Incidental Mutation 'R6291:Vmn2r67'
ID 508425
Institutional Source Beutler Lab
Gene Symbol Vmn2r67
Ensembl Gene ENSMUSG00000095664
Gene Name vomeronasal 2, receptor 67
Synonyms EG620672
Accession Numbers
Essential gene? Probably non essential (E-score: 0.111) question?
Stock # R6291 (G1)
Quality Score 225.009
Status Validated
Chromosome 7
Chromosomal Location 84785448-84805110 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to A at 84799142 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Proline to Serine at position 522 (P522S)
Ref Sequence ENSEMBL: ENSMUSP00000126007 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000168730]
AlphaFold K7N6T2
Predicted Effect possibly damaging
Transcript: ENSMUST00000168730
AA Change: P522S

PolyPhen 2 Score 0.885 (Sensitivity: 0.82; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000126007
Gene: ENSMUSG00000095664
AA Change: P522S

DomainStartEndE-ValueType
signal peptide 1 23 N/A INTRINSIC
Pfam:ANF_receptor 77 464 2.1e-31 PFAM
Pfam:NCD3G 507 559 4.8e-19 PFAM
Pfam:7tm_3 590 827 1.4e-53 PFAM
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.7%
  • 10x: 98.6%
  • 20x: 96.3%
Validation Efficiency 98% (86/88)
Allele List at MGI
Other mutations in this stock
Total: 91 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcc12 C T 8: 87,293,173 (GRCm39) G5D possibly damaging Het
Adamts9 T C 6: 92,867,101 (GRCm39) K95R probably damaging Het
Adap1 G T 5: 139,259,246 (GRCm39) L314M probably benign Het
Alkbh1 T A 12: 87,475,864 (GRCm39) E306V possibly damaging Het
Alpk2 T A 18: 65,438,972 (GRCm39) D1274V possibly damaging Het
Ankrd31 A C 13: 97,014,746 (GRCm39) K1188N possibly damaging Het
Aox1 T A 1: 58,369,965 (GRCm39) M759K probably damaging Het
Atp13a3 T A 16: 30,155,061 (GRCm39) D961V probably damaging Het
Bcl11a G A 11: 24,108,321 (GRCm39) G100R probably damaging Het
Bpifc G A 10: 85,812,122 (GRCm39) A362V probably damaging Het
Btaf1 C T 19: 36,950,408 (GRCm39) T546I probably benign Het
Casd1 C A 6: 4,619,834 (GRCm39) P193Q probably damaging Het
Cdhr1 T C 14: 36,811,422 (GRCm39) T230A probably benign Het
Celsr3 T G 9: 108,706,041 (GRCm39) D841E probably damaging Het
Cenpj T C 14: 56,789,433 (GRCm39) D872G probably benign Het
Cep95 G T 11: 106,706,422 (GRCm39) A559S probably damaging Het
Chpt1 A T 10: 88,311,306 (GRCm39) C62* probably null Het
Cspg4b T A 13: 113,456,981 (GRCm39) I1009N possibly damaging Het
Cspp1 A G 1: 10,134,559 (GRCm39) K103R probably damaging Het
Ctla4 T C 1: 60,951,837 (GRCm39) V122A probably benign Het
Cyp3a11 A G 5: 145,799,237 (GRCm39) F317L possibly damaging Het
Daam1 T C 12: 71,993,025 (GRCm39) L338P unknown Het
Dcc T A 18: 71,815,238 (GRCm39) I379L probably benign Het
Dennd2c C A 3: 103,038,925 (GRCm39) C24* probably null Het
Dnai3 G A 3: 145,772,648 (GRCm39) S466L probably benign Het
Dnajc12 A G 10: 63,233,053 (GRCm39) I65V probably benign Het
Dock3 T A 9: 106,785,631 (GRCm39) M208L probably benign Het
Dsg1b T C 18: 20,537,848 (GRCm39) I588T possibly damaging Het
Eif1b T C 9: 120,323,206 (GRCm39) L22S probably benign Het
Ep300 T A 15: 81,532,708 (GRCm39) S1649T unknown Het
