Incidental Mutation 'R6299:Vmn2r75'
ID 508969
Institutional Source Beutler Lab
Gene Symbol Vmn2r75
Ensembl Gene ENSMUSG00000090436
Gene Name vomeronasal 2, receptor 75
Synonyms EG546981
MMRRC Submission 044465-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.090) question?
Stock # R6299 (G1)
Quality Score 225.009
Status Validated
Chromosome 7
Chromosomal Location 85797250-85820932 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 85814482 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Histidine to Leucine at position 337 (H337L)
Ref Sequence ENSEMBL: ENSMUSP00000126973 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000167830]
AlphaFold G5E8Z7
Predicted Effect probably benign
Transcript: ENSMUST00000167830
AA Change: H337L

PolyPhen 2 Score 0.122 (Sensitivity: 0.93; Specificity: 0.86)
SMART Domains Protein: ENSMUSP00000126973
Gene: ENSMUSG00000090436
AA Change: H337L

DomainStartEndE-ValueType
signal peptide 1 21 N/A INTRINSIC
Pfam:ANF_receptor 80 466 2.8e-31 PFAM
Pfam:NCD3G 510 562 4.6e-20 PFAM
Pfam:7tm_3 593 829 7.7e-51 PFAM
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.4%
  • 20x: 98.2%
Validation Efficiency 100% (61/61)
Allele List at MGI
Other mutations in this stock
Total: 61 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Bms1 G A 6: 118,395,476 (GRCm39) R24W probably damaging Het
C130050O18Rik A T 5: 139,400,126 (GRCm39) S60C probably damaging Het
Cabcoco1 A G 10: 68,272,720 (GRCm39) Y222H probably damaging Het
Cc2d1b T C 4: 108,485,335 (GRCm39) V559A probably benign Het
Cgrrf1 T A 14: 47,077,647 (GRCm39) N46K probably damaging Het
Clca3a1 T C 3: 144,464,275 (GRCm39) D114G probably damaging Het
Clcnkb T A 4: 141,138,034 (GRCm39) L279F probably damaging Het
Cr2 T C 1: 194,850,954 (GRCm39) T151A probably damaging Het
Creb3l3 C T 10: 80,924,447 (GRCm39) E236K probably damaging Het
Dcstamp T A 15: 39,618,599 (GRCm39) V336D probably damaging Het
Dop1a T G 9: 86,386,265 (GRCm39) F379V probably damaging Het
Esf1 T C 2: 139,965,554 (GRCm39) K714R possibly damaging Het
Exoc3l4 A T 12: 111,388,513 (GRCm39) M1L possibly damaging Het
Extl3 T C 14: 65,314,121 (GRCm39) R354G probably benign Het
Fastkd3 T C 13: 68,735,855 (GRCm39) L535P probably damaging Het
Gab2 A G 7: 96,731,066 (GRCm39) T12A probably benign Het
Gm10549 C A 18: 33,597,358 (GRCm39) probably benign Het
Golga4 T A 9: 118,386,438 (GRCm39) S1187T probably benign Het
Haus3 A G 5: 34,325,140 (GRCm39) V173A probably benign Het
Herc2 T A 7: 55,784,803 (GRCm39) Y1416N possibly damaging Het
Hspg2 A G 4: 137,272,016 (GRCm39) Y2566C probably damaging Het
Inpp5f A T 7: 128,237,884 (GRCm39) T34S possibly damaging Het
Iqck G A 7: 118,475,485 (GRCm39) G70S unknown Het
Jade1 T C 3: 41,568,160 (GRCm39) F743L probably damaging Het
Kif5a T C 10: 127,069,690 (GRCm39) K845R probably damaging Het
Klhl30 A G 1: 91,285,636 (GRCm39) probably null Het
Map2k1 T C 9: 64,121,772 (GRCm39) D67G possibly damaging Het
Mcm9 A C 10: 53,413,777 (GRCm39) C434W probably damaging Het
Muc4 T G 16: 32,570,853 (GRCm39) S638A possibly damaging Het
Nectin3 A G 16: 46,284,345 (GRCm39) V113A probably damaging Het
Nfya T C 17: 48,699,938 (GRCm39) probably benign Het
Nup155 G T 15: 8,157,922 (GRCm39) A460S possibly damaging Het
Nup210 T C 6: 91,051,270 (GRCm39) E371G possibly damaging Het
Olfm3 T C 3: 114,914,632 (GRCm39) S228P probably damaging Het
Or52n20 C A 7: 104,320,075 (GRCm39) D55E probably benign Het
Or8b51 A T 9: 38,569,073 (GRCm39) I205N possibly damaging Het
