Incidental Mutation 'R6295:Or10a3m'
ID 508707
Institutional Source Beutler Lab
Gene Symbol Or10a3m
Ensembl Gene ENSMUSG00000056946
Gene Name olfactory receptor family 10 subfamily A member 3M
Synonyms Olfr512, MOR268-3, GA_x6K02T2PBJ9-11043421-11044365
MMRRC Submission 044463-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.115) question?
Stock # R6295 (G1)
Quality Score 225.009
Status Validated
Chromosome 7
Chromosomal Location 108312562-108313542 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 108312845 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Alanine at position 95 (V95A)
Ref Sequence ENSEMBL: ENSMUSP00000074291 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000074730] [ENSMUST00000209620]
AlphaFold Q8VFZ4
Predicted Effect probably damaging
Transcript: ENSMUST00000074730
AA Change: V95A

PolyPhen 2 Score 0.980 (Sensitivity: 0.75; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000074291
Gene: ENSMUSG00000056946
AA Change: V95A

DomainStartEndE-ValueType
Pfam:7tm_4 43 320 7.8e-62 PFAM
Pfam:7TM_GPCR_Srsx 47 317 2.5e-6 PFAM
Pfam:7tm_1 53 302 2.3e-25 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000209620
AA Change: V83A

PolyPhen 2 Score 0.931 (Sensitivity: 0.81; Specificity: 0.94)
Meta Mutation Damage Score 0.2606 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.6%
  • 20x: 98.7%
Validation Efficiency 98% (49/50)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 50 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcb5 A C 12: 118,838,379 (GRCm39) V1061G probably damaging Het
Acap1 A G 11: 69,781,413 (GRCm39) probably null Het
Apbb1 A G 7: 105,215,902 (GRCm39) F112L probably benign Het
Atg9a A G 1: 75,161,702 (GRCm39) S615P probably benign Het
Atp8a2 G A 14: 60,249,848 (GRCm39) R548* probably null Het
Bbof1 A T 12: 84,457,942 (GRCm39) N69I possibly damaging Het
Bcl2l14 T A 6: 134,404,370 (GRCm39) V186D probably benign Het
Bmp1 T G 14: 70,728,823 (GRCm39) Y583S possibly damaging Het
Boc A C 16: 44,312,711 (GRCm39) S586R probably benign Het
Btbd9 A T 17: 30,518,710 (GRCm39) probably null Het
Cacna1e T C 1: 154,317,919 (GRCm39) M1180V probably damaging Het
Ciao1 T C 2: 127,088,376 (GRCm39) H149R probably damaging Het
Cops5 T C 1: 10,100,920 (GRCm39) probably benign Het
Doc2b C T 11: 75,671,093 (GRCm39) R209Q probably damaging Het
Doc2b T C 11: 75,686,451 (GRCm39) Y90C probably benign Het
Ep400 A G 5: 110,901,675 (GRCm39) F481L probably benign Het
Fat4 T A 3: 39,061,229 (GRCm39) probably null Het
Fbxw16 T A 9: 109,277,837 (GRCm39) probably benign Het
Fbxw27 T C 9: 109,601,154 (GRCm39) E17G possibly damaging Het
Gm29735 G A 7: 141,710,367 (GRCm39) P162S unknown Het
Gypa T G 8: 81,222,969 (GRCm39) S24R unknown Het
Hdhd5 T C 6: 120,495,485 (GRCm39) N153D probably benign Het
Ibsp C A 5: 104,449,987 (GRCm39) probably null Het
Klhdc3 C T 17: 46,988,972 (GRCm39) V73I probably benign Het
Lrrc37a T C 11: 103,388,459 (GRCm39) E2322G unknown Het
Lrrtm3 T C 10: 63,765,913 (GRCm39) H558R probably benign Het
Mbtd1 C T 11: 93,823,058 (GRCm39) H493Y possibly damaging Het
Mphosph9 A G 5: 124,458,978 (GRCm39) V64A possibly damaging Het
Nthl1 C T 17: 24,857,475 (GRCm39) R251C probably damaging Het
Numa1 G A 7: 101,649,974 (GRCm39) R1235H probably benign Het
Opn1sw T A 6: 29,379,413 (GRCm39) Y197F possibly damaging Het
Pcca A T 14: 122,896,187 (GRCm39) I268F probably benign Het
Per2 A T 1: 91,377,594 (GRCm39) D76E unknown Het
Pfas T C 11: 68,888,825 (GRCm39) N374S probably benign Het
