17	23,565,382 (GRCm39)	missense	possibly damaging	0.65
R1124:Vmn2r115	UTSW	17	23,578,962 (GRCm39)	small deletion	probably benign
R1145:Vmn2r115	UTSW	17	23,578,962 (GRCm39)	small deletion	probably benign
R1146:Vmn2r115	UTSW	17	23,578,962 (GRCm39)	small deletion	probably benign
R1207:Vmn2r115	UTSW	17	23,578,962 (GRCm39)	small deletion	probably benign
R1266:Vmn2r115	UTSW	17	23,578,962 (GRCm39)	small deletion	probably benign
R1318:Vmn2r115	UTSW	17	23,578,962 (GRCm39)	small deletion	probably benign
R1367:Vmn2r115	UTSW	17	23,578,962 (GRCm39)	small deletion	probably benign
R1376:Vmn2r115	UTSW	17	23,578,962 (GRCm39)	small deletion	probably benign
R1376:Vmn2r115	UTSW	17	23,578,962 (GRCm39)	small deletion	probably benign
R1420:Vmn2r115	UTSW	17	23,578,962 (GRCm39)	small deletion	probably benign
R1469:Vmn2r115	UTSW	17	23,564,992 (GRCm39)	missense	probably damaging	0.99
R1469:Vmn2r115	UTSW	17	23,564,992 (GRCm39)	missense	probably damaging	0.99
R1604:Vmn2r115	UTSW	17	23,564,245 (GRCm39)	missense	probably benign	0.12
R1645:Vmn2r115	UTSW	17	23,565,192 (GRCm39)	missense	possibly damaging	0.69
R1646:Vmn2r115	UTSW	17	23,578,513 (GRCm39)	missense	probably damaging	1.00
R1650:Vmn2r115	UTSW	17	23,578,962 (GRCm39)	small deletion	probably benign
R1678:Vmn2r115	UTSW	17	23,578,962 (GRCm39)	small deletion	probably benign
R1716:Vmn2r115	UTSW	17	23,566,795 (GRCm39)	missense	probably benign
R1846:Vmn2r115	UTSW	17	23,578,357 (GRCm39)	missense	probably damaging	1.00
R1847:Vmn2r115	UTSW	17	23,578,962 (GRCm39)	small deletion	probably benign
R1885:Vmn2r115	UTSW	17	23,578,962 (GRCm39)	small deletion	probably benign
R1887:Vmn2r115	UTSW	17	23,565,007 (GRCm39)	missense	possibly damaging	0.91
R1937:Vmn2r115	UTSW	17	23,578,388 (GRCm39)	missense	probably damaging	1.00
R2007:Vmn2r115	UTSW	17	23,566,927 (GRCm39)	missense	possibly damaging	0.94
R2120:Vmn2r115	UTSW	17	23,578,297 (GRCm39)	missense	probably damaging	1.00
R3161:Vmn2r115	UTSW	17	23,575,998 (GRCm39)	missense	possibly damaging	0.82
R3780:Vmn2r115	UTSW	17	23,564,146 (GRCm39)	missense	probably damaging	1.00
R3806:Vmn2r115	UTSW	17	23,578,962 (GRCm39)	small deletion	probably benign
R3982:Vmn2r115	UTSW	17	23,578,948 (GRCm39)	missense	probably damaging	1.00
R4019:Vmn2r115	UTSW	17	23,579,017 (GRCm39)	missense	probably damaging	1.00
R4039:Vmn2r115	UTSW	17	23,564,077 (GRCm39)	missense	probably benign	0.26
R4087:Vmn2r115	UTSW	17	23,565,358 (GRCm39)	missense	probably benign	0.35
R4089:Vmn2r115	UTSW	17	23,565,358 (GRCm39)	missense	probably benign	0.35
R4379:Vmn2r115	UTSW	17	23,564,197 (GRCm39)	missense	possibly damaging	0.95
R4417:Vmn2r115	UTSW	17	23,564,854 (GRCm39)	missense	probably benign	0.02