Plin1 A C 7: 79,371,224 (GRCm39) V500G probably benign Het
Ppfia1 A C 7: 144,064,049 (GRCm39) M513R probably benign Het
Ppp1cb T A 5: 32,640,798 (GRCm39) C27* probably null Het
Prss22 T A 17: 24,215,408 (GRCm39) I123F probably damaging Het
Rbm24 G T 13: 46,572,549 (GRCm39) V15L probably damaging Het
Reln T C 5: 22,491,942 (GRCm39) T97A possibly damaging Het
Sipa1l2 T C 8: 126,180,203 (GRCm39) T1065A possibly damaging Het
Sipa1l3 A C 7: 29,065,974 (GRCm39) probably null Het
Snrnp200 T A 2: 127,064,081 (GRCm39) Y689* probably null Het
Srcap T C 7: 127,129,626 (GRCm39) probably benign Het
Sv2a T C 3: 96,095,565 (GRCm39) probably null Het
Tcf12 A T 9: 71,766,211 (GRCm39) V474D probably damaging Het
Tpcn2 A T 7: 144,815,980 (GRCm39) S403T probably damaging Het
Trim65 C A 11: 116,017,377 (GRCm39) A362S probably benign Het
Trmt1 T A 8: 85,423,919 (GRCm39) C36* probably null Het
Trpm8 T A 1: 88,282,201 (GRCm39) L699Q probably damaging Het
Ube2m A C 7: 12,769,797 (GRCm39) I116R probably damaging Het
Ulk1 T C 5: 110,938,963 (GRCm39) K492E possibly damaging Het
Usp40 T A 1: 87,925,649 (GRCm39) K193N probably damaging Het
Vmn1r3 A G 4: 3,185,098 (GRCm39) S70P possibly damaging Het
Vmn2r2 T A 3: 64,024,074 (GRCm39) K836* probably null Het
Wars1 G A 12: 108,827,309 (GRCm39) T437M probably benign Het
Zdhhc5 T C 2: 84,520,825 (GRCm39) T451A probably benign Het
Zfp788 T G 7: 41,297,965 (GRCm39) H180Q possibly damaging Het
Zkscan7 A G 9: 122,717,782 (GRCm39) E59G probably damaging Het
Other mutations in Vmn2r75
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01133:Vmn2r75 APN 7 85,797,240 (GRCm39) unclassified probably benign
IGL01287:Vmn2r75 APN 7 85,797,801 (GRCm39) missense probably damaging 0.97
IGL01318:Vmn2r75 APN 7 85,814,774 (GRCm39) missense probably benign 0.06
IGL01331:Vmn2r75 APN 7 85,820,870 (GRCm39) nonsense probably null
IGL01406:Vmn2r75 APN 7 85,812,500 (GRCm39) splice site probably benign
IGL01615:Vmn2r75 APN 7 85,797,681 (GRCm39) missense probably benign 0.03
IGL01657:Vmn2r75 APN 7 85,813,455 (GRCm39) missense probably damaging 1.00
IGL02237:Vmn2r75 APN 7 85,814,786 (GRCm39) missense possibly damaging 0.88
IGL02275:Vmn2r75 APN 7 85,814,348 (GRCm39) missense probably benign 0.04
IGL02307:Vmn2r75 APN 7 85,814,974 (GRCm39) missense probably benign 0.00
IGL03136:Vmn2r75 APN 7 85,797,911 (GRCm39) missense possibly damaging 0.89
IGL03160:Vmn2r75 APN 7 85,797,644 (GRCm39) missense probably damaging 1.00
IGL03244:Vmn2r75 APN 7 85,820,933 (GRCm39) unclassified probably benign
PIT4449001:Vmn2r75 UTSW 7 85,814,791 (GRCm39) missense probably damaging 1.00
R0049:Vmn2r75 UTSW 7 85,797,309 (GRCm39) nonsense probably null
R0049:Vmn2r75 UTSW 7 85,797,309 (GRCm39) nonsense probably null
R0083:Vmn2r75 UTSW 7 85,814,866 (GRCm39) missense probably benign 0.00
R0108:Vmn2r75 UTSW 7 85,814,866 (GRCm39) missense probably benign 0.00
R0276:Vmn2r75 UTSW 7 85,797,515 (GRCm39) missense probably benign 0.01
R0320:Vmn2r75 UTSW 7 85,814,288 (GRCm39) missense probably benign 0.36
R0471:Vmn2r75 UTSW 7 85,814,721 (GRCm39) missense probably benign 0.01
R0562:Vmn2r75 UTSW 7 85,797,449 (GRCm39) nonsense probably null
R0631:Vmn2r75 UTSW 7 85,812,478 (GRCm39) missense probably null 1.00
R0661:Vmn2r75 UTSW 7 85,814,866 (GRCm39) missense probably benign 0.00
R0811:Vmn2r75 UTSW 7 85,814,575 (GRCm39) missense probably benign 0.38
R0812:Vmn2r75 UTSW 7 85,814,575 (GRCm39) missense probably benign 0.38