Pomk C A 8: 26,472,955 (GRCm39) V333F probably damaging Het
Ptgfr T C 3: 151,540,926 (GRCm39) E194G probably benign Het
Ptpn14 C T 1: 189,582,997 (GRCm39) P615S probably damaging Het
Pyroxd1 T C 6: 142,300,479 (GRCm39) I203T probably benign Het
Rgs22 T C 15: 36,087,520 (GRCm39) N466S probably benign Het
Rpl3l G A 17: 24,952,966 (GRCm39) V309I probably benign Het
Rtkn2 C T 10: 67,815,529 (GRCm39) probably benign Het
Sec16a C T 2: 26,318,253 (GRCm39) A1613T probably damaging Het
Sis T A 3: 72,874,103 (GRCm39) T33S probably damaging Het
Slc22a4 C A 11: 53,898,634 (GRCm39) V153F possibly damaging Het
Stxbp1 C G 2: 32,684,621 (GRCm39) E603Q probably damaging Het
Tiam2 A G 17: 3,559,831 (GRCm39) S1291G probably damaging Het
Tmem94 T A 11: 115,687,572 (GRCm39) L1144M probably damaging Het
Ttn G A 2: 76,579,673 (GRCm39) T23740M probably damaging Het
Vmn1r201 T C 13: 22,659,533 (GRCm39) V249A probably benign Het
Wdr7 T A 18: 63,888,182 (GRCm39) C552S probably damaging Het
Other mutations in Or10a3m
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01889:Or10a3m APN 7 108,313,089 (GRCm39) missense probably benign 0.02
IGL01912:Or10a3m APN 7 108,313,465 (GRCm39) missense possibly damaging 0.60
IGL02182:Or10a3m APN 7 108,313,075 (GRCm39) missense probably benign 0.02
IGL02409:Or10a3m APN 7 108,313,366 (GRCm39) missense probably benign 0.00
IGL02554:Or10a3m APN 7 108,312,949 (GRCm39) missense possibly damaging 0.94
IGL03210:Or10a3m APN 7 108,312,775 (GRCm39) missense probably damaging 1.00
IGL03373:Or10a3m APN 7 108,313,339 (GRCm39) missense probably damaging 1.00
IGL03400:Or10a3m APN 7 108,312,733 (GRCm39) missense probably benign 0.28
R0092:Or10a3m UTSW 7 108,313,031 (GRCm39) missense probably benign
R0741:Or10a3m UTSW 7 108,312,811 (GRCm39) missense probably benign 0.00
R1515:Or10a3m UTSW 7 108,313,148 (GRCm39) missense possibly damaging 0.94
R1982:Or10a3m UTSW 7 108,312,902 (GRCm39) missense probably damaging 1.00
R2176:Or10a3m UTSW 7 108,313,339 (GRCm39) missense probably damaging 1.00
R3967:Or10a3m UTSW 7 108,313,060 (GRCm39) missense probably benign
R4009:Or10a3m UTSW 7 108,313,366 (GRCm39) missense probably benign 0.00
R4010:Or10a3m UTSW 7 108,313,366 (GRCm39) missense probably benign 0.00
R4011:Or10a3m UTSW 7 108,313,366 (GRCm39) missense probably benign 0.00
R5095:Or10a3m UTSW 7 108,313,019 (GRCm39) missense probably damaging 1.00
R5271:Or10a3m UTSW 7 108,313,424 (GRCm39) missense probably damaging 1.00
R5864:Or10a3m UTSW 7 108,312,671 (GRCm39) missense probably benign
R5926:Or10a3m UTSW 7 108,312,794 (GRCm39) missense probably damaging 1.00
R6528:Or10a3m UTSW 7 108,312,638 (GRCm39) missense probably damaging 1.00
R6624:Or10a3m UTSW 7 108,312,743 (GRCm39) missense possibly damaging 0.50
R8029:Or10a3m UTSW 7 108,313,037 (GRCm39) missense possibly damaging 0.70
R8443:Or10a3m UTSW 7 108,313,418 (GRCm39) missense possibly damaging 0.79
R8737:Or10a3m UTSW 7 108,312,964 (GRCm39) missense probably damaging 1.00
R9415:Or10a3m UTSW 7 108,313,042 (GRCm39) missense probably damaging 1.00
R9622:Or10a3m UTSW 7 108,312,677 (GRCm39) missense probably benign 0.30
X0023:Or10a3m UTSW 7 108,313,217 (GRCm39) missense possibly damaging 0.79
Z1088:Or10a3m UTSW 7 108,312,745 (GRCm39) missense probably benign 0.06
Predicted Primers PCR Primer
(F):5'- CCTGAACTTCAAGATCAGATGTTTGG -3'
(R):5'- TGGTACCTGAGACCCATGAG -3'

Sequencing Primer
(F):5'- CAAGATCAGATGTTTGGGACTTTCC -3'
(R):5'- GTACCTGAGACCCATGAGAACATAAC -3'
Posted On 2018-04-02