Incidental Mutation 'R6297:Or5m10'
ID 508820
Institutional Source Beutler Lab
Gene Symbol Or5m10
Ensembl Gene ENSMUSG00000050128
Gene Name olfactory receptor family 5 subfamily M member 10
Synonyms GA_x6K02T2Q125-47363965-47364900, MOR196-3, Olfr1023
MMRRC Submission 044464-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.066) question?
Stock # R6297 (G1)
Quality Score 225.009
Status Validated
Chromosome 2
Chromosomal Location 85717146-85718081 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 85717159 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Asparagine to Serine at position 5 (N5S)
Ref Sequence ENSEMBL: ENSMUSP00000149138 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000056408] [ENSMUST00000213441]
AlphaFold A2ASU6
Predicted Effect probably benign
Transcript: ENSMUST00000056408
AA Change: N5S

PolyPhen 2 Score 0.353 (Sensitivity: 0.90; Specificity: 0.89)
SMART Domains Protein: ENSMUSP00000059849
Gene: ENSMUSG00000050128
AA Change: N5S

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 2.6e-52 PFAM
Pfam:7TM_GPCR_Srsx 35 304 2.6e-7 PFAM
Pfam:7tm_1 41 290 2.4e-25 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000082871
Predicted Effect probably benign
Transcript: ENSMUST00000213441
AA Change: N5S