Eps15 CAAA CAA 4: 109,162,900 (GRCm39) probably null Het
Ercc6 A T 14: 32,291,943 (GRCm39) E1102D probably benign Het
Gsdmc3 T C 15: 63,732,090 (GRCm39) N312S probably benign Het
Guca2b A T 4: 119,514,890 (GRCm39) L57Q probably damaging Het
Heatr5b G T 17: 79,069,526 (GRCm39) H1740Q probably benign Het
Hecw1 G A 13: 14,697,592 (GRCm39) probably benign Het
Icam5 A G 9: 20,948,217 (GRCm39) H675R probably benign Het
Il18rap T C 1: 40,564,049 (GRCm39) F56L probably benign Het
Iqgap3 T A 3: 87,997,037 (GRCm39) probably null Het
Itsn1 T C 16: 91,664,984 (GRCm39) probably benign Het
Jakmip3 A T 7: 138,622,585 (GRCm39) D315V probably damaging Het
Kif24 A G 4: 41,413,959 (GRCm39) Y328H probably damaging Het
Kmt2a A T 9: 44,744,171 (GRCm39) probably benign Het
Kng1 A G 16: 22,898,475 (GRCm39) E625G probably damaging Het
Man2b1 C T 8: 85,823,675 (GRCm39) T973I probably benign Het
Masp2 G A 4: 148,687,210 (GRCm39) V31M probably damaging Het
Myo18b C T 5: 113,013,601 (GRCm39) R785H possibly damaging Het
Naa15 G A 3: 51,350,212 (GRCm39) G103D probably damaging Het
Or4f15 A G 2: 111,813,969 (GRCm39) V150A probably benign Het
Or5m11b A G 2: 85,805,926 (GRCm39) Y113C probably damaging Het
Or7e177 T A 9: 20,211,899 (GRCm39) D134E probably damaging Het
Papln A G 12: 83,829,789 (GRCm39) N970S probably benign Het
Pick1 T A 15: 79,135,928 (GRCm39) probably null Het
Pigr A C 1: 130,769,498 (GRCm39) D103A probably benign Het
Plekhf1 A C 7: 37,921,029 (GRCm39) F180V possibly damaging Het
Plxnc1 A G 10: 94,669,504 (GRCm39) probably null Het
Polr3f A G 2: 144,376,308 (GRCm39) I136V probably damaging Het
Ppp2r2c T C 5: 37,097,468 (GRCm39) M218T possibly damaging Het
Prox2 C T 12: 85,136,420 (GRCm39) V466I probably damaging Het
Prrc2a G A 17: 35,373,909 (GRCm39) L1479F probably damaging Het
Rbm24 T A 13: 46,575,313 (GRCm39) probably null Het
Rcc1l A T 5: 134,195,560 (GRCm39) probably null Het
Ripk4 A C 16: 97,556,323 (GRCm39) L140R probably damaging Het
Rmnd1 A T 10: 4,372,135 (GRCm39) L188Q probably damaging Het
Rnf170 C T 8: 26,630,992 (GRCm39) P249S probably damaging Het
Rras A G 7: 44,667,595 (GRCm39) probably null Het
Rsf1 G A 7: 97,229,117 (GRCm39) probably benign Het
Scn7a T A 2: 66,530,458 (GRCm39) D629V probably damaging Het
Sipa1l3 A G 7: 29,087,558 (GRCm39) S556P probably damaging Het
Smarca2 C T 19: 26,608,292 (GRCm39) A117V probably damaging Het
Snca C T 6: 60,792,702 (GRCm39) A69T probably damaging Het
Snx2 T C 18: 53,342,737 (GRCm39) probably null Het
Spp1 T A 5: 104,587,242 (GRCm39) S109T possibly damaging Het
Stoml3 T C 3: 53,414,937 (GRCm39) L243P probably damaging Het
Susd2 A G 10: 75,473,408 (GRCm39) F789L possibly damaging Het
Sycp1 A G 3: 102,816,277 (GRCm39) M419T probably damaging Het
Thoc1 T C 18: 9,993,330 (GRCm39) V563A probably benign Het
Tmprss11g T C 5: 86,635,281 (GRCm39) I398V probably damaging Het
Tox3 A G 8: 90,975,566 (GRCm39) L355P probably damaging Het
Tpp1 A G 7: 105,396,223 (GRCm39) I492T probably benign Het
Trim21 A T 7: 102,213,289 (GRCm39) L3Q probably damaging Het
Ttn A C 2: 76,738,080 (GRCm39) V4153G probably benign Het
