Incidental Mutation 'R6297:Tas1r2'
ID 508831
Institutional Source Beutler Lab
Gene Symbol Tas1r2
Ensembl Gene ENSMUSG00000028738
Gene Name taste receptor, type 1, member 2
Synonyms TR2, Gpr71, T1r2
MMRRC Submission 044464-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.108) question?
Stock # R6297 (G1)
Quality Score 225.009
Status Validated
Chromosome 4
Chromosomal Location 139380849-139397591 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 139389361 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Methionine to Lysine at position 419 (M419K)
Ref Sequence ENSEMBL: ENSMUSP00000127737 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000030510] [ENSMUST00000166773] [ENSMUST00000178644]
AlphaFold Q925I4
Predicted Effect probably benign
Transcript: ENSMUST00000030510
AA Change: M448K

PolyPhen 2 Score 0.082 (Sensitivity: 0.93; Specificity: 0.85)
SMART Domains Protein: ENSMUSP00000030510
Gene: ENSMUSG00000028738
AA Change: M448K

DomainStartEndE-ValueType
signal peptide 1 24 N/A INTRINSIC
Pfam:ANF_receptor 73 459 2e-90 PFAM
Pfam:NCD3G 495 548 2.4e-17 PFAM
Pfam:7tm_3 581 818 2.8e-33 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000166773
AA Change: M419K

PolyPhen 2 Score 0.473 (Sensitivity: 0.89; Specificity: 0.90)
SMART Domains Protein: ENSMUSP00000127737
Gene: ENSMUSG00000028738
AA Change: M419K

DomainStartEndE-ValueType
signal peptide 1 24 N/A INTRINSIC
Pfam:ANF_receptor 73 213 5.3e-38 PFAM
Pfam:ANF_receptor 217 429 8.4e-31 PFAM
Pfam:NCD3G 466 519 7.4e-19 PFAM
Pfam:7tm_3 550 790 3e-47 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000178644
SMART Domains Protein: ENSMUSP00000136776
Gene: ENSMUSG00000094439