PolyPhen 2 Score 0.353 (Sensitivity: 0.90; Specificity: 0.89)
Meta Mutation Damage Score 0.0997 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.5%
  • 20x: 98.4%
Validation Efficiency 98% (45/46)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 47 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca4 T C 3: 121,926,179 (GRCm39) V1205A probably benign Het
Adgra3 G A 5: 50,118,189 (GRCm39) P1120S probably benign Het
Ate1 A G 7: 130,105,570 (GRCm39) V316A probably damaging Het
Bpifa1 A G 2: 153,986,180 (GRCm39) I102V probably benign Het
Catsperb A G 12: 101,557,655 (GRCm39) probably null Het
Ccdc47 T C 11: 106,094,427 (GRCm39) Y324C probably damaging Het
Cdh22 T C 2: 164,985,564 (GRCm39) K341E possibly damaging Het
Cenpb A G 2: 131,020,289 (GRCm39) probably benign Het
Dgkd A G 1: 87,853,866 (GRCm39) I570V possibly damaging Het
Dhx32 A T 7: 133,344,529 (GRCm39) Y27N probably damaging Het
Dnah10 A G 5: 124,852,144 (GRCm39) D1824G possibly damaging Het
Fbxo8 T A 8: 57,022,323 (GRCm39) C112S probably damaging Het
Fndc3a T C 14: 72,800,980 (GRCm39) D590G probably damaging Het
Gm19965 T A 1: 116,750,410 (GRCm39) I697N possibly damaging Het
Greb1l G A 18: 10,469,494 (GRCm39) D170N probably damaging Het
Haus5 C T 7: 30,358,401 (GRCm39) W298* probably null Het
Igfn1 A T 1: 135,892,399 (GRCm39) probably null Het
Ighg2b T C 12: 113,270,512 (GRCm39) E206G unknown Het
Ints15 A T 5: 143,293,787 (GRCm39) L230Q possibly damaging Het
Lman2 T C 13: 55,496,244 (GRCm39) N267S probably damaging Het
Lrfn5 A T 12: 61,890,348 (GRCm39) I546F probably benign Het
Lrrc4c T C 2: 97,459,964 (GRCm39) S197P probably damaging Het
Mbtd1 C T 11: 93,823,058 (GRCm39) H493Y possibly damaging Het
Mdga2 A G 12: 66,553,027 (GRCm39) Y793H probably damaging Het
Mdn1 C T 4: 32,730,054 (GRCm39) R2799* probably null Het
Mup13 T A 4: 61,181,634 (GRCm39) I148F probably benign Het
Or2aj5 A C 16: 19,424,680 (GRCm39) V246G possibly damaging Het
Or8g53 A T 9: 39,683,522 (GRCm39) D191E possibly damaging Het
Pdgfra A G 5: 75,334,135 (GRCm39) K403E possibly damaging Het
Pigz A T 16: 31,763,755 (GRCm39) Y271F probably damaging Het
Plekhg4 T C 8: 106,104,472 (GRCm39) L517P probably damaging Het
Rnf20 T C 4: 49,642,132 (GRCm39) L232P probably damaging Het
Rpa3 C A 6: 8,256,767 (GRCm39) G71* probably null Het
Rsf1 GCG GCGACGGCGTCG 7: 97,229,114 (GRCm39) probably benign Het
Rubcnl A G 14: 75,287,584 (GRCm39) T623A probably benign Het
Sltm A G 9: 70,488,641 (GRCm39) D597G probably damaging Het
Stpg2 T C 3: 139,407,432 (GRCm39) V528A possibly damaging Het
Supt6 C T 11: 78,116,885 (GRCm39) R589Q possibly damaging Het
Tas1r2 T A 4: 139,389,361 (GRCm39) M419K possibly damaging Het
Txndc16 T C 14: 45,389,243 (GRCm39) T486A probably benign Het
Vamp9 A G 5: 100,089,092 (GRCm39) Y119C probably damaging Het
Vmn1r185 A G 7: 26,311,046 (GRCm39) V153A probably benign Het
Vmn2r48 T C 7: 9,668,807 (GRCm39) N548D probably damaging Het
Washc5 A G 15: 59,215,895 (GRCm39) I378T possibly damaging Het
Wdr37 A G 13: 8,892,764 (GRCm39) probably null Het
Xrn2 G A 2: 146,868,490 (GRCm39) R181H probably damaging Het
Ylpm1 C G 12: 85,062,051 (GRCm39) P651A unknown Het
Other mutations in Or5m10
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01536:Or5m10 APN 2 85,717,944 (GRCm39) missense probably damaging 1.00
IGL01622:Or5m10 APN 2 85,717,306 (GRCm39) missense probably benign 0.01
IGL01623:Or5m10 APN 2 85,717,306 (GRCm39) missense probably benign 0.01
IGL01977:Or5m10 APN 2 85,717,711 (GRCm39) missense probably damaging 1.00
IGL02057:Or5m10 APN 2 85,717,275 (GRCm39) missense probably benign 0.00
IGL02555:Or5m10 APN 2 85,717,742 (GRCm39) missense probably benign 0.34
IGL03133:Or5m10 APN 2 85,717,478 (GRCm39) missense probably damaging 1.00
IGL03180:Or5m10 APN 2 85,717,740 (GRCm39) missense probably benign 0.00
R0415:Or5m10 UTSW 2 85,717,782 (GRCm39) missense possibly damaging 0.94
R1476:Or5m10 UTSW 2 85,717,592 (GRCm39) nonsense probably null
R1544:Or5m10 UTSW 2 85,717,615 (GRCm39) missense probably damaging 1.00
R2058:Or5m10 UTSW 2 85,717,296 (GRCm39) missense possibly damaging 0.48
R4096:Or5m10 UTSW 2 85,717,767 (GRCm39) missense probably damaging 0.98
R5055:Or5m10 UTSW 2 85,717,585 (GRCm39) missense probably benign 0.12
R5703:Or5m10 UTSW 2 85,717,783 (GRCm39) missense probably benign 0.06
R7041:Or5m10 UTSW 2 85,717,965 (GRCm39) missense probably benign 0.01
R7070:Or5m10 UTSW 2 85,718,034 (GRCm39) missense probably benign 0.13
R7563:Or5m10 UTSW 2 85,717,482 (GRCm39) missense probably damaging 0.98
R7777:Or5m10 UTSW 2 85,717,951 (GRCm39) missense possibly damaging 0.83
R7913:Or5m10 UTSW 2 85,718,074 (GRCm39) missense probably damaging 0.96
R9060:Or5m10 UTSW 2 85,717,920 (GRCm39) missense probably benign 0.06
R9789:Or5m10 UTSW 2 85,717,338 (GRCm39) missense probably damaging 1.00
S24628:Or5m10 UTSW 2 85,717,782 (GRCm39) missense possibly damaging 0.94
Predicted Primers PCR Primer
(F):5'- GCATGTGTACATTATGCATACAGAG -3'
(R):5'- TCTACAAAGGAGAGGTGGCC -3'

Sequencing Primer
(F):5'- TGTACATTATGCATACAGAGAAAGTG -3'
(R):5'- CAAGGAAGAAATACATAGGTGTTTGC -3'
Posted On 2018-04-02