R0891:Vmn2r75 UTSW 7 85,813,476 (GRCm39) missense possibly damaging 0.81
R1340:Vmn2r75 UTSW 7 85,797,798 (GRCm39) missense probably damaging 0.98
R1501:Vmn2r75 UTSW 7 85,814,850 (GRCm39) missense possibly damaging 0.85
R1760:Vmn2r75 UTSW 7 85,798,019 (GRCm39) missense probably damaging 1.00
R1970:Vmn2r75 UTSW 7 85,797,470 (GRCm39) missense probably damaging 1.00
R2060:Vmn2r75 UTSW 7 85,814,372 (GRCm39) missense probably benign 0.00
R2292:Vmn2r75 UTSW 7 85,798,144 (GRCm39) missense probably damaging 1.00
R3688:Vmn2r75 UTSW 7 85,797,629 (GRCm39) missense probably damaging 0.99
R3892:Vmn2r75 UTSW 7 85,813,494 (GRCm39) missense probably null 1.00
R4532:Vmn2r75 UTSW 7 85,797,349 (GRCm39) nonsense probably null
R4583:Vmn2r75 UTSW 7 85,813,290 (GRCm39) missense possibly damaging 0.81
R4592:Vmn2r75 UTSW 7 85,815,494 (GRCm39) missense probably benign 0.00
R4792:Vmn2r75 UTSW 7 85,812,378 (GRCm39) missense possibly damaging 0.46
R4859:Vmn2r75 UTSW 7 85,797,611 (GRCm39) missense probably benign 0.35
R4896:Vmn2r75 UTSW 7 85,820,787 (GRCm39) missense probably benign 0.01
R4943:Vmn2r75 UTSW 7 85,814,705 (GRCm39) missense probably damaging 1.00
R4992:Vmn2r75 UTSW 7 85,815,375 (GRCm39) critical splice donor site probably null
R5048:Vmn2r75 UTSW 7 85,814,735 (GRCm39) missense possibly damaging 0.66
R5063:Vmn2r75 UTSW 7 85,813,372 (GRCm39) missense probably benign
R5156:Vmn2r75 UTSW 7 85,813,436 (GRCm39) missense possibly damaging 0.51
R5243:Vmn2r75 UTSW 7 85,813,447 (GRCm39) missense probably damaging 1.00
R5277:Vmn2r75 UTSW 7 85,815,500 (GRCm39) missense probably benign
R5574:Vmn2r75 UTSW 7 85,815,510 (GRCm39) missense probably benign 0.22
R5622:Vmn2r75 UTSW 7 85,797,702 (GRCm39) missense probably benign 0.15
R5680:Vmn2r75 UTSW 7 85,820,779 (GRCm39) missense probably benign 0.10
R5884:Vmn2r75 UTSW 7 85,814,578 (GRCm39) missense probably benign
R6021:Vmn2r75 UTSW 7 85,820,820 (GRCm39) missense probably benign 0.01
R6217:Vmn2r75 UTSW 7 85,815,375 (GRCm39) critical splice donor site probably benign
R6242:Vmn2r75 UTSW 7 85,814,592 (GRCm39) missense probably damaging 1.00
R6441:Vmn2r75 UTSW 7 85,820,784 (GRCm39) missense probably damaging 0.99
R6495:Vmn2r75 UTSW 7 85,813,287 (GRCm39) missense probably benign 0.00
R6553:Vmn2r75 UTSW 7 85,813,453 (GRCm39) missense probably benign 0.28
R6670:Vmn2r75 UTSW 7 85,797,644 (GRCm39) missense probably damaging 1.00
R7078:Vmn2r75 UTSW 7 85,815,568 (GRCm39) missense probably damaging 1.00
R7164:Vmn2r75 UTSW 7 85,814,592 (GRCm39) missense probably damaging 1.00
R8411:Vmn2r75 UTSW 7 85,797,722 (GRCm39) missense probably damaging 1.00
R8507:Vmn2r75 UTSW 7 85,797,685 (GRCm39) nonsense probably null
R8559:Vmn2r75 UTSW 7 85,815,480 (GRCm39) missense possibly damaging 0.65
R8677:Vmn2r75 UTSW 7 85,814,410 (GRCm39) missense possibly damaging 0.86
R8708:Vmn2r75 UTSW 7 85,812,476 (GRCm39) missense probably damaging 0.99
R8778:Vmn2r75 UTSW 7 85,813,497 (GRCm39) missense probably benign 0.40
R8968:Vmn2r75 UTSW 7 85,820,765 (GRCm39) nonsense probably null
R9145:Vmn2r75 UTSW 7 85,813,447 (GRCm39) missense probably damaging 1.00
R9316:Vmn2r75 UTSW 7 85,797,313 (GRCm39) missense possibly damaging 0.63
R9363:Vmn2r75 UTSW 7 85,815,423 (GRCm39) missense probably benign 0.03
Predicted Primers PCR Primer
(F):5'- CCGTCCCAGCATTTGTTGAC -3'
(R):5'- CCCTCATTATGTGGAAATCTGAAGG -3'

Sequencing Primer
(F):5'- CCATATGTCTACTTGTTGCAGAAGC -3'
(R):5'- ATCTGAAGGCATTTGGAGAATCTG -3'
Posted On 2018-04-02