DomainStartEndE-ValueType
SCOP:d1lbva_ 1 60 5e-3 SMART
Pfam:Filament 165 253 7.3e-13 PFAM
low complexity region 255 268 N/A INTRINSIC
Meta Mutation Damage Score 0.1795 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.5%
  • 20x: 98.4%
Validation Efficiency 98% (45/46)
MGI Phenotype PHENOTYPE: Homozygous mutant mice show diminished behavioral and nervous responses to sweet tastants. Response to umami tastants is unimpaired. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 47 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca4 T C 3: 121,926,179 (GRCm39) V1205A probably benign Het
Adgra3 G A 5: 50,118,189 (GRCm39) P1120S probably benign Het
Ate1 A G 7: 130,105,570 (GRCm39) V316A probably damaging Het
Bpifa1 A G 2: 153,986,180 (GRCm39) I102V probably benign Het
Catsperb A G 12: 101,557,655 (GRCm39) probably null Het
Ccdc47 T C 11: 106,094,427 (GRCm39) Y324C probably damaging Het
Cdh22 T C 2: 164,985,564 (GRCm39) K341E possibly damaging Het
Cenpb A G 2: 131,020,289 (GRCm39) probably benign Het
Dgkd A G 1: 87,853,866 (GRCm39) I570V possibly damaging Het
Dhx32 A T 7: 133,344,529 (GRCm39) Y27N probably damaging Het
Dnah10 A G 5: 124,852,144 (GRCm39) D1824G possibly damaging Het
Fbxo8 T A 8: 57,022,323 (GRCm39) C112S probably damaging Het
Fndc3a T C 14: 72,800,980 (GRCm39) D590G probably damaging Het
Gm19965 T A 1: 116,750,410 (GRCm39) I697N possibly damaging Het
Greb1l G A 18: 10,469,494 (GRCm39) D170N probably damaging Het
Haus5 C T 7: 30,358,401 (GRCm39) W298* probably null Het
Igfn1 A T 1: 135,892,399 (GRCm39) probably null Het
Ighg2b T C 12: 113,270,512 (GRCm39) E206G unknown Het
Ints15 A T 5: 143,293,787 (GRCm39) L230Q possibly damaging Het
Lman2 T C 13: 55,496,244 (GRCm39) N267S probably damaging Het
Lrfn5 A T 12: 61,890,348 (GRCm39) I546F probably benign Het
Lrrc4c T C 2: 97,459,964 (GRCm39) S197P probably damaging Het
Mbtd1 C T 11: 93,823,058 (GRCm39) H493Y possibly damaging Het
Mdga2 A G 12: 66,553,027 (GRCm39) Y793H probably damaging Het
Mdn1 C T 4: 32,730,054 (GRCm39) R2799* probably null Het
Mup13 T A 4: 61,181,634 (GRCm39) I148F probably benign Het
Or2aj5 A C 16: 19,424,680 (GRCm39) V246G possibly damaging Het
Or5m10 A G 2: 85,717,159 (GRCm39) N5S probably benign Het
Or8g53 A T 9: 39,683,522 (GRCm39) D191E possibly damaging Het
Pdgfra A G 5: 75,334,135 (GRCm39) K403E possibly damaging Het
Pigz A T 16: 31,763,755 (GRCm39) Y271F probably damaging Het
Plekhg4 T C 8: 106,104,472 (GRCm39) L517P probably damaging Het
Rnf20 T C 4: 49,642,132 (GRCm39) L232P probably damaging Het
Rpa3 C A 6: 8,256,767 (GRCm39) G71* probably null Het
Rsf1 GCG GCGACGGCGTCG 7: 97,229,114 (GRCm39) probably benign Het
Rubcnl A G 14: 75,287,584 (GRCm39) T623A probably benign Het
Sltm A G 9: 70,488,641 (GRCm39) D597G probably damaging Het
Stpg2 T C 3: 139,407,432 (GRCm39) V528A possibly damaging Het
Supt6 C T 11: 78,116,885 (GRCm39) R589Q possibly damaging Het
Txndc16 T C 14: 45,389,243 (GRCm39) T486A probably benign Het
Vamp9 A G 5: 100,089,092 (GRCm39) Y119C probably damaging Het
Vmn1r185 A G 7: 26,311,046 (GRCm39) V153A probably benign Het
Vmn2r48 T C 7: 9,668,807 (GRCm39) N548D probably damaging Het
Washc5 A G 15: 59,215,895 (GRCm39) I378T possibly damaging Het
Wdr37 A G 13: 8,892,764 (GRCm39) probably null Het
Xrn2 G A 2: 146,868,490 (GRCm39) R181H probably damaging Het
Ylpm1 C G 12: 85,062,051 (GRCm39) P651A unknown Het
Other mutations in Tas1r2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00911:Tas1r2 APN 4 139,387,602 (GRCm39) missense probably benign 0.03
IGL00952:Tas1r2 APN 4 139,382,563 (GRCm39) missense probably benign 0.00
IGL00972:Tas1r2 APN 4 139,387,347 (GRCm39) missense probably damaging 0.99
IGL01939:Tas1r2 APN 4 139,396,488 (GRCm39) missense probably damaging 1.00