Ttn T C 2: 76,744,638 (GRCm39) probably benign Het
Unc80 A G 1: 66,560,756 (GRCm39) E828G possibly damaging Het
Vav3 A G 3: 109,416,170 (GRCm39) N263S possibly damaging Het
Vmn1r183 A C 7: 23,754,982 (GRCm39) T262P possibly damaging Het
Vps35 T A 8: 86,026,086 (GRCm39) M1L probably benign Het
Xpo7 A T 14: 70,942,130 (GRCm39) L79* probably null Het
Zc3h14 G A 12: 98,726,087 (GRCm39) R324H probably damaging Het
Zfp330 T C 8: 83,499,613 (GRCm39) T6A probably damaging Het
Zfp948 T A 17: 21,807,286 (GRCm39) H159Q unknown Het
Other mutations in Vmn2r67
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00096:Vmn2r67 APN 7 84,801,138 (GRCm39) missense probably damaging 1.00
IGL01346:Vmn2r67 APN 7 84,786,127 (GRCm39) missense probably damaging 1.00
IGL01373:Vmn2r67 APN 7 84,785,834 (GRCm39) missense probably benign 0.10
IGL01674:Vmn2r67 APN 7 84,785,651 (GRCm39) missense probably damaging 1.00
IGL01978:Vmn2r67 APN 7 84,800,649 (GRCm39) critical splice donor site probably null
IGL02013:Vmn2r67 APN 7 84,800,863 (GRCm39) missense probably benign 0.09
IGL02115:Vmn2r67 APN 7 84,800,787 (GRCm39) missense probably damaging 0.99
IGL02250:Vmn2r67 APN 7 84,805,008 (GRCm39) missense probably benign
IGL02252:Vmn2r67 APN 7 84,805,008 (GRCm39) missense probably benign
IGL02328:Vmn2r67 APN 7 84,799,898 (GRCm39) missense probably benign 0.41
IGL02740:Vmn2r67 APN 7 84,785,818 (GRCm39) missense probably damaging 1.00
IGL02940:Vmn2r67 APN 7 84,785,951 (GRCm39) missense probably benign 0.07
IGL03237:Vmn2r67 APN 7 84,799,118 (GRCm39) missense probably damaging 1.00
R0512:Vmn2r67 UTSW 7 84,799,900 (GRCm39) missense probably damaging 1.00
R1029:Vmn2r67 UTSW 7 84,785,974 (GRCm39) missense probably damaging 1.00
R1193:Vmn2r67 UTSW 7 84,800,653 (GRCm39) missense probably damaging 0.98
R1282:Vmn2r67 UTSW 7 84,785,932 (GRCm39) missense probably benign
R1416:Vmn2r67 UTSW 7 84,800,824 (GRCm39) missense probably benign 0.06
R1429:Vmn2r67 UTSW 7 84,802,031 (GRCm39) missense possibly damaging 0.65
R1462:Vmn2r67 UTSW 7 84,805,046 (GRCm39) missense probably benign 0.00
R1462:Vmn2r67 UTSW 7 84,805,046 (GRCm39) missense probably benign 0.00
R1970:Vmn2r67 UTSW 7 84,801,013 (GRCm39) missense probably benign
R2229:Vmn2r67 UTSW 7 84,801,250 (GRCm39) missense probably benign 0.21
R2246:Vmn2r67 UTSW 7 84,785,764 (GRCm39) missense probably damaging 1.00
R2262:Vmn2r67 UTSW 7 84,786,182 (GRCm39) missense probably damaging 0.96
R2398:Vmn2r67 UTSW 7 84,785,921 (GRCm39) missense probably damaging 1.00
R4249:Vmn2r67 UTSW 7 84,799,722 (GRCm39) splice site probably null
R4666:Vmn2r67 UTSW 7 84,799,831 (GRCm39) missense probably benign
R4669:Vmn2r67 UTSW 7 84,799,732 (GRCm39) missense probably benign 0.11
R4966:Vmn2r67 UTSW 7 84,785,593 (GRCm39) missense probably damaging 1.00
R5264:Vmn2r67 UTSW 7 84,801,453 (GRCm39) missense probably damaging 1.00
R5296:Vmn2r67 UTSW 7 84,786,230 (GRCm39) missense probably damaging 1.00
R5327:Vmn2r67 UTSW 7 84,785,698 (GRCm39) missense probably damaging 1.00
R5401:Vmn2r67 UTSW 7 84,785,765 (GRCm39) missense probably damaging 1.00