R4601:Vmn2r115	UTSW	17	23,565,373 (GRCm39)	missense	probably benign	0.01
R4874:Vmn2r115	UTSW	17	23,578,825 (GRCm39)	missense	probably damaging	1.00
R5466:Vmn2r115	UTSW	17	23,579,030 (GRCm39)	missense	probably damaging	1.00
R5613:Vmn2r115	UTSW	17	23,564,307 (GRCm39)	missense	probably benign
R5821:Vmn2r115	UTSW	17	23,566,937 (GRCm39)	missense	probably damaging	0.99
R6120:Vmn2r115	UTSW	17	23,565,003 (GRCm39)	missense	probably damaging	1.00
R6193:Vmn2r115	UTSW	17	23,575,983 (GRCm39)	missense	probably benign	0.01
R6213:Vmn2r115	UTSW	17	23,578,962 (GRCm39)	small deletion	probably benign
R6319:Vmn2r115	UTSW	17	23,566,877 (GRCm39)	missense	possibly damaging	0.70
R6495:Vmn2r115	UTSW	17	23,578,572 (GRCm39)	missense	probably benign	0.02
R6599:Vmn2r115	UTSW	17	23,565,006 (GRCm39)	missense	probably benign	0.00
R6764:Vmn2r115	UTSW	17	23,565,046 (GRCm39)	missense	probably damaging	1.00
R6970:Vmn2r115	UTSW	17	23,564,989 (GRCm39)	missense	probably benign	0.23
R7023:Vmn2r115	UTSW	17	23,578,785 (GRCm39)	missense	probably damaging	1.00
R7236:Vmn2r115	UTSW	17	23,578,576 (GRCm39)	missense	probably benign	0.01
R7353:Vmn2r115	UTSW	17	23,564,887 (GRCm39)	missense	possibly damaging	0.65
R7483:Vmn2r115	UTSW	17	23,565,371 (GRCm39)	missense	possibly damaging	0.95
R7743:Vmn2r115	UTSW	17	23,564,772 (GRCm39)	nonsense	probably null
R8005:Vmn2r115	UTSW	17	23,563,124 (GRCm39)	nonsense	probably null
R8191:Vmn2r115	UTSW	17	23,578,530 (GRCm39)	missense	probably damaging	1.00
R8544:Vmn2r115	UTSW	17	23,564,773 (GRCm39)	missense	possibly damaging	0.88
R8890:Vmn2r115	UTSW	17	23,578,497 (GRCm39)	missense	probably damaging	0.98
R9098:Vmn2r115	UTSW	17	23,564,803 (GRCm39)	missense	probably benign
R9114:Vmn2r115	UTSW	17	23,564,307 (GRCm39)	missense	probably benign
R9189:Vmn2r115	UTSW	17	23,564,784 (GRCm39)	missense	probably damaging	1.00
R9351:Vmn2r115	UTSW	17	23,578,482 (GRCm39)	missense	probably benign	0.05
R9397:Vmn2r115	UTSW	17	23,564,152 (GRCm39)	nonsense	probably null
R9410:Vmn2r115	UTSW	17	23,578,915 (GRCm39)	missense	possibly damaging	0.67
R9593:Vmn2r115	UTSW	17	23,578,184 (GRCm39)	missense	probably damaging	0.99
V5622:Vmn2r115	UTSW	17	23,578,333 (GRCm39)	missense	probably benign
V5622:Vmn2r115	UTSW	17	23,565,201 (GRCm39)	missense	probably damaging	1.00
X0023:Vmn2r115	UTSW	17	23,578,962 (GRCm39)	small deletion	probably benign
X0033:Vmn2r115	UTSW	17	23,578,962 (GRCm39)	small deletion	probably benign

Predicted Primers

PCR Primer
(F):5'- TCTGGGATACTTGGCTACCCTG -3'
(R):5'- TATTCCACCATCAGAAAGGTATGGC -3'

Sequencing Primer
(F):5'- TGGCCATTGGGAGCTTCACTC -3'
(R):5'- ATCAGAAAGGTATGGCAATATAATCC -3'

Posted On

2018-03-15