IGL02247:Tas1r2 APN 4 139,396,827 (GRCm39) missense probably damaging 1.00
IGL02663:Tas1r2 APN 4 139,387,593 (GRCm39) missense probably benign
IGL03155:Tas1r2 APN 4 139,396,467 (GRCm39) missense possibly damaging 0.95
R0395:Tas1r2 UTSW 4 139,382,665 (GRCm39) missense possibly damaging 0.86
R0798:Tas1r2 UTSW 4 139,397,024 (GRCm39) missense probably damaging 1.00
R1221:Tas1r2 UTSW 4 139,396,436 (GRCm39) missense probably benign 0.00
R1223:Tas1r2 UTSW 4 139,387,515 (GRCm39) missense probably damaging 1.00
R1261:Tas1r2 UTSW 4 139,382,599 (GRCm39) missense probably damaging 0.99
R1262:Tas1r2 UTSW 4 139,382,599 (GRCm39) missense probably damaging 0.99
R1330:Tas1r2 UTSW 4 139,396,640 (GRCm39) missense probably benign 0.05
R1466:Tas1r2 UTSW 4 139,396,722 (GRCm39) missense probably damaging 1.00
R1466:Tas1r2 UTSW 4 139,396,722 (GRCm39) missense probably damaging 1.00
R1879:Tas1r2 UTSW 4 139,397,006 (GRCm39) missense probably damaging 1.00
R2112:Tas1r2 UTSW 4 139,382,666 (GRCm39) missense probably benign 0.00
R2156:Tas1r2 UTSW 4 139,396,352 (GRCm39) missense possibly damaging 0.79
R2509:Tas1r2 UTSW 4 139,387,162 (GRCm39) missense probably damaging 1.00
R2510:Tas1r2 UTSW 4 139,387,162 (GRCm39) missense probably damaging 1.00
R2511:Tas1r2 UTSW 4 139,387,162 (GRCm39) missense probably damaging 1.00
R3429:Tas1r2 UTSW 4 139,396,886 (GRCm39) missense probably damaging 1.00
R3430:Tas1r2 UTSW 4 139,396,886 (GRCm39) missense probably damaging 1.00
R3703:Tas1r2 UTSW 4 139,394,729 (GRCm39) missense probably damaging 1.00
R4105:Tas1r2 UTSW 4 139,387,363 (GRCm39) missense probably benign 0.06
R4106:Tas1r2 UTSW 4 139,387,363 (GRCm39) missense probably benign 0.06
R4107:Tas1r2 UTSW 4 139,387,363 (GRCm39) missense probably benign 0.06
R4614:Tas1r2 UTSW 4 139,387,098 (GRCm39) missense probably damaging 1.00
R4811:Tas1r2 UTSW 4 139,396,311 (GRCm39) missense probably damaging 1.00
R5314:Tas1r2 UTSW 4 139,382,672 (GRCm39) missense probably damaging 1.00
R5461:Tas1r2 UTSW 4 139,387,320 (GRCm39) missense probably benign 0.01
R5639:Tas1r2 UTSW 4 139,387,107 (GRCm39) missense probably damaging 1.00
R5703:Tas1r2 UTSW 4 139,394,647 (GRCm39) missense probably damaging 1.00
R6176:Tas1r2 UTSW 4 139,396,199 (GRCm39) missense probably damaging 1.00
R6441:Tas1r2 UTSW 4 139,396,467 (GRCm39) missense probably damaging 0.99
R6748:Tas1r2 UTSW 4 139,396,922 (GRCm39) missense probably damaging 0.98
R6863:Tas1r2 UTSW 4 139,397,030 (GRCm39) missense probably damaging 1.00
R6975:Tas1r2 UTSW 4 139,397,031 (GRCm39) missense probably damaging 1.00
R7106:Tas1r2 UTSW 4 139,389,360 (GRCm39) missense probably benign
R7265:Tas1r2 UTSW 4 139,396,963 (GRCm39) missense probably benign 0.01
R7580:Tas1r2 UTSW 4 139,387,056 (GRCm39) missense probably benign 0.05
R7651:Tas1r2 UTSW 4 139,396,938 (GRCm39) missense probably benign 0.14
R8041:Tas1r2 UTSW 4 139,387,290 (GRCm39) missense possibly damaging 0.65
R8530:Tas1r2 UTSW 4 139,389,460 (GRCm39) missense probably benign
R8747:Tas1r2 UTSW 4 139,387,318 (GRCm39) missense probably benign
R8824:Tas1r2 UTSW 4 139,381,074 (GRCm39) splice site probably benign
R8904:Tas1r2 UTSW 4 139,394,714 (GRCm39) missense probably damaging 1.00
R8906:Tas1r2 UTSW 4 139,397,046 (GRCm39) missense probably damaging 1.00
R9315:Tas1r2 UTSW 4 139,381,046 (GRCm39) missense possibly damaging 0.91
R9336:Tas1r2 UTSW 4 139,389,316 (GRCm39) missense probably damaging 1.00
R9419:Tas1r2 UTSW 4 139,387,036 (GRCm39) missense possibly damaging 0.65
R9776:Tas1r2 UTSW 4 139,396,208 (GRCm39) missense possibly damaging 0.68
Z1088:Tas1r2 UTSW 4 139,387,735 (GRCm39) missense possibly damaging 0.90
Predicted Primers PCR Primer
(F):5'- GTTCCATGGCCCCAATGTTC -3'
(R):5'- AGGACATGACCCTAGCTAGAC -3'

Sequencing Primer
(F):5'- CCCAATGTTCCTAATAGACAGGTG -3'
(R):5'- GGAGCCCCTTCCTGACAAG -3'
Posted On 2018-04-02