R5510:Vmn2r67 UTSW 7 84,801,023 (GRCm39) missense probably benign 0.39
R5574:Vmn2r67 UTSW 7 84,801,099 (GRCm39) missense probably benign 0.00
R5643:Vmn2r67 UTSW 7 84,799,151 (GRCm39) nonsense probably null
R5914:Vmn2r67 UTSW 7 84,801,044 (GRCm39) missense probably damaging 1.00
R6248:Vmn2r67 UTSW 7 84,799,768 (GRCm39) missense probably damaging 0.99
R6309:Vmn2r67 UTSW 7 84,801,124 (GRCm39) missense probably benign
R6442:Vmn2r67 UTSW 7 84,805,046 (GRCm39) missense possibly damaging 0.82
R6665:Vmn2r67 UTSW 7 84,785,900 (GRCm39) missense probably benign 0.07
R6701:Vmn2r67 UTSW 7 84,802,023 (GRCm39) missense probably damaging 1.00
R6848:Vmn2r67 UTSW 7 84,801,840 (GRCm39) missense probably benign 0.00
R6852:Vmn2r67 UTSW 7 84,801,361 (GRCm39) missense probably damaging 0.99
R6991:Vmn2r67 UTSW 7 84,804,953 (GRCm39) missense possibly damaging 0.55
R7143:Vmn2r67 UTSW 7 84,801,846 (GRCm39) missense probably benign
R7197:Vmn2r67 UTSW 7 84,785,774 (GRCm39) missense possibly damaging 0.77
R7393:Vmn2r67 UTSW 7 84,805,086 (GRCm39) missense probably null 0.87
R7420:Vmn2r67 UTSW 7 84,785,944 (GRCm39) missense possibly damaging 0.52
R7622:Vmn2r67 UTSW 7 84,785,662 (GRCm39) missense probably damaging 1.00
R7664:Vmn2r67 UTSW 7 84,805,019 (GRCm39) missense probably benign 0.21
R7665:Vmn2r67 UTSW 7 84,801,196 (GRCm39) nonsense probably null
R7896:Vmn2r67 UTSW 7 84,785,920 (GRCm39) missense probably damaging 1.00
R7913:Vmn2r67 UTSW 7 84,801,036 (GRCm39) missense possibly damaging 0.87
R8026:Vmn2r67 UTSW 7 84,785,924 (GRCm39) missense probably damaging 1.00
R8114:Vmn2r67 UTSW 7 84,805,097 (GRCm39) missense probably benign 0.01
R8317:Vmn2r67 UTSW 7 84,785,834 (GRCm39) missense probably benign 0.10
R8363:Vmn2r67 UTSW 7 84,804,969 (GRCm39) missense probably benign 0.00
R8421:Vmn2r67 UTSW 7 84,785,893 (GRCm39) missense probably damaging 0.98
R8444:Vmn2r67 UTSW 7 84,785,854 (GRCm39) missense probably benign 0.01
R8751:Vmn2r67 UTSW 7 84,801,450 (GRCm39) missense probably benign 0.01
R8810:Vmn2r67 UTSW 7 84,786,346 (GRCm39) missense probably damaging 1.00
R8811:Vmn2r67 UTSW 7 84,799,895 (GRCm39) missense probably damaging 0.98
R9215:Vmn2r67 UTSW 7 84,802,008 (GRCm39) missense probably benign 0.00
R9342:Vmn2r67 UTSW 7 84,785,788 (GRCm39) missense probably benign 0.00
R9433:Vmn2r67 UTSW 7 84,804,917 (GRCm39) missense possibly damaging 0.60
R9453:Vmn2r67 UTSW 7 84,800,697 (GRCm39) missense probably benign 0.32
R9471:Vmn2r67 UTSW 7 84,799,723 (GRCm39) critical splice donor site probably null
R9526:Vmn2r67 UTSW 7 84,785,834 (GRCm39) missense probably benign 0.10
R9538:Vmn2r67 UTSW 7 84,801,327 (GRCm39) missense
R9544:Vmn2r67 UTSW 7 84,786,317 (GRCm39) missense possibly damaging 0.53
R9574:Vmn2r67 UTSW 7 84,786,017 (GRCm39) missense probably benign 0.00
R9599:Vmn2r67 UTSW 7 84,804,941 (GRCm39) missense probably damaging 0.96
R9768:Vmn2r67 UTSW 7 84,802,037 (GRCm39) missense probably benign 0.23
Predicted Primers PCR Primer
(F):5'- AGGAAATCATTGTCCAGGTATCTAG -3'
(R):5'- GCTTTACACTGCCCTAAATAGTCTC -3'

Sequencing Primer
(F):5'- TGTCCAGGTATCTAGAATAATGAGAC -3'
(R):5'- GGAACTCACTTTATAATCCAGGCTGG -3'
Posted On 2018-03-15