Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01085:Ifna16'

50874

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Ifna16

Ensembl Gene

ENSMUSG00000078355

Gene Name

interferon alpha 16

Synonyms

Gm13280, Ifna6t

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.049) question?

Stock #

IGL01085

Quality Score

Status

Chromosome

Chromosomal Location

88594524-88595093 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 88594969 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Lysine at position 42 (I42K)

Ref Sequence

ENSEMBL: ENSMUSP00000100779 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000105148]

AlphaFold

Q810G1

Predicted Effect

probably benign
Transcript: ENSMUST00000105148
AA Change: I42K

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

SMART Domains

Protein: ENSMUSP00000100779
Gene: ENSMUSG00000078355
AA Change: I42K

Domain	Start	End	E-Value	Type
signal peptide	1	23	N/A	INTRINSIC
IFabd	58	175	2.69e-66	SMART

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 40 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Aadac	A	G	3: 59,944,763 (GRCm39)		probably benign	Het
Acp7	T	C	7: 28,310,478 (GRCm39)	Y453C	probably damaging	Het
Bop1	T	C	15: 76,337,576 (GRCm39)	D683G	probably damaging	Het
Cacna1b	G	T	2: 24,569,006 (GRCm39)	R974S	probably damaging	Het
Ceacam23	A	T	7: 17,649,616 (GRCm39)	H729L	possibly damaging	Het
Cenpt	T	C	8: 106,573,297 (GRCm39)	E350G	possibly damaging	Het
Cep112	G	T	11: 108,377,432 (GRCm39)	R270L	probably damaging	Het
Crem	T	C	18: 3,299,236 (GRCm39)	T26A	probably damaging	Het
Crot	T	C	5: 9,023,955 (GRCm39)	H387R	probably damaging	Het
Fdxr	A	T	11: 115,160,402 (GRCm39)	V351E	probably benign	Het
Fkbpl	T	C	17: 34,864,718 (GRCm39)	L162P	probably damaging	Het
Fmn2	T	A	1: 174,523,220 (GRCm39)	N1358K	probably damaging	Het
Hectd4	G	T	5: 121,469,764 (GRCm39)	G2553V	probably damaging	Het
Igfals	C	T	17: 25,100,634 (GRCm39)	T575I	probably benign	Het
Il6	G	T	5: 30,218,487 (GRCm39)	V28F	probably damaging	Het
Irx1	A	G	13: 72,107,816 (GRCm39)	S289P	probably benign	Het
Ncoa2	T	C	1: 13,219,303 (GRCm39)	T1245A	possibly damaging	Het
Nr3c2	G	T	8: 77,634,983 (GRCm39)	R28L	probably benign	Het
Nudt5	G	A	2: 5,869,238 (GRCm39)	V155I	probably benign	Het
Or9s13	G	T	1: 92,547,921 (GRCm39)	V98F	possibly damaging	Het
Pcm1	T	C	8: 41,762,640 (GRCm39)	S1395P	probably damaging	Het
Pkhd1l1	G	A	15: 44,426,148 (GRCm39)		probably null	Het
Prodh	A	T	16: 17,894,208 (GRCm39)	V339E	probably damaging	Het
Rbm48	C	T	5: 3,634,762 (GRCm39)	V401M	probably benign	Het
Retreg3	G	A	11: 100,991,751 (GRCm39)	Q61*	probably null	Het
Rif1	A	G	2: 51,975,152 (GRCm39)	M354V	possibly damaging	Het
Rrn3	G	A	16: 13,626,926 (GRCm39)	V507M	probably damaging	Het
Safb2	T	A	17: 56,872,242 (GRCm39)	R197*	probably null	Het
Slc22a26	A	G	19: 7,767,464 (GRCm39)	V314A	probably benign	Het
Slfnl1	G	T	4: 120,390,553 (GRCm39)	R68L	probably damaging	Het
Spata1	G	T	3: 146,181,997 (GRCm39)	Q10K	possibly damaging	Het
Swi5	T	C	2: 32,170,739 (GRCm39)	M95V	possibly damaging	Het
Thpo	T	C	16: 20,547,205 (GRCm39)	D52G	probably damaging	Het
Tmem101	A	T	11: 102,045,486 (GRCm39)	L121Q	probably damaging	Het
Trim40	T	C	17: 37,194,133 (GRCm39)	I187V	probably benign	Het
Usp33	A	G	3: 152,074,206 (GRCm39)	K351E	possibly damaging	Het
Uvrag	T	C	7: 98,767,431 (GRCm39)	T67A	probably damaging	Het
Vcan	T	C	13: 89,828,077 (GRCm39)	D2163G	probably damaging	Het
Wnt7a	C	T	6: 91,385,771 (GRCm39)	V61I	probably benign	Het
Zfp804b	A	G	5: 6,820,931 (GRCm39)	S675P	probably damaging	Het

Other mutations in Ifna16

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01779:Ifna16	APN	4	88,594,882 (GRCm39)	missense	probably damaging	1.00
IGL02717:Ifna16	APN	4	88,594,777 (GRCm39)	missense	possibly damaging	0.95
IGL03226:Ifna16	APN	4	88,594,741 (GRCm39)	missense	probably benign	0.18
R0040:Ifna16	UTSW	4	88,594,867 (GRCm39)	missense	probably benign	0.35
R0040:Ifna16	UTSW	4	88,594,867 (GRCm39)	missense	probably benign	0.35
R1514:Ifna16	UTSW	4	88,594,979 (GRCm39)	missense	possibly damaging	0.84
R2341:Ifna16	UTSW	4	88,594,565 (GRCm39)	missense	probably damaging	1.00
R4877:Ifna16	UTSW	4	88,594,681 (GRCm39)	missense	probably benign	0.00
R8989:Ifna16	UTSW	4	88,594,912 (GRCm39)	missense	probably damaging	1.00
R9619:Ifna16	UTSW	4	88,594,762 (GRCm39)	missense	probably benign	0.30
R9648:Ifna16	UTSW	4	88,595,060 (GRCm39)	missense	probably benign	0.18
R9688:Ifna16	UTSW	4	88,594,874 (GRCm39)	nonsense	probably null
R9743:Ifna16	UTSW	4	88,594,930 (GRCm39)	missense	probably damaging	1.00
Z1088:Ifna16	UTSW	4	88,594,615 (GRCm39)	missense	probably damaging	1.00

Posted On

2013